AR002280A1 - Un compuesto derivado del acido poli-pirrol-carboxamidonaftalenico, un procedimiento para su preparacion, una composicion farmaceutica que lo contieney un procedimiento para mejorar la biodisponibilidad sistemica de un compuesto biologicamente activo. - Google Patents

Un compuesto derivado del acido poli-pirrol-carboxamidonaftalenico, un procedimiento para su preparacion, una composicion farmaceutica que lo contieney un procedimiento para mejorar la biodisponibilidad sistemica de un compuesto biologicamente activo.

Info

Publication number
AR002280A1
AR002280A1 ARP960101576A AR10157696A AR002280A1 AR 002280 A1 AR002280 A1 AR 002280A1 AR P960101576 A ARP960101576 A AR P960101576A AR 10157696 A AR10157696 A AR 10157696A AR 002280 A1 AR002280 A1 AR 002280A1
Authority
AR
Argentina
Prior art keywords
procedure
biologically active
acid
poly
active compound
Prior art date
Application number
ARP960101576A
Other languages
English (en)
Inventor
Nicola Mongelli
Giovanni Biasoli
Borgia Andrea Lombardi
Ciomei
Original Assignee
Pharmacia Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Spa filed Critical Pharmacia Spa
Publication of AR002280A1 publication Critical patent/AR002280A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Compositions Of Macromolecular Compounds (AREA)

Abstract

Se provee un compuesto derivado del ácido ácido-poli-pirrol-carboxamidonaftalénico de fórmula (II); en donde R es ungrupo ácido; m es un entero de 1 a 3; n es cero o un entero de 1 a 3; A es un espaciador enzimáticamente hidrolizable; y X es un compuesto biológicamenteactivo; o una sal farmacéuticamente aceptable del mismo, para usar como un agente antiproliferativo, en particular antitumoral y antiangiogénico y como unagente antiinflamatorio. Además se provee un procedimiento para su preparación, una composición farmacéutica que lo contiene y un procedimiento para mejorarla biodisponibilidad sistémica de un compuesto X biológicamente activo.
ARP960101576A 1995-03-01 1996-02-29 Un compuesto derivado del acido poli-pirrol-carboxamidonaftalenico, un procedimiento para su preparacion, una composicion farmaceutica que lo contieney un procedimiento para mejorar la biodisponibilidad sistemica de un compuesto biologicamente activo. AR002280A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9504065.5A GB9504065D0 (en) 1995-03-01 1995-03-01 Poly-pyrrolecarboxamidonaphthalenic acid derivatives

Publications (1)

Publication Number Publication Date
AR002280A1 true AR002280A1 (es) 1998-03-11

Family

ID=10770421

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP960101576A AR002280A1 (es) 1995-03-01 1996-02-29 Un compuesto derivado del acido poli-pirrol-carboxamidonaftalenico, un procedimiento para su preparacion, una composicion farmaceutica que lo contieney un procedimiento para mejorar la biodisponibilidad sistemica de un compuesto biologicamente activo.

Country Status (18)

Country Link
EP (1) EP0758339A1 (es)
JP (1) JPH10504319A (es)
KR (1) KR970702868A (es)
CN (1) CN1148391A (es)
AR (1) AR002280A1 (es)
AU (1) AU696470B2 (es)
CA (1) CA2189358A1 (es)
EA (1) EA000006B1 (es)
FI (1) FI964331A (es)
GB (1) GB9504065D0 (es)
HU (1) HUP9603305A3 (es)
IL (1) IL117193A0 (es)
MX (1) MX9605089A (es)
NO (1) NO964610L (es)
NZ (1) NZ302267A (es)
PL (1) PL317094A1 (es)
WO (1) WO1996026950A1 (es)
ZA (1) ZA961636B (es)

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WO1998014459A1 (de) * 1996-09-30 1998-04-09 Bayer Aktiengesellschaft Glycokonjugate von modifizierten camptothecin-derivaten (20-o-verknüpfung)
DE19640969A1 (de) * 1996-10-04 1998-04-16 Bayer Ag 20-0-verknüpfte Glycokonjugate von Camptothecin
ID23424A (id) * 1997-05-14 2000-04-20 Bayer Ag Glikokonjugat dari 20(s)-kamptotesin
GB9713732D0 (en) * 1997-06-27 1997-09-03 Pharmacia & Upjohn Spa Substituted triazinic compounds
GB9713733D0 (en) * 1997-06-27 1997-09-03 Pharmacia & Upjohn Spa Poly-branched polycarboxamido compounds
US6485514B1 (en) 1997-12-12 2002-11-26 Supergen, Inc. Local delivery of therapeutic agents
US6288072B1 (en) * 1999-12-29 2001-09-11 Monroe E. Wall Camptothecin β-alanine esters with topoisomerase I inhibition
US6350756B1 (en) 2001-01-18 2002-02-26 California Pacific Medical Center Camptothecin derivatives
US6403604B1 (en) 2001-03-01 2002-06-11 California Pacific Medical Center Nitrogen-based camptothecin derivatives
US6855720B2 (en) 2001-03-01 2005-02-15 California Pacific Medical Center Nitrogen-based camptothecin derivatives
JP2005505507A (ja) 2001-06-13 2005-02-24 ジーンソフト ファーマシューティカルズ インコーポレイテッド 抗感染活性を有するイソキノリン化合物
CA2486106C (en) * 2002-05-16 2013-07-16 Glycomimetics, Inc. Compounds and methods for inhibiting selectin-mediated function
AU2003243380A1 (en) 2002-06-03 2003-12-19 California Pacific Medical Center Nitrogen-based homo-camptothecin derivatives
DE60326735D1 (de) 2002-08-02 2009-04-30 Genesoft Pharmaceuticals Inc Biaryl-verbindungen mit antiinfektiver wirkung
WO2004039318A2 (en) 2002-10-25 2004-05-13 Genesoft Pharmaceuticals, Inc. Anti-infective biaryl compounds
JP2006509027A (ja) 2002-12-10 2006-03-16 オーシェント ファーマシューティカルズ コーポレーション （ピロールカルボキサミド）−（ベンズアミド）−（イミダゾールカルボキサミド）モチーフを有する抗菌化合物
AU2006284578B2 (en) 2005-09-02 2011-01-27 Glycomimetics, Inc. Heterobifunctional pan-selectin inhibitors
US7875602B2 (en) * 2005-10-21 2011-01-25 Sutter West Bay Hospitals Camptothecin derivatives as chemoradiosensitizing agents
WO2009126556A1 (en) 2008-04-08 2009-10-15 Glycomimetics, Inc. Pan-selectin inhibitor with enhanced pharmacokinetic activity
WO2011163568A1 (en) * 2010-06-24 2011-12-29 University Of Kansas Conjugates comprising an n-oxime bond and associated methods
WO2012037034A1 (en) 2010-09-14 2012-03-22 Glycomimetics, Inc. E-selectin antagonists
JP2015500887A (ja) 2011-12-22 2015-01-08 グリコミメティクス， インコーポレイテッド Ｅ−セレクチンアンタゴニスト化合物、組成物および使用方法
AU2013355238B2 (en) 2012-12-07 2017-12-14 Glycomimetics, Inc. Compounds, compositions and methods using E-selectin antagonists for mobilization of hematopoietic cells
SI3227310T1 (sl) 2014-12-03 2019-11-29 Glycomimetics Inc Heterobifunkcionalni inhibitorji e-selektinov in receptorjev kemokina CXCR4
CA3009836A1 (en) 2016-01-22 2017-07-27 Glycomimetics, Inc. Glycomimetic inhibitors of pa-il and pa-iil lectins
US11291678B2 (en) 2016-03-02 2022-04-05 Glycomimetics, Inc Methods for the treatment and/or prevention of cardiovascular disease by inhibition of E-selectin
WO2018031445A1 (en) 2016-08-08 2018-02-15 Glycomimetics, Inc. Combination of t-cell checkpoint inhibitors with inhibitors of e-selectin or cxcr4, or with heterobifunctional inhibitors of both e-selectin and cxcr4
JP7069136B2 (ja) 2016-10-07 2022-05-17 グリコミメティクス， インコーポレイテッド 極めて強力な多量体ｅ－セレクチンアンタゴニスト
EP3596096A1 (en) 2017-03-15 2020-01-22 GlycoMimetics, Inc. Galactopyranosyl-cyclohexyl derivatives as e-selectin antagonists
EP3381897A1 (en) 2017-03-27 2018-10-03 Leadiant Biosciences SA Derivatives of the disodium 2,2'-{carbonylbis[imino-3,1-phenylenecarbonylimino(1-methyl-1h-pyrrole-4,2-diyl)carbonylimino]}dinaphthalene-1,5-disulfonate salt and related compounds as heparanase inhibitors for the treatment of cancer
JP7275131B2 (ja) 2017-11-30 2023-05-17 グリコミメティクス， インコーポレイテッド 骨髄浸潤リンパ球を動員する方法、およびその使用
CN111566117A (zh) 2017-12-29 2020-08-21 糖模拟物有限公司 E-选择蛋白和半乳凝素-3的异双功能抑制剂
JP7455064B2 (ja) 2018-03-05 2024-03-25 グリコミメティクス， インコーポレイテッド 急性骨髄性白血病および関連状態を処置する方法
WO2020139962A1 (en) 2018-12-27 2020-07-02 Glycomimetics, Inc. Heterobifunctional inhibitors of e-selectin and galectin-3
WO2021118927A1 (en) 2019-12-13 2021-06-17 Insideoutbio, Inc. Methods and compositions for targeted delivery of nucleic acid therapeutics
CN114933569A (zh) * 2022-04-07 2022-08-23 澳门科技大学 鞘脂类化合物、含有鞘脂类化合物的脂质体和应用

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GB9000644D0 (en) * 1990-01-11 1990-03-14 Erba Carlo Spa New ureido derivatives of poly-4-amino-2-carboxy-1-methyl compounds
GB9216962D0 (en) * 1992-08-11 1992-09-23 Erba Carlo Spa Therapeutically active naphthalenesulfonic-pyrrolecarboxamido derivatives
GB9304589D0 (en) * 1993-03-05 1993-04-21 Erba Carlo Spa Biologically active ureido derivatives useful as antimetastic agents
GB9307948D0 (en) * 1993-04-16 1993-06-02 Erba Carlo Spa Biologically active ureido derivatives useful in the treatment of lentivirus-induced disease
GB9403909D0 (en) * 1994-03-01 1994-04-20 Erba Carlo Spa Ureido derivatives of naphthalenephosphonic acids and process for their preparation

Also Published As

Publication number Publication date
EP0758339A1 (en) 1997-02-19
EA199600104A1 (ru) 1997-09-30
PL317094A1 (en) 1997-03-17
CA2189358A1 (en) 1996-09-06
HUP9603305A2 (en) 1997-08-28
GB9504065D0 (en) 1995-04-19
ZA961636B (en) 1996-09-06
KR970702868A (ko) 1997-06-10
FI964331A (fi) 1996-11-01
AU696470B2 (en) 1998-09-10
FI964331A0 (fi) 1996-10-28
NO964610D0 (no) 1996-10-31
MX9605089A (es) 1997-12-31
WO1996026950A1 (en) 1996-09-06
NO964610L (no) 1996-10-31
IL117193A0 (en) 1996-06-18
NZ302267A (en) 1997-10-24
AU4869896A (en) 1996-09-18
JPH10504319A (ja) 1998-04-28
HUP9603305A3 (en) 1998-01-28
CN1148391A (zh) 1997-04-23
EA000006B1 (ru) 1997-12-30

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