AP9901635A0 - Anti-convulsant isoquinolyl-benzamide derivatives. - Google Patents

Anti-convulsant isoquinolyl-benzamide derivatives.

Info

Publication number: AP9901635A0
Authority: AP; ARIPO
Prior art keywords: 4alkyl; groups; hydrogen; substituted; 6alkylso2
Prior art date: 1997-03-18

Application number

APAP/P/1999/001635A

Other languages

English (en)

Inventor

John David Harling

Barry Sidney Orlek

Mervyn Thompson

Original Assignee

Smithkline Beecham Plc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-03-18

Filing date

1998-03-16

Publication date

1999-09-30

1997-03-18 Priority claimed from GBGB9705620.4A external-priority patent/GB9705620D0/en

1997-12-17 Priority claimed from GBGB9726660.5A external-priority patent/GB9726660D0/en

1998-03-16 Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc

1999-09-30 Publication of AP9901635A0 publication Critical patent/AP9901635A0/en

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Psychology (AREA)
Addiction (AREA)
Hospice & Palliative Care (AREA)
Anesthesiology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

APAP/P/1999/001635A 1997-03-18 1998-03-16 Anti-convulsant isoquinolyl-benzamide derivatives. AP9901635A0 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GBGB9705620.4A GB9705620D0 (en)	1997-03-18	1997-03-18	Novel compounds
GBGB9726660.5A GB9726660D0 (en)	1997-12-17	1997-12-17	Novel compounds
PCT/GB1998/000781 WO1998041507A1 (fr)	1997-03-18	1998-03-16	Derives anticonvulsivants d'isoquinolyl-benzamide

Publications (1)

Publication Number	Publication Date
AP9901635A0 true AP9901635A0 (en)	1999-09-30

Family

ID=26311216

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
APAP/P/1999/001635A AP9901635A0 (en)	1997-03-18	1998-03-16	Anti-convulsant isoquinolyl-benzamide derivatives.

Country Status (26)

Country	Link
US (1)	US6277861B1 (fr)
EP (1)	EP0971897A1 (fr)
JP (1)	JP2001516357A (fr)
KR (1)	KR20000076343A (fr)
CN (1)	CN1255917A (fr)
AP (1)	AP9901635A0 (fr)
AR (1)	AR012078A1 (fr)
AU (1)	AU732162B2 (fr)
BG (1)	BG103807A (fr)
BR (1)	BR9809048A (fr)
CA (1)	CA2283682A1 (fr)
CO (1)	CO4950554A1 (fr)
DZ (1)	DZ2446A1 (fr)
EA (1)	EA199900836A1 (fr)
ID (1)	ID22730A (fr)
IL (1)	IL131958A0 (fr)
MA (1)	MA24499A1 (fr)
NO (1)	NO313753B1 (fr)
NZ (1)	NZ337579A (fr)
OA (1)	OA11390A (fr)
PE (1)	PE62199A1 (fr)
PL (1)	PL335675A1 (fr)
SK (1)	SK126799A3 (fr)
TR (1)	TR199902282T2 (fr)
TW (1)	TW509679B (fr)
WO (1)	WO1998041507A1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1999016752A1 (fr) *	1997-09-30	1999-04-08	Molecular Designs International, Inc.	AGONISTES DE β3-ADRENORECEPTEURS, COMPOSITIONS D'AGONISTES ET PROCEDES D'UTILISATION
GB9817424D0 (en) *	1998-08-11	1998-10-07	Smithkline Beecham Plc	Novel compounds
GB9915589D0 (en)	1999-07-02	1999-09-01	Smithkline Beecham Plc	Novel compounds
US6593341B2 (en)	2001-03-29	2003-07-15	Molecular Design International, Inc.	β3-adrenoreceptor agonists, agonist compositions and methods of making and using the same
US6596734B1 (en)	2002-10-11	2003-07-22	Molecular Design International, Inc.	Tetrahydroisoquinoline compounds for use as β3-adrenoreceptor agonists
CN109608325A (zh) *	2018-12-27	2019-04-12	先尼科化工（上海）有限公司	一种卤代苯甲酸衍生物的工业化合成方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4022900A (en) *	1970-09-09	1977-05-10	Marion Laboratories, Inc.	Compositions containing 1,2,3,4-tetrahydroisoquinolines used as hypotensive agents
DE3766472D1 (de) *	1986-10-28	1991-01-10	Smith Kline French Lab	Tetrahydroisochinolin-2-yl-derivate von carbonsaeuren als thromboxan a2-antagonisten.
GB8807922D0 (en) *	1988-04-05	1988-05-05	Fujisawa Pharmaceutical Co	Isoquinoline compound & process for preparation thereof
US4883593A (en) *	1988-10-27	1989-11-28	Bend Research, Inc.	Ultrathin-skinned asymmetric membranes by immiscible solvents treatment
GB9112721D0 (en) *	1991-06-13	1991-07-31	Smithkline Beecham Plc	Novel treatment
BR9709906A (pt) *	1996-06-17	1999-08-10	Smithkline Beecham Plc	Derivados de benzamida substituídos e o uso dos mesmos como anticonvulsivantes

1998
- 1998-03-07 DZ DZ980056A patent/DZ2446A1/fr active
- 1998-03-16 TR TR1999/02282T patent/TR199902282T2/xx unknown
- 1998-03-16 BR BR9809048-8A patent/BR9809048A/pt not_active IP Right Cessation
- 1998-03-16 EA EA199900836A patent/EA199900836A1/ru unknown
- 1998-03-16 CN CN98805128A patent/CN1255917A/zh active Pending
- 1998-03-16 MA MA25000A patent/MA24499A1/fr unknown
- 1998-03-16 US US09/381,369 patent/US6277861B1/en not_active Expired - Fee Related
- 1998-03-16 AP APAP/P/1999/001635A patent/AP9901635A0/en unknown
- 1998-03-16 KR KR1019997008444A patent/KR20000076343A/ko not_active Application Discontinuation
- 1998-03-16 SK SK1267-99A patent/SK126799A3/sk unknown
- 1998-03-16 ID IDW991041D patent/ID22730A/id unknown
- 1998-03-16 AU AU64127/98A patent/AU732162B2/en not_active Ceased
- 1998-03-16 IL IL13195898A patent/IL131958A0/xx unknown
- 1998-03-16 NZ NZ337579A patent/NZ337579A/en unknown
- 1998-03-16 CA CA002283682A patent/CA2283682A1/fr not_active Abandoned
- 1998-03-16 AR ARP980101173A patent/AR012078A1/es not_active Application Discontinuation
- 1998-03-16 JP JP54024798A patent/JP2001516357A/ja not_active Withdrawn
- 1998-03-16 PL PL98335675A patent/PL335675A1/xx unknown
- 1998-03-16 WO PCT/GB1998/000781 patent/WO1998041507A1/fr not_active Application Discontinuation
- 1998-03-16 EP EP98909646A patent/EP0971897A1/fr not_active Withdrawn
- 1998-03-16 CO CO98014463A patent/CO4950554A1/es unknown
- 1998-03-17 PE PE1998000190A patent/PE62199A1/es not_active Application Discontinuation
- 1998-03-20 TW TW087104134A patent/TW509679B/zh not_active IP Right Cessation
1999
- 1999-09-17 OA OA9900210A patent/OA11390A/en unknown
- 1999-09-17 NO NO19994504A patent/NO313753B1/no not_active IP Right Cessation
- 1999-10-13 BG BG103807A patent/BG103807A/bg unknown

Also Published As

Publication number	Publication date
KR20000076343A (ko)	2000-12-26
EA199900836A1 (ru)	2000-04-24
OA11390A (en)	2004-04-14
MA24499A1 (fr)	1998-10-01
NO313753B1 (no)	2002-11-25
US6277861B1 (en)	2001-08-21
CA2283682A1 (fr)	1998-09-24
DZ2446A1 (fr)	2003-01-11
PE62199A1 (es)	1999-09-10
IL131958A0 (en)	2001-03-19
SK126799A3 (en)	2000-05-16
PL335675A1 (en)	2000-05-08
AU732162B2 (en)	2001-04-12
AR012078A1 (es)	2000-09-27
TR199902282T2 (en)	2000-07-21
TW509679B (en)	2002-11-11
NO994504D0 (no)	1999-09-17
EP0971897A1 (fr)	2000-01-19
CO4950554A1 (es)	2000-09-01
BG103807A (bg)	2001-05-31
WO1998041507A1 (fr)	1998-09-24
CN1255917A (zh)	2000-06-07
ID22730A (id)	1999-12-09
AU6412798A (en)	1998-10-12
NZ337579A (en)	2001-04-27
NO994504L (no)	1999-09-17
BR9809048A (pt)	2000-08-01
JP2001516357A (ja)	2001-09-25

Publication	Publication Date	Title
MY117896A (en)	2004-08-30	Quinazoline derivatives
AP2002002637A0 (en)	2002-09-30	Novel piperazine
HUT59109A (en)	1992-04-28	Process for producing hydroxymethyl-(methylenecyclopentyl)-purines and -pyrimidines, their pharmaceutically acceptable salts and pharmaceutical compositions comprising same
DE69831868D1 (en)	2006-02-23	Antithrombosemittel
CY1107391T1 (el)	2010-07-28	Αρυλσυμπυκνωμενες αζαπολυκυκλικες ενωσεις
AU7077894A (en)	1995-01-24	Immunosuppressant and antiallergic compounds, e.g. n-(3-oxohexanoyl) homoserine lactone
DE69830504D1 (de)	2005-07-14	Antithrombotische mitteln
AR038430A2 (es)	2005-01-12	Derivados de parahercuamida b
FI931888A (fi)	1993-10-29	Kramploesande cykliska fruktopyranossulfiter -och sulfater
FI970150A0 (fi)	1997-01-14	Substituoituja pyrimidiiniyhdisteitä ja niiden käyttö
TR199801782T2 (xx)	1998-12-21	Kinoksalindionlar
ZA93267B (en)	1993-08-23	Novel arylcyloakyl derivatives their production and their use
JO1704B1 (en)	1992-12-15	New potent compounds
CA1271747C (fr)	1990-07-17	Derives de benzazepines
AP9901635A0 (en)	1999-09-30	Anti-convulsant isoquinolyl-benzamide derivatives.
CO5011066A1 (es)	2001-02-28	Compuestos de triazina
TR199800813T2 (xx)	1998-07-21	Nitrik oksit sintaz�n�n �nleyicileri olarak amidin, isot�re t�revleri.
DK526087A (da)	1988-04-08	Antikonvulsive aminosyrederivater
AP2000002009A0 (en)	2000-12-31	Tetrahydronaphthyridinyl-carboxamides having anti-convulsant activity.
UY26568A1 (es)	2001-08-27	Nuevos derivados de amidas heterocíclicas
IL104478A (en)	1997-06-10	N-5-protected 2,5-diamino-4, 6-dichloropyrimidines and processes for their preparation
AU4507989A (en)	1990-05-01	Aryloxy-, arylthio-, heteroaryloxy-, heteroarylthio- alkenylene derivatives of amines
TR199902387T2 (xx)	2000-01-21	Antibakteriyal ornat�lm�� 7-a�ilamino-3-(Metilhidrazono) Metil-Sefalosporinler ve ara �r�nleri.
SE9701438D0 (sv)	1997-04-17	A new process
ES2175228T3 (es)	2002-11-16	Metilsulfomicina i, un procedimiento para su produccion y su uso.