ZA984358B - Substituted pyrazoles as p38 kinase inhibitors - Google Patents
Substituted pyrazoles as p38 kinase inhibitorsInfo
- Publication number
- ZA984358B ZA984358B ZA984358A ZA984358A ZA984358B ZA 984358 B ZA984358 B ZA 984358B ZA 984358 A ZA984358 A ZA 984358A ZA 984358 A ZA984358 A ZA 984358A ZA 984358 B ZA984358 B ZA 984358B
- Authority
- ZA
- South Africa
- Prior art keywords
- kinase inhibitors
- substituted pyrazoles
- pyrazoles
- substituted
- kinase
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4757097P | 1997-05-22 | 1997-05-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA984358B true ZA984358B (en) | 1999-05-24 |
Family
ID=21949743
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA984358A ZA984358B (en) | 1997-05-22 | 1998-05-22 | Substituted pyrazoles as p38 kinase inhibitors |
Country Status (24)
Country | Link |
---|---|
EP (1) | EP1000055A1 (en) |
JP (1) | JP2002508754A (en) |
KR (1) | KR20010012854A (en) |
CN (1) | CN1264377A (en) |
AP (1) | AP1246A (en) |
AU (1) | AU754830C (en) |
BG (1) | BG64313B1 (en) |
BR (1) | BR9809147A (en) |
CA (1) | CA2291115A1 (en) |
EA (1) | EA003925B1 (en) |
EE (1) | EE9900527A (en) |
GE (1) | GEP20033053B (en) |
HU (1) | HUP0001880A3 (en) |
ID (1) | ID22982A (en) |
IL (1) | IL132991A (en) |
IS (1) | IS5257A (en) |
NO (1) | NO995695L (en) |
NZ (1) | NZ501112A (en) |
OA (1) | OA12981A (en) |
PL (1) | PL337020A1 (en) |
SK (1) | SK157899A3 (en) |
TR (1) | TR200000235T2 (en) |
WO (1) | WO1998052940A1 (en) |
ZA (1) | ZA984358B (en) |
Families Citing this family (77)
Publication number | Priority date | Publication date | Assignee | Title |
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TW289752B (en) * | 1994-03-11 | 1996-11-01 | Ciba Geigy Ag | |
US5559137A (en) * | 1994-05-16 | 1996-09-24 | Smithkline Beecham Corp. | Compounds |
US6514977B1 (en) | 1997-05-22 | 2003-02-04 | G.D. Searle & Company | Substituted pyrazoles as p38 kinase inhibitors |
JP2002502380A (en) | 1997-05-22 | 2002-01-22 | ジー.ディー.サール アンド カンパニー | Pyrazole derivatives as p38 kinase inhibitors |
US6979686B1 (en) | 2001-12-07 | 2005-12-27 | Pharmacia Corporation | Substituted pyrazoles as p38 kinase inhibitors |
JP2002504909A (en) | 1997-06-13 | 2002-02-12 | スミスクライン・ビーチャム・コーポレイション | New substituted pyrazole and pyrazoline compounds |
US7301021B2 (en) | 1997-07-02 | 2007-11-27 | Smithkline Beecham Corporation | Substituted imidazole compounds |
US6184226B1 (en) * | 1998-08-28 | 2001-02-06 | Scios Inc. | Quinazoline derivatives as inhibitors of P-38 α |
CA2346665A1 (en) | 1998-10-07 | 2000-04-13 | Smithkline Beecham Corporation | Novel treatment for stroke management |
DE69903976T2 (en) | 1998-12-16 | 2003-07-24 | Aventis Pharma Ltd | HETEROARYL CYCLIC ACETALS |
US6191147B1 (en) * | 1998-12-24 | 2001-02-20 | Ppd Discovery, Inc. | Pyrazole compounds and uses thereof |
EP1142890B1 (en) | 1998-12-25 | 2005-08-03 | Teikoku Hormone Mfg. Co., Ltd. | Aminopyrazole derivatives |
CN1353605A (en) | 1999-03-26 | 2002-06-12 | 欧洲凯尔特股份有限公司 | Aryl substituted pyrazoles, imidazoles, oxazoles, thiazoles and pyrroles, and use thereof |
CN1281604C (en) * | 1999-06-03 | 2006-10-25 | 帝国脏器制药株式会社 | Substituted pyrazole compounds |
US7122666B2 (en) | 1999-07-21 | 2006-10-17 | Sankyo Company, Limited | Heteroaryl-substituted pyrrole derivatives, their preparation and their therapeutic uses |
EP1218369B1 (en) * | 1999-08-13 | 2008-07-23 | Vertex Pharmaceuticals Incorporated | INHIBITORS OF c-JUN N-TERMINAL KINASES (JNK) AND OTHER PROTEIN KINASES |
AU7922100A (en) * | 1999-10-25 | 2001-05-08 | Basf Aktiengesellschaft | Agrochemical compositions containing pyrazoles as the active agents and use of said compositions as plant protection agents with a fungicidal action |
DE19952147A1 (en) | 1999-10-29 | 2001-05-03 | Boehringer Ingelheim Pharma | New cyclopropanes, pharmaceutical compositions containing these compounds and process for their preparation |
US7053099B1 (en) | 1999-11-23 | 2006-05-30 | Smithkline Beecham Corporation | 3,4-dihydro-(1H)quinazolin-2-one compounds as CSBP/p38 kinase inhibitors |
JP4911864B2 (en) | 2000-08-14 | 2012-04-04 | オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド | Substituted pyrazoles |
GB0102687D0 (en) | 2001-02-02 | 2001-03-21 | Pharmacia & Upjohn Spa | Oxazolyl-pyrazole derivatives active as kinase inhibitors,process for their preparation and pharmaceutical compositions comprising them |
EP1364949A4 (en) * | 2001-02-02 | 2005-11-23 | Takeda Pharmaceutical | Jnk inhibitor |
EP1382603B1 (en) | 2001-04-26 | 2008-07-23 | Eisai R&D Management Co., Ltd. | Nitrogenous fused-ring compound having pyrazolyl group as substituent and medicinal composition thereof |
ES2289116T3 (en) | 2001-05-24 | 2008-02-01 | Eli Lilly And Company | NEW DERIVATIVES OF PIRROL AS PHARMACEUTICAL AGENTS. |
YU30504A (en) | 2001-09-25 | 2006-08-17 | Pharmacia Corporation | Process for making substituted pyrazoles |
US7057049B2 (en) | 2001-09-25 | 2006-06-06 | Pharmacia Corporation | Process for making substituted pyrazoles |
BR0311619A (en) * | 2002-06-05 | 2005-03-08 | Pharmacia Corp | Pyrazole derivatives as p38 kinase inhibitors |
GB0215844D0 (en) | 2002-07-09 | 2002-08-14 | Novartis Ag | Organic compounds |
AU2003245989A1 (en) | 2002-07-09 | 2004-01-23 | Boehringer Ingelheim Pharma Gmbh And Co. Kg | Pharmaceutical compositions of anticholinergics and p38 kinase inhibitors in the treatment of respiratory diseases |
GB0217786D0 (en) * | 2002-07-31 | 2002-09-11 | Glaxo Group Ltd | Compounds |
AU2003265395A1 (en) | 2002-08-14 | 2004-03-03 | Ppd Discovery, Inc. | Prenylation inhibitors and methods of their synthesis and use |
US6649638B1 (en) | 2002-08-14 | 2003-11-18 | Ppd Discovery, Inc. | Prenylation inhibitors and methods of their synthesis and use |
WO2004026302A1 (en) * | 2002-09-19 | 2004-04-01 | Eli Lilly And Company | Methods of inhibiting tgf beta with substituted pyrazoles |
GB0229618D0 (en) * | 2002-12-19 | 2003-01-22 | Cancer Rec Tech Ltd | Pyrazole compounds |
AU2004209495A1 (en) | 2003-02-07 | 2004-08-19 | Daiichi Pharmaceutical Co., Ltd. | Pyrazole derivative |
US20060035893A1 (en) | 2004-08-07 | 2006-02-16 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders |
PL1778686T3 (en) | 2004-08-12 | 2009-04-30 | Pfizer | Triazolopyridinylsulfanyl derivatives as p38 map kinase inhibitors |
PE20060777A1 (en) | 2004-12-24 | 2006-10-06 | Boehringer Ingelheim Int | INDOLINONE DERIVATIVES FOR THE TREATMENT OR PREVENTION OF FIBROTIC DISEASES |
CA2591912C (en) | 2004-12-28 | 2013-06-25 | Aska Pharmaceutical Co., Ltd. | Pyrimidinylisoxazole derivatives |
EP2024353A2 (en) * | 2006-03-16 | 2009-02-18 | Pfizer Products Inc. | Pyrazole compounds |
US8207203B2 (en) | 2006-06-28 | 2012-06-26 | Aska Pharmaceutical Co., Ltd. | Pyridylisoxazole derivatives |
US20090192164A1 (en) * | 2006-06-28 | 2009-07-30 | Aska Pharmaceutical Co., Ltd. | Treating agent of inflammatory bowel disease |
JP4588791B2 (en) | 2007-02-16 | 2010-12-01 | あすか製薬株式会社 | Pharmaceutical composition comprising a particulate oily suspension |
EP1992344A1 (en) | 2007-05-18 | 2008-11-19 | Institut Curie | P38 alpha as a therapeutic target in pathologies linked to FGFR3 mutation |
AU2008277730B2 (en) * | 2007-07-13 | 2013-01-31 | Addex Pharma S.A. | Pyrazole derivatives as modulators of metabotropic glutamate receptors |
CL2008003407A1 (en) | 2007-11-16 | 2010-01-11 | Boehringer Ingelheim Int | Substituted heterobicyclo aryl- and heteroarylcarbonyl derivative compounds; pharmaceutical composition; preparation procedure; and its use in the treatment and / or prevention of metabolic disorders, mediated by the inhibition of the enzyme hsd-1. |
CL2009000904A1 (en) * | 2008-04-21 | 2010-04-30 | Shionogi & Co | Compounds derived from cyclohexyl sulfonamides having antagonist activity at the npy y5 receptor, pharmaceutical composition and pharmaceutical formulation comprising them. |
CA2724214A1 (en) | 2008-05-13 | 2009-11-19 | Boehringer Ingelheim International Gmbh | Alicyclic carboxylic acid derivatives of benzomorphans and related scaffolds, medicaments containing such compounds and their use |
WO2010010154A1 (en) | 2008-07-24 | 2010-01-28 | Nerviano Medical Sciences S.R.L. | 3,4-diarylpyrazoles as protein kinase inhibitors |
US8609690B2 (en) * | 2008-08-25 | 2013-12-17 | Boehringer Ingelheim International Gmbh | Aryl- and heteroarylcarbonyl derivatives of substituted nortropanes, medicaments containing such compounds and their use |
JP2012506388A (en) * | 2008-10-23 | 2012-03-15 | ロンザ リミテッド | Method for the synthesis of substituted pyrazoles |
CN102224142B (en) * | 2008-11-21 | 2015-07-22 | 拉夸里亚创药株式会社 | Novel pyrazole-3-carboxamide derivative having 5-ht2b receptor antagonist activity |
WO2010139673A1 (en) | 2009-06-02 | 2010-12-09 | Boehringer Ingelheim International Gmbh | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
JP5656986B2 (en) | 2009-06-11 | 2015-01-21 | ヴァイティー ファーマシューティカルズ,インコーポレイテッド | Cyclic inhibitor of 11β-hydroxysteroid dehydrogenase 1 based on 1,3-oxazinan-2-one structure |
EA201200321A1 (en) * | 2009-08-26 | 2012-09-28 | Новартис Аг | TETRA-SUBSTITUTED HETEROARRYL COMPOUNDS AND THEIR USE AS MDM2 AND / OR MDM4 MODULATORS |
AR077975A1 (en) | 2009-08-28 | 2011-10-05 | Irm Llc | PIRAZOL PYRIMIDINE DERIVATIVES AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS |
EP2308866A1 (en) | 2009-10-09 | 2011-04-13 | Bayer CropScience AG | Phenylpyri(mi)dinylpyrazoles and their use as fungicides |
CN102762551A (en) | 2009-12-21 | 2012-10-31 | 拜尔农作物科学股份公司 | Thienylpyri (mi) dinylazole and their use for controlling phytopathogenic fungi |
EP2528909B1 (en) | 2010-01-27 | 2016-06-22 | Nerviano Medical Sciences S.r.l. | Sulfonamido derivatives of 3,4-diarylpyrazoles as protein kinase inhibitors |
AR081810A1 (en) | 2010-04-07 | 2012-10-24 | Bayer Cropscience Ag | BICYCLE PIRIDINYL PIRAZOLS |
JP5860042B2 (en) | 2010-06-16 | 2016-02-16 | ヴァイティー ファーマシューティカルズ,インコーポレイテッド | Substituted 5, 6 and 7 membered heterocycles, medicaments containing such compounds and their use |
WO2012016993A1 (en) | 2010-08-03 | 2012-02-09 | Nerviano Medical Sciences S.R.L. | Derivatives of pyrazolophenyl-benzenesulfonamide compounds and use thereof as antitumor agents |
PL3181133T3 (en) * | 2010-12-20 | 2019-12-31 | Pfizer Inc. | Novel fused pyridine compounds as casein kinase inhibitors |
AR086992A1 (en) | 2011-06-20 | 2014-02-05 | Bayer Ip Gmbh | TIENILPIRI (MI) DINILPIRAZOLES |
WO2013025664A1 (en) | 2011-08-17 | 2013-02-21 | Boehringer Ingelheim International Gmbh | Indenopyridine derivatives |
DK2763993T3 (en) | 2011-10-06 | 2017-07-24 | Bayer Ip Gmbh | HETEROCYCLYLPYRI (MI) DINYLPYRAZOL |
AU2012320581B2 (en) | 2011-10-06 | 2017-03-30 | Bayer Intellectual Property Gmbh | Heterocyclylpyri (mi) dinylpyrazole as fungicidals |
DE102011115525A1 (en) | 2011-10-11 | 2013-04-11 | Boehringer Ingelheim International Gmbh | Two-part bottle packaging device for containing pharmaceutical tablets or capsules, has bottle body and bottle base, where bottle is closed with pressure lock or with pressure lock injected at bottle body or with separate rotary lock |
CN103917236A (en) | 2011-11-11 | 2014-07-09 | 诺华股份有限公司 | Method of treating proliferative disease |
PL2782557T3 (en) | 2011-11-23 | 2019-03-29 | Array Biopharma, Inc. | Pharmaceutical formulations |
AU2014236719B2 (en) | 2013-03-15 | 2018-06-21 | The California Institute For Biomedical Research | Compounds and methods for inducing chondrogenesis |
CN105814024B (en) * | 2013-12-12 | 2018-04-17 | 住友化学株式会社 | Aromatic compounds and application thereof |
CN104829536B (en) * | 2015-05-04 | 2017-12-29 | 陕西科技大学 | A kind of Phenylpyrazole carboxylic acid compound and its synthetic method for having antitumor activity |
EP3303284B1 (en) * | 2015-05-27 | 2020-04-08 | Kyorin Pharmaceutical Co., Ltd. | Urea derivative or pharmacologically acceptable salt thereof |
CN112457255B (en) * | 2017-11-08 | 2022-08-19 | 北京嘉林药业股份有限公司 | Compounds and their use for treating cancer |
US11034669B2 (en) | 2018-11-30 | 2021-06-15 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
CA3166630A1 (en) | 2020-01-03 | 2021-07-08 | Berg Llc | Polycyclic amides as ube2k modulators for treating cancer |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5559137A (en) * | 1994-05-16 | 1996-09-24 | Smithkline Beecham Corp. | Compounds |
US5486534A (en) * | 1994-07-21 | 1996-01-23 | G. D. Searle & Co. | 3,4-substituted pyrazoles for the treatment of inflammation |
-
1998
- 1998-05-22 IL IL13299198A patent/IL132991A/en not_active IP Right Cessation
- 1998-05-22 BR BR9809147-6A patent/BR9809147A/en not_active Application Discontinuation
- 1998-05-22 PL PL98337020A patent/PL337020A1/en unknown
- 1998-05-22 GE GEAP19985095A patent/GEP20033053B/en unknown
- 1998-05-22 JP JP55065098A patent/JP2002508754A/en not_active Withdrawn
- 1998-05-22 NZ NZ501112A patent/NZ501112A/en unknown
- 1998-05-22 SK SK1578-99A patent/SK157899A3/en unknown
- 1998-05-22 CN CN98807369A patent/CN1264377A/en active Pending
- 1998-05-22 EA EA199900953A patent/EA003925B1/en not_active IP Right Cessation
- 1998-05-22 KR KR19997010820A patent/KR20010012854A/en not_active Application Discontinuation
- 1998-05-22 CA CA002291115A patent/CA2291115A1/en not_active Abandoned
- 1998-05-22 ZA ZA984358A patent/ZA984358B/en unknown
- 1998-05-22 TR TR2000/00235T patent/TR200000235T2/en unknown
- 1998-05-22 EE EEP199900527A patent/EE9900527A/en unknown
- 1998-05-22 WO PCT/US1998/010436 patent/WO1998052940A1/en not_active Application Discontinuation
- 1998-05-22 HU HU0001880A patent/HUP0001880A3/en unknown
- 1998-05-22 AP APAP/P/1999/001715A patent/AP1246A/en active
- 1998-05-22 ID IDW991425A patent/ID22982A/en unknown
- 1998-05-22 EP EP98923642A patent/EP1000055A1/en not_active Withdrawn
- 1998-05-22 AU AU75883/98A patent/AU754830C/en not_active Ceased
-
1999
- 1999-11-19 NO NO995695A patent/NO995695L/en not_active Application Discontinuation
- 1999-11-19 IS IS5257A patent/IS5257A/en unknown
- 1999-11-22 OA OA9900252A patent/OA12981A/en unknown
- 1999-12-08 BG BG103964A patent/BG64313B1/en unknown
Also Published As
Publication number | Publication date |
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EE9900527A (en) | 2000-06-15 |
NO995695D0 (en) | 1999-11-19 |
PL337020A1 (en) | 2000-07-31 |
WO1998052940A1 (en) | 1998-11-26 |
NO995695L (en) | 2000-01-21 |
AU754830C (en) | 2004-02-12 |
AP1246A (en) | 2004-02-07 |
BR9809147A (en) | 2000-08-01 |
EA003925B1 (en) | 2003-10-30 |
KR20010012854A (en) | 2001-02-26 |
GEP20033053B (en) | 2003-08-25 |
IL132991A0 (en) | 2001-03-19 |
HUP0001880A2 (en) | 2001-03-28 |
BG103964A (en) | 2000-08-31 |
HUP0001880A3 (en) | 2002-03-28 |
SK157899A3 (en) | 2000-08-14 |
IL132991A (en) | 2005-11-20 |
EP1000055A1 (en) | 2000-05-17 |
EA199900953A1 (en) | 2000-10-30 |
NZ501112A (en) | 2002-10-25 |
AU754830B2 (en) | 2002-11-28 |
CN1264377A (en) | 2000-08-23 |
IS5257A (en) | 1999-11-19 |
AU7588398A (en) | 1998-12-11 |
ID22982A (en) | 1999-12-23 |
OA12981A (en) | 2006-10-13 |
JP2002508754A (en) | 2002-03-19 |
TR200000235T2 (en) | 2000-05-22 |
CA2291115A1 (en) | 1998-11-26 |
BG64313B1 (en) | 2004-09-30 |
AP9901715A0 (en) | 1999-12-31 |
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