ZA9811796B - New tetracyclic analogues of camptothecins, their preparation processes, their use as medicaments and the pharmaceutical compositions containing them. - Google Patents

New tetracyclic analogues of camptothecins, their preparation processes, their use as medicaments and the pharmaceutical compositions containing them.

Info

Publication number
ZA9811796B
ZA9811796B ZA9811796A ZA9811796A ZA9811796B ZA 9811796 B ZA9811796 B ZA 9811796B ZA 9811796 A ZA9811796 A ZA 9811796A ZA 9811796 A ZA9811796 A ZA 9811796A ZA 9811796 B ZA9811796 B ZA 9811796B
Authority
ZA
South Africa
Prior art keywords
camptothecins
medicaments
pharmaceutical compositions
compositions containing
preparation processes
Prior art date
Application number
ZA9811796A
Other languages
English (en)
Inventor
Dennis Bigg
Olivier Lavergne
Alain Rolland
Christophe Lanco
Gerard Ulibarri
Original Assignee
Sod Conseils Rech Applic
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sod Conseils Rech Applic filed Critical Sod Conseils Rech Applic
Publication of ZA9811796B publication Critical patent/ZA9811796B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
ZA9811796A 1997-12-24 1998-12-22 New tetracyclic analogues of camptothecins, their preparation processes, their use as medicaments and the pharmaceutical compositions containing them. ZA9811796B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9716461A FR2772763B1 (fr) 1997-12-24 1997-12-24 Nouveaux analogues tetracycliques de camptothecines, leurs procedes de preparation, leur application comme medicaments et les compositions pharmaceutiques les contenant

Publications (1)

Publication Number Publication Date
ZA9811796B true ZA9811796B (en) 1999-06-29

Family

ID=9515095

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9811796A ZA9811796B (en) 1997-12-24 1998-12-22 New tetracyclic analogues of camptothecins, their preparation processes, their use as medicaments and the pharmaceutical compositions containing them.

Country Status (22)

Country Link
US (2) US6436951B1 (es)
EP (1) EP1042323B1 (es)
JP (1) JP2001527075A (es)
AR (1) AR016440A1 (es)
AT (1) ATE215951T1 (es)
AU (1) AU749224B2 (es)
CA (1) CA2315897C (es)
DE (1) DE69804856T2 (es)
DK (1) DK1042323T3 (es)
ES (1) ES2175834T3 (es)
FR (1) FR2772763B1 (es)
HU (1) HUP0004628A3 (es)
IL (1) IL136732A0 (es)
MY (1) MY117585A (es)
NO (1) NO316676B1 (es)
NZ (1) NZ505339A (es)
PL (1) PL193468B1 (es)
PT (1) PT1042323E (es)
RU (1) RU2220144C2 (es)
TW (1) TW513429B (es)
WO (1) WO1999033829A1 (es)
ZA (1) ZA9811796B (es)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040077674A1 (en) * 2002-03-01 2004-04-22 Curran Dennis P. Mappicine analogs, intermediates in the synthesis of mappicine analogs and methods of synthesis of mappicine analogs
CA2480335A1 (en) * 2002-03-26 2003-10-02 Banyu Pharmaceutical Co., Ltd. Combined use of antitumor indolopyrrolocarbazole derivative and other antitumor agent
GB2436226A (en) * 2004-12-08 2007-09-19 Fuji Electric Holdings Co Organic EL element
TWI417095B (zh) 2006-03-15 2013-12-01 Janssen Pharmaceuticals Inc １，４-二取代之３-氰基-吡啶酮衍生物及其作為ｍＧｌｕＲ２-受體之正向異位性調節劑之用途
TW200845978A (en) 2007-03-07 2008-12-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
TW200900065A (en) 2007-03-07 2009-01-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
JP5126707B2 (ja) * 2007-04-23 2013-01-23 有機合成薬品工業株式会社 α−ヒドロキシアシルピリジンの製造方法
ATE496906T1 (de) 2007-09-14 2011-02-15 Ortho Mcneil Janssen Pharm 1',3'-disubstituierte 4-phenyl-3,4,5,6-tetrahydro-2h,1'h-ä1,4'übipyri inyl-2'-one
CA2735764C (en) 2008-09-02 2016-06-14 Ortho-Mcneil-Janssen Pharmaceuticals, Inc. 3-azabicyclo[3.1.0]hexyl derivatives as modulators of metabotropic glutamate receptors
US8691813B2 (en) 2008-11-28 2014-04-08 Janssen Pharmaceuticals, Inc. Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors
CA2760259C (en) 2009-05-12 2018-05-01 Janssen Pharmaceuticals, Inc. 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
MY153913A (en) 2009-05-12 2015-04-15 Janssen Pharmaceuticals Inc 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
RS53075B (en) 2009-05-12 2014-04-30 Janssen Pharmaceuticals Inc. 1,2,4-TRIAZOLO [4,3-A] PYRIDINE DERIVATIVES AND THEIR USE IN THE TREATMENT OR PREVENTION OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS
EP2661435B1 (en) 2010-11-08 2015-08-19 Janssen Pharmaceuticals, Inc. 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
EP2643320B1 (en) 2010-11-08 2015-03-04 Janssen Pharmaceuticals, Inc. 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
PL2649069T3 (pl) 2010-11-08 2016-01-29 Janssen Pharmaceuticals Inc Pochodne 1,2,4-triazolo[4,3-a]pirydyny i ich zastosowanie jako dodatnich allosterycznych modulatorów receptorów mGluR2
JP6669499B2 (ja) 2013-02-15 2020-03-18 カラ ファーマシューティカルズ インコーポレイテッド 治療用化合物
KR102277833B1 (ko) 2013-02-20 2021-07-14 칼라 파마슈티컬스, 인크. 치료 화합물 및 그의 용도
US9688688B2 (en) 2013-02-20 2017-06-27 Kala Pharmaceuticals, Inc. Crystalline forms of 4-((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxyquinazolin-7-yl)oxy)-1-(2-oxa-7-azaspiro[3.5]nonan-7-yl)butan-1-one and uses thereof
JO3368B1 (ar) 2013-06-04 2019-03-13 Janssen Pharmaceutica Nv مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2
JO3367B1 (ar) 2013-09-06 2019-03-13 Janssen Pharmaceutica Nv مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2
US9458169B2 (en) 2013-11-01 2016-10-04 Kala Pharmaceuticals, Inc. Crystalline forms of therapeutic compounds and uses thereof
US9890173B2 (en) 2013-11-01 2018-02-13 Kala Pharmaceuticals, Inc. Crystalline forms of therapeutic compounds and uses thereof
CN103588660B (zh) * 2013-11-18 2016-06-01 中国医学科学院生物医学工程研究所 一种新型的酰基苯胺化合物及用途
KR101768402B1 (ko) 2013-12-13 2017-08-14 에프. 호프만-라 로슈 아게 브루톤 티로신 키나제의 억제제
KR20200126026A (ko) 2014-01-21 2020-11-05 얀센 파마슈티카 엔.브이. 대사 조절형 글루탐산 작동성 수용체 제2아형의 양성 알로스테릭 조절제 또는 오르토스테릭 작동제를 포함하는 조합 및 그 용도
CN109999033B (zh) 2014-01-21 2022-12-23 詹森药业有限公司 包括代谢型谷氨酸能受体亚型2的正别构调节物或正位激动剂的组合及其用途
AU2017324251A1 (en) 2016-09-08 2019-03-21 Kala Pharmaceuticals, Inc. Crystalline forms of therapeutic compounds and uses thereof
AU2017324713B2 (en) 2016-09-08 2020-08-13 KALA BIO, Inc. Crystalline forms of therapeutic compounds and uses thereof
WO2018048750A1 (en) 2016-09-08 2018-03-15 Kala Pharmaceuticals, Inc. Crystalline forms of therapeutic compounds and uses thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1114608C (zh) * 1995-06-21 2003-07-16 科学研究与运用咨询公司 喜树碱类似物、其制备方法和药物应用及其药物组合物
GB9624482D0 (en) * 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds

Also Published As

Publication number Publication date
AR016440A1 (es) 2001-07-04
DE69804856D1 (de) 2002-05-16
AU1764599A (en) 1999-07-19
DE69804856T2 (de) 2002-11-07
DK1042323T3 (da) 2002-08-05
NZ505339A (en) 2003-01-31
WO1999033829A1 (fr) 1999-07-08
PL193468B1 (pl) 2007-02-28
MY117585A (en) 2004-07-31
CA2315897A1 (fr) 1999-07-08
PL341288A1 (en) 2001-04-09
NO20003314L (no) 2000-06-30
US6632946B2 (en) 2003-10-14
NO20003314D0 (no) 2000-06-23
EP1042323A1 (fr) 2000-10-11
AU749224B2 (en) 2002-06-20
US6436951B1 (en) 2002-08-20
ES2175834T3 (es) 2002-11-16
FR2772763A1 (fr) 1999-06-25
TW513429B (en) 2002-12-11
RU2220144C2 (ru) 2003-12-27
IL136732A0 (en) 2001-06-14
ATE215951T1 (de) 2002-04-15
JP2001527075A (ja) 2001-12-25
CA2315897C (fr) 2010-01-19
HUP0004628A3 (en) 2001-11-28
FR2772763B1 (fr) 2004-01-23
US20010000521A1 (en) 2001-04-26
NO316676B1 (no) 2004-03-29
PT1042323E (pt) 2002-09-30
EP1042323B1 (fr) 2002-04-10
HUP0004628A1 (hu) 2001-05-28

Similar Documents

Publication Publication Date Title
ZA9811796B (en) New tetracyclic analogues of camptothecins, their preparation processes, their use as medicaments and the pharmaceutical compositions containing them.
HUP0001508A3 (en) 4-arylmethylene-2-imino-2,3-dihydrothiazole derivatives, their use, process for the preparation thereof and pharmaceutical compositions containing them
HUP0104574A3 (en) Analogues of glp-1, pharmaceutical compositions comprising thereof and their use
HUP0200308A3 (en) Quinolinecarboxamides as antiviral agents, pharmaceutical compositions containing them and their use
HUP0204413A3 (en) Quinazoline compounds, their preparation, their use and pharmaceutical compositions containing them
HUP0302969A3 (en) Npyy5 antagonists, pharmaceutical compositions containing them and their use
HUP0002517A3 (en) Derivatives of acyl-piperazinil-pyrimidins, preparation thereof, pharmaceutical compositions containing them and their use as medicaments
HUP0400784A3 (en) Bicyclic heterocondensated pyrrolcarboxamide derivatives, their use and pharmaceutical compositions containing them
HUP0203052A3 (en) Bicyclic imidazo-3-yl-amine derivatives, process for their preparation, pharmaceutical compositions containing them and their use
HUP0204143A3 (en) Tricyclic 1-benzylpyrazole-3-carboxylic acid derivatives, preparation of the compounds, their use and pharmaceutical compositions containing them
HUP0102512A3 (en) Bridged indenopyrrolocarbazoles, process for their preparation, pharmaceutical compositions containing them and their use
HUP0002272A3 (en) Aroyl-piperazine derivatives, their preparation pharmaceutical compositions containing them and their use
ZA985392B (en) New derivatives of 2-(iminomethyl) amino-phenyl, their preparation their use as medicaments and the pharmaceutical compositions containing them
PL345354A1 (en) 2-aminopyridine erivatives, their use as medicines and pharmaceutical compositions containing them
HUP0203645A3 (en) Phenylpiperazinyl derivatives, pharmaceutical compositions containing them and their use
HUP0202233A3 (en) Derivatives and analogues of galanthamin, their use, pharmaceutical compositions containing them and process for the preparation of them
AU5326498A (en) Prodrug forms and new analogues of camptothecin, their use as medicaments
HUP0201543A2 (en) Use of substituted imidazothiazoles as antidepressant agents, pharmaceutical compositions containing them and their preparation
HK1035719A1 (en) Azabicyclic compounds, pharmaceutical composition containing them and their medicinal use
AU5326598A (en) New analogues of camptothecin, their use as medicaments and the pharmaceutical compositions containing them
HUP0104834A3 (en) Sulphonyloxazolamines, their use, pharmaceutical compositions containing them and their preparation
HUP0104002A3 (en) Alpha2-antagonists tricyclic delta3-piperidines, process for their producing the pharmaceutical compositions containing them and their use as medicament
ZA973289B (en) Steroids, their use as medicaments, their preparation process, the intermediates of this process and the compositions containing them.
ZA989781B (en) Novel bicyclic compounds and their use in medicine, process for their preparation and pharmaceutical compositions containing them.
IL164513A0 (en) Pyrazolopyrimidines, pharmaceutical compositions containing them, and their use in the preparation of medicaments