ZA96298B - Tricyclic benzazepine vasopressin antagonists - Google Patents

Tricyclic benzazepine vasopressin antagonists

Info

Publication number: ZA96298B
Authority: ZA; South Africa
Prior art keywords: vasopressin antagonists; tricyclic benzazepine; benzazepine vasopressin; tricyclic; antagonists
Prior art date: 1995-01-17

Application number

ZA96298A

Other languages

English (en)

Inventor

Jay D Albright

Santos Efren G Delos

Original Assignee

American Cyanamid Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-01-17

Filing date

1996-01-15

Publication date

1997-07-15

1996-01-15 Application filed by American Cyanamid Co filed Critical American Cyanamid Co

1997-07-15 Publication of ZA96298B publication Critical patent/ZA96298B/xx

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
- A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Cardiology (AREA)
Endocrinology (AREA)
Diabetes (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Reproductive Health (AREA)
Pulmonology (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)

ZA96298A 1995-01-17 1996-01-15 Tricyclic benzazepine vasopressin antagonists ZA96298B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US08/373,839 US5696112A (en)	1995-01-17	1995-01-17	Fused heterocyclic azepines as vasopressin antagonists

Publications (1)

Publication Number	Publication Date
ZA96298B true ZA96298B (en)	1997-07-15

Family

ID=23474102

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA96298A ZA96298B (en)	1995-01-17	1996-01-15	Tricyclic benzazepine vasopressin antagonists

Country Status (23)

Country	Link
US (2)	US5696112A (fr)
EP (1)	EP0811008B1 (fr)
JP (1)	JPH10512572A (fr)
KR (1)	KR19980703098A (fr)
CN (1)	CN1177356A (fr)
AR (1)	AR010195A1 (fr)
AT (1)	ATE251166T1 (fr)
AU (1)	AU716008B2 (fr)
BR (1)	BR9607153A (fr)
CA (1)	CA2210571A1 (fr)
CZ (1)	CZ224697A3 (fr)
DE (1)	DE69630209T2 (fr)
DK (1)	DK0811008T3 (fr)
EA (1)	EA001427B1 (fr)
ES (1)	ES2207672T3 (fr)
HU (1)	HUP9800466A3 (fr)
IL (1)	IL116776A (fr)
MX (1)	MX9705312A (fr)
NZ (1)	NZ302119A (fr)
PT (1)	PT811008E (fr)
TW (1)	TW342385B (fr)
WO (1)	WO1996022294A1 (fr)
ZA (1)	ZA96298B (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1997017349A1 (fr) *	1995-11-09	1997-05-15	Japan Tobacco Inc.	Derives heterocycliques fusionnes pentagonaux d'azepine et leur emploi pharmaceutique
US6297234B1 (en)	1999-02-04	2001-10-02	American Home Products Corporation	Arylthiophene vasopressin agonists
US6235900B1 (en)	1999-02-04	2001-05-22	American Home Products Corporation	Tricyclic pyridine N-oxides vasopressin agonists
US6437006B1 (en)	1999-09-27	2002-08-20	American Cyanamid Company	Pharmaceutical carrier formulation
US6977254B2 (en) *	2001-04-12	2005-12-20	Wyeth	Hydroxy cyclohexenyl phenyl carboxamides tocolytic oxytocin receptor antagonists
BR0208823A (pt)	2001-04-12	2004-03-09	Wyeth Corp	Composto, método de tratamento de distúrbios que são remediados ou aliviados pela atividade de agonista de vasopressina em um mamìfero necessitando do mesmo, e, composição farmacêutica
US7022699B2 (en)	2001-04-12	2006-04-04	Wyeth	Cyclohexenyl phenyl diazepines vasopressin and oxytocin receptor modulators
US6900200B2 (en)	2001-04-12	2005-05-31	Wyeth	Tricyclic hydroxy carboxamides and derivatives thereof tocolytic oxytocin receptor antagonists
US7064120B2 (en) *	2001-04-12	2006-06-20	Wyeth	Tricyclic pyridyl carboxamides and derivatives thereof tocolytic oxytocin receptor antagonists
US7053083B2 (en)	2001-04-12	2006-05-30	Wyeth	Cyclohexylphenyl vasopressin agonists
US7109193B2 (en)	2001-04-12	2006-09-19	Wyeth	Tricyclic diazepines tocolytic oxytocin receptor antagonists
US7326700B2 (en) *	2001-04-12	2008-02-05	Wyeth	Cyclohexenyl phenyl carboxamides tocolytic oxytocin receptor antagonists
US7202239B2 (en) *	2001-04-12	2007-04-10	Wyeth	Cyclohexylphenyl carboxamides tocolytic oxytocin receptor antagonists
SE0102299D0 (sv)	2001-06-26	2001-06-26	Astrazeneca Ab	Compounds
SE0102764D0 (sv)	2001-08-17	2001-08-17	Astrazeneca Ab	Compounds
EP1632494A1 (fr) *	2004-08-24	2006-03-08	Ferring B.V.	Antagonistes de la v1a vasopressine
US7645773B2 (en)	2006-01-18	2010-01-12	Hoffmann-La Roche Inc.	Thiazoles as inhibitors of 11β-hydroxysteroid dehydrogenase
WO2010101967A2 (fr) *	2009-03-04	2010-09-10	Idenix Pharmaceuticals, Inc.	Inhibiteurs de phosphothiophène et phosphothiazole vhc polymérase
WO2010116176A1 (fr)	2009-04-09	2010-10-14	Astrazeneca Ab	Dérivé de pyrazolo [4, 5-e] pyrimidine et son utilisation pour traiter le diabète et l'obésité
US10626126B2 (en)	2016-04-08	2020-04-21	Pulmocide Limited	Compounds

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ZA821020B (en) *	1981-02-18	1983-10-26	Thomae Gmbh Dr K	Azepine derivatives, process for their preparation and pharmaceutical compositions thereof
US4766108A (en) *	1986-12-04	1988-08-23	Smith Kline Beckman Corporation	Tyr-Arg-vasopressin antagonists
US5055448A (en) *	1987-06-25	1991-10-08	Medical College Of Ohio	Linear derivatives of arginine vasopressin antagonists
DK0382185T3 (da) *	1989-02-10	1994-07-04	Otsuka Pharma Co Ltd	Carbostyrilderivater
US5258510A (en) *	1989-10-20	1993-11-02	Otsuka Pharma Co Ltd	Benzoheterocyclic compounds
KR0167349B1 (ko) *	1989-10-20	1999-02-18	오스카 아끼히꼬	벤조헤테로 고리 화합물
US5070187A (en) *	1989-11-03	1991-12-03	Trustees Of Boston University	Pharmacologically effective antagonists of arginine-vasopressin
TW199153B (fr) *	1990-08-07	1993-02-01	Dtsuka Seiyaku Kk
TW198715B (fr) *	1991-04-19	1993-01-21	Dtsuka Seiyaku Kk
US5204349A (en) *	1991-09-16	1993-04-20	Merck & Co., Inc.	Amide-substituted derivatives of spiroindanylcamphorsulfonyl oxytocin antagonists
EP0533242A3 (en) *	1991-09-16	1993-09-15	Merck & Co. Inc.	Substituted derivatives of piperazinylcamphorsulfonyl oxytocin antagonists
EP0533240A3 (en) *	1991-09-16	1993-09-29	Merck & Co. Inc.	Substituted amine derivatives of piperazinylcamphorsulfonyl oxytocin antagonists
DE69223573D1 (de) *	1991-09-16	1998-01-29	Merck & Co Inc	Hydantoin und Succinimid-substituierte Spiroindanylcamphorsulfonyl als Oxytocin-Antagonisten
AU657431B2 (en) *	1992-08-20	1995-03-09	Otsuka Pharmaceutical Co., Ltd.	Benzoheterocyclic compounds as oxytocin and vasopressin antagonists
TW270927B (fr) *	1992-10-16	1996-02-21	Otsuka Pharma Co Ltd
WO1994012476A1 (fr) *	1992-11-25	1994-06-09	Yamanouchi Pharmaceutical Co., Ltd.	Derive de benzanilide
AU5692094A (en) *	1992-12-21	1994-07-19	Yamanouchi Pharmaceutical Co., Ltd.	Novel n-(pyridylcarbonyl)benzazepine derivative and intermediate therefor
WO1994020473A1 (fr) *	1993-03-11	1994-09-15	Yamanouchi Pharmaceutical Co., Ltd.	Compose avec action antagoniste de la vasopressine
GB9307527D0 (en) *	1993-04-13	1993-06-02	Fujisawa Pharmaceutical Co	New venzamide derivatives,processes for the preparation thereof and pharmaceutical composition comprising the same

1995
- 1995-01-17 US US08/373,839 patent/US5696112A/en not_active Expired - Lifetime
- 1995-06-02 US US08/460,418 patent/US5654297A/en not_active Expired - Lifetime
1996
- 1996-01-15 AR ARP960101028A patent/AR010195A1/es not_active Application Discontinuation
- 1996-01-15 ZA ZA96298A patent/ZA96298B/xx unknown
- 1996-01-16 AU AU47706/96A patent/AU716008B2/en not_active Ceased
- 1996-01-16 CZ CZ972246A patent/CZ224697A3/cs unknown
- 1996-01-16 HU HU9800466A patent/HUP9800466A3/hu unknown
- 1996-01-16 DK DK96903711T patent/DK0811008T3/da active
- 1996-01-16 JP JP8522453A patent/JPH10512572A/ja not_active Ceased
- 1996-01-16 EP EP96903711A patent/EP0811008B1/fr not_active Expired - Lifetime
- 1996-01-16 CA CA002210571A patent/CA2210571A1/fr not_active Abandoned
- 1996-01-16 PT PT96903711T patent/PT811008E/pt unknown
- 1996-01-16 BR BR9607153A patent/BR9607153A/pt unknown
- 1996-01-16 DE DE69630209T patent/DE69630209T2/de not_active Expired - Fee Related
- 1996-01-16 IL IL11677696A patent/IL116776A/xx not_active IP Right Cessation
- 1996-01-16 KR KR1019970704946A patent/KR19980703098A/ko not_active Application Discontinuation
- 1996-01-16 MX MX9705312A patent/MX9705312A/es not_active IP Right Cessation
- 1996-01-16 AT AT96903711T patent/ATE251166T1/de not_active IP Right Cessation
- 1996-01-16 TW TW085100460A patent/TW342385B/zh active
- 1996-01-16 CN CN96192356A patent/CN1177356A/zh active Pending
- 1996-01-16 EA EA199700115A patent/EA001427B1/ru not_active IP Right Cessation
- 1996-01-16 WO PCT/US1996/001096 patent/WO1996022294A1/fr active IP Right Grant
- 1996-01-16 ES ES96903711T patent/ES2207672T3/es not_active Expired - Lifetime
- 1996-01-16 NZ NZ302119A patent/NZ302119A/en unknown

Also Published As

Publication number	Publication date
EA001427B1 (ru)	2001-02-26
ES2207672T3 (es)	2004-06-01
DE69630209D1 (de)	2003-11-06
HUP9800466A3 (en)	1998-12-28
EP0811008B1 (fr)	2003-10-01
US5654297A (en)	1997-08-05
WO1996022294A1 (fr)	1996-07-25
MX9705312A (es)	1997-10-31
AR010195A1 (es)	2000-06-07
TW342385B (en)	1998-10-11
CN1177356A (zh)	1998-03-25
PT811008E (pt)	2004-02-27
IL116776A (en)	2000-10-31
NZ302119A (en)	2000-02-28
ATE251166T1 (de)	2003-10-15
EP0811008A1 (fr)	1997-12-10
HUP9800466A2 (hu)	1998-07-28
CA2210571A1 (fr)	1996-07-25
US5696112A (en)	1997-12-09
AU716008B2 (en)	2000-02-17
KR19980703098A (ko)	1998-10-15
EA199700115A1 (ru)	1997-12-30
DK0811008T3 (da)	2004-01-26
IL116776A0 (en)	1996-05-14
AU4770696A (en)	1996-08-07
CZ224697A3 (cs)	1998-01-14
BR9607153A (pt)	1997-11-11
DE69630209T2 (de)	2004-08-19
JPH10512572A (ja)	1998-12-02

Publication	Publication Date	Title
HK1004132A1 (en)	1998-11-20	Tricyclic benzazepine vasopressin antagonists
ZA96303B (en)	1997-07-15	Tricyclic benzazepine vasopressin antagonists
ZA96300B (en)	1997-07-15	Tricyclic benzazepine vasopressin antagonists
IL127470A0 (en)	1999-10-28	Tricyclic benzazepine vasopressin antagonists
ZA96299B (en)	1997-07-15	Tricyclic benzazepine vasopressin antagonists
IL116777A0 (en)	1996-05-14	Tricyclic benzazepine vasopressin antagonists and their preparation
ZA96298B (en)	1997-07-15	Tricyclic benzazepine vasopressin antagonists
HK1016973A1 (en)	1999-11-12	Benzazepine derivatives with vasopressin agonistic activity
IL133788A0 (en)	2001-04-30	Tricyclic vasopressin agonists
HK1038361A1 (en)	2002-03-15	Tricyclic benzodiazepines as vasopressin receptor antagonists
HU9601176D0 (en)	1996-06-28	Adhesion-receptor antagonists
AU5844896A (en)	1996-12-18	Tricyclic diazepines useful as gnrh receptor antagonists
AU3641497A (en)	1998-01-14	Tricyclic benzazepine vasopressin antagonists
HK1018057A1 (en)	1999-12-10	Tricyclic benzazepine compounds
AU3296597A (en)	1998-01-07	Tricyclic benzazepine vasopressin antagonists
IL118299A0 (en)	1996-09-12	Pharmacological use of AII-receptor antagonists
AU3296497A (en)	1998-01-07	Tricyclic benzazepine vasopressin antagonists
SI0804438T1 (sl)	2006-08-31	Triciklicni benzazepinski antagonisti vazopresina
GB9525388D0 (en)	1996-02-14	Benzazepine derivatives
GB9525365D0 (en)	1996-02-14	Benzazepine derivatives
ZA961293B (en)	1996-08-19	Muscarinic antagonists
GB9507788D0 (en)	1995-05-31	Antitumour compounds