ZA9610725B - Tyrosine derivatives - Google Patents
Tyrosine derivativesInfo
- Publication number
- ZA9610725B ZA9610725B ZA9610725A ZA9610725A ZA9610725B ZA 9610725 B ZA9610725 B ZA 9610725B ZA 9610725 A ZA9610725 A ZA 9610725A ZA 9610725 A ZA9610725 A ZA 9610725A ZA 9610725 B ZA9610725 B ZA 9610725B
- Authority
- ZA
- South Africa
- Prior art keywords
- tyrosine derivatives
- tyrosine
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C247/00—Compounds containing azido groups
- C07C247/02—Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton
- C07C247/04—Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/26—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
- C07C271/28—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a non-condensed six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
- C07C279/08—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/03—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C311/06—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms to acyclic carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/14—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
- C07C311/19—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19548709A DE19548709A1 (en) | 1995-12-23 | 1995-12-23 | Tyrosine derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA9610725B true ZA9610725B (en) | 1997-06-26 |
Family
ID=7781401
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA9610725A ZA9610725B (en) | 1995-12-23 | 1996-12-19 | Tyrosine derivatives |
Country Status (14)
Country | Link |
---|---|
EP (1) | EP0879227A1 (en) |
JP (1) | JP2000502664A (en) |
KR (1) | KR19990076676A (en) |
AU (1) | AU1301697A (en) |
BR (1) | BR9612201A (en) |
CA (1) | CA2241149A1 (en) |
CZ (1) | CZ195198A3 (en) |
DE (1) | DE19548709A1 (en) |
HU (1) | HUP9903716A2 (en) |
NO (1) | NO982907D0 (en) |
PL (1) | PL327185A1 (en) |
SK (1) | SK78398A3 (en) |
WO (1) | WO1997023451A1 (en) |
ZA (1) | ZA9610725B (en) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19629816A1 (en) | 1996-07-24 | 1998-01-29 | Hoechst Ag | New cycloalkyl derivatives as inhibitors of bone resorption and vitronectin receptor antagonists |
US5900414A (en) * | 1996-08-29 | 1999-05-04 | Merck & Co., Inc. | Methods for administering integrin receptor antagonists |
EP0963370B1 (en) * | 1996-12-09 | 2003-03-19 | Eli Lilly And Company | Integrin antagonists |
US6245809B1 (en) | 1996-12-09 | 2001-06-12 | Cor Therapeutics Inc. | Integrin antagonists |
DE19705450A1 (en) * | 1997-02-13 | 1998-08-20 | Merck Patent Gmbh | Bicyclic aromatic amino acids |
US6559144B2 (en) | 1997-02-13 | 2003-05-06 | Merck Patent Gesellschaft Mit | Bicyclic amino acids |
RU2220950C2 (en) * | 1997-08-22 | 2004-01-10 | Ф.Хоффманн-Ля Рош Аг | N-alkanoylphenylalanine derivatives |
US6455550B1 (en) | 1997-08-22 | 2002-09-24 | Hoffmann-La Roche Inc. | N-alkanoylphenylalanine derivatives |
EP1005446B1 (en) * | 1997-08-22 | 2004-02-25 | F. Hoffmann-La Roche Ag | N-aroylphenylalanine derivatives |
CA2327673C (en) | 1998-04-09 | 2009-08-25 | Meiji Seika Kaisha, Ltd. | Aminopiperidine derivatives as integrin .alpha.v.beta.3 antagonists |
JP2002521444A (en) * | 1998-07-31 | 2002-07-16 | イーライ・リリー・アンド・カンパニー | Heterocyclic sulfonamide derivatives |
DE19842415A1 (en) * | 1998-09-16 | 2000-03-23 | Merck Patent Gmbh | Pharmaceutical preparation for treating e.g. tumors, thrombosis or inflammation, contains cyclic pentapeptide integrin inhibitor and chemotherapeutic agent and/or angiogenesis inhibitor |
US6677360B2 (en) | 1998-12-16 | 2004-01-13 | Bayer Aktiengesellschaft | Biphenyl and biphenyl-analogous compounds as integrin antagonists |
ES2249059T3 (en) * | 1998-12-16 | 2006-03-16 | Bayer Healthcare Ag | NEW BIFENYL COMPOUNDS AND BIFENYL ANALOGS AS INTEGRINE ANTAGONIST |
US6833373B1 (en) | 1998-12-23 | 2004-12-21 | G.D. Searle & Co. | Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia |
CA2359115C (en) | 1999-01-22 | 2011-06-21 | Elan Pharmaceuticals, Inc. | Acyl derivatives which treat vla-4 related disorders |
AU2623900A (en) * | 1999-01-22 | 2000-08-07 | American Home Products Corporation | Compounds which inhibit leukocyte adhesion mediated by vla-4 |
AR035476A1 (en) | 1999-01-22 | 2004-06-02 | Elan Pharm Inc | HETEROARILO AND HETEROCICLIC COMPOUNDS WITH FUSIONED RING, WHICH INHIBIT THE ADHESION OF LEUKOCYTES THROUGH VLA-4, PHARMACEUTICAL COMPOSITIONS, THE USE OF THE SAME FOR THE MANUFACTURE OF A MEDICINAL PRODUCT AND A BIOLOGICAL METHOD 4 |
US6436904B1 (en) | 1999-01-25 | 2002-08-20 | Elan Pharmaceuticals, Inc. | Compounds which inhibit leukocyte adhesion mediated by VLA-4 |
US6344484B1 (en) | 1999-02-12 | 2002-02-05 | 3-Dimensional Pharmaceuticals, Inc. | Tyrosine alkoxyguanidines as integrin inhibitors |
EP1028114A1 (en) * | 1999-02-13 | 2000-08-16 | Aventis Pharma Deutschland GmbH | Novel guanidine derivatives as inhibitors of cell adhesion |
EP1154993B1 (en) | 1999-02-18 | 2004-10-06 | F. Hoffmann-La Roche Ag | Thioamide derivatives |
DE60009883T2 (en) | 1999-03-01 | 2005-04-07 | Elan Pharmaceuticals, Inc., San Francisco | ALPHA AMINO ACETIC ACID DERIVATIVES THAN ALPHA 4 BETA 7-RECEPTOR ANTAGONISTS |
HUP0203338A2 (en) | 1999-04-13 | 2003-03-28 | Abbott Gmbh & Co. Kg | Integrin receptor ligands |
US6750219B1 (en) | 1999-08-05 | 2004-06-15 | Meiji Seika Kaisha, Ltd. | Ω-amino-α-hydroxycarboxylic acid derivatives having integrin ανβ3 antagonistic activity |
BR0007183A (en) | 1999-09-29 | 2002-02-05 | Ortho Mcneil Pharm Inc | Isonipectoamides for the treatment of integrin-mediated disorders |
US6531495B1 (en) | 1999-10-02 | 2003-03-11 | Aventis Pharma Deutschland Gmbh | 2′-Substituted 1,1′-biphenyl-2-carboxamides, processes for their preparation, their use as medicaments, and pharmaceutical preparations comprising them |
EP1227083A4 (en) * | 1999-10-08 | 2002-11-20 | Meiji Seika Kaisha | 3-AMINOPIPERIDINE DERIVATIVES AS INTEGRIN $g(a)v$g(b)3 ANTAGONISTS |
US20020037897A1 (en) * | 2000-08-07 | 2002-03-28 | 3-Dimensional Pharmaceuticals, Inc. | Tetrahydroisoquinoline-3-carboxylic acid alkoxyguanidines as integrin antagonists |
US6486174B2 (en) | 2000-08-07 | 2002-11-26 | 3-Dimensional Pharmaceuticals, Inc. | Tetrahydroisoquinoline-3-carboxylic acid alkoxyguanidines as integrin antagonists |
MXPA03006772A (en) | 2001-01-29 | 2004-10-15 | Dimensional Pharm Inc | Substituted indoles and their use as integrin antagonists. |
FR2822827B1 (en) * | 2001-03-28 | 2003-05-16 | Sanofi Synthelabo | NOVEL N- (ARYLSULFONYL) BETA-AMINOACIDS DERIVATIVES COMPRISING A SUBSTITUTED AMINOMETHYL GROUP, THEIR PREPARATION METHOD AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME |
US7081460B2 (en) | 2001-04-09 | 2006-07-25 | Ortho-Mcneil Pharmaceutical, Inc. | Quinazoline and quinazoline-like compounds for the treatment of integrin-mediated disorders |
US6872730B2 (en) | 2001-04-27 | 2005-03-29 | 3-Dimensional Pharmaceuticals, Inc. | Substituted benzofurans and benzothiophenes, methods of making and methods of use as integrin antagonists |
WO2003008373A1 (en) * | 2001-07-19 | 2003-01-30 | Merck Patent Gmbh | Tyrosine hydrazides |
TWI281470B (en) | 2002-05-24 | 2007-05-21 | Elan Pharm Inc | Heterocyclic compounds which inhibit leukocyte adhesion mediated by alpha4 integrins |
TW200307671A (en) | 2002-05-24 | 2003-12-16 | Elan Pharm Inc | Heteroaryl compounds which inhibit leukocyte adhesion mediated by α 4 integrins |
EP1940827B1 (en) | 2005-09-29 | 2011-03-16 | Elan Pharmaceuticals Inc. | Carbamate compounds which inhibit leukocyte adhesion mediated by vla-4 |
DK1940826T3 (en) | 2005-09-29 | 2011-04-18 | Elan Pharm Inc | Pyrimidinylamide compounds that inhibit leukocyte adhesion mediated through BLA-4 |
JP5135235B2 (en) | 2006-02-27 | 2013-02-06 | エラン ファーマシューティカルズ,インコーポレイテッド | Pyrimidinylsulfonamide compounds that inhibit leukocyte adhesion mediated by VAL-4 |
WO2010126914A1 (en) | 2009-04-27 | 2010-11-04 | Elan Pharmaceuticals, Inc. | Pyridinone antagonists of alpha-4 integrins |
WO2012103328A1 (en) | 2011-01-26 | 2012-08-02 | The Methodist Hospital Research Institute | Labeled, non- peptidic multivalent integrin alpha -v - beta - 3 antagonists, compositions containing them and their use |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL99537A (en) * | 1990-09-27 | 1995-11-27 | Merck & Co Inc | Fibrinogen receptor antagonists and pharmaceutical compositions containing them |
NZ239846A (en) * | 1990-09-27 | 1994-11-25 | Merck & Co Inc | Sulphonamide derivatives and pharmaceutical compositions thereof |
-
1995
- 1995-12-23 DE DE19548709A patent/DE19548709A1/en not_active Withdrawn
-
1996
- 1996-12-16 AU AU13016/97A patent/AU1301697A/en not_active Abandoned
- 1996-12-16 PL PL96327185A patent/PL327185A1/en unknown
- 1996-12-16 EP EP96944578A patent/EP0879227A1/en not_active Withdrawn
- 1996-12-16 WO PCT/EP1996/005646 patent/WO1997023451A1/en not_active Application Discontinuation
- 1996-12-16 SK SK783-98A patent/SK78398A3/en unknown
- 1996-12-16 KR KR1019980704788A patent/KR19990076676A/en not_active Application Discontinuation
- 1996-12-16 JP JP9523282A patent/JP2000502664A/en active Pending
- 1996-12-16 CA CA002241149A patent/CA2241149A1/en not_active Abandoned
- 1996-12-16 BR BR9612201A patent/BR9612201A/en not_active Application Discontinuation
- 1996-12-16 HU HU9903716A patent/HUP9903716A2/en unknown
- 1996-12-16 CZ CZ981951A patent/CZ195198A3/en unknown
- 1996-12-19 ZA ZA9610725A patent/ZA9610725B/en unknown
-
1998
- 1998-06-22 NO NO982907A patent/NO982907D0/en unknown
Also Published As
Publication number | Publication date |
---|---|
NO982907L (en) | 1998-06-22 |
NO982907D0 (en) | 1998-06-22 |
DE19548709A1 (en) | 1997-07-03 |
CZ195198A3 (en) | 1998-11-11 |
HUP9903716A2 (en) | 2000-03-28 |
SK78398A3 (en) | 1998-11-04 |
JP2000502664A (en) | 2000-03-07 |
EP0879227A1 (en) | 1998-11-25 |
WO1997023451A1 (en) | 1997-07-03 |
MX9804971A (en) | 1998-09-30 |
PL327185A1 (en) | 1998-11-23 |
CA2241149A1 (en) | 1997-07-03 |
KR19990076676A (en) | 1999-10-15 |
BR9612201A (en) | 1999-07-13 |
AU1301697A (en) | 1997-07-17 |
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