ZA959044B - Spiro [heterocycle-imidazo (1,2-a) indeno (1,2-e) pyrazine]-4'ones and preparation thereof - Google Patents

Spiro [heterocycle-imidazo (1,2-a) indeno (1,2-e) pyrazine]-4'ones and preparation thereof

Info

Publication number: ZA959044B
Authority: ZA; South Africa
Prior art keywords: alk; coor6; het; pct; receptor
Prior art date: 1994-11-02

Application number

ZA959044A

Other languages

English (en)

Inventor

Jean-Claude Aloup

Michel Barreau

Arielle Genevois-Borella

Serge Mignani

Francois Audiau

Dominique Damour

Patric Jimonet

Yves Ribeill

Original Assignee

Rhone Poulenc Rorer Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-11-02

Filing date

1995-10-25

Publication date

1996-05-22

1995-10-25 Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa

1996-05-22 Publication of ZA959044B publication Critical patent/ZA959044B/xx

Links

KYQCOXFCLRTKLS-UHFFFAOYSA-N Pyrazine Chemical compound C1=CN=CC=N1 KYQCOXFCLRTKLS-UHFFFAOYSA-N 0.000 title 2
PCNDJXKNXGMECE-UHFFFAOYSA-N Phenazine Natural products C1=CC=CC2=NC3=CC=CC=C3N=C21 PCNDJXKNXGMECE-UHFFFAOYSA-N 0.000 title 1
125000003003 spiro group Chemical group 0.000 title 1
UUDAMDVQRQNNHZ-UHFFFAOYSA-N (S)-AMPA Chemical compound CC=1ONC(=O)C=1CC(N)C(O)=O UUDAMDVQRQNNHZ-UHFFFAOYSA-N 0.000 abstract 2
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 2
HOKKHZGPKSLGJE-GSVOUGTGSA-N N-Methyl-D-aspartic acid Chemical compound CN[C@@H](C(O)=O)CC(O)=O HOKKHZGPKSLGJE-GSVOUGTGSA-N 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
239000002464 receptor antagonist Substances 0.000 abstract 2
229940044551 receptor antagonist Drugs 0.000 abstract 2
FUFZNHHSSMCXCZ-UHFFFAOYSA-N 5-piperidin-4-yl-3-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazole Chemical group FC(F)(F)C1=CC=CC(C=2N=C(ON=2)C2CCNCC2)=C1 FUFZNHHSSMCXCZ-UHFFFAOYSA-N 0.000 abstract 1
102000003678 AMPA Receptors Human genes 0.000 abstract 1
108090000078 AMPA Receptors Proteins 0.000 abstract 1
239000004471 Glycine Substances 0.000 abstract 1
102000004868 N-Methyl-D-Aspartate Receptors Human genes 0.000 abstract 1
108090001041 N-Methyl-D-Aspartate Receptors Proteins 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
ZSIQJIWKELUFRJ-UHFFFAOYSA-N azepane Chemical group C1CCCNCC1 ZSIQJIWKELUFRJ-UHFFFAOYSA-N 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
239000003446 ligand Substances 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
230000036963 noncompetitive effect Effects 0.000 abstract 1
ORTFAQDWJHRMNX-UHFFFAOYSA-M oxidooxomethyl Chemical compound [O-][C]=O ORTFAQDWJHRMNX-UHFFFAOYSA-M 0.000 abstract 1
230000000144 pharmacologic effect Effects 0.000 abstract 1
102000005962 receptors Human genes 0.000 abstract 1
108020003175 receptors Proteins 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/20—Spiro-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/20—Spiro-condensed systems

ZA959044A 1994-11-02 1995-10-25 Spiro [heterocycle-imidazo (1,2-a) indeno (1,2-e) pyrazine]-4'ones and preparation thereof ZA959044B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9413060A FR2726275B1 (fr)	1994-11-02	1994-11-02	Spiro heterocycle-imidazo(1,2-a)indeno(1,2-e)pyrazine)-4'- ones, leur preparation et les medicaments les contenants

Publications (1)

Publication Number	Publication Date
ZA959044B true ZA959044B (en)	1996-05-22

Family

ID=9468413

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA959044A ZA959044B (en)	1994-11-02	1995-10-25	Spiro [heterocycle-imidazo (1,2-a) indeno (1,2-e) pyrazine]-4'ones and preparation thereof

Country Status (12)

Country	Link
US (1)	US5777114A (de)
EP (1)	EP0789699B1 (de)
JP (1)	JPH10508311A (de)
AT (1)	ATE177747T1 (de)
AU (1)	AU3848595A (de)
DE (1)	DE69508421T2 (de)
DK (1)	DK0789699T3 (de)
ES (1)	ES2130669T3 (de)
FR (1)	FR2726275B1 (de)
GR (1)	GR3029714T3 (de)
WO (1)	WO1996014318A1 (de)
ZA (1)	ZA959044B (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7375136B2 (en) *	2001-03-08	2008-05-20	Emory University	pH-dependent NMDA receptor antagonists
US7045527B2 (en)	2002-09-24	2006-05-16	Amgen Inc.	Piperidine derivatives
US7732162B2 (en)	2003-05-05	2010-06-08	Probiodrug Ag	Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases
NZ576606A (en) *	2006-10-30	2012-04-27	Hybrigenics Sa	Novel tetracyclic inhibitors of cysteine proteases, the pharmaceutical compositions thereof and their therapeutic applications
WO2008055945A1 (en)	2006-11-09	2008-05-15	Probiodrug Ag	3-hydr0xy-1,5-dihydr0-pyrr0l-2-one derivatives as inhibitors of glutaminyl cyclase for the treatment of ulcer, cancer and other diseases
WO2008065141A1 (en)	2006-11-30	2008-06-05	Probiodrug Ag	Novel inhibitors of glutaminyl cyclase
ZA200905537B (en)	2007-03-01	2010-10-27	Probiodrug Ag	New use of glutaminyl cyclase inhibitors
JP5667440B2 (ja)	2007-04-18	2015-02-12	プロビオドルグエージー	グルタミニルシクラーゼ阻害剤としてのチオ尿素誘導体
US8420680B2 (en) *	2007-06-29	2013-04-16	Emory University	NMDA receptor antagonists for neuroprotection
MX2012002993A (es)	2009-09-11	2012-04-19	Probiodrug Ag	Derivados heterociclicos como inhibidores de ciclasa glutaminilo.
EP2338492A1 (de)	2009-12-24	2011-06-29	Universidad del Pais Vasco	Verfahren und Zusammensetzung zur Behandlung von Alzheimer
JP6026284B2 (ja)	2010-03-03	2016-11-16	プロビオドルグエージー	グルタミニルシクラーゼの阻害剤
MX2012010470A (es)	2010-03-10	2012-10-09	Probiodrug Ag	Inhibidores heterociclicos d ciclasa de glutaminilo (qc, ec .3 2. 5).
US8541596B2 (en)	2010-04-21	2013-09-24	Probiodrug Ag	Inhibitors
WO2012123563A1 (en)	2011-03-16	2012-09-20	Probiodrug Ag	Benz imidazole derivatives as inhibitors of glutaminyl cyclase
EP3461819B1 (de)	2017-09-29	2020-05-27	Probiodrug AG	Hemmer der glutaminylcyclase

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4354027A (en) *	1980-05-19	1982-10-12	Usv Pharmaceutical Corporation	Triazoloquinoxalin-4-ones
DK101290D0 (da) *	1990-04-24	1990-04-24	Novo Nordisk As	Heterocykliske forbindelser, deres fremstilling og anvendelse
FR2696466B1 (fr) *	1992-10-02	1994-11-25	Rhone Poulenc Rorer Sa	Dérivés de 5H,10H-imidazo[1,2-a]indeno[1,2-e]pyrazine-4-one, leur préparation et les médicaments les contenant.
FR2707643B1 (fr) *	1993-07-16	1995-08-11	Rhone Poulenc Rorer Sa	Dérivés d'imidazo[1,2-a]pyrazine-4-one, leur préparation et les médicaments les contenant.

1994
- 1994-11-02 FR FR9413060A patent/FR2726275B1/fr not_active Expired - Fee Related
1995
- 1995-10-25 ZA ZA959044A patent/ZA959044B/xx unknown
- 1995-10-30 US US08/836,410 patent/US5777114A/en not_active Expired - Fee Related
- 1995-10-30 ES ES95936624T patent/ES2130669T3/es not_active Expired - Lifetime
- 1995-10-30 WO PCT/FR1995/001430 patent/WO1996014318A1/fr active IP Right Grant
- 1995-10-30 DK DK95936624T patent/DK0789699T3/da active
- 1995-10-30 DE DE69508421T patent/DE69508421T2/de not_active Expired - Fee Related
- 1995-10-30 EP EP95936624A patent/EP0789699B1/de not_active Expired - Lifetime
- 1995-10-30 JP JP8515088A patent/JPH10508311A/ja not_active Ceased
- 1995-10-30 AT AT95936624T patent/ATE177747T1/de not_active IP Right Cessation
- 1995-10-30 AU AU38485/95A patent/AU3848595A/en not_active Abandoned
1999
- 1999-03-18 GR GR990400113T patent/GR3029714T3/el unknown

Also Published As

Publication number	Publication date
FR2726275B1 (fr)	1996-12-06
EP0789699B1 (de)	1999-03-17
ES2130669T3 (es)	1999-07-01
GR3029714T3 (en)	1999-06-30
WO1996014318A1 (fr)	1996-05-17
AU3848595A (en)	1996-05-31
EP0789699A1 (de)	1997-08-20
US5777114A (en)	1998-07-07
ATE177747T1 (de)	1999-04-15
JPH10508311A (ja)	1998-08-18
DE69508421D1 (de)	1999-04-22
DE69508421T2 (de)	1999-07-15
FR2726275A1 (fr)	1996-05-03
DK0789699T3 (da)	1999-10-11

Publication	Publication Date	Title
ZA959044B (en)	1996-05-22	Spiro [heterocycle-imidazo (1,2-a) indeno (1,2-e) pyrazine]-4'ones and preparation thereof
DE69509886D1 (de)	1999-07-01	5H-INDENO[1,2-b]PYRAZIN-2,3-DION-DERIVATE ANTAGONISTEN DER AMPA UND NMDA REZEPTOREN
NZ331060A (en)	2000-01-28	Quinoxalinediones, preparation and pharmaceutical compositions thereof
FR2707643B1 (fr)	1995-08-11	Dérivés d'imidazo[1,2-a]pyrazine-4-one, leur préparation et les médicaments les contenant.
DE69509888D1 (de)	1999-07-01	IMIDAZO[1,2-a]INDENO [1,2-e] PYRAZINONE ANTAGONISTEN DER AMPA UND NMDA REZEPTOREN
ES2158099T3 (es)	2001-09-01	Derivados de imidazo(1,2-a)indeno(1,2-e)pirazina-4-ona y composiciones farmaceuticas que los contienen.
EP1081136A4 (de)	2002-07-03	Optisch aktive tetrahydrobenzindol-derivate
MX9805167A (es)	1998-10-31	Derivados de 5h,10h-imidazo[1,2-a]indeno[1,2-3]-pirazin-4- ona, su preparacion, sus intermediarios y los medicamentos que los contienen.
IL97913A0 (en)	1992-06-21	Heterocyclic compounds,their preparation and pharmaceutical compositions containing them
ATE269329T1 (de)	2004-07-15	Neue basische derivate von benz(e)isoindol-1-onen und pyrrolo(3,4-c)chinolin-1-onen mit 5-ht3- antagonistischer aktivität, ihre herstellung und ihre therapeutische verwendung
MX9707528A (es)	1997-11-29	Derivados de 5h,10h-imidazo[1,2-a]indeno[1,2-e]pirazin-4-ona, su preparacion y los medicamentos que los contienen.