ZA948909B - 7beta-substitute -4-AZA-5alpha-cholestan-ones as selective 5alpha-reductase 1 inhibitors - Google Patents

7beta-substitute -4-AZA-5alpha-cholestan-ones as selective 5alpha-reductase 1 inhibitors

Info

Publication number
ZA948909B
ZA948909B ZA948909A ZA948909A ZA948909B ZA 948909 B ZA948909 B ZA 948909B ZA 948909 A ZA948909 A ZA 948909A ZA 948909 A ZA948909 A ZA 948909A ZA 948909 B ZA948909 B ZA 948909B
Authority
ZA
South Africa
Prior art keywords
5alpha
7beta
cholestan
aza
reductase
Prior art date
Application number
ZA948909A
Inventor
Raman K Bakshi
Gary H Rasmusson
Richard L Tolman
Gool F Patel
Georginanna Harris
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of ZA948909B publication Critical patent/ZA948909B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
ZA948909A 1993-11-12 1994-11-10 7beta-substitute -4-AZA-5alpha-cholestan-ones as selective 5alpha-reductase 1 inhibitors ZA948909B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US15300693A 1993-11-12 1993-11-12

Publications (1)

Publication Number Publication Date
ZA948909B true ZA948909B (en) 1995-10-10

Family

ID=22545401

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA948909A ZA948909B (en) 1993-11-12 1994-11-10 7beta-substitute -4-AZA-5alpha-cholestan-ones as selective 5alpha-reductase 1 inhibitors

Country Status (4)

Country Link
AU (1) AU8133294A (en)
IL (1) IL111467A0 (en)
WO (1) WO1995013077A1 (en)
ZA (1) ZA948909B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69518515T2 (en) 1994-05-19 2001-04-19 Merck & Co Inc OXIDATION OF STEROIDS WITH ALLYLIC GROUPS
US5543417A (en) * 1994-10-21 1996-08-06 Merck & Co., Inc. Combination method of treating acne using 4-AZA-5α-cholestan-ones and 4-AZA-5α-androstan-ones as selective 5α-reductase inhibitors with anti-bacterial, keratolytic, or anti-inflammatory agents
WO1996012487A1 (en) * 1994-10-21 1996-05-02 Merck & Co., Inc. Combination method for acne treatment
JP2001523259A (en) * 1997-05-07 2001-11-20 ノヴォファーム リミテッド 4-aza-steroids
US20080125403A1 (en) * 2004-04-02 2008-05-29 Merck & Co., Inc. Method of Treating Men with Metabolic and Anthropometric Disorders
GB201102913D0 (en) 2011-02-18 2011-04-06 Univ Birmingham Novel therapeutic

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9006023D0 (en) * 1990-03-16 1990-05-09 Smithkline Beecham Corp Synergistic compositions
EP0555309A1 (en) * 1990-10-31 1993-08-18 BEECHAM GROUP plc Topical composition with retinoid penetration enhancer
IL101245A0 (en) * 1991-03-20 1992-11-15 Merck & Co Inc Pharmaceutical compositions for the treatment of prostatic cancer
HUT71484A (en) * 1992-05-20 1995-11-28 Merck & Co Inc Process for producing of 7beta-substituted-4-aza-5alpha-cholestan-ones as 5-alpha-reductase inhibitors and pharmaceuticals compositions containing them
US5237064A (en) * 1992-05-20 1993-08-17 Merck & Co., Inc. Process for producing 7β-substituted-aza-5αandrostan-3-ones

Also Published As

Publication number Publication date
IL111467A0 (en) 1994-12-29
AU8133294A (en) 1995-05-29
WO1995013077A1 (en) 1995-05-18

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