ZA933494B - Xanthine phosphodiesterase inhibitors - Google Patents

Xanthine phosphodiesterase inhibitors

Info

Publication number
ZA933494B
ZA933494B ZA933494A ZA933494A ZA933494B ZA 933494 B ZA933494 B ZA 933494B ZA 933494 A ZA933494 A ZA 933494A ZA 933494 A ZA933494 A ZA 933494A ZA 933494 B ZA933494 B ZA 933494B
Authority
ZA
South Africa
Prior art keywords
phosphodiesterase inhibitors
xanthine phosphodiesterase
xanthine
inhibitors
phosphodiesterase
Prior art date
Application number
ZA933494A
Inventor
Ashley Edward Fenwick
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of ZA933494B publication Critical patent/ZA933494B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ZA933494A 1992-05-21 1993-05-19 Xanthine phosphodiesterase inhibitors ZA933494B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB929210839A GB9210839D0 (en) 1992-05-21 1992-05-21 Novel compounds

Publications (1)

Publication Number Publication Date
ZA933494B true ZA933494B (en) 1994-03-01

Family

ID=10715834

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA933494A ZA933494B (en) 1992-05-21 1993-05-19 Xanthine phosphodiesterase inhibitors

Country Status (10)

Country Link
EP (1) EP0641344A1 (en)
JP (1) JPH07506591A (en)
CN (1) CN1094046A (en)
AU (1) AU4081493A (en)
CA (1) CA2136196A1 (en)
GB (1) GB9210839D0 (en)
MX (1) MX9302957A (en)
TW (1) TW277062B (en)
WO (1) WO1993023401A1 (en)
ZA (1) ZA933494B (en)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5684153A (en) * 1984-08-16 1997-11-04 Beecham Group Plc Process for the preparation of purine derivatives
GB9623859D0 (en) * 1996-11-15 1997-01-08 Chiroscience Ltd Novel compounds
GB9703044D0 (en) * 1997-02-14 1997-04-02 Glaxo Group Ltd Phenyl xanthine esters and amides
CA2309350C (en) 1997-11-12 2007-04-03 Mitsubishi Chemical Corporation Purine derivatives and medicaments comprising the same as active ingredient
GB9817623D0 (en) 1998-08-13 1998-10-07 Glaxo Group Ltd Pharmaceutical compounds
EP1178046B1 (en) 1999-05-11 2003-11-19 Mitsubishi Chemical Corporation Purine derivative dihydrate, drugs containing the same as the active ingredient and intermediate in the production thereof
USRE47351E1 (en) 1999-06-22 2019-04-16 Gilead Sciences, Inc. 2-(N-pyrazolo)adenosines with application as adenosine A2A receptor agonists
US6403567B1 (en) 1999-06-22 2002-06-11 Cv Therapeutics, Inc. N-pyrazole A2A adenosine receptor agonists
TR200201132T2 (en) * 1999-08-31 2002-08-21 Vanderbilt University Selective antagonists of A2B adenosine receptors.
US6815446B1 (en) 1999-08-31 2004-11-09 Vanderbilt University Selective antagonists of A2B adenosine receptors
CA2439222C (en) 2000-02-23 2009-07-14 Cv Therapeutics, Inc. Identification of partial agonists of the a2a adenosine receptor
US6821978B2 (en) 2000-09-19 2004-11-23 Schering Corporation Xanthine phosphodiesterase V inhibitors
CN1315835C (en) 2001-08-28 2007-05-16 先灵公司 Polycyclic guanine phosphodiesterase v inhibitors
CN1585771A (en) 2001-11-09 2005-02-23 先灵公司 Polycyclic guanine derivative phosphodiesterase V inhibitors
SI1509525T1 (en) 2002-05-31 2006-12-31 Schering Corp Process for preparing xanthine phosphodiesterase v inhibitors and precursors thereof
JP4491344B2 (en) 2002-06-17 2010-06-30 グラクソ グループ リミテッド Purine derivatives as liver X receptor agonists
US7683037B2 (en) 2002-07-29 2010-03-23 Gilead Palo Alto, Inc. Myocardial perfusion imaging method
US8470801B2 (en) 2002-07-29 2013-06-25 Gilead Sciences, Inc. Myocardial perfusion imaging methods and compositions
US20050020915A1 (en) 2002-07-29 2005-01-27 Cv Therapeutics, Inc. Myocardial perfusion imaging methods and compositions
JP2007500714A (en) 2003-07-31 2007-01-18 シェーリング　コーポレイション Metabolites of xanthine phosphodiesterase 5 inhibitors and derivatives thereof useful for treating erectile dysfunction
US7655636B2 (en) 2004-10-20 2010-02-02 Gilead Palo Alto, Inc. Use of A2A adenosine receptor agonists
EP1989214B8 (en) 2006-02-03 2016-12-21 Gilead Sciences, Inc. Process for preparing an a2a-adenosine receptor agonist and its polymorphs

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0258191B1 (en) * 1986-08-28 1992-05-27 Sandoz Ag Xanthine derivatives
IT1229195B (en) * 1989-03-10 1991-07-25 Poli Ind Chimica Spa XANTHINIC DERIVATIVES WITH BRONCODILATORY ACTIVITY AND THEIR THERAPEUTIC APPLICATIONS.
GB8906792D0 (en) * 1989-03-23 1989-05-10 Beecham Wuelfing Gmbh & Co Kg Treatment and compounds
GB9020921D0 (en) * 1990-09-26 1990-11-07 Beecham Group Plc Novel compounds
GB9020959D0 (en) * 1990-09-26 1990-11-07 Beecham Group Plc Novel compounds
JPH06504534A (en) * 1990-12-21 1994-05-26 ビーチャム・グループ・パブリック・リミテッド・カンパニー xanthine derivative

Also Published As

Publication number Publication date
CN1094046A (en) 1994-10-26
GB9210839D0 (en) 1992-07-08
AU4081493A (en) 1993-12-13
EP0641344A1 (en) 1995-03-08
MX9302957A (en) 1994-05-31
WO1993023401A1 (en) 1993-11-25
JPH07506591A (en) 1995-07-20
CA2136196A1 (en) 1993-11-25
TW277062B (en) 1996-06-01

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