ZA924975B - Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides - Google Patents
Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosidesInfo
- Publication number
- ZA924975B ZA924975B ZA924975A ZA924975A ZA924975B ZA 924975 B ZA924975 B ZA 924975B ZA 924975 A ZA924975 A ZA 924975A ZA 924975 A ZA924975 A ZA 924975A ZA 924975 B ZA924975 B ZA 924975B
- Authority
- ZA
- South Africa
- Prior art keywords
- treatment
- pyrimidine nucleosides
- toxicity
- antiviral
- agent
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Toxicology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The subject invention discloses compounds, compositions and methods for treatment and prevention of toxicity due to chemotherapeutic agents and antiviral agents. Disclosed are acylated derivatives of non-methylated pyrimidine nucleosides. These compounds are capable of attenuating damage to the hematopoietic system in animals receiving antiviral or antineoplastic chemotherapy.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US72434091A | 1991-07-05 | 1991-07-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA924975B true ZA924975B (en) | 1993-04-28 |
Family
ID=24910042
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA924975A ZA924975B (en) | 1991-07-05 | 1992-07-03 | Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides |
Country Status (13)
Country | Link |
---|---|
EP (1) | EP0594667B1 (en) |
JP (1) | JP2584947B2 (en) |
KR (1) | KR100256144B1 (en) |
AT (1) | ATE205850T1 (en) |
AU (1) | AU667676B2 (en) |
CA (2) | CA2111571C (en) |
DE (1) | DE69232070T2 (en) |
DK (1) | DK0594667T3 (en) |
ES (1) | ES2160579T3 (en) |
GR (1) | GR3036749T3 (en) |
HK (1) | HK1003424A1 (en) |
WO (1) | WO1993001202A1 (en) |
ZA (1) | ZA924975B (en) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5691320A (en) | 1987-10-28 | 1997-11-25 | Pro-Neuron, Inc. | Acylated pyrimidine nucleosides for treatment of systemic inflammation and inflammatory hepatitis |
US6329350B1 (en) | 1987-10-28 | 2001-12-11 | Pro-Neuron, Inc. | Pyrimidine nucleotide precursors for treatment of systemic inflammation and inflammatory hepatitis |
US5968914A (en) * | 1987-10-28 | 1999-10-19 | Pro-Neuron, Inc. | Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides |
KR100290132B1 (en) | 1994-07-01 | 2001-05-15 | 마이클 바마트 | Pyrimidine nucleotide precursors for systemic inflammation and inflammatory hepatitis |
CA2189097A1 (en) * | 1995-11-15 | 1997-05-16 | Pin-Fang Lin | Composition and method of treating retroviral infection |
US5719132A (en) * | 1996-06-27 | 1998-02-17 | Bristol-Myers Squibb Company | Compositions and methods of treating HIV with d4T, 5-fluorouracil/tegafur, and uracil |
US6875751B2 (en) | 2000-06-15 | 2005-04-05 | Idenix Pharmaceuticals, Inc. | 3′-prodrugs of 2′-deoxy-β-L-nucleosides |
DE10110355A1 (en) | 2001-03-03 | 2002-09-12 | Ulrich Walker | Combating side effects |
US6905669B2 (en) | 2001-04-24 | 2005-06-14 | Supergen, Inc. | Compositions and methods for reestablishing gene transcription through inhibition of DNA methylation and histone deacetylase |
US6982253B2 (en) | 2002-06-05 | 2006-01-03 | Supergen, Inc. | Liquid formulation of decitabine and use of the same |
US7250416B2 (en) | 2005-03-11 | 2007-07-31 | Supergen, Inc. | Azacytosine analogs and derivatives |
US7700567B2 (en) | 2005-09-29 | 2010-04-20 | Supergen, Inc. | Oligonucleotide analogues incorporating 5-aza-cytosine therein |
JP5504179B2 (en) | 2008-03-03 | 2014-05-28 | トスク インコーポレーティッド | Methotrexate adjuvant and method of use thereof for reducing toxicity |
UA116528C2 (en) | 2011-08-30 | 2018-04-10 | Астекс Фармасьютікалз, Інк. | Decitabine derivative formulations |
WO2013055252A1 (en) * | 2011-10-14 | 2013-04-18 | Закрытое Акционерное Общество " Производственно-Коммерческая Ассоциация Азт" | Salts of carbamoyl phosphonic acid esters which act as selective inhibitors of human immunodeficiency virus hiv-1 production |
US10485764B2 (en) | 2015-07-02 | 2019-11-26 | Otsuka Pharmaceutical Co., Ltd. | Lyophilized pharmaceutical compositions |
WO2017156380A1 (en) * | 2016-03-10 | 2017-09-14 | Emory University | N4-hydroxycytidine and derivatives and anti-viral uses related thereto |
CA3043640A1 (en) * | 2016-11-11 | 2018-05-17 | Whitehead Institute For Biomedical Research | Human plasma-like medium |
AU2018310857A1 (en) | 2017-08-03 | 2020-02-13 | Otsuka Pharmaceutical Co., Ltd. | Drug compound and purification methods thereof |
WO2020036974A1 (en) * | 2018-08-14 | 2020-02-20 | Tosk, Inc. | Methods and compositions for reducing radiation induced toxicity |
WO2020036975A1 (en) * | 2018-08-14 | 2020-02-20 | Tosk, Inc. | Methods and compositions for reducing fluorouracil induced toxicity |
WO2020036982A1 (en) * | 2018-08-14 | 2020-02-20 | Tosk, Inc. | Methods and compositions for treating mucositis |
US11446303B2 (en) | 2019-06-21 | 2022-09-20 | Tosk, Inc. | Uridine phosphorylase (UPase) inhibitors for treatment of liver conditions |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3100478A1 (en) * | 1981-01-09 | 1982-08-12 | Dr. Thilo & Co GmbH, 8021 Sauerlach | 5'ESTERS OF PYRIMIDINE NUCLEOSIDES WITH ANTIVIRAL EFFECTIVENESS, METHOD FOR THE PRODUCTION AND MEDICINAL PRODUCTS THEREOF |
WO1985000608A1 (en) * | 1983-07-20 | 1985-02-14 | Teijin Limited | Antineoplastic agent |
ATE93236T1 (en) * | 1987-10-28 | 1993-09-15 | Pro Neuron Inc | ACYLATED URIDIN AND CYTIDIN AND THEIR USES. |
KR890701609A (en) * | 1987-10-28 | 1989-12-21 | 원본미기재 | Acyl deoxyribonucleoside derivatives and use thereof |
AU7623991A (en) * | 1990-05-17 | 1991-11-21 | Syntex (U.S.A.) Inc. | Antiviral agents |
IL100874A (en) * | 1991-02-08 | 1996-01-19 | Pro Neuron Inc | Oxypurine nucleosides and related compounds for use as medicaments their preparation and pharmaceutical compositions containing them |
-
1992
- 1992-06-25 AU AU22544/92A patent/AU667676B2/en not_active Ceased
- 1992-06-25 WO PCT/US1992/005324 patent/WO1993001202A1/en active IP Right Grant
- 1992-06-25 DK DK92914215T patent/DK0594667T3/en active
- 1992-06-25 KR KR1019940700025A patent/KR100256144B1/en not_active IP Right Cessation
- 1992-06-25 DE DE69232070T patent/DE69232070T2/en not_active Expired - Lifetime
- 1992-06-25 ES ES92914215T patent/ES2160579T3/en not_active Expired - Lifetime
- 1992-06-25 AT AT92914215T patent/ATE205850T1/en not_active IP Right Cessation
- 1992-06-25 JP JP5502244A patent/JP2584947B2/en not_active Expired - Lifetime
- 1992-06-25 EP EP92914215A patent/EP0594667B1/en not_active Expired - Lifetime
- 1992-06-25 CA CA002111571A patent/CA2111571C/en not_active Expired - Lifetime
- 1992-06-25 CA CA002504078A patent/CA2504078C/en not_active Expired - Lifetime
- 1992-07-03 ZA ZA924975A patent/ZA924975B/en unknown
-
1998
- 1998-03-27 HK HK98102605A patent/HK1003424A1/en not_active IP Right Cessation
-
2001
- 2001-09-27 GR GR20010401606T patent/GR3036749T3/en unknown
Also Published As
Publication number | Publication date |
---|---|
DE69232070D1 (en) | 2001-10-25 |
EP0594667B1 (en) | 2001-09-19 |
CA2504078A1 (en) | 1993-01-21 |
CA2111571C (en) | 2005-08-23 |
AU2254492A (en) | 1993-02-11 |
JPH06508846A (en) | 1994-10-06 |
EP0594667A4 (en) | 1996-01-10 |
GR3036749T3 (en) | 2001-12-31 |
JP2584947B2 (en) | 1997-02-26 |
DE69232070T2 (en) | 2002-06-06 |
CA2111571A1 (en) | 1993-01-21 |
KR100256144B1 (en) | 2000-05-15 |
HK1003424A1 (en) | 1998-10-30 |
EP0594667A1 (en) | 1994-05-04 |
DK0594667T3 (en) | 2001-11-12 |
AU667676B2 (en) | 1996-04-04 |
ATE205850T1 (en) | 2001-10-15 |
ES2160579T3 (en) | 2001-11-16 |
WO1993001202A1 (en) | 1993-01-21 |
CA2504078C (en) | 2007-08-28 |
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