ZA917766B - Hybrid growth factors. - Google Patents

Hybrid growth factors.

Info

Publication number: ZA917766B
Authority: ZA; South Africa
Prior art keywords: growth factors; hybrid growth; hybrid; factors; growth
Prior art date: 1990-09-28

Application number

ZA917766A

Inventor

Jonathan I Rosen

Original Assignee

Ortho Pharma Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-09-28

Filing date

1991-09-27

Publication date

1993-03-29

1991-09-27 Application filed by Ortho Pharma Corp filed Critical Ortho Pharma Corp

1993-03-29 Publication of ZA917766B publication Critical patent/ZA917766B/en

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/505—Erythropoietin [EPO]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5403—IL-3
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Gastroenterology & Hepatology (AREA)
Genetics & Genomics (AREA)
Zoology (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Toxicology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Hematology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Peptides Or Proteins (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
Enzymes And Modification Thereof (AREA)

ZA917766A 1990-09-28 1991-09-27 Hybrid growth factors. ZA917766B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US58995890A	1990-09-28	1990-09-28

Publications (1)

Publication Number	Publication Date
ZA917766B true ZA917766B (en)	1993-03-29

Family

ID=24360286

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA917766A ZA917766B (en)	1990-09-28	1991-09-27	Hybrid growth factors.

Country Status (8)

Country	Link
EP (1)	EP0503050A4 (en)
JP (1)	JPH05502463A (en)
AU (2)	AU8735991A (en)
CA (1)	CA2069746A1 (en)
IE (1)	IE913426A1 (en)
PT (1)	PT99107A (en)
WO (1)	WO1992006116A1 (en)
ZA (1)	ZA917766B (en)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5718893A (en) *	1984-04-15	1998-02-17	Foster; Preston F.	Use of G-CSF to reduce acute rejection
ES2118756T5 (en) *	1990-08-29	2004-01-16	Genetics Institute, Llc	HEMATOPOYESIS STIMULATORS OF MULTIPLE DOMAINS.
US5738849A (en) *	1992-11-24	1998-04-14	G. D. Searle & Co.	Interleukin-3 (IL-3) variant fusion proteins, their recombinant production, and therapeutic compositions comprising them
JPH08503706A (en) *	1992-11-24	1996-04-23	ジー．ディー．サールアンドカンパニー	Interleukin-3 (IL-3) multiple mutant polypeptide
US6153183A (en)	1992-11-24	2000-11-28	G. D. Searle & Company	Co-administration of interleukin-3 mutant polypeptides with CSF's or cytokines for multi-lineage hematopoietic cell production
US6057133A (en) *	1992-11-24	2000-05-02	G. D. Searle	Multivariant human IL-3 fusion proteins and their recombinant production
US5501962A (en) *	1993-06-21	1996-03-26	G. D. Searle & Co.	Interleuken-3 (IL-3) human/murine hybrid polypeptides and recombinant production of the same
WO1995028427A1 (en) *	1994-04-15	1995-10-26	Imclone Systems Incorporated	Chimeric interleukin-3/mutein interleukin-6 lymphokine
US5536495A (en) *	1994-04-15	1996-07-16	Foster; Preston F.	Use of G-CSF to reduce acute rejection
ITFI940106A1 (en) *	1994-05-27	1995-11-27	Menarini Ricerche Sud Spa	HYBRID MOLECULE OF GM-CSF-L-EPO OR EPO-L-GM-CSF FORMULA FOR ERYTHROPOIETIC STIMULATION
IT1271688B (en) *	1994-08-04	1997-06-04	Menarini Ricerche Sud Spa	HYBRID MOLECULES FOR ANTI-CANCER TREATMENT THEIR PREPARATION AND THEIR USE IN PHARMACEUTICAL COMPOSITIONS
ES2276401T3 (en) *	1995-04-26	2007-06-16	Kyowa Hakko Kogyo Co., Ltd.	FUSION PROTEINS G-CSF TPO.
US6066318A (en)	1995-10-05	2000-05-23	G.D. Searle & Co.	Multi-functional hematopoietic fusion proteins between sequence rearranged C-MPL receptor agonists and other hematopoietic factors
IL129028A0 (en) *	1996-09-20	2000-02-17	Ortho Mcneil Pharm Inc	Method for in vitro determination of erythropoietin bioactivity
US6967092B1 (en)	1996-10-25	2005-11-22	Mc Kearn John P	Multi-functional chimeric hematopoietic receptor agonists
WO1998018926A1 (en) *	1996-10-25	1998-05-07	G.D. Searle & Co.	Circularly permuted erythropoietin receptor agonists
CA2268742A1 (en) *	1996-10-25	1998-04-30	G.D. Searle & Co.	Multi-functional chimeric hematopoietic receptor agonists
US6165476A (en) *	1997-07-10	2000-12-26	Beth Israel Deaconess Medical Center	Fusion proteins with an immunoglobulin hinge region linker
US6187564B1 (en) *	1997-07-10	2001-02-13	Beth Israel Deaconess Medical Center	DNA encoding erythropoietin multimers having modified 5′ and 3′ sequences and its use to prepare EPO therapeutics
ES2208798T3 (en) *	1997-09-01	2004-06-16	Aventis Pharma Deutschland Gmbh	RECOMBINANT HUMAN ERYTHROPOYETIN WITH AN ADVANTAGE GLICOSILATION PROFILE.
WO1999041382A2 (en) *	1998-02-17	1999-08-19	Hyseq, Inc.	A novel interleukin-3 and uses thereof
BR9917606A (en) *	1998-11-06	2002-12-31	Bio Sidus S A	Procedure for the purification of recombinant human erythropoietin from cell culture supernatants and recombinant human erythropoietin obtained with such procedure
JP3967594B2 (en)	2000-05-15	2007-08-29	エフ．ホフマン−ラロシュアーゲー	New pharmaceutical composition
US7220407B2 (en)	2003-10-27	2007-05-22	Amgen Inc.	G-CSF therapy as an adjunct to reperfusion therapy in the treatment of acute myocardial infarction
AU2005306894B2 (en)	2004-11-05	2011-11-24	Northwestern University	Use of SCF and G-CSF in the treatment of cerebral ischemia and neurological disorders
WO2011109556A2 (en)	2010-03-04	2011-09-09	Pfenex Inc.	Method for producing soluble recombinant interferon protein without denaturing
WO2011123570A2 (en)	2010-04-01	2011-10-06	Pfenex Inc.	Methods for g-csf production in a pseudomonas host cell
JP5860151B2 (en)	2012-07-31	2016-02-16	旭化成イーマテリアルズ株式会社	Epoxy resin composition, epoxy resin, and cured product
LT6161B (en)	2013-09-27	2015-06-25	Uab Profarma	Fused proteins of granulocyte colony-stimulating factor with other partners of growh factor, preferably with stem cell factor, and method of preparation thereof

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE25197T1 (en) *	1982-05-12	1987-02-15	Harvard College	FUSIONED GENES ENCODING HYBRID PROTEIN, CLONING VECTORS CONTAINING THEM AND THEIR USE.
US4935352A (en) *	1985-10-21	1990-06-19	Takeda Chemical Industries, Ltd.	Expression vector for animal cell line and use thereof
US4935233A (en) *	1985-12-02	1990-06-19	G. D. Searle And Company	Covalently linked polypeptide cell modulators
DE3751664T2 (en) *	1986-08-01	1996-06-05	Commw Scient Ind Res Org	RECOMBINANT VACCINE
EP0425536A4 (en) *	1988-07-20	1992-01-02	Immunex Corporation	Nonglycosylated human interleukin-3 compositions
US5166322A (en) *	1989-04-21	1992-11-24	Genetics Institute	Cysteine added variants of interleukin-3 and chemical modifications thereof
WO1991001004A1 (en) *	1989-07-06	1991-01-24	Seragen, Inc.	Hybrid molecules
US5073627A (en) *	1989-08-22	1991-12-17	Immunex Corporation	Fusion proteins comprising GM-CSF and IL-3
WO1991002754A1 (en) *	1989-08-22	1991-03-07	Immunex Corporation	Fusion proteins comprising gm-csf and il-3
IL96477A0 (en) *	1989-12-01	1991-08-16	Amgen Inc	Megakaryocyte production
ES2118756T5 (en) *	1990-08-29	2004-01-16	Genetics Institute, Llc	HEMATOPOYESIS STIMULATORS OF MULTIPLE DOMAINS.

1991
- 1991-09-26 WO PCT/US1991/007053 patent/WO1992006116A1/en not_active Application Discontinuation
- 1991-09-26 CA CA002069746A patent/CA2069746A1/en not_active Abandoned
- 1991-09-26 AU AU87359/91A patent/AU8735991A/en not_active Abandoned
- 1991-09-26 EP EP19910918221 patent/EP0503050A4/en not_active Withdrawn
- 1991-09-26 JP JP3517013A patent/JPH05502463A/en active Pending
- 1991-09-27 IE IE342691A patent/IE913426A1/en not_active Application Discontinuation
- 1991-09-27 ZA ZA917766A patent/ZA917766B/en unknown
- 1991-09-27 PT PT99107A patent/PT99107A/en not_active Application Discontinuation
1995
- 1995-02-06 AU AU11576/95A patent/AU1157695A/en not_active Abandoned

Also Published As

Publication number	Publication date
AU8735991A (en)	1992-04-28
IE913426A1 (en)	1992-04-08
WO1992006116A1 (en)	1992-04-16
CA2069746A1 (en)	1992-03-29
PT99107A (en)	1992-08-31
JPH05502463A (en)	1993-04-28
EP0503050A4 (en)	1994-07-06
EP0503050A1 (en)	1992-09-16
AU1157695A (en)	1995-04-13

Publication	Publication Date	Title
ZA917766B (en)	1993-03-29	Hybrid growth factors.
DE69107059D1 (en)	1995-03-09	Sigma-delta-modulator.
AR244753A1 (en)	1993-11-30	Azo-colouring.
GR3022463T3 (en)	1997-04-30	1-H-3-aryl-pyrrolidin-2,4-dion-derivatives
GB2251034B (en)	1995-05-17	Shrouded aerofoils
EP0679163A4 (en)	1997-07-16	Growth differentiation factor-3.
EP0565582A4 (en)	1995-01-11	Novel csaids.
DE69104185D1 (en)	1994-10-27	Luftreservoir.
DE69112211D1 (en)	1995-09-21	Luftreinigungsvorrichtung.
DE69111595D1 (en)	1995-08-31	Squarylium- und crokonyliumfarbstoffe.
ZA928647B (en)	1993-06-21	Novel hybrid transforming growth factors.
EP0649734A3 (en)	1996-02-07	Packaging.
DE69106281D1 (en)	1995-02-09	Phenanthrenderivat.
AU9030991A (en)	1992-05-26	Improved capacitor-sensor
DE69102074D1 (en)	1994-06-23	Thermographische elemente.
DE69110012D1 (en)	1995-06-29	Linienerkennungsverfahren.
DE69114491D1 (en)	1995-12-14	Olefincopolymere.
AR245079A1 (en)	1993-12-30	Procedure for preparing peroxomonosulphuric acid.
DE59102290D1 (en)	1994-08-25	Thermo-fixierstation mit bandtransport.
ZA931481B (en)	1993-09-23	Implants.
EP0481950A3 (en)	1992-09-02	1,4-dideoxy-4-fluoronojirimycin
EP0586848A3 (en)	1995-01-25	Implant.
DE59100097D1 (en)	1993-06-03	Plungerzylinder.
IL96902A0 (en)	1992-03-29	T cell growth factor
ZA919371B (en)	1993-05-27	Containers.