ZA913513B - Photodynamic inactivation of viruses in cell-containing compositions - Google Patents

Photodynamic inactivation of viruses in cell-containing compositions

Info

Publication number
ZA913513B
ZA913513B ZA913513A ZA913513A ZA913513B ZA 913513 B ZA913513 B ZA 913513B ZA 913513 A ZA913513 A ZA 913513A ZA 913513 A ZA913513 A ZA 913513A ZA 913513 B ZA913513 B ZA 913513B
Authority
ZA
South Africa
Prior art keywords
virus
inactivation
composition
cell
viruses
Prior art date
Application number
ZA913513A
Inventor
Bernard Horowitz
Horowitz Bernard
Jay E Valinsky
E Valinsky Jay
Nicholas E Geacintov
E Geacintov Nicholas
Bolanle Williams
Williams Bolanle
Shanti B Rywkin
B Rywkin Shanti
Henrietta Nunno
Nunno Henrietta
Original Assignee
New York Blood Centre
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by New York Blood Centre filed Critical New York Blood Centre
Publication of ZA913513B publication Critical patent/ZA913513B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
    • A61L2/0029—Radiation
    • A61L2/0052—Visible light
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C12N7/04—Inactivation or attenuation; Producing viral sub-units
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0023—Agression treatment or altering
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0038—Radiosensitizing, i.e. administration of pharmaceutical agents that enhance the effect of radiotherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/10—Inactivation or decontamination of a medicinal preparation prior to administration to an animal or a person
    • A61K41/17—Inactivation or decontamination of a medicinal preparation prior to administration to an animal or a person by ultraviolet [UV] or infrared [IR] light, X-rays or gamma rays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
    • A61L2/08—Radiation
    • A61L2/10—Ultraviolet radiation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C12N7/04—Inactivation or attenuation; Producing viral sub-units
    • C12N7/06—Inactivation or attenuation by chemical treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
    • A61L2202/20—Targets to be treated
    • A61L2202/22—Blood or products thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/20011—Rhabdoviridae
    • C12N2760/20211—Vesiculovirus, e.g. vesicular stomatitis Indiana virus
    • C12N2760/20261—Methods of inactivation or attenuation
    • C12N2760/20263—Methods of inactivation or attenuation by chemical treatment

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)

Abstract

The present invention concerns the product produced by inactivating extracellular lipid enveloped pathogenic virus or intracellular pathogenic virus in a composition containing >1 X 10<9> cells/ml and said virus without incurring substantial disruption or inactivation of such cells, the inactivation process comprising contacting the composition with a virucidally effective amount of at least one photoreactive compound having an absorption maximum of >/= 630 nm, light and an oxidizer, thereby substantially to inactivate the virus with retention of cell functionality, greater than 80%. The present invention also concerns the product produced by inactivating virus in a biological composition without incurring substantial disruption or inactivation thereof, the inactivation process comprising contacting said composition with a virucidally effective amount of at least one photoreactive compound, light, and a quencher thereby to inactivate said virus while retaining functionality of said substance. <IMAGE>
ZA913513A 1990-05-15 1991-05-08 Photodynamic inactivation of viruses in cell-containing compositions ZA913513B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/524,208 US5120649A (en) 1990-05-15 1990-05-15 Photodynamic inactivation of viruses in blood cell-containing compositions

Publications (1)

Publication Number Publication Date
ZA913513B true ZA913513B (en) 1992-04-29

Family

ID=24088240

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA913513A ZA913513B (en) 1990-05-15 1991-05-08 Photodynamic inactivation of viruses in cell-containing compositions

Country Status (11)

Country Link
US (1) US5120649A (en)
EP (1) EP0457196B1 (en)
JP (1) JP2831155B2 (en)
KR (1) KR0180917B1 (en)
AT (1) ATE204602T1 (en)
AU (1) AU660411B2 (en)
CA (1) CA2042494C (en)
DE (1) DE69132696T2 (en)
FI (1) FI911389A (en)
NO (1) NO308749B1 (en)
ZA (1) ZA913513B (en)

Families Citing this family (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5109016A (en) * 1988-05-23 1992-04-28 Georgia State University Foundation, Inc. Method for inhibiting infection or replication of human immunodeficiency virus with porphyrin and phthalocyanine antiviral compositions
US5571666A (en) 1988-10-28 1996-11-05 Oklahoma Medical Research Foundation Thiazine dyes used to inactivate HIV in biological fluids
US5955256A (en) * 1990-04-16 1999-09-21 Baxter International Inc. Method of inactivation of viral and bacterial blood contaminants
US5798238A (en) * 1990-04-16 1998-08-25 Baxter International Inc. Method of inactivation of viral and bacterial blood contaminants with quinolines as photosensitizer
US5418130A (en) * 1990-04-16 1995-05-23 Cryopharm Corporation Method of inactivation of viral and bacterial blood contaminants
US6187572B1 (en) 1990-04-16 2001-02-13 Baxter International Inc. Method of inactivation of viral and bacterial blood contaminants
US5545516A (en) * 1990-05-01 1996-08-13 The American National Red Cross Inactivation of extracellular enveloped viruses in blood and blood components by phenthiazin-5-ium dyes plus light
US6077659A (en) * 1990-05-15 2000-06-20 New York Blood Center, Inc. Vitamin E and derivatives thereof prevent potassium ion leakage and other types of damage in red cells that are virus sterilized by phthalocyanines and light
US5658722A (en) * 1990-05-15 1997-08-19 New York Blood Center, Inc. Process for the sterilization of biological compositions using UVA1 irradiation
US5712086A (en) * 1990-05-15 1998-01-27 New York Blood Center, Inc. Process for transfusing cell containing fractions sterilized with radiation and a quencher of type I and type II photodynamic reactions
US5981163A (en) * 1990-05-15 1999-11-09 New York Blood Center, Inc. Process for the sterilization of biological compositions using irradiation and quenchers of type I and type II photodynamic reactions
US5232844A (en) * 1990-05-15 1993-08-03 New York Blood Center Photodynamic inactivation of viruses in cell-containing compositions
CA2089005C (en) * 1991-06-21 1999-01-19 John Chapman Method for inactivating pathogens in a body fluid
EP0633786B1 (en) * 1992-01-27 2001-08-01 Baxter International Inc. Method of inactivation of viral, parasitic and bacterial blood contaminants
TW235298B (en) * 1992-02-27 1994-12-01 Ciba Geigy
US6433343B1 (en) 1992-03-02 2002-08-13 Cerus Corporation Device and method for photoactivation
WO1996014740A1 (en) 1992-03-02 1996-05-23 Cerus Corporation Synthetic media for blood components
EP0702719B1 (en) * 1993-05-28 2005-08-03 New York Blood Center, Inc. Process for the sterilization of biological compositions and the product produced thereby
US6420570B1 (en) 1993-06-28 2002-07-16 Cerus Corporation Psoralen compounds
US5399719A (en) 1993-06-28 1995-03-21 Steritech, Inc. Compounds for the photodecontamination of pathogens in blood
US5625079A (en) 1993-06-28 1997-04-29 Cerus Corporation Synthesizing psoralen compounds useful as intermediates
US5362442A (en) * 1993-07-22 1994-11-08 2920913 Canada Inc. Method for sterilizing products with gamma radiation
GB9317881D0 (en) * 1993-08-27 1993-10-13 Secr Defence Photosensitizers
US5438192A (en) * 1993-12-09 1995-08-01 The United States Of America As Represented By The Secretary Of The Army Photodynamic protein-based photodetector and photodetector system for image detection and processing
US5527704A (en) * 1994-12-06 1996-06-18 Baxter International Inc. Apparatus and method for inactivating viral contaminants in body fluids
US5637451A (en) * 1995-03-29 1997-06-10 New York Blood Center, Inc. Photodynamic treatment of red blood cells with phthalocyanines and red light at higher light fluence rates is protective of red blood cells
BR9608776A (en) * 1995-05-19 2000-10-24 New York Blood Ct Inc Process of using phthalocyanines to inactivate blood parasites
US6235508B1 (en) 1995-06-07 2001-05-22 Baxter International Inc. Method of inactivation of viral and bacterial blood contaminants
US20040048235A1 (en) * 1995-08-29 2004-03-11 V.I. Technologies, Inc. Methods and compositions for the selective modification of nucleic acids
US20040053208A1 (en) * 1995-08-29 2004-03-18 V. I. TECHNOLOGIES, Inc. Methods to selectively inactivate parasites in biological compositions
US6114108A (en) * 1995-08-29 2000-09-05 V.I. Technologies, Inc. Methods and compositions for the selective modification of viral nucleic acids
US6136586A (en) * 1995-08-29 2000-10-24 Vi Technologies, Inc. Methods for the selective modification of viral nucleic acids
CA2236873A1 (en) * 1995-11-06 1997-05-15 New York Blood Center, Inc. Viral inactivation treatment of red blood cells using phthalocyanines and red light
US5895786A (en) * 1996-05-08 1999-04-20 New York Blood Center, Inc. Method for treating viral infections
US6159733A (en) * 1996-06-20 2000-12-12 New York Blood Center, Inc. Method for photoinactivating malignant cells
US5891705A (en) * 1997-04-08 1999-04-06 Pentose Pharmaceuticals, Inc. Method for inactivating a virus
US6482585B2 (en) * 1997-04-16 2002-11-19 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Storage and maintenance of blood products including red blood cells and platelets
US6103706A (en) * 1997-04-29 2000-08-15 New York Blood Center, Inc. Methods for treating viral infections
NL1006219C2 (en) * 1997-06-04 1998-12-07 Univ Leiden Method for lightly inactivating viruses in a cell-containing liquid.
US6093564A (en) * 1997-10-03 2000-07-25 V.I. Technologies, Inc. Methods and compositions for the selective modification of nucleic acids
US6352695B1 (en) 1997-10-03 2002-03-05 V.I. Technologies, Inc. Methods and compositions for the selective modification of nucleic acids
WO1999026476A1 (en) * 1997-11-20 1999-06-03 Cerus Corporation New psoralens for pathogen inactivation
CN1203900C (en) 1998-01-06 2005-06-01 塞鲁斯公司 Methods for quenching pathogen inactivators in biological materials
US6248733B1 (en) 1998-01-09 2001-06-19 3M Innovative Properties Company Method for limiting the growth of microorganisms using metal-containing compounds
US6369048B1 (en) 1998-01-12 2002-04-09 V.I. Technologies, Inc. Methods and compositions for inactivating viruses
CA2321995A1 (en) 1998-02-26 1999-09-02 Eric Kin-Lam Lee Method and apparatus for irradiating a biological fluid
US6277337B1 (en) 1998-07-21 2001-08-21 Gambro, Inc. Method and apparatus for inactivation of biological contaminants using photosensitizers
US6258577B1 (en) 1998-07-21 2001-07-10 Gambro, Inc. Method and apparatus for inactivation of biological contaminants using endogenous alloxazine or isoalloxazine photosensitizers
US20030215784A1 (en) * 1998-07-21 2003-11-20 Dumont Larry Joe Method and apparatus for inactivation of biological contaminants using photosensitizers
US6617100B2 (en) 1998-09-25 2003-09-09 V.I. Technologies, Inc. Solid phase quenching systems
US6403359B1 (en) 1998-09-25 2002-06-11 V. I. TECHNOLOGIES, Inc. Solid phase quenching systems
US6565802B1 (en) 1999-06-03 2003-05-20 Baxter International Inc. Apparatus, systems and methods for processing and treating a biological fluid with light
US7068361B2 (en) * 1999-06-03 2006-06-27 Baxter International Apparatus, systems and methods for processing and treating a biological fluid with light
US7220747B2 (en) * 1999-07-20 2007-05-22 Gambro, Inc. Method for preventing damage to or rejuvenating a cellular blood component using mitochondrial enhancer
US6268120B1 (en) 1999-10-19 2001-07-31 Gambro, Inc. Isoalloxazine derivatives to neutralize biological contaminants
US7648699B2 (en) 2000-06-02 2010-01-19 Caridianbct Biotechnologies, Llc Preventing transfusion related complications in a recipient of a blood transfusion
TW590780B (en) 2000-06-02 2004-06-11 Gambro Inc Additive solutions containing riboflavin
US7985588B2 (en) 2000-06-02 2011-07-26 Caridianbct Biotechnologies, Llc Induction of and maintenance of nucleic acid damage in pathogens using riboflavin and light
US9044523B2 (en) 2000-06-15 2015-06-02 Terumo Bct, Inc. Reduction of contaminants in blood and blood products using photosensitizers and peak wavelengths of light
US6432396B1 (en) 2000-07-06 2002-08-13 3M Innovative Properties Company Limiting the presence of microorganisms using polymer-bound metal-containing compositions
US6548241B1 (en) * 2000-11-28 2003-04-15 Gambro, Inc. Storage solution containing photosensitizer for inactivation of biological contaminants
US20030228564A1 (en) * 2001-05-30 2003-12-11 Edrich Richard Alan Nitric oxide in a pathogen inactivation process
US20090023130A1 (en) * 2003-02-28 2009-01-22 Caridianbct Biotechnologies, Llc Prevention of Transfusion Related Acute Lung Injury Using Riboflavin and Light
WO2005003719A2 (en) * 2003-06-04 2005-01-13 American National Red Cross Decontamination of biological fluids using diphenylpyrilium compounds
US6881573B2 (en) * 2003-09-12 2005-04-19 Allan L. Louderback Augmented solvent/detergent method for inactivating enveloped and non-enveloped viruses
US7461968B2 (en) * 2003-10-30 2008-12-09 Deka Products Limited Partnership System, device, and method for mixing liquids
CN101094692A (en) * 2004-10-29 2007-12-26 塞鲁斯公司 Improved quenching methods for red blood cell inactivation process
EP1767225A1 (en) * 2005-09-21 2007-03-28 Insense Limited Method for stabilisation of a protein solution by addition of hydroxyl radical quenchers and its sterilisation by ionising radiation
US9358292B2 (en) 2007-04-08 2016-06-07 Immunolight, Llc Methods and systems for treating cell proliferation disorders
JP5207436B2 (en) * 2007-05-22 2013-06-12 国立大学法人埼玉大学 Image sensor and manufacturing method thereof
RU2010107157A (en) * 2007-08-01 2011-09-10 Каридианбст Байотекнолоджиз, Ллс (Us) INACTIVATION OF THE WHOLE BLOOD PATHOGEN
US20090104212A1 (en) * 2007-08-06 2009-04-23 Immunolight Methods and systems for treating cell proliferation disorders using two-photon simultaneous absorption
TWI458512B (en) 2008-02-21 2014-11-01 Immunolight Llc Compositions for treating cell proliferation disorders and systems for producing auto-vaccines using plasmonics enhanced photospectral therapy (pepst) and exciton-plasmon enhanced phototherapy (epep)
WO2013009688A1 (en) 2011-07-08 2013-01-17 Bourke Frederic A Phosphors and scintillators for light stimulation within a medium
CA2906990A1 (en) 2008-04-04 2009-10-08 Immunolight, Llc Non-invasive systems and methods for in-situ photobiomodulation
WO2009126786A2 (en) 2008-04-09 2009-10-15 Cerus Corporation Improved quenching methods for red blood cell pathogen inactivation
DE102008060549A1 (en) 2008-12-04 2010-06-10 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Drug-peptide construct for extracellular accumulation
EP2645854B1 (en) 2010-11-29 2017-10-18 New York Blood Center, Inc. Method of blood pooling and storage
US20140127077A1 (en) 2012-11-05 2014-05-08 Gail Rock Device and method for sterilization of instruments and surfaces
US20190070323A1 (en) 2015-10-02 2019-03-07 The US of America, as represented by the Secretary Dept. of Health and Human Servics Inactivation of pathogens in ex vivo blood products in storage bags using visible light

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4008136A (en) * 1974-08-09 1977-02-15 Temple University Process for the treatment of waste water by heterogeneous photosensitized oxidation
FR2387658A1 (en) * 1977-03-25 1978-11-17 Ciba Geigy Ag PROCEDURE FOR FIGHTING MICROORGANISMS
US4568542A (en) * 1981-06-09 1986-02-04 Lee Biomolecular Research Laboratories, Inc. Vaccine compositions
ATE59145T1 (en) * 1983-05-02 1991-01-15 Diamond Scient Co PHOTOCHEMICAL PURIFICATION TREATMENT OF WHOLE BLOOD OR BLOOD COMPONENTS.
US4693981A (en) * 1983-12-20 1987-09-15 Advanced Genetics Research Institute Preparation of inactivated viral vaccines
US4791062A (en) * 1985-02-28 1988-12-13 Diamond Scientific Co. FVR vaccine
US4775625A (en) * 1986-11-21 1988-10-04 The Medical College Of Wisconsin, Inc. Inactivating enveloped viruses with a merocyanine dye
US4920143A (en) * 1987-04-23 1990-04-24 University Of British Columbia Hydro-monobenzoporphyrin wavelength-specific cytotoxic agents
US4878891A (en) * 1987-06-25 1989-11-07 Baylor Research Foundation Method for eradicating infectious biological contaminants in body tissues
US5192788A (en) * 1988-05-23 1993-03-09 Georgia State University Foundation, Inc. Porphyrin antiviral compositions
IL92996A (en) * 1989-01-10 1996-06-18 Bisaccia Emil Photoactive compounds as medicaments for the treatment of virus infections and method for production of vaccines
US5041078A (en) * 1989-03-06 1991-08-20 Baylor Research Foundation, A Nonprofit Corporation Of The State Of Texas Photodynamic viral deactivation with sapphyrins
US4935498A (en) * 1989-03-06 1990-06-19 Board Of Regents, The University Of Texas System Expanded porphyrins: large porphyrin-like tripyrroledimethine-derived macrocycles
DE3930510A1 (en) * 1989-09-13 1991-03-21 Blutspendedienst Dt Rote Kreuz PROCESS FOR INACTIVATING VIRUSES IN BLOOD AND BLOOD PRODUCTS

Also Published As

Publication number Publication date
CA2042494C (en) 1998-12-01
CA2042494A1 (en) 1991-11-16
FI911389A0 (en) 1991-03-21
ATE204602T1 (en) 2001-09-15
JP2831155B2 (en) 1998-12-02
KR910019633A (en) 1991-12-19
NO911876L (en) 1991-11-18
NO911876D0 (en) 1991-05-14
EP0457196B1 (en) 2001-08-22
KR0180917B1 (en) 1999-04-01
FI911389A (en) 1991-11-16
US5120649A (en) 1992-06-09
DE69132696T2 (en) 2002-06-20
AU7646991A (en) 1991-11-21
EP0457196A2 (en) 1991-11-21
DE69132696D1 (en) 2001-09-27
AU660411B2 (en) 1995-06-29
EP0457196A3 (en) 1992-03-04
NO308749B1 (en) 2000-10-23
JPH04226919A (en) 1992-08-17

Similar Documents

Publication Publication Date Title
EP0457196A3 (en) Photodynamic inactivation of viruses in cell-containing compositions
EP0562877A3 (en) Cell fixative and method of staining cells without destroying the cell surface
AU3690193A (en) Absorbent structure
KR960702864A (en) Method for sterilizing biological compositions and products produced therefrom (PROCESS FOR THE STERILIZATION OF BIOLOGICAL COMPOSITIONS AND THE PRODUCT PRODUCED THEREBY)
HK1013965A1 (en) Ophthalmic compositions and methods for preserving and using same
KR19980700976A (en)
IL96786A0 (en) Non oxidative ophthalmic compositions and methods for preserving and using same
MA22389A1 (en) DETERGENT COMPOSITIONS COMPRISING A HIGH ACTIVITY CELLULASE AND QUATERNARY AMONIUM COMPOUNDS
AU8133291A (en) Zwitterionic compounds and their N-halo derivatives for use in the treatment of clinical conditions
ES2082872T3 (en) ANTIGLAUCOMA COMPOSITIONS CONTAINING 3-ARYL CARBONYL-1-AMINOALKYL - 1H-INDOL.
BR9608776A (en) Process of using phthalocyanines to inactivate blood parasites
ATE203021T1 (en) USE OF LACTAM COMPOUNDS AS PHARMACEUTICAL ACTIVE INGREDIENTS
DE3769691D1 (en) SUBSTITUTED OXIMETERS, THEIR USE AS BIOREGULATORS FOR REDUCING THE ENDOGENIC ETHYLENE LEVEL IN PLANTS.
AU7970387A (en) Disinfecting composition for soft contact lenses containing a stabilized hydrogen peroxide solution
CA2080820A1 (en) Azo-derivatives, pharmaceutical preparations containing them, and their uses
BR9610932A (en) Process for storing microorganisms, microorganism composition and use
AU2636588A (en) Radiation stabilized fabric
PT97663A (en) PREPARATION PROCEDURE OF 3&#39;-DESAMINO-4&#39;-DESOXY-4&#39;-AMINO-8-FLUORO-ANTHRACYCLINES, OF PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR INTERMEDIARIES
ES2097201T3 (en) LIQUID DETERGENTS.
Armando [Enviromental risks assessment of raw logs importation into Mexico].[Spanish]
DE69110570D1 (en) Medicament containing an N6-substituted adenosine derivative for the treatment of hyperlipidemia or hypertriglyceridemia.