ZA911061B - Novel benzimidazole and azabenzimidazole derivatives which are thromboxane receptor antagonists,their methods of preparation,synthesis intermediates and pharmaceutical compositions in which they are present - Google Patents

Novel benzimidazole and azabenzimidazole derivatives which are thromboxane receptor antagonists,their methods of preparation,synthesis intermediates and pharmaceutical compositions in which they are present

Info

Publication number: ZA911061B
Authority: ZA; South Africa
Prior art keywords: radical; lower alkyl; group; hydrogen atom; cycloalkyl
Prior art date: 1990-02-16

Application number

ZA911061A

Other languages

English (en)

Inventor

Nicole Bru-Magniez

Bru-Magniez Nicole

Eric Nicolai

Nicolai Eric

Jean-Marie Teulon

Teulon Jean-Marie

Original Assignee

Union Pharma Scient Appl

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-02-16

Filing date

1991-02-13

Publication date

1991-11-27

1991-02-13 Application filed by Union Pharma Scient Appl filed Critical Union Pharma Scient Appl

1991-11-27 Publication of ZA911061B publication Critical patent/ZA911061B/xx

Links

HYZJCKYKOHLVJF-UHFFFAOYSA-N 1H-benzimidazole Chemical compound C1=CC=C2NC=NC2=C1 HYZJCKYKOHLVJF-UHFFFAOYSA-N 0.000 title 1
GAMYYCRTACQSBR-UHFFFAOYSA-N 4-azabenzimidazole Chemical class C1=CC=C2NC=NC2=N1 GAMYYCRTACQSBR-UHFFFAOYSA-N 0.000 title 1
102000003938 Thromboxane Receptors Human genes 0.000 title 1
108090000300 Thromboxane Receptors Proteins 0.000 title 1
230000015572 biosynthetic process Effects 0.000 title 1
239000000543 intermediate Substances 0.000 title 1
238000000034 method Methods 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
238000002360 preparation method Methods 0.000 title 1
239000002464 receptor antagonist Substances 0.000 title 1
229940044551 receptor antagonist Drugs 0.000 title 1
238000003786 synthesis reaction Methods 0.000 title 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 7
125000000217 alkyl group Chemical group 0.000 abstract 4
UFWIBTONFRDIAS-UHFFFAOYSA-N Naphthalene Chemical compound C1=CC=CC2=CC=CC=C21 UFWIBTONFRDIAS-UHFFFAOYSA-N 0.000 abstract 2
125000004432 carbon atom Chemical group C* 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000003118 aryl group Chemical group 0.000 abstract 1
125000003636 chemical group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
150000001925 cycloalkenes Chemical class 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000001174 sulfone group Chemical group 0.000 abstract 1
125000003375 sulfoxide group Chemical group 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1
125000004434 sulfur atom Chemical group 0.000 abstract 1
239000002396 thromboxane receptor blocking agent Substances 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/16—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/28—Sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6503—Five-membered rings
- C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
- C07F9/65068—Five-membered rings having the nitrogen atoms in positions 1 and 3 condensed with carbocyclic rings or carbocyclic ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Biochemistry (AREA)
Immunology (AREA)
Molecular Biology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Pulmonology (AREA)
Transplantation (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Vascular Medicine (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pyridine Compounds (AREA)

ZA911061A 1990-02-16 1991-02-13 Novel benzimidazole and azabenzimidazole derivatives which are thromboxane receptor antagonists,their methods of preparation,synthesis intermediates and pharmaceutical compositions in which they are present ZA911061B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9001925A FR2658511B1 (fr)	1990-02-16	1990-02-16	Nouveaux derives de benzimidazole et d'azabenzimidazole, antagonistes des recepteurs au thromboxane; leurs procedes de preparation, compositions pharmaceutiques les contenant.

Publications (1)

Publication Number	Publication Date
ZA911061B true ZA911061B (en)	1991-11-27

Family

ID=9393829

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA911061A ZA911061B (en)	1990-02-16	1991-02-13	Novel benzimidazole and azabenzimidazole derivatives which are thromboxane receptor antagonists,their methods of preparation,synthesis intermediates and pharmaceutical compositions in which they are present

Country Status (18)

Country	Link
US (2)	US5021443A (xx)
EP (1)	EP0442820B1 (xx)
JP (1)	JPH05155858A (xx)
KR (1)	KR910021382A (xx)
AT (1)	ATE127794T1 (xx)
AU (1)	AU638096B2 (xx)
CA (1)	CA2035710A1 (xx)
DE (1)	DE69112863T2 (xx)
DK (1)	DK0442820T3 (xx)
ES (1)	ES2080919T3 (xx)
FR (1)	FR2658511B1 (xx)
GR (1)	GR3018000T3 (xx)
IE (1)	IE910339A1 (xx)
IL (2)	IL97191A (xx)
LV (1)	LV11028B (xx)
NZ (1)	NZ237121A (xx)
PT (1)	PT96792A (xx)
ZA (1)	ZA911061B (xx)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
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US5128359A (en) *	1990-02-16	1992-07-07	Laboratoires Upsa	Benzimidazole and azabenzimidazole derivatives which are thromboxane receptor antagonists, their methods of preparation
DE4200954A1 (de) *	1991-04-26	1992-10-29	Bayer Ag	Heterocyclisch substituierte phenylessigsaeurederivate
TW300219B (xx) *	1991-09-14	1997-03-11	Hoechst Ag
US5187159A (en) *	1991-10-07	1993-02-16	Merck & Co., Inc.	Angiotensin II antagonists incorporating a substituted 1,3-benzodioxole or 1,3-benzodithiole
US5468757A (en) *	1994-01-31	1995-11-21	Eli Lilly And Company	6-azaindole thromboxane synthase inhibitors
AU6452098A (en)	1997-03-07	1998-09-22	Metabasis Therapeutics, Inc.	Novel purine inhibitors of fructose-1,6-bisphosphatase
EP1402895A1 (en) *	1997-03-07	2004-03-31	Metabasis Therapeutics, Inc.	Benzimidazole inhibitors of fructose 1,6-biphosphatase
JP2001515482A (ja) *	1997-03-07	2001-09-18	メタバシス・セラピューティクス・インコーポレイテッド	フルクトース−１，６−ビスホスファターゼの新規なベンズイミダゾールインヒビター
ES2241192T3 (es) *	1997-12-17	2005-10-16	MERCK & CO., INC. (A NEW JERSEY CORP.)	Antagonistas del receptor de integrina.
US6919366B2 (en) *	1998-05-22	2005-07-19	Avanir Pharmaceuticals	Benzimidazole derivatives as modulators of IgE
US6911462B2 (en) *	1998-05-22	2005-06-28	Avanir Pharmaceuticals	Benzimidazole compounds for regulating IgE
US20050267148A1 (en) *	1998-07-15	2005-12-01	Teijin Limited	Benzimidazole derivative
TR200100047T2 (tr) *	1998-07-15	2001-10-22	Teijin Limited	Tiyobenzimidazol türevleri
US6268385B1 (en)	1999-08-26	2001-07-31	Robert R. Whittle	Dry blend pharmaceutical formulations
US6312723B1 (en)	1999-08-26	2001-11-06	Robert R. Whittle	Pharmaceutical unit dosage form
US6326384B1 (en)	1999-08-26	2001-12-04	Robert R. Whittle	Dry blend pharmaceutical unit dosage form
US6312712B1 (en)	1999-08-26	2001-11-06	Robert R. Whittle	Method of improving bioavailability
US6262086B1 (en)	1999-08-26	2001-07-17	Robert R. Whittle	Pharmaceutical unit dosage form
US6262085B1 (en)	1999-08-26	2001-07-17	Robert R. Whittle	Alkoxy substituted Benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same
US6780880B1 (en)	1999-08-26	2004-08-24	Robert R. Whittle	FT-Raman spectroscopic measurement
US6316020B1 (en)	1999-08-26	2001-11-13	Robert R. Whittle	Pharmaceutical formulations
US6369087B1 (en)	1999-08-26	2002-04-09	Robert R. Whittle	Alkoxy substituted benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same
EP1167360A1 (en) *	2000-01-17	2002-01-02	Teijin Limited	Human chymase inhibitors
AU2001264729A1 (en) *	2000-05-22	2001-12-03	Nitromed, Inc.	Thromboxane inhibitors, compositions and methods of use related applications
CZ20032691A3 (en) *	2001-03-12	2004-04-14	Avanir Pharmaceuticals	Benzimidazole compounds for modulating ige and inhibiting cellular proliferation
KR100902799B1 (ko) *	2001-08-24	2009-06-12	데이진 가부시키가이샤	키마제 저해제 및 ａｃｅ 저해제를 유효성분으로 함유하는약제
TW200304820A (en) *	2002-03-25	2003-10-16	Avanir Pharmaceuticals	Use of benzimidazole analogs in the treatment of cell proliferation
WO2004010996A1 (ja) *	2002-07-29	2004-02-05	Shizuoka Coffein Co., Ltd.	1,3アゾール誘導体及び同誘導体を含む血栓症治療のための医薬組成物
TWI276631B (en) *	2002-09-12	2007-03-21	Avanir Pharmaceuticals	Phenyl-aza-benzimidazole compounds for modulating IgE and inhibiting cellular proliferation
AU2003270426A1 (en)	2002-09-12	2004-04-30	Avanir Pharmaceuticals	PHENYL-INDOLE COMPOUNDS FOR MODULATING IgE AND INHIBITING CELLULAR PROLIFERATION
WO2004032861A2 (en) *	2002-10-11	2004-04-22	Bristol-Myers Squibb Company	Hexahydro-benzimidazolone compounds useful as anti-inflammatory agents
CA2533990A1 (en) *	2003-08-08	2005-02-17	Avanir Pharmaceuticals	Selective pharmacologic inhibition of protein trafficking and related methods of treating human diseases
DE102004027821A1 (de) *	2004-06-08	2006-01-05	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Benzimidazole, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
AU2005292317B2 (en) *	2004-09-30	2011-09-08	Janssen Pharmaceutica N.V.	Novel benzimidazole derivatives useful as selective androgen receptor modulators (sarms)
WO2008153129A1 (ja) *	2007-06-14	2008-12-18	Teijin Pharma Limited	尿酸値低下剤
EP2593541A4 (en) *	2010-07-14	2014-01-22	Cumberland Emerging Technologies Inc	METHOD FOR THE TREATMENT OF HEPATORENAL SYNDROME AND HEPATIC ENZEPHALOPATHY WITH THROMBOXANE A2 RECEPTOR ANTAGONISTS
WO2014020038A1 (en) *	2012-08-03	2014-02-06	Boehringer Ingelheim International Gmbh	Process for preparing spiro[2.5]octane-5,7-dione
WO2014151380A1 (en)	2013-03-15	2014-09-25	Janssen Pharmaceutica Nv	1,2,6-substituted benzimidazoles as flap modulators
WO2014151367A1 (en)	2013-03-15	2014-09-25	Janssen Pharmaceutica Nv	1,2,5-substituted benzimidazoles as flap modulators
CN113329996B (zh) *	2018-06-25	2023-03-10	博远医药(苏州)有限公司	用于治疗刺猬途径相关病症的化合物和方法

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DE1131688B (de) *	1960-12-16	1962-06-20	Hoechst Ag	Verfahren zur Herstellung von Benzimidazolderivaten
NL6715600A (xx) *	1966-12-02	1968-06-04
US3819640A (en) *	1972-08-07	1974-06-25	Degussa	Aza-benzimidazoles and process for their production
EP0178413A1 (en) *	1984-08-17	1986-04-23	Beecham Group Plc	Benzimidazoles
US4880804A (en) *	1988-01-07	1989-11-14	E. I. Du Pont De Nemours And Company	Angiotensin II receptor blocking benzimidazoles

1990
- 1990-02-16 FR FR9001925A patent/FR2658511B1/fr not_active Expired - Fee Related
- 1990-03-15 US US07/493,880 patent/US5021443A/en not_active Expired - Lifetime
1991
- 1991-01-31 IE IE033991A patent/IE910339A1/en not_active IP Right Cessation
- 1991-02-05 CA CA002035710A patent/CA2035710A1/en not_active Abandoned
- 1991-02-05 US US07/650,732 patent/US5124336A/en not_active Expired - Lifetime
- 1991-02-07 AU AU70874/91A patent/AU638096B2/en not_active Expired
- 1991-02-08 IL IL9719195A patent/IL97191A/en not_active IP Right Cessation
- 1991-02-08 IL IL97191A patent/IL97191A0/xx unknown
- 1991-02-13 ZA ZA911061A patent/ZA911061B/xx unknown
- 1991-02-14 NZ NZ237121A patent/NZ237121A/en unknown
- 1991-02-15 EP EP91400393A patent/EP0442820B1/fr not_active Expired - Lifetime
- 1991-02-15 DE DE69112863T patent/DE69112863T2/de not_active Expired - Lifetime
- 1991-02-15 DK DK91400393.4T patent/DK0442820T3/da active
- 1991-02-15 PT PT96792A patent/PT96792A/pt not_active Application Discontinuation
- 1991-02-15 ES ES91400393T patent/ES2080919T3/es not_active Expired - Lifetime
- 1991-02-15 JP JP3042378A patent/JPH05155858A/ja active Pending
- 1991-02-15 AT AT91400393T patent/ATE127794T1/de not_active IP Right Cessation
- 1991-02-18 KR KR1019910002673A patent/KR910021382A/ko not_active Application Discontinuation
1995
- 1995-10-12 LV LVP-95-309A patent/LV11028B/en unknown
- 1995-11-08 GR GR950403109T patent/GR3018000T3/el unknown

Also Published As

Publication number	Publication date
GR3018000T3 (en)	1996-02-29
NZ237121A (en)	1993-12-23
IE910339A1 (en)	1991-08-28
AU638096B2 (en)	1993-06-17
EP0442820B1 (fr)	1995-09-13
DE69112863T2 (de)	1996-03-28
PT96792A (pt)	1991-10-31
LV11028B (en)	1996-06-20
LV11028A (lv)	1996-02-20
US5021443A (en)	1991-06-04
AU7087491A (en)	1991-08-22
CA2035710A1 (en)	1991-08-17
ES2080919T3 (es)	1996-02-16
EP0442820A1 (fr)	1991-08-21
IL97191A (en)	1995-03-15
DE69112863D1 (de)	1995-10-19
FR2658511A1 (fr)	1991-08-23
IL97191A0 (en)	1992-05-25
ATE127794T1 (de)	1995-09-15
FR2658511B1 (fr)	1992-06-19
DK0442820T3 (da)	1996-02-05
JPH05155858A (ja)	1993-06-22
US5124336A (en)	1992-06-23
KR910021382A (ko)	1991-12-20

Publication	Publication Date	Title
ZA911061B (en)	1991-11-27	Novel benzimidazole and azabenzimidazole derivatives which are thromboxane receptor antagonists,their methods of preparation,synthesis intermediates and pharmaceutical compositions in which they are present
EA200600364A1 (ru)	2006-06-30	Производные (тио)карбамоилциклогексана в качестве антагонистов d/dрецептора
DE69229874D1 (de)	1999-09-30	Pyrido pyridazinon und pyridazinthionverbindungen mit pde iv inhibierender wirkung
ZA200505273B (en)	2006-04-26	Novel compound
IL107869A0 (en)	1994-04-12	Benzodiazepine derivatives, their preparation and pharmaceutical compositions containing them
DE69101141D1 (de)	1994-03-17	Neue Guanidinderivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen.
IL83092A0 (en)	1987-12-31	Carbamate or urea derivatives,their preparation and pharmaceutical compositions comprising them
DE69409734D1 (de)	1998-05-28	Neue Derivate des 2-(1H)-Chinolinones, Verfahren zu ihrer Herstellung und sie enthaltende Arzneimittel
ES8107212A1 (es)	1981-10-01	Procedimiento para la preparacion de derivados de 3-amino-1-benzoxepin-5(2h)-ona
GR69358B (xx)	1982-05-20
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