ZA878812B - 3-(omega(3,5-di-t-butyl-4-hydroxyphenyl)-alkanoyl)pyrroles their deoxy analogs,and therapeutic uses thereof - Google Patents
3-(omega(3,5-di-t-butyl-4-hydroxyphenyl)-alkanoyl)pyrroles their deoxy analogs,and therapeutic uses thereofInfo
- Publication number
- ZA878812B ZA878812B ZA878812A ZA878812A ZA878812B ZA 878812 B ZA878812 B ZA 878812B ZA 878812 A ZA878812 A ZA 878812A ZA 878812 A ZA878812 A ZA 878812A ZA 878812 B ZA878812 B ZA 878812B
- Authority
- ZA
- South Africa
- Prior art keywords
- pyrroles
- alkanoyl
- omega
- hydroxyphenyl
- butyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/323—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to the ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/333—Radicals substituted by oxygen or sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/936,551 US4833155A (en) | 1986-11-25 | 1986-11-25 | 3-(ω-(3,5,-di-t-butyl-4-hydroxyphenyl)-alkanoyl)pyrroles, and anti-inflammatory uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA878812B true ZA878812B (en) | 1989-06-28 |
Family
ID=25468795
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA878812A ZA878812B (en) | 1986-11-25 | 1987-11-24 | 3-(omega(3,5-di-t-butyl-4-hydroxyphenyl)-alkanoyl)pyrroles their deoxy analogs,and therapeutic uses thereof |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US4833155A (da) |
| EP (1) | EP0269981A1 (da) |
| JP (1) | JPS63154658A (da) |
| KR (1) | KR880006191A (da) |
| AU (1) | AU8164287A (da) |
| DK (1) | DK617487A (da) |
| FI (1) | FI875184A (da) |
| HU (2) | HUT46303A (da) |
| IL (1) | IL84577A0 (da) |
| NO (1) | NO874892L (da) |
| PH (1) | PH24245A (da) |
| PT (1) | PT86205B (da) |
| ZA (1) | ZA878812B (da) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5086064A (en) * | 1990-03-27 | 1992-02-04 | Warner-Lambert Company | 3,5-di-tertiary-butyl-4-hydroxyphenyl thiazolyl, oxazolyl, and imidazolyl methanones and related compounds as antiinflammatory agents |
| US5234939A (en) * | 1990-03-27 | 1993-08-10 | Warner-Lambert Company | 3,5-di-tertiary-butyl-4-hydroxyphenyl imidazolyl methanones and related compounds as antiinflammatory agents |
| US5234937A (en) * | 1990-03-27 | 1993-08-10 | Warner-Lambert Company | 3,5-di-tertiary-butyl-4-hydroxphenyl oxazolyl methanones and related compounds as antiinflammatory agents |
| US5102897A (en) * | 1990-03-27 | 1992-04-07 | Warner-Lambert Company | 3,5-ditertiarybutyl-4-hydroxyphenyl, 1,3,4-thiadiazoles and oxadiazoles linked by carbon, oxygen, and sulfur residues |
| FR2669029B1 (fr) * | 1990-11-14 | 1994-09-02 | Adir | Nouveaux derives de la n-benzoyl proline, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| US5684204A (en) * | 1995-11-15 | 1997-11-04 | The Procter & Gamble Company | Sulfur containing di-tert-butylphenol compounds useful as anti-inflammatory agents |
| MY128323A (en) * | 1996-09-30 | 2007-01-31 | Otsuka Pharma Co Ltd | Thiazole derivatives for inhibition of cytokine production and of cell adhesion |
| ES2230624T5 (es) * | 1996-11-27 | 2010-10-25 | Aventis Pharmaceuticals Inc. | Composicion farmaceutica que comprende un compuesto que tiene actividad anti-xa y un compuesto antagonista de la agregacion plaquetaria. |
| WO2004064781A2 (en) * | 2003-01-14 | 2004-08-05 | Adam Heller | Anti-inflammatory substituted phenols and elastomeric compositions for oral delivery of drugs |
| EP1582531A1 (en) | 2004-03-24 | 2005-10-05 | Aventis Pharma S.A. | Process for oxidizing unfractionated heparins and detecting presence or absence of glycoserine in heparin and heparin products |
| AU2007311084A1 (en) | 2006-10-17 | 2008-04-24 | Albemarle Corporation | Alkylated heterocyclic reaction products useful as antioxidants |
| FR2934998B1 (fr) * | 2008-08-12 | 2010-09-03 | Robert Vachy | Nouveaux derives de glucopyranose, leur preparation et leurs applications biologiques |
| WO2022015794A1 (en) | 2020-07-14 | 2022-01-20 | Optimvia, Llc | Methods for synthesizing non-anticoagulant heparan sulfate |
| EP3997238A1 (en) | 2019-07-09 | 2022-05-18 | Optimvia, LLC | Methods for synthesizing anticoagulant polysaccharides |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3644631A (en) * | 1969-05-13 | 1972-02-22 | Endo Lab | Therapeutic methods utilizing aryl pyrrol-3-yl ketones |
| US4000160A (en) * | 1973-04-11 | 1976-12-28 | Sterling Drug Inc. | Pyrrolyl oxyphenyl ketones |
| US4124725A (en) * | 1977-05-16 | 1978-11-07 | Riker Laboratories, Inc. | Anti-inflammatory method |
| US4418074A (en) * | 1981-11-23 | 1983-11-29 | Riker Laboratories, Inc. | 2,6 Di(t-butyl)-4-(2'-pyrrol)-phenol and anti-inflammatory use thereof |
-
1986
- 1986-11-25 US US06/936,551 patent/US4833155A/en not_active Expired - Fee Related
-
1987
- 1987-11-24 KR KR870013217A patent/KR880006191A/ko not_active Application Discontinuation
- 1987-11-24 PH PH36112A patent/PH24245A/en unknown
- 1987-11-24 JP JP62295916A patent/JPS63154658A/ja active Pending
- 1987-11-24 DK DK617487A patent/DK617487A/da not_active Application Discontinuation
- 1987-11-24 PT PT86205A patent/PT86205B/pt not_active IP Right Cessation
- 1987-11-24 AU AU81642/87A patent/AU8164287A/en not_active Abandoned
- 1987-11-24 IL IL84577A patent/IL84577A0/xx unknown
- 1987-11-24 ZA ZA878812A patent/ZA878812B/xx unknown
- 1987-11-24 HU HU875244A patent/HUT46303A/hu unknown
- 1987-11-24 FI FI875184A patent/FI875184A/fi not_active IP Right Cessation
- 1987-11-24 HU HU884130A patent/HU201010B/hu not_active IP Right Cessation
- 1987-11-24 NO NO874892A patent/NO874892L/no unknown
- 1987-11-24 EP EP87117332A patent/EP0269981A1/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| PH24245A (en) | 1990-05-04 |
| US4833155A (en) | 1989-05-23 |
| HUT47904A (en) | 1989-04-28 |
| NO874892L (no) | 1988-06-17 |
| AU8164287A (en) | 1988-05-26 |
| PT86205A (en) | 1987-12-01 |
| HUT46303A (en) | 1988-10-28 |
| FI875184A0 (fi) | 1987-11-24 |
| DK617487D0 (da) | 1987-11-24 |
| KR880006191A (ko) | 1988-07-22 |
| EP0269981A1 (en) | 1988-06-08 |
| NO874892D0 (no) | 1987-11-24 |
| PT86205B (pt) | 1990-11-07 |
| JPS63154658A (ja) | 1988-06-27 |
| DK617487A (da) | 1988-05-26 |
| HU201010B (en) | 1990-09-28 |
| FI875184A (fi) | 1988-05-26 |
| IL84577A0 (en) | 1988-04-29 |
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