ZA874107B - - Google Patents

Info

Publication number: ZA874107B
Authority: ZA; South Africa

Application number

ZA874107A

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-06-13

Filing date

1987-06-08

Publication date

1987-12-09

1987-06-08 Application filed filed Critical

1987-12-09 Publication of ZA874107B publication Critical patent/ZA874107B/xx

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

ZA874107A 1986-06-13 1987-06-08 ZA874107B (zh)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US87375486A	1986-06-13	1986-06-13
AT0269187A AT398425B (de)	1986-06-13	1987-10-12	Neue tricyclische lactame

Publications (1)

Publication Number	Publication Date
ZA874107B true ZA874107B (zh)	1987-12-09

Family

ID=25598925

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA874107A ZA874107B (zh)	1986-06-13	1987-06-08

Country Status (12)

Country	Link
EP (1)	EP0249223B1 (zh)
JP (1)	JP2542213B2 (zh)
KR (1)	KR950014572B1 (zh)
AR (1)	AR247213A1 (zh)
AT (1)	AT398425B (zh)
AU (1)	AU601433B2 (zh)
CA (1)	CA1337654C (zh)
DK (1)	DK170840B1 (zh)
ES (1)	ES2044870T3 (zh)
GR (1)	GR3006802T3 (zh)
IE (1)	IE61476B1 (zh)
ZA (1)	ZA874107B (zh)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4824832A (en) *	1987-12-30	1989-04-25	Merrell Dow Pharmaceuticals Inc.	Sulfhydryl containing tricyclic lactams and their pharmacological methods of use
CA2053340C (en) *	1990-10-18	2002-04-02	Timothy P. Burkholder	Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
AU642321B2 (en) *	1990-12-21	1993-10-14	Merrell Pharmaceuticals Inc.	Novel amino and nitro containing tricyclic compounds useful as inhibitors of ace
US5208230A (en) *	1990-12-21	1993-05-04	Merrell Dow Pharmaceuticals	Amino and nitro containing tricyclic compounds useful as inhibitors of ACE
DE69220744T2 (de) *	1991-09-27	1997-11-13	Merrell Pharma Inc	2-Substituierte Indan-2-Mercaptoacetylamid-Verbindungen mit Enkephalinase und ACE-Hemmwirkung
ZA927211B (en) *	1991-09-27	1993-03-24	Merrell Dow Pharma	Novel carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE.
US5455242A (en) *	1991-09-27	1995-10-03	Merrell Dow Pharmaceuticals Inc.	Carboxyalkyl tricyclic derivatives useful as inhibitors of enkephalinase and ace
US5457196A (en) *	1991-09-27	1995-10-10	Merrell Dow Pharmaceuticals Inc.	2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE
AU657793B2 (en) *	1991-09-27	1995-03-23	Merrell Pharmaceuticals Inc.	Novel 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE
AU668707B2 (en) *	1992-02-14	1996-05-16	Merrell Pharmaceuticals Inc.	Aminoacetylmercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ACE
US5552397A (en) *	1992-05-18	1996-09-03	E. R. Squibb & Sons, Inc.	Substituted azepinone dual inhibitors of angiotensin converting enzyme and neutral exdopeptidase
US5646276A (en) *	1992-05-13	1997-07-08	Bristol-Myers Squibb Co.	Diazepine containing dual action inhibitors
KR100281450B1 (ko) *	1992-05-15	2001-02-01	슈테펜 엘. 네스비트	엔케팔리나제 및 안지오텐신 전환 효소의 억제제로서 유용한 신규 메르캅토아세틸아미도 피리다조[1,2]피리다진, 피라졸로[1,2]피리다진, 피리다조[1,2-a][1,2]디아제핀 및 피라졸로[1,2-a][1,2]디아제핀 유도체
US5238932A (en) *	1992-05-20	1993-08-24	Merrell Dow Pharmaceuticals Inc.	Mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase
ES2155852T3 (es) *	1992-10-30	2001-06-01	Merrell Pharma Inc	Derivados de lactama biciclica de mercaptoacetilamida utiles como inhibidores de encefalinasa y eca.
US5362727A (en) *	1993-07-26	1994-11-08	Bristol-Myers Squibb	Substituted azepino[2,1-a]isoquinoline compounds
WO1995014663A2 (en) *	1993-11-19	1995-06-01	Merrell Pharmaceuticals Inc.	Novel process for preparing (s)-1-[2(s)-(1,3-dihydro-1,3-dioxo-isoindo-2-yl)-1-oxo-3-phenylpropyl]-1,2,3,4-tetrahydro-2-pyridine-carboxylic acid methyl ester and intermediates thereof
HUT76479A (en) *	1994-02-14	1997-09-29	Merrell Pharma Inc	Novel fused benzazepinone derivatives, process for preparation thereof and pharmaceutical composition containing them
WO1995021839A1 (en) *	1994-02-14	1995-08-17	Merrell Pharmaceuticals Inc.	Novel mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and ace
US5530013A (en) *	1994-02-14	1996-06-25	American Home Products Corporation	Venlafaxine in the inducement of cognition enhancement
NZ279396A (en) *	1994-02-14	1997-08-22	Merrell Pharma Inc	Octahydro-6-hetring[2,1-a][2]benzazepine disulphide derivatives
KR100364947B1 (ko) *	1994-02-14	2003-03-06	메렐 파마슈티칼스 인크.	엔케팔리나제및ace의억제제로서유용한신규의머캅토아세틸아미도1,3,4,5-테트라히드로-벤조[c]아제핀-3-온디술파이드유도체
US5484783A (en) *	1994-03-24	1996-01-16	Merrell Dow Pharmaceuticals Inc.	Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide and benzazapine derivatives
WO1995025532A1 (en) *	1994-03-24	1995-09-28	Merrell Pharmaceuticals Inc.	Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic aminoacetylmercapto derivatives
EP0751774B1 (en) *	1994-03-24	2003-08-13	Merrell Pharmaceuticals Inc.	Hypocholesterolemic mercaptoacetylamide disulfide derivatives
US5641880A (en) *	1994-12-21	1997-06-24	Hoechst Marion Roussel, Inc.	Processes for preparing intermediates of inhibitors of enkephalinase and angiotensin converting enzyme and intermediates thereof
DE69515517T2 (de) *	1994-12-21	2000-07-06	Hoechst Marion Roussel Inc	Verfahren zur herstellung von zwischenprodukten von inhibitoren der enkephalinase und des angiotensin konvertierenden enzyms und zwischenprodukte davon
US5587375A (en) *	1995-02-17	1996-12-24	Bristol-Myers Squibb Company	Azepinone compounds useful in the inhibition of ACE and NEP
US5877313A (en)	1995-05-17	1999-03-02	Bristol-Myers Squibb	Benzo-fused azepinone and piperidinone compounds useful in the inhibition of ACE and NEP
US5635504A (en) *	1995-06-07	1997-06-03	Bristol-Myers Squibb Co.	Diazepine containing dual action inhibitors
US5650408A (en) *	1995-06-07	1997-07-22	Karanewsky; Donald S.	Thiazolo benzazepine containing dual action inhibitors
GB0119305D0 (en)	2001-04-12	2001-10-03	Aventis Pharma Gmbh	Mercaptoacetylamide derivatives,a process for their preparation and their use

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0107095B1 (en) *	1982-09-30	1987-09-09	Merck & Co. Inc.	1-n-alkylcarboxy-benzofused lactams useful as antihypertensive agents
EP0166357A3 (en) *	1984-06-26	1988-10-26	Merck & Co. Inc.	Benzofused lactams and pharmaceutical compositions containing them

1987
- 1987-06-08 ZA ZA874107A patent/ZA874107B/xx unknown
- 1987-06-08 CA CA000539111A patent/CA1337654C/en not_active Expired - Lifetime
- 1987-06-09 AU AU74022/87A patent/AU601433B2/en not_active Expired
- 1987-06-09 AR AR87307816A patent/AR247213A1/es active
- 1987-06-11 IE IE154787A patent/IE61476B1/en not_active IP Right Cessation
- 1987-06-11 KR KR1019870005908A patent/KR950014572B1/ko not_active IP Right Cessation
- 1987-06-11 EP EP87108410A patent/EP0249223B1/en not_active Expired - Lifetime
- 1987-06-11 ES ES87108410T patent/ES2044870T3/es not_active Expired - Lifetime
- 1987-06-12 JP JP62145419A patent/JP2542213B2/ja not_active Expired - Lifetime
- 1987-06-12 DK DK300487A patent/DK170840B1/da not_active IP Right Cessation
- 1987-10-12 AT AT0269187A patent/AT398425B/de not_active IP Right Cessation
1993
- 1993-01-14 GR GR930400057T patent/GR3006802T3/el unknown

Also Published As

Publication number	Publication date
IE61476B1 (en)	1994-11-02
JPS62298591A (ja)	1987-12-25
KR880000399A (ko)	1988-03-25
DK170840B1 (da)	1996-02-05
AU601433B2 (en)	1990-09-13
AT398425B (de)	1994-12-27
CA1337654C (en)	1995-11-28
EP0249223B1 (en)	1992-10-14
AR247213A1 (es)	1994-11-30
DK300487A (da)	1987-12-14
EP0249223A2 (en)	1987-12-16
ATA269187A (de)	1994-04-15
JP2542213B2 (ja)	1996-10-09
GR3006802T3 (zh)	1993-06-30
KR950014572B1 (ko)	1995-12-08
DK300487D0 (da)	1987-06-12
ES2044870T3 (es)	1994-01-16
AU7402287A (en)	1987-12-17
EP0249223A3 (en)	1989-01-25
IE871547L (en)	1987-12-13

Publication	Publication Date	Title
US4797170B1 (zh)	1991-05-21
FR2604628B1 (zh)	1997-02-07
AU7131891A (zh)	1991-05-23
GR3006802T3 (zh)	1993-06-30
DE8712831U1 (zh)	1987-11-19
GR3005837T3 (zh)	1993-06-07
DE3790259T1 (zh)	1988-06-23
CH678999GA3 (zh)	1991-12-13
DE8625285U1 (zh)	1987-01-29
AU7354491A (zh)	1991-06-20
IN169180B (zh)	1991-09-14
DE8626520U1 (zh)	1989-02-23
DE8625465U1 (zh)	1986-12-04
CH669517B (zh)	1989-03-31
AU7131791A (zh)	1992-02-20
AU6014586A (zh)	1986-11-13
AU5878886A (zh)	1986-08-07
AU6019186A (zh)	1986-12-09
AU5130385A (zh)	1986-11-13
AU5614486A (zh)	1986-11-27
DE8603180U1 (zh)	1987-12-23
BE905088A (zh)	1986-11-03
DE8609416U1 (zh)	1987-08-13
BE905208A (zh)	1986-12-01
AU5344086A (zh)	1986-10-14