ZA81973B - Microbiologically prepared polypeptide with the aminoacid sequence of human interferon, dna and plasmids which act as codings for this sequence, microorganismus which contain this genetic information, and processes for their preparation - Google Patents

Microbiologically prepared polypeptide with the aminoacid sequence of human interferon, dna and plasmids which act as codings for this sequence, microorganismus which contain this genetic information, and processes for their preparation

Info

Publication number
ZA81973B
ZA81973B ZA00810973A ZA81973A ZA81973B ZA 81973 B ZA81973 B ZA 81973B ZA 00810973 A ZA00810973 A ZA 00810973A ZA 81973 A ZA81973 A ZA 81973A ZA 81973 B ZA81973 B ZA 81973B
Authority
ZA
South Africa
Prior art keywords
sequence
genetic information
microorganismus
codings
plasmids
Prior art date
Application number
ZA00810973A
Inventor
J Groneberg
J Hilfenhaus
F Wengenmayer
E Winnacker
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of ZA81973B publication Critical patent/ZA81973B/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/565—IFN-beta

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

There is utilised recombinant DNA technology in the production of interferon, which provides a microbiologically produced polypeptide, all or part of which comprises the amino acid sequence of human interferon, especially fibroblast (???) interferon. There is also provided CDNA which codes for such a polypeptide; a plasmid, especially plasmid pBR 322, which comprises the cDNA; and a microorganism, for example Escherichia coli, especially E. coli K12 or E. coli X1776, which comprises the genetic information required for the production of such a polypeptide. The cDNA is preferably prepared using mRNA obtained from human fibroblasts.
ZA00810973A 1980-02-16 1981-02-13 Microbiologically prepared polypeptide with the aminoacid sequence of human interferon, dna and plasmids which act as codings for this sequence, microorganismus which contain this genetic information, and processes for their preparation ZA81973B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19803005843 DE3005843A1 (en) 1980-02-16 1980-02-16 GENERAL PRODUCT OF A HIGHER ORGANISM FROM A MICROORGANISM CONTAINING THIS GENE

Publications (1)

Publication Number Publication Date
ZA81973B true ZA81973B (en) 1982-03-31

Family

ID=6094790

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA00810973A ZA81973B (en) 1980-02-16 1981-02-13 Microbiologically prepared polypeptide with the aminoacid sequence of human interferon, dna and plasmids which act as codings for this sequence, microorganismus which contain this genetic information, and processes for their preparation

Country Status (13)

Country Link
EP (1) EP0034306B1 (en)
JP (1) JPS56131522A (en)
AT (1) ATE26999T1 (en)
AU (1) AU6728781A (en)
BE (1) BE887530A (en)
DE (2) DE3005843A1 (en)
ES (3) ES499290A0 (en)
FR (1) FR2482132A1 (en)
GB (1) GB2069504A (en)
IT (1) IT1141976B (en)
NL (1) NL8100719A (en)
SE (1) SE8101004L (en)
ZA (1) ZA81973B (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK33181A (en) * 1980-02-06 1981-08-07 Searle & Co PROCEDURE FOR THE PREPARATION OF AN INTERFERONOUS PROTEIN
IN156128B (en) * 1980-04-03 1985-05-18 Biogen Nv
DE3176011D1 (en) * 1980-06-12 1987-04-23 Japan Found Cancer Plasmid
NZ198445A (en) * 1980-09-25 1984-05-31 Genentech Inc Production of human fibroblast interferon by recombinant dna technology
WO1983002461A1 (en) * 1982-01-19 1983-07-21 Cetus Corp Multiclass hybrid interferons
US5827694A (en) * 1982-03-08 1998-10-27 Genentech, Inc. DNA encoding non-human animal interferons, vectors and hosts therefor, and recombinant production of IFN polypeptides
US6432677B1 (en) 1982-03-08 2002-08-13 Genentech, Inc. Non-human animal interferons
IE54592B1 (en) * 1982-03-08 1989-12-06 Genentech Inc Anumal interferons, processes involved in their production, compositions containing them, dna sequences coding therefor and espression vehicles containing such sequences and cells transformed thereby
DE3220116A1 (en) * 1982-05-28 1983-12-01 Dr. Karl Thomae Gmbh, 7950 Biberach MICROBIOLOGICALLY MANUFACTURED (ALPHA) AND SS INTERFERONES, DNA SEQUENCES CODING FOR THESE INTERFERONES, MICROORGANISMS CONTAINING THIS GENETIC INFORMATION, AND METHOD FOR THE PRODUCTION THEREOF
US5831023A (en) * 1982-11-01 1998-11-03 Genentech, Inc. Recombinant animal interferon polypeptides

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI77877C (en) * 1979-04-20 1989-05-10 Technobiotic Ltd Process for the preparation and purification of human Le-shaped interferon protein.
AU538665B2 (en) * 1979-10-30 1984-08-23 Juridical Foundation, Japanese Foundation For Cancer Research Human interferon dna
IL58765A (en) * 1979-11-21 1986-09-30 Yeda Res & Dev Process for the production of essentially pure messenger rna of human fibroblast interferon and process for the production of interferon beta
AU553400B2 (en) * 1980-01-08 1986-07-17 Biogen, Inc. Recombinant dna for producing interferon
DK33181A (en) * 1980-02-06 1981-08-07 Searle & Co PROCEDURE FOR THE PREPARATION OF AN INTERFERONOUS PROTEIN
AU545912B2 (en) * 1980-03-10 1985-08-08 Cetus Corporation Cloned heterologous jive products in bacillies
IN156128B (en) * 1980-04-03 1985-05-18 Biogen Nv

Also Published As

Publication number Publication date
DE3176161D1 (en) 1987-06-11
NL8100719A (en) 1981-09-16
EP0034306A2 (en) 1981-08-26
IT1141976B (en) 1986-10-08
ATE26999T1 (en) 1987-05-15
IT8119759A0 (en) 1981-02-13
GB2069504A (en) 1981-08-26
ES8205430A1 (en) 1982-06-01
BE887530A (en) 1981-08-17
ES499289A0 (en) 1982-06-01
EP0034306B1 (en) 1987-05-06
ES499285A0 (en) 1983-01-01
FR2482132A1 (en) 1981-11-13
ES499290A0 (en) 1982-06-01
DE3005843A1 (en) 1981-09-10
ES8205429A1 (en) 1982-06-01
SE8101004L (en) 1981-08-17
JPS56131522A (en) 1981-10-15
EP0034306A3 (en) 1981-11-04
AU6728781A (en) 1981-08-27
ES8302089A1 (en) 1983-01-01

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