ZA813141B - New 1,4-dihydropyridine compounds having different substittuents in the 2-position and 6-position, their porduction, and their medicinal use - Google Patents
New 1,4-dihydropyridine compounds having different substittuents in the 2-position and 6-position, their porduction, and their medicinal useInfo
- Publication number
- ZA813141B ZA813141B ZA00813141A ZA813141A ZA813141B ZA 813141 B ZA813141 B ZA 813141B ZA 00813141 A ZA00813141 A ZA 00813141A ZA 813141 A ZA813141 A ZA 813141A ZA 813141 B ZA813141 B ZA 813141B
- Authority
- ZA
- South Africa
- Prior art keywords
- different
- substittuents
- porduction
- new
- medicinal use
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Abstract
1. Compound of the general formula I see diagramm : EP0039863,P18,F1 in which R represents a phenyl radical which optionally contains 1 or 2 identical or different substituents from the group comprising nitro, chlorine, cyano or trifluoromethyl, with the exception of a phenyl radical which is at the same time ortho- and metadichlorosubstituted, when R**2 denotes methyl and R**4 denotes alkyl with 2-3 carbon atoms, R**1 represents a saturated hydrocarbon radical with up to 6 carbon atons which is optionally interrupted by an oxygen atom, R**2 and R**4 are always different and each represents hydrogen, alkyl with 1 to 4 carbon atoms or cyclohexylmethyl, with the exception of the compound diethyl-2-methyl-6-propyl-4-(3-nitrophenyl)-1,4- dihydropyridine-3,5-carboxylate.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19803018259 DE3018259A1 (en) | 1980-05-13 | 1980-05-13 | 1,4-DIHYDROPYRIDINE WITH DIFFERENT SUBSTITUENTS IN 2- AND 6-POSITIONS, METHODS FOR THEIR PRODUCTION AND THEIR USE IN MEDICINAL PRODUCTS |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA813141B true ZA813141B (en) | 1982-04-28 |
Family
ID=6102290
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA00813141A ZA813141B (en) | 1980-05-13 | 1981-05-12 | New 1,4-dihydropyridine compounds having different substittuents in the 2-position and 6-position, their porduction, and their medicinal use |
Country Status (17)
Country | Link |
---|---|
EP (1) | EP0039863B1 (en) |
JP (1) | JPS577468A (en) |
AT (1) | ATE5718T1 (en) |
AU (1) | AU541935B2 (en) |
CA (2) | CA1175438A (en) |
DE (2) | DE3018259A1 (en) |
DK (1) | DK210281A (en) |
ES (2) | ES502132A0 (en) |
FI (1) | FI811437L (en) |
GR (1) | GR74910B (en) |
HU (1) | HU184434B (en) |
IE (1) | IE51267B1 (en) |
IL (1) | IL62841A (en) |
NO (1) | NO811424L (en) |
PH (1) | PH18747A (en) |
PT (1) | PT72964B (en) |
ZA (1) | ZA813141B (en) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3207982A1 (en) * | 1982-03-05 | 1983-09-08 | Bayer Ag, 5090 Leverkusen | NEW 1,4-DIHYDROPYRIDINE, METHOD FOR THE PRODUCTION AND USE THEREOF IN MEDICINAL PRODUCTS |
DE3208628A1 (en) * | 1982-03-10 | 1983-09-22 | Bayer Ag, 5090 Leverkusen | NEW COMPOUNDS, METHOD FOR THEIR PRODUCTION AND THEIR USE AS MEDICINAL PRODUCTS |
US4414213A (en) * | 1982-03-22 | 1983-11-08 | Mead Johnson & Company | Dihydropyridyl cyclic imidate esters and their pharmaceutical use |
JPS58208271A (en) * | 1982-04-30 | 1983-12-03 | Kyowa Hakko Kogyo Co Ltd | 1,4-dihydropyridine derivative |
JPS6094963A (en) * | 1983-10-31 | 1985-05-28 | Teijin Ltd | 1,4-dihydropyridine-3,5-dicarboxylic acid diester derivative and production thereof |
NZ212895A (en) * | 1984-08-22 | 1988-07-28 | Glaxo Spa | 1,4-dihydropyridine derivatives and pharmaceutical compositions |
DE3447169A1 (en) * | 1984-12-22 | 1986-07-03 | Bayer Ag, 5090 Leverkusen | OPTICALLY ACTIVE NITRODIHYDROPYRIDINE, METHOD FOR THE PRODUCTION AND THEIR USE IN MEDICINAL PRODUCTS |
JPS625958A (en) * | 1985-07-03 | 1987-01-12 | Suntory Ltd | 1,4-dihydropyridine derivative, production thereof and remedy for circulatory disease |
US4761420A (en) * | 1986-06-13 | 1988-08-02 | Laboratoires Syntex S.A. | Antihypertensive dihydropyridine derivatives |
JPH02501736A (en) * | 1986-12-24 | 1990-06-14 | ベリンガー マンハイム イタリア エッセ ピ ア | Novel aralkyl-1,4-dihydropyridine and method for producing the same, and pharmaceutical compositions containing the same |
US5158963A (en) * | 1989-08-02 | 1992-10-27 | Kaken Pharmaceutical Co., Ltd. | 1-4-dihydropyridine derivative, process for preparing the same and pharmaceutical composition containing the same |
WO1991009847A1 (en) * | 1989-12-29 | 1991-07-11 | Kaken Pharmaceutical Co., Ltd. | Ethynylphenyl derivative, production thereof, and remedy for diseases of circulatory organs containing the same as active ingredient |
ATE234286T1 (en) * | 1993-12-10 | 2003-03-15 | Bayer Ag | PHENYL-SUBSTITUTED 1,4-DIHYDROPYRIDINES WITH CEREBRAL ACTIVITY |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1792764C3 (en) * | 1967-03-20 | 1981-04-23 | Bayer Ag, 5090 Leverkusen | Coronary drugs |
GB1430961A (en) * | 1972-01-22 | 1976-04-07 | Yamanouchi Pharma Co Ltd | 1-substituted-1,4-dihyddrypyridine derivatives |
DE2508181A1 (en) * | 1975-02-26 | 1976-09-09 | Bayer Ag | 1,4-DIHYDROPYRIDINCARBONIC ACID ARAL KYLESTER, METHOD FOR MANUFACTURING AND USING THEY AS A MEDICINAL PRODUCT |
GB1591089A (en) * | 1976-12-17 | 1981-06-10 | Fujisawa Pharmaceutical Co | 1,4-dihydropyridine derivatives and process for preparation thereof |
SE7910521L (en) * | 1979-12-20 | 1981-06-21 | Haessle Ab | NEW 2-METHYL-6-SUBSTITUTED-4- (2,3-DISUBSTITUTED PHENYL) -1,4-DIHYDROPYRIDINE-3,5-DIESTERS WITH HYPOTHESIVE PROPERTIES, AND PROCEDURES FOR THEIR PREPARATION AND PHARMACEUTICAL PREPARATION |
-
1980
- 1980-05-13 DE DE19803018259 patent/DE3018259A1/en not_active Withdrawn
-
1981
- 1981-04-27 NO NO811424A patent/NO811424L/en unknown
- 1981-05-04 DE DE8181103338T patent/DE3161760D1/en not_active Expired
- 1981-05-04 EP EP81103338A patent/EP0039863B1/en not_active Expired
- 1981-05-04 PT PT72964A patent/PT72964B/en unknown
- 1981-05-04 AT AT81103338T patent/ATE5718T1/en not_active IP Right Cessation
- 1981-05-08 JP JP6841081A patent/JPS577468A/en active Pending
- 1981-05-11 GR GR64908A patent/GR74910B/el unknown
- 1981-05-11 PH PH25616A patent/PH18747A/en unknown
- 1981-05-11 CA CA000377326A patent/CA1175438A/en not_active Expired
- 1981-05-11 FI FI811437A patent/FI811437L/en not_active Application Discontinuation
- 1981-05-11 IL IL62841A patent/IL62841A/en unknown
- 1981-05-12 AU AU70473/81A patent/AU541935B2/en not_active Ceased
- 1981-05-12 IE IE1061/81A patent/IE51267B1/en unknown
- 1981-05-12 ZA ZA00813141A patent/ZA813141B/en unknown
- 1981-05-12 ES ES502132A patent/ES502132A0/en active Granted
- 1981-05-12 DK DK210281A patent/DK210281A/en not_active Application Discontinuation
- 1981-05-13 HU HU811323A patent/HU184434B/en unknown
-
1982
- 1982-05-27 ES ES512592A patent/ES512592A0/en active Granted
-
1984
- 1984-02-08 CA CA000447060A patent/CA1185182A/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
CA1185182A (en) | 1985-04-09 |
IL62841A (en) | 1984-11-30 |
ATE5718T1 (en) | 1984-01-15 |
HU184434B (en) | 1984-08-28 |
IL62841A0 (en) | 1981-07-31 |
GR74910B (en) | 1984-07-12 |
AU541935B2 (en) | 1985-01-31 |
PT72964B (en) | 1982-06-25 |
ES8304082A1 (en) | 1983-02-16 |
PT72964A (en) | 1981-06-01 |
DK210281A (en) | 1981-11-14 |
IE51267B1 (en) | 1986-11-26 |
ES8300093A1 (en) | 1982-10-01 |
DE3018259A1 (en) | 1981-11-19 |
FI811437L (en) | 1981-11-14 |
AU7047381A (en) | 1981-11-19 |
CA1175438A (en) | 1984-10-02 |
EP0039863A1 (en) | 1981-11-18 |
DE3161760D1 (en) | 1984-02-02 |
ES502132A0 (en) | 1982-10-01 |
EP0039863B1 (en) | 1983-12-28 |
ES512592A0 (en) | 1983-02-16 |
JPS577468A (en) | 1982-01-14 |
IE811061L (en) | 1981-11-13 |
NO811424L (en) | 1981-11-16 |
PH18747A (en) | 1985-09-19 |
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