ZA201301042B - 2'-fluoro substituted carba-nucleoside analogs for antiviral treatment - Google Patents
2'-fluoro substituted carba-nucleoside analogs for antiviral treatmentInfo
- Publication number
- ZA201301042B ZA201301042B ZA2013/01042A ZA201301042A ZA201301042B ZA 201301042 B ZA201301042 B ZA 201301042B ZA 2013/01042 A ZA2013/01042 A ZA 2013/01042A ZA 201301042 A ZA201301042 A ZA 201301042A ZA 201301042 B ZA201301042 B ZA 201301042B
- Authority
- ZA
- South Africa
- Prior art keywords
- nucleoside analogs
- fluoro substituted
- antiviral treatment
- substituted carba
- carba
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12/885,917 US7973013B2 (en) | 2009-09-21 | 2010-09-20 | 2'-fluoro substituted carba-nucleoside analogs for antiviral treatment |
US13/050,820 US8455451B2 (en) | 2009-09-21 | 2011-03-17 | 2'-fluoro substituted carba-nucleoside analogs for antiviral treatment |
PCT/US2011/029441 WO2012039791A1 (en) | 2010-09-20 | 2011-03-22 | 2' -fluoro substituted carba-nucleoside analogs for antiviral treatment |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA201301042B true ZA201301042B (en) | 2014-07-30 |
Family
ID=47748238
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA2013/01042A ZA201301042B (en) | 2010-09-20 | 2013-02-07 | 2'-fluoro substituted carba-nucleoside analogs for antiviral treatment |
Country Status (21)
Country | Link |
---|---|
EP (1) | EP2619206A1 (en) |
JP (4) | JP2013538230A (en) |
KR (1) | KR101879887B1 (en) |
CN (1) | CN103108876A (en) |
AP (1) | AP3699A (en) |
AU (1) | AU2011306066B2 (en) |
BR (1) | BR112013008017A2 (en) |
CA (1) | CA2807496C (en) |
CL (1) | CL2013000727A1 (en) |
CO (1) | CO6680669A2 (en) |
CR (1) | CR20130172A (en) |
EA (1) | EA026523B1 (en) |
EC (1) | ECSP13012560A (en) |
IL (1) | IL225221A0 (en) |
MA (1) | MA34593B1 (en) |
MX (1) | MX2013003179A (en) |
NZ (1) | NZ608070A (en) |
PE (3) | PE20171624A1 (en) |
SG (1) | SG188223A1 (en) |
WO (1) | WO2012039791A1 (en) |
ZA (1) | ZA201301042B (en) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT2268642E (en) | 2008-04-23 | 2015-06-02 | Gilead Sciences Inc | 1' -substituted carba-nucleoside analogs for antiviral treatment |
CA2773773C (en) | 2009-09-21 | 2019-04-23 | Gilead Sciences, Inc. | Processes and intermediates for the preparation of 1'-substituted carba-nucleoside analogs |
JP5937073B2 (en) | 2010-07-19 | 2016-06-22 | ギリード・サイエンシズ・インコーポレーテッド | Process for the preparation of diastereomeric pure phosphoramidate prodrugs |
AU2011280910B2 (en) | 2010-07-22 | 2015-07-09 | Gilead Sciences, Inc. | Methods and compounds for treating Paramyxoviridae virus infections |
US20130273005A1 (en) | 2010-12-20 | 2013-10-17 | Gilead Sciences, Inc. | Methods for treating hcv |
WO2013039920A1 (en) | 2011-09-12 | 2013-03-21 | Idenix Pharmaceuticals, Inc. | Substituted carbonyloxymethylphosphoramidate compounds and pharmaceutical compositions for the treatment of viral infections |
NZ623396A (en) | 2011-09-16 | 2016-07-29 | Gilead Pharmasset Llc | Methods for treating hcv |
LT2950786T (en) | 2013-01-31 | 2020-03-10 | Gilead Pharmasset Llc | Combination formulation of two antiviral compounds |
UA119050C2 (en) * | 2013-11-11 | 2019-04-25 | Ґілеад Саєнсиз, Інк. | Pyrrolo [1,2,f] [1,2,4] triazines useful for treating respiratory syncitial virus infections |
TWI678369B (en) * | 2014-07-28 | 2019-12-01 | 美商基利科學股份有限公司 | Thieno[3,2-d]pyrimidine, furo[3,2-d]pyrimidine, and pyrrolo[3,2-d]pyrimidines useful for treating respiratory syncitial virus infections |
CN104230985B (en) * | 2014-09-01 | 2017-01-18 | 北京天弘天达医药科技有限公司 | Preparation method of (s)-2-[(s)-(4-nitro-phenoxy)-phenoxy-phosphoryl amino] isopropyl propionate |
TWI698444B (en) | 2014-10-29 | 2020-07-11 | 美商基利科學股份有限公司 | Methods for the preparation of ribosides |
KR20170123308A (en) | 2014-12-26 | 2017-11-07 | 에모리 유니버시티 | N4-hydroxycytidine, derivatives thereof and their antiviral uses |
PT3785717T (en) | 2015-09-16 | 2022-04-14 | Gilead Sciences Inc | Methods for treating coronaviridae infections |
ES2961460T3 (en) | 2017-03-14 | 2024-03-12 | Gilead Sciences Inc | Methods to treat feline coronavirus infections |
AR111490A1 (en) | 2017-05-01 | 2019-07-17 | Gilead Sciences Inc | CRYSTALLINE FORMS OF PROPANOATE OF (S) -2-ETILBUTIL 2 - (((S) - (((2R, 3S, 4R, 5R) -5- (4-AMINOPIRROLO [2,1-F] [1,2, 4] TRIAZIN-7-IL) -5-CIANO-3,4-DIHYDROXITETRAHIDROFURAN-2-IL) METOXI) (FENOXI) FOSFORIL) AMINO) |
CN111093627B (en) | 2017-07-11 | 2024-03-08 | 吉利德科学公司 | Compositions comprising an RNA polymerase inhibitor and a cyclodextrin for treating viral infections |
BR122022008466B1 (en) | 2017-12-07 | 2023-12-05 | Emory University | USE OF A COMPOUND |
CA3163424A1 (en) | 2020-01-27 | 2021-08-05 | Gilead Sciences, Inc. | Methods for treating sars cov-2 infections |
AU2021234308C1 (en) | 2020-03-12 | 2024-02-22 | Gilead Sciences, Inc. | Methods of preparing 1'-cyano nucleosides |
CN115362004A (en) | 2020-04-06 | 2022-11-18 | 吉利德科学公司 | Inhalation formulations of 1' -cyano-substituted carbon nucleoside analogs |
JP2023528810A (en) | 2020-05-29 | 2023-07-06 | ギリアード サイエンシーズ, インコーポレイテッド | remdesivir treatment method |
EP4172160A2 (en) | 2020-06-24 | 2023-05-03 | Gilead Sciences, Inc. | 1'-cyano nucleoside analogs and uses thereof |
TW202233204A (en) | 2020-08-27 | 2022-09-01 | 美商基利科學股份有限公司 | Compounds and methods for treatment of viral infections |
TW202400185A (en) | 2022-03-02 | 2024-01-01 | 美商基利科學股份有限公司 | Compounds and methods for treatment of viral infections |
US20230338409A1 (en) * | 2022-04-25 | 2023-10-26 | Miracure Biotechnology Limited | Nucleoside drugs for the treatment or prevention of coronavirus infection and their uses |
Family Cites Families (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4816570A (en) | 1982-11-30 | 1989-03-28 | The Board Of Regents Of The University Of Texas System | Biologically reversible phosphate and phosphonate protective groups |
US4968788A (en) | 1986-04-04 | 1990-11-06 | Board Of Regents, The University Of Texas System | Biologically reversible phosphate and phosphonate protective gruops |
JP3347723B2 (en) | 1990-06-13 | 2002-11-20 | グラツィエル,アーノルド | Phosphorus-containing prodrug |
DE10399025I2 (en) | 1990-09-14 | 2007-11-08 | Acad Of Science Czech Republic | Active substance precursors of phosphonates |
US6312662B1 (en) | 1998-03-06 | 2001-11-06 | Metabasis Therapeutics, Inc. | Prodrugs phosphorus-containing compounds |
DE19912636A1 (en) | 1999-03-20 | 2000-09-21 | Aventis Cropscience Gmbh | Bicyclic heterocycles, processes for their preparation and their use as herbicides and pharmaceutical agents |
WO2001032153A2 (en) | 1999-11-04 | 2001-05-10 | Shire Biochem Inc. | Method for the treatment or prevention of flaviviridae viral infection using nucleoside analogues |
NZ521210A (en) | 2000-02-18 | 2004-11-26 | Shire Biochem Inc | Method for the treatment or prevention of flavivirus infections using nucleoside analogues |
MY164523A (en) | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
US20030008841A1 (en) | 2000-08-30 | 2003-01-09 | Rene Devos | Anti-HCV nucleoside derivatives |
PT1411954E (en) | 2000-10-18 | 2011-03-16 | Pharmasset Inc | Modified nucleosides for treatment of viral infections and abnormal cellular proliferation |
MY134070A (en) * | 2001-01-22 | 2007-11-30 | Isis Pharmaceuticals Inc | Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase |
JP2005536440A (en) | 2001-09-28 | 2005-12-02 | イデニクス(ケイマン)リミテツド | Methods and compositions for the treatment of flaviviruses and pestiviruses using nucleosides modified at the 4 'position |
HUE033832T2 (en) | 2002-11-15 | 2018-01-29 | Idenix Pharmaceuticals Llc | 2'-methyl nucleosides in combination with interferon and flaviviridae mutation |
ES2586668T3 (en) * | 2003-05-30 | 2016-10-18 | Gilead Pharmasset Llc | Modified fluorinated nucleoside analogs |
MX2007003085A (en) | 2004-09-14 | 2007-08-02 | Pharmasset Inc | Preparation of 2' ifluoro-2'- alkyl- substituted or other optionally substituted ribofuranosyl pyrimidines and purines and their derivatives. |
CN101043893A (en) * | 2004-10-21 | 2007-09-26 | 默克公司 | Fluorinated pyrrolo[2,3-d]pyrimidine nucleosides for the treatment of rna-dependent rna viral infection |
US20080280842A1 (en) * | 2004-10-21 | 2008-11-13 | Merck & Co., Inc. | Fluorinated Pyrrolo[2,3-D]Pyrimidine Nucleosides for the Treatment of Rna-Dependent Rna Viral Infection |
WO2006121820A1 (en) | 2005-05-05 | 2006-11-16 | Valeant Research & Development | Phosphoramidate prodrugs for treatment of viral infection |
WO2007027248A2 (en) | 2005-05-16 | 2007-03-08 | Valeant Research & Development | 3', 5' - cyclic nucleoside analogues for treatment of hcv |
WO2007056170A2 (en) | 2005-11-02 | 2007-05-18 | Bayer Healthcare Ag | Pyrrolo[2,1-f] [1,2,4] triazin-4-ylamines igf-1r kinase inhibitors for the treatment of cancer and other hyperproliferative diseases |
US7951789B2 (en) | 2006-12-28 | 2011-05-31 | Idenix Pharmaceuticals, Inc. | Compounds and pharmaceutical compositions for the treatment of viral infections |
AU2007342367B2 (en) | 2007-01-05 | 2012-12-06 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. | Nucleoside aryl phosphoramidates for the treatment of RNA-dependent RNA viral infection |
ES2390188T3 (en) | 2007-01-12 | 2012-11-07 | Biocryst Pharmaceuticals, Inc. | Antiviral Nucleoside Analogs |
EP2125819B1 (en) | 2007-03-21 | 2014-10-22 | Bristol-Myers Squibb Company | Fused heterocyclic compounds useful for the treatment of proliferative, allergic, autoimmune or inflammatory diseases |
DK2155758T3 (en) | 2007-05-10 | 2012-11-05 | Biocryst Pharm Inc | TETRAHYDROFURO [3,4-D] DIOXOLAN COMPOUNDS FOR USE IN THE TREATMENT OF VIRUS INFECTIONS AND CANCER |
PT2268642E (en) | 2008-04-23 | 2015-06-02 | Gilead Sciences Inc | 1' -substituted carba-nucleoside analogs for antiviral treatment |
WO2010036407A2 (en) * | 2008-05-15 | 2010-04-01 | Biocryst Pharmaceuticals, Inc. | Antiviral nucleoside analogs |
EP2313102A2 (en) | 2008-07-03 | 2011-04-27 | Biota Scientific Management | Bycyclic nucleosides and nucleotides as therapeutic agents |
ES2453078T3 (en) * | 2009-02-10 | 2014-04-03 | Gilead Sciences, Inc. | Carba-nucleoside analogues for antiviral treatment |
PE20210668A1 (en) * | 2009-09-21 | 2021-04-05 | Gilead Sciences Inc | CARBA-NUCLEOSID ANALOGS REPLACED WITH 2'-FLUORINE ANTIVIRALS |
-
2011
- 2011-03-22 CA CA2807496A patent/CA2807496C/en active Active
- 2011-03-22 CN CN2011800449231A patent/CN103108876A/en active Pending
- 2011-03-22 WO PCT/US2011/029441 patent/WO2012039791A1/en active Application Filing
- 2011-03-22 EA EA201390141A patent/EA026523B1/en unknown
- 2011-03-22 AU AU2011306066A patent/AU2011306066B2/en active Active
- 2011-03-22 BR BR112013008017A patent/BR112013008017A2/en not_active Application Discontinuation
- 2011-03-22 JP JP2013529139A patent/JP2013538230A/en not_active Withdrawn
- 2011-03-22 KR KR1020137010012A patent/KR101879887B1/en active IP Right Grant
- 2011-03-22 PE PE2017001530A patent/PE20171624A1/en unknown
- 2011-03-22 MX MX2013003179A patent/MX2013003179A/en not_active Application Discontinuation
- 2011-03-22 EP EP11715792.5A patent/EP2619206A1/en not_active Withdrawn
- 2011-03-22 NZ NZ608070A patent/NZ608070A/en unknown
- 2011-03-22 PE PE2022003082A patent/PE20230684A1/en unknown
- 2011-03-22 PE PE2013000530A patent/PE20131165A1/en active IP Right Grant
- 2011-03-22 AP AP2013006767A patent/AP3699A/en active
- 2011-03-22 SG SG2013011325A patent/SG188223A1/en unknown
-
2013
- 2013-02-07 ZA ZA2013/01042A patent/ZA201301042B/en unknown
- 2013-02-26 CO CO13038918A patent/CO6680669A2/en not_active Application Discontinuation
- 2013-03-14 IL IL225221A patent/IL225221A0/en unknown
- 2013-03-18 CL CL2013000727A patent/CL2013000727A1/en unknown
- 2013-04-04 MA MA35795A patent/MA34593B1/en unknown
- 2013-04-17 CR CR20130172A patent/CR20130172A/en unknown
- 2013-04-18 EC ECSP13012560 patent/ECSP13012560A/en unknown
-
2016
- 2016-01-18 JP JP2016006833A patent/JP2016074732A/en not_active Withdrawn
-
2017
- 2017-04-10 JP JP2017077366A patent/JP6475280B2/en active Active
-
2018
- 2018-09-18 JP JP2018173758A patent/JP2019014726A/en not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
JP2017119726A (en) | 2017-07-06 |
CO6680669A2 (en) | 2013-05-31 |
ECSP13012560A (en) | 2013-06-28 |
EA201390141A1 (en) | 2013-09-30 |
AP2013006767A0 (en) | 2013-03-31 |
MX2013003179A (en) | 2013-04-24 |
PE20131165A1 (en) | 2013-10-14 |
CA2807496C (en) | 2019-01-22 |
IL225221A0 (en) | 2013-06-27 |
PE20230684A1 (en) | 2023-04-21 |
AU2011306066A1 (en) | 2013-02-28 |
CR20130172A (en) | 2013-05-29 |
EA026523B1 (en) | 2017-04-28 |
JP2019014726A (en) | 2019-01-31 |
BR112013008017A2 (en) | 2016-06-14 |
CA2807496A1 (en) | 2012-03-29 |
KR101879887B1 (en) | 2018-07-18 |
PE20171624A1 (en) | 2017-11-02 |
AP3699A (en) | 2016-05-31 |
CN103108876A (en) | 2013-05-15 |
SG188223A1 (en) | 2013-04-30 |
CL2013000727A1 (en) | 2013-08-23 |
MA34593B1 (en) | 2013-10-02 |
KR20130110168A (en) | 2013-10-08 |
JP6475280B2 (en) | 2019-02-27 |
JP2016074732A (en) | 2016-05-12 |
NZ608070A (en) | 2015-11-27 |
EP2619206A1 (en) | 2013-07-31 |
WO2012039791A1 (en) | 2012-03-29 |
JP2013538230A (en) | 2013-10-10 |
AU2011306066B2 (en) | 2015-01-29 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HRP20170197T1 (en) | 2' -fluoro substituted carba-nucleoside analogs for antiviral treatment | |
AP3699A (en) | 2'-fluoro substituted carba-nucleoside analogs for antiviral treatment | |
HUS2000055I1 (en) | 1' -substituted carba-nucleoside analogs for antiviral treatment | |
HK1256856A1 (en) | 2'- substituted carba-nucleoside analogs for antiviral treatment | |
SI2576534T1 (en) | 1'-substituted-carba-nucleoside prodrugs for antiviral treatment | |
AP2922A (en) | Carbra-nucleoside analogs for antiviral treatment | |
EP2627655A4 (en) | Therapeutic 5,6,5-tricyclic analogs |