ZA200709689B - Pyrido[2,3-d]pyrimidines useful as HCV inhibitors, and method for the preparation thereof - Google Patents

Pyrido[2,3-d]pyrimidines useful as HCV inhibitors, and method for the preparation thereof

Info

Publication number
ZA200709689B
ZA200709689B ZA200709689A ZA200709689A ZA200709689B ZA 200709689 B ZA200709689 B ZA 200709689B ZA 200709689 A ZA200709689 A ZA 200709689A ZA 200709689 A ZA200709689 A ZA 200709689A ZA 200709689 B ZA200709689 B ZA 200709689B
Authority
ZA
South Africa
Prior art keywords
pyrido
preparation
hcv inhibitors
pyrimidines useful
pyrimidines
Prior art date
Application number
ZA200709689A
Other languages
English (en)
Inventor
Simmen Kenneth Alan
Tse-I Lin
Raboisson Pierre Jean-Marie Bernard
Surleraux Dominique L Ghislain
Lenz Oliver
Original Assignee
Tibotec Pharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tibotec Pharm Ltd filed Critical Tibotec Pharm Ltd
Publication of ZA200709689B publication Critical patent/ZA200709689B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ZA200709689A 2005-05-12 2007-11-09 Pyrido[2,3-d]pyrimidines useful as HCV inhibitors, and method for the preparation thereof ZA200709689B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US68040505P 2005-05-12 2005-05-12
EP05106214 2005-07-07
EP06075855 2006-04-06

Publications (1)

Publication Number Publication Date
ZA200709689B true ZA200709689B (en) 2009-07-29

Family

ID=37198763

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200709689A ZA200709689B (en) 2005-05-12 2007-11-09 Pyrido[2,3-d]pyrimidines useful as HCV inhibitors, and method for the preparation thereof

Country Status (20)

Country Link
US (1) US8022077B2 (ja)
EP (1) EP1888580B1 (ja)
JP (1) JP5464686B2 (ja)
KR (1) KR20080007268A (ja)
CN (1) CN101203515B (ja)
AR (1) AR054122A1 (ja)
AT (1) ATE459623T1 (ja)
AU (1) AU2006245676B2 (ja)
BR (1) BRPI0609098A2 (ja)
CA (1) CA2608301C (ja)
DE (1) DE602006012666D1 (ja)
DK (1) DK1888580T3 (ja)
ES (1) ES2341572T3 (ja)
IL (1) IL186881A (ja)
MX (1) MX2007014082A (ja)
RU (1) RU2444522C2 (ja)
SI (1) SI1888580T1 (ja)
TW (1) TW200716631A (ja)
WO (1) WO2006120252A2 (ja)
ZA (1) ZA200709689B (ja)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0516751A (pt) * 2004-09-30 2008-09-16 Tibotec Pharm Ltd pirimidinas bicìclicas que inibem hcv
BRPI0609650A2 (pt) * 2005-03-25 2010-04-20 Tibotec Pharm Ltd inibidores heterobicìlicos de hvc
AR056347A1 (es) 2005-05-12 2007-10-03 Tibotec Pharm Ltd Uso de compuestos de pteridina para fabricar medicamentos y composiciones farmaceuticas
ATE541844T1 (de) * 2005-12-21 2012-02-15 Abbott Lab Antivirale verbindungen
US7763731B2 (en) 2005-12-21 2010-07-27 Abbott Laboratories Anti-viral compounds
WO2007081517A2 (en) * 2005-12-21 2007-07-19 Abbott Laboratories Anti-viral compounds
RU2441010C2 (ru) * 2005-12-21 2012-01-27 Эбботт Лэборетриз Противовирусные соединения
WO2008133753A2 (en) 2006-12-20 2008-11-06 Abbott Laboratories Anti-viral compounds
US7964580B2 (en) 2007-03-30 2011-06-21 Pharmasset, Inc. Nucleoside phosphoramidate prodrugs
EP2376514A2 (en) 2008-12-23 2011-10-19 Pharmasset, Inc. Nucleoside analogs
NZ593647A (en) 2008-12-23 2013-08-30 Gilead Pharmasset Llc Synthesis of purine nucleosides
MX2011006891A (es) 2008-12-23 2011-10-06 Pharmasset Inc Fosforamidatos de nucleosidos.
TWI576352B (zh) 2009-05-20 2017-04-01 基利法瑪席特有限責任公司 核苷磷醯胺
US8618076B2 (en) 2009-05-20 2013-12-31 Gilead Pharmasset Llc Nucleoside phosphoramidates
CA2792601C (en) * 2010-03-10 2015-09-29 Abbott Laboratories Solid compositions of amorphous hcv inhibitors
US8563530B2 (en) 2010-03-31 2013-10-22 Gilead Pharmassel LLC Purine nucleoside phosphoramidate
JP5872539B2 (ja) 2010-03-31 2016-03-01 ギリアド ファーマセット エルエルシー プリンヌクレオシドホスホルアミダート
AU2011235112B2 (en) 2010-03-31 2015-07-09 Gilead Pharmasset Llc Nucleoside phosphoramidates
AU2011336632B2 (en) 2010-11-30 2015-09-03 Gilead Pharmasset Llc Compounds
RS60191B1 (sr) 2011-04-08 2020-06-30 Janssen Sciences Ireland Unlimited Co Derivati pirimidina za tretman virusnih infekcija
AU2012334127B2 (en) 2011-11-09 2017-05-18 Janssen Sciences Ireland Uc Purine derivatives for the treatment of viral infections
US8889159B2 (en) 2011-11-29 2014-11-18 Gilead Pharmasset Llc Compositions and methods for treating hepatitis C virus
HUE030685T2 (en) 2012-07-13 2017-05-29 Janssen Sciences Ireland Uc Macrocyclic purines for treating viral infections
TR201807076T4 (tr) 2012-10-10 2018-06-21 Janssen Sciences Ireland Uc Viral enfeksiyonların ve diğer hastalıkların tedavisine yönelik pirolo[3,2-d]pirimidin derivatları.
EP2925729B1 (en) 2012-11-16 2017-10-18 Janssen Sciences Ireland UC Heterocyclic substituted 2-amino-quinazoline derivatives for the treatment of viral infections
KR102300861B1 (ko) 2013-02-21 2021-09-10 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 바이러스 감염의 치료를 위한 2-아미노피리미딘 유도체
DK2978429T3 (en) 2013-03-29 2017-05-15 Janssen Sciences Ireland Uc MACROCYCLIC DEAZA PURINONES FOR TREATING VIRUS INFECTIONS
AU2014270418B2 (en) 2013-05-24 2017-11-30 Janssen Sciences Ireland Uc Pyridone derivatives for the treatment of viral infections and further diseases
ES2645950T3 (es) 2013-06-27 2017-12-11 Janssen Sciences Ireland Uc Derivados de pirrolo[3,2-d]pirimidina para el tratamiento de infecciones víricas y otras enfermedades
CA2913691C (en) 2013-07-30 2022-01-25 Janssen Sciences Ireland Uc Thieno[3,2-d]pyrimidines derivatives for the treatment of viral infections
NZ716840A (en) 2013-08-27 2017-06-30 Gilead Pharmasset Llc Combination formulation of two antiviral compounds
ES2813875T3 (es) 2014-01-01 2021-03-25 Medivation Tech Llc Compuestos y procedimientos de uso
EP2905024A1 (en) 2014-02-07 2015-08-12 Institut Quimic De Sarriá Cets, Fundació Privada Pyrido[2,3-d]pyrimidine-7(8H)-one derivatives for the treatment of infections caused by Flaviviridae
WO2018002319A1 (en) 2016-07-01 2018-01-04 Janssen Sciences Ireland Uc Dihydropyranopyrimidines for the treatment of viral infections
ES2912945T3 (es) 2016-09-29 2022-05-30 Janssen Sciences Ireland Unlimited Co Profármacos de pirimidina para el tratamiento de infecciones virales y otras enfermedades
TW201945003A (zh) 2018-03-01 2019-12-01 愛爾蘭商健生科學愛爾蘭無限公司 ２，４－二胺基喹唑啉衍生物及其醫學用途

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE789496A (ja) * 1971-10-05 1973-03-29 S M B Anciens Ets J Muelberger
IL112249A (en) 1994-01-25 2001-11-25 Warner Lambert Co Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds
US6184226B1 (en) 1998-08-28 2001-02-06 Scios Inc. Quinazoline derivatives as inhibitors of P-38 α
RU2340611C2 (ru) * 2000-09-15 2008-12-10 Вертекс Фармасьютикалз Инкорпорейтед Производные пиразола, используемые в качестве ингибиторов протеинкиназы
AU2003202263A1 (en) 2002-01-10 2003-07-30 Bayer Healthcare Ag Roh-kinase inhibitors
JP2003321472A (ja) 2002-02-26 2003-11-11 Takeda Chem Ind Ltd Ｇｒｋ阻害剤
EP1511738A4 (en) * 2002-05-17 2007-05-09 Scios Inc TREATMENT OF FIBROPROLIFERATIVE DISEASES USING TGF BETA INHIBITORS
WO2004020584A2 (en) 2002-08-27 2004-03-11 Bristol-Myers Squibb Company Antagonists of chemokine receptors
US7148226B2 (en) 2003-02-21 2006-12-12 Agouron Pharmaceuticals, Inc. Inhibitors of hepatitis C virus RNA-dependent RNA polymerase, and compositions and treatments using the same
WO2005032481A2 (en) * 2003-09-30 2005-04-14 Scios Inc. Quinazoline derivatives as medicaments
BRPI0609650A2 (pt) * 2005-03-25 2010-04-20 Tibotec Pharm Ltd inibidores heterobicìlicos de hvc
US20070066632A1 (en) * 2005-03-25 2007-03-22 Scios, Inc. Fused bicyclic inhibitors of TGFbeta

Also Published As

Publication number Publication date
MX2007014082A (es) 2008-04-17
DE602006012666D1 (de) 2010-04-15
RU2007146173A (ru) 2009-06-20
CN101203515A (zh) 2008-06-18
CN101203515B (zh) 2014-02-26
RU2444522C2 (ru) 2012-03-10
WO2006120252A3 (en) 2007-02-22
IL186881A0 (en) 2008-02-09
TW200716631A (en) 2007-05-01
CA2608301A1 (en) 2006-11-16
DK1888580T3 (da) 2010-06-14
BRPI0609098A2 (pt) 2010-02-17
ES2341572T3 (es) 2010-06-22
KR20080007268A (ko) 2008-01-17
ATE459623T1 (de) 2010-03-15
SI1888580T1 (sl) 2010-06-30
AU2006245676A1 (en) 2006-11-16
AR054122A1 (es) 2007-06-06
CA2608301C (en) 2014-04-22
JP2008540494A (ja) 2008-11-20
WO2006120252A2 (en) 2006-11-16
IL186881A (en) 2015-06-30
EP1888580B1 (en) 2010-03-03
US8022077B2 (en) 2011-09-20
AU2006245676B2 (en) 2012-08-02
JP5464686B2 (ja) 2014-04-09
EP1888580A2 (en) 2008-02-20
US20090131460A1 (en) 2009-05-21

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