ZA200704246B - Solid medicinal preparation improved in solubility and stability and process for producing the same - Google Patents

Solid medicinal preparation improved in solubility and stability and process for producing the same

Info

Publication number
ZA200704246B
ZA200704246B ZA200704246A ZA200704246A ZA200704246B ZA 200704246 B ZA200704246 B ZA 200704246B ZA 200704246 A ZA200704246 A ZA 200704246A ZA 200704246 A ZA200704246 A ZA 200704246A ZA 200704246 B ZA200704246 B ZA 200704246B
Authority
ZA
South Africa
Prior art keywords
solubility
stability
producing
same
medicinal preparation
Prior art date
Application number
ZA200704246A
Inventor
Yamane Shogo
Yamane Hirofumi
Sunami Masaki
Original Assignee
Japan Tobacco Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Japan Tobacco Inc filed Critical Japan Tobacco Inc
Publication of ZA200704246B publication Critical patent/ZA200704246B/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/2027Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/225Polycarboxylic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/143Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1635Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1652Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2009Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/205Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Zoology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
ZA200704246A 2004-10-25 2005-10-20 Solid medicinal preparation improved in solubility and stability and process for producing the same ZA200704246B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2004310254 2004-10-25

Publications (1)

Publication Number Publication Date
ZA200704246B true ZA200704246B (en) 2009-09-30

Family

ID=38772175

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200704246A ZA200704246B (en) 2004-10-25 2005-10-20 Solid medicinal preparation improved in solubility and stability and process for producing the same

Country Status (4)

Country Link
JP (1) JP4782695B2 (en)
KR (1) KR101129456B1 (en)
CN (1) CN101048180B (en)
ZA (1) ZA200704246B (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20130069484A (en) * 2011-12-15 2013-06-26 주식회사 삼양바이오팜 Solid dispersion comprising celecoxib and a preparation method thereof
CN104415340A (en) * 2013-08-23 2015-03-18 中国科学院大连化学物理研究所 Solid drug preparation and preparing method thereof
KR101631846B1 (en) * 2014-07-08 2016-06-20 한국유나이티드제약 주식회사 Solid preparations containing choline alfoscerate and preparing method thereof
CN104523599A (en) * 2014-12-20 2015-04-22 长沙佰顺生物科技有限公司 Anacetrapib containing solid dispersion and preparation method thereof
CN104666260B (en) * 2015-02-03 2018-01-19 山东新时代药业有限公司 A kind of Ezetimibe tablet
CN104546774B (en) * 2015-02-03 2017-08-25 山东新时代药业有限公司 A kind of glimepiride tablet
CN104666261B (en) * 2015-02-03 2017-11-10 山东新时代药业有限公司 A kind of tablet of everolimus
CN104523632B (en) * 2015-02-03 2017-09-29 山东新时代药业有限公司 A kind of Azilsartan tablet
CN104666262B (en) * 2015-02-03 2017-09-15 山东新时代药业有限公司 A kind of razaxaban piece
CN104546775B (en) * 2015-02-03 2017-08-25 山东新时代药业有限公司 A kind of atorvastatin agent
CN104586814B (en) * 2015-02-04 2017-11-10 山东新时代药业有限公司 A kind of Aprepitant capsule
CN104688698B (en) * 2015-02-04 2018-01-19 山东新时代药业有限公司 A kind of Cefditoren pivoxil Cephalosporins tablet
CN105030703B (en) * 2015-06-23 2018-03-23 上海旭东海普药业有限公司 A kind of razaxaban piece of anti-treatment embolism class diseases and preparation method thereof
CN107998085A (en) * 2017-11-29 2018-05-08 乐普制药科技有限公司 A kind of tablet containing Atorvastatin calcium alkali solid dispersion and preparation method thereof
WO2019135420A1 (en) * 2018-01-03 2019-07-11 김배용 Composite using porous material and polymer, and use thereof
CN114456781B (en) * 2020-10-21 2023-05-26 中国石油化工股份有限公司 Method for preparing solid dosage form from viscous salt-resistant fluid loss additive solution, solid dosage form fluid loss additive and application

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57206612A (en) * 1982-04-16 1982-12-18 Bayer Ag Collapsible absorptive compressed mold article of hard soluble medicine
JPH0597672A (en) * 1991-10-08 1993-04-20 Terumo Corp Amide derivative-containing solid preparation and its production
JP4027535B2 (en) * 1998-05-26 2007-12-26 エーザイ・アール・アンド・ディー・マネジメント株式会社 Powder containing fat-soluble drug
DE19945594A1 (en) * 1999-09-23 2001-03-29 Boehringer Ingelheim Pharma Substituted piperazine derivatives, their preparation and their use as medicines
CA2324800A1 (en) * 1999-11-10 2001-05-10 Mary Anne Hickman Use of apo b secretion/mtp inhibitors
JP2001316248A (en) * 2000-02-28 2001-11-13 Eisai Co Ltd Method of producing oily medicine containing composition
WO2002069932A1 (en) * 2001-03-05 2002-09-12 Nippon Shinyaku Co., Ltd. Foaming compositions
JP3662566B2 (en) 2002-02-28 2005-06-22 日本たばこ産業株式会社 Ester compound and its pharmaceutical use
SG165154A1 (en) * 2002-02-28 2010-10-28 Japan Tobacco Inc Ester compound and medical use thereof
US20050181049A1 (en) * 2003-11-19 2005-08-18 Dong Liang C. Composition and method for enhancing bioavailability

Also Published As

Publication number Publication date
JP4782695B2 (en) 2011-09-28
KR20100120244A (en) 2010-11-12
CN101048180A (en) 2007-10-03
KR101129456B1 (en) 2012-03-28
JPWO2006046623A1 (en) 2008-05-22
CN101048180B (en) 2011-06-29

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