ZA200502214B - Test strip and method for determining LDL cholesterol concentration from whole blood - Google Patents

Test strip and method for determining LDL cholesterol concentration from whole blood Download PDF

Info

Publication number: ZA200502214B
Authority: ZA; South Africa
Prior art keywords: ldl; cholesterol; test strip; sample; ldl cholesterol
Prior art date: 2002-09-16

Application number

ZA200502214A

Other languages

English (en)

Inventor

Bruce Shull

Hyeon-Sook Lee Zeng Su Anaokar

Gena Lynn Antonopoulos

Original Assignee

Polymer Technology Systems Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-09-16

Filing date

2005-03-16

Publication date

2006-05-31

2005-03-16 Application filed by Polymer Technology Systems Inc filed Critical Polymer Technology Systems Inc

2006-05-31 Publication of ZA200502214B publication Critical patent/ZA200502214B/en

Links

238000012360 testing method Methods 0.000 title claims description 105
238000008214 LDL Cholesterol Methods 0.000 title claims description 87
210000004369 blood Anatomy 0.000 title claims description 44
239000008280 blood Substances 0.000 title claims description 44
238000000034 method Methods 0.000 title claims description 21
HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims description 129
108010007622 LDL Lipoproteins Proteins 0.000 claims description 103
102000007330 LDL Lipoproteins Human genes 0.000 claims description 103
235000012000 cholesterol Nutrition 0.000 claims description 64
239000003153 chemical reaction reagent Substances 0.000 claims description 36
239000011159 matrix material Substances 0.000 claims description 22
238000000926 separation method Methods 0.000 claims description 21
239000012530 fluid Substances 0.000 claims description 11
239000004094 surface-active agent Substances 0.000 claims description 10
230000004044 response Effects 0.000 claims description 9
210000000601 blood cell Anatomy 0.000 claims description 6
238000004891 communication Methods 0.000 claims description 4
239000010410 layer Substances 0.000 description 96
238000006243 chemical reaction Methods 0.000 description 47
238000003556 assay Methods 0.000 description 21
108010010234 HDL Lipoproteins Proteins 0.000 description 20
102000015779 HDL Lipoproteins Human genes 0.000 description 20
238000005259 measurement Methods 0.000 description 19
239000012071 phase Substances 0.000 description 16
239000007791 liquid phase Substances 0.000 description 11
238000004519 manufacturing process Methods 0.000 description 11
-1 polyoxyethylene monolaurate Polymers 0.000 description 11
RLFWWDJHLFCNIJ-UHFFFAOYSA-N 4-aminoantipyrine Chemical compound CN1C(C)=C(N)C(=O)N1C1=CC=CC=C1 RLFWWDJHLFCNIJ-UHFFFAOYSA-N 0.000 description 10
230000008901 benefit Effects 0.000 description 10
239000012528 membrane Substances 0.000 description 10
108010062497 VLDL Lipoproteins Proteins 0.000 description 9
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 9
238000009472 formulation Methods 0.000 description 8
239000000203 mixture Substances 0.000 description 8
108010089254 Cholesterol oxidase Proteins 0.000 description 7
108010055297 Sterol Esterase Proteins 0.000 description 7
102000000019 Sterol Esterase Human genes 0.000 description 7
230000007480 spreading Effects 0.000 description 7
238000003892 spreading Methods 0.000 description 7
150000003626 triacylglycerols Chemical class 0.000 description 7
241001191009 Gymnomyza Species 0.000 description 6
MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 6
102000004895 Lipoproteins Human genes 0.000 description 6
108090001030 Lipoproteins Proteins 0.000 description 6
238000004364 calculation method Methods 0.000 description 6
239000007859 condensation product Substances 0.000 description 6
239000007788 liquid Substances 0.000 description 6
HLXGRHNZZSMNRX-UHFFFAOYSA-M sodium;3-(n-ethyl-3,5-dimethylanilino)-2-hydroxypropane-1-sulfonate Chemical compound [Na+].[O-]S(=O)(=O)CC(O)CN(CC)C1=CC(C)=CC(C)=C1 HLXGRHNZZSMNRX-UHFFFAOYSA-M 0.000 description 6
108010004103 Chylomicrons Proteins 0.000 description 5
KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 5
102000003992 Peroxidases Human genes 0.000 description 5
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238000005516 engineering process Methods 0.000 description 5
108040007629 peroxidase activity proteins Proteins 0.000 description 5
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208000029078 coronary artery disease Diseases 0.000 description 4
230000005693 optoelectronics Effects 0.000 description 4
239000000243 solution Substances 0.000 description 4
UMCMPZBLKLEWAF-BCTGSCMUSA-N 3-[(3-cholamidopropyl)dimethylammonio]propane-1-sulfonate Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(=O)NCCC[N+](C)(C)CCCS([O-])(=O)=O)C)[C@@]2(C)[C@@H](O)C1 UMCMPZBLKLEWAF-BCTGSCMUSA-N 0.000 description 3
239000007993 MOPS buffer Substances 0.000 description 3
229930006000 Sucrose Natural products 0.000 description 3
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 3
238000002835 absorbance Methods 0.000 description 3
238000013459 approach Methods 0.000 description 3
210000003743 erythrocyte Anatomy 0.000 description 3
UPBDXRPQPOWRKR-UHFFFAOYSA-N furan-2,5-dione;methoxyethene Chemical compound COC=C.O=C1OC(=O)C=C1 UPBDXRPQPOWRKR-UHFFFAOYSA-N 0.000 description 3
150000002632 lipids Chemical class 0.000 description 3
229920000642 polymer Polymers 0.000 description 3
230000035484 reaction time Effects 0.000 description 3
239000005720 sucrose Substances 0.000 description 3
AZQWKYJCGOJGHM-UHFFFAOYSA-N 1,4-benzoquinone Chemical compound O=C1C=CC(=O)C=C1 AZQWKYJCGOJGHM-UHFFFAOYSA-N 0.000 description 2
PAYRUJLWNCNPSJ-UHFFFAOYSA-N Aniline Chemical compound NC1=CC=CC=C1 PAYRUJLWNCNPSJ-UHFFFAOYSA-N 0.000 description 2
102000016938 Catalase Human genes 0.000 description 2
108010053835 Catalase Proteins 0.000 description 2
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
108010023302 HDL Cholesterol Proteins 0.000 description 2
108010028554 LDL Cholesterol Proteins 0.000 description 2
ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 2
229920003171 Poly (ethylene oxide) Polymers 0.000 description 2
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 2
239000007983 Tris buffer Substances 0.000 description 2
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230000009471 action Effects 0.000 description 2
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WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
210000001124 body fluid Anatomy 0.000 description 2
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DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 description 2
230000003247 decreasing effect Effects 0.000 description 2
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235000014113 dietary fatty acids Nutrition 0.000 description 2
239000000194 fatty acid Substances 0.000 description 2
229930195729 fatty acid Natural products 0.000 description 2
150000004665 fatty acids Chemical class 0.000 description 2
239000003365 glass fiber Substances 0.000 description 2
238000010438 heat treatment Methods 0.000 description 2
230000000977 initiatory effect Effects 0.000 description 2
239000000463 material Substances 0.000 description 2
229910052700 potassium Inorganic materials 0.000 description 2
239000011591 potassium Substances 0.000 description 2
238000002360 preparation method Methods 0.000 description 2
210000002966 serum Anatomy 0.000 description 2
125000006850 spacer group Chemical group 0.000 description 2
LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 2
FFJCNSLCJOQHKM-CLFAGFIQSA-N (z)-1-[(z)-octadec-9-enoxy]octadec-9-ene Chemical compound CCCCCCCC\C=C/CCCCCCCCOCCCCCCCC\C=C/CCCCCCCC FFJCNSLCJOQHKM-CLFAGFIQSA-N 0.000 description 1
238000012935 Averaging Methods 0.000 description 1
239000005711 Benzoic acid Substances 0.000 description 1
QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 description 1
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
102000008946 Fibrinogen Human genes 0.000 description 1
108010049003 Fibrinogen Proteins 0.000 description 1
108010069201 VLDL Cholesterol Proteins 0.000 description 1
239000012790 adhesive layer Substances 0.000 description 1
239000011543 agarose gel Substances 0.000 description 1
150000001298 alcohols Chemical class 0.000 description 1
150000003973 alkyl amines Chemical class 0.000 description 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
235000010233 benzoic acid Nutrition 0.000 description 1
WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 description 1
210000004027 cell Anatomy 0.000 description 1
229940109239 creatinine Drugs 0.000 description 1
230000007423 decrease Effects 0.000 description 1
239000008367 deionised water Substances 0.000 description 1
229910021641 deionized water Inorganic materials 0.000 description 1
238000000151 deposition Methods 0.000 description 1
238000013461 design Methods 0.000 description 1
238000002405 diagnostic procedure Methods 0.000 description 1
150000004683 dihydrates Chemical class 0.000 description 1
238000001962 electrophoresis Methods 0.000 description 1
229940012952 fibrinogen Drugs 0.000 description 1
238000001914 filtration Methods 0.000 description 1
208000019622 heart disease Diseases 0.000 description 1
239000000852 hydrogen donor Substances 0.000 description 1
238000005470 impregnation Methods 0.000 description 1
238000007373 indentation Methods 0.000 description 1
239000004615 ingredient Substances 0.000 description 1
238000001746 injection moulding Methods 0.000 description 1
150000002576 ketones Chemical class 0.000 description 1
239000006193 liquid solution Substances 0.000 description 1
230000013011 mating Effects 0.000 description 1
238000013508 migration Methods 0.000 description 1
230000005012 migration Effects 0.000 description 1
239000002736 nonionic surfactant Substances 0.000 description 1
229920002114 octoxynol-9 Polymers 0.000 description 1
229910052760 oxygen Inorganic materials 0.000 description 1
239000001301 oxygen Substances 0.000 description 1
229920000233 poly(alkylene oxides) Polymers 0.000 description 1
229920000728 polyester Polymers 0.000 description 1
229920000259 polyoxyethylene lauryl ether Polymers 0.000 description 1
239000000276 potassium ferrocyanide Substances 0.000 description 1
238000009597 pregnancy test Methods 0.000 description 1
102000004169 proteins and genes Human genes 0.000 description 1
108090000623 proteins and genes Proteins 0.000 description 1
230000009257 reactivity Effects 0.000 description 1
230000000717 retained effect Effects 0.000 description 1
150000003839 salts Chemical class 0.000 description 1
238000012883 sequential measurement Methods 0.000 description 1
239000002356 single layer Substances 0.000 description 1
NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
IRQRBVOQGUPTLG-UHFFFAOYSA-M sodium;3-(n-ethyl-3-methylanilino)-2-hydroxypropane-1-sulfonate Chemical compound [Na+].[O-]S(=O)(=O)CC(O)CN(CC)C1=CC=CC(C)=C1 IRQRBVOQGUPTLG-UHFFFAOYSA-M 0.000 description 1
239000002904 solvent Substances 0.000 description 1
239000012086 standard solution Substances 0.000 description 1
238000006467 substitution reaction Methods 0.000 description 1
238000010998 test method Methods 0.000 description 1
XOGGUFAVLNCTRS-UHFFFAOYSA-N tetrapotassium;iron(2+);hexacyanide Chemical compound [K+].[K+].[K+].[K+].[Fe+2].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-] XOGGUFAVLNCTRS-UHFFFAOYSA-N 0.000 description 1
238000012546 transfer Methods 0.000 description 1
GPRLSGONYQIRFK-MNYXATJNSA-N triton Chemical compound [3H+] GPRLSGONYQIRFK-MNYXATJNSA-N 0.000 description 1
238000005199 ultracentrifugation Methods 0.000 description 1

Classifications

- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
- G01N33/525—Multi-layer analytical elements
- G01N33/526—Multi-layer analytical elements the element being adapted for a specific analyte
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/04—Endocrine or metabolic disorders
- G01N2800/044—Hyperlipemia or hypolipemia, e.g. dyslipidaemia, obesity

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Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Hematology (AREA)
Immunology (AREA)
Biomedical Technology (AREA)
Chemical & Material Sciences (AREA)
Urology & Nephrology (AREA)
Food Science & Technology (AREA)
Biochemistry (AREA)
Cell Biology (AREA)
Biotechnology (AREA)
Medicinal Chemistry (AREA)
Physics & Mathematics (AREA)
Analytical Chemistry (AREA)
Microbiology (AREA)
General Health & Medical Sciences (AREA)
General Physics & Mathematics (AREA)
Pathology (AREA)
Biophysics (AREA)
Endocrinology (AREA)
Investigating Or Analysing Biological Materials (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

ZA200502214A 2002-09-16 2005-03-16 Test strip and method for determining LDL cholesterol concentration from whole blood ZA200502214B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US41120902P	2002-09-16	2002-09-16

Publications (1)

Publication Number	Publication Date
ZA200502214B true ZA200502214B (en)	2006-05-31

Family

ID=31994248

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200502214A ZA200502214B (en)	2002-09-16	2005-03-16	Test strip and method for determining LDL cholesterol concentration from whole blood

Country Status (6)

Country	Link
EP (1)	EP1540353A4 (fr)
AU (1)	AU2003272453A1 (fr)
CA (1)	CA2499058A1 (fr)
MX (1)	MXPA05002955A (fr)
WO (1)	WO2004025265A2 (fr)
ZA (1)	ZA200502214B (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE10204606C1 (de)	2002-01-18	2003-10-16	Cholestech Corp	Vorrichtung und Verfahren für Lipoproteine hoher Dichte
ES2252358T3 (es)	2002-04-09	2006-05-16	Cholestech Corporation	Metodo y dispositivo de ensayo para la cuantificacion del colesterol asociado a lipoproteinas de alta densidad.
US7772007B2 (en)	2004-04-02	2010-08-10	Cholestech Corporation	Assay device for direct measurement of LDL cholesterol
WO2008086019A1 (fr) *	2007-01-09	2008-07-17	Cholestech Corporation	Dispositif et procédé de mesure du cholestérol associé au ldl
CN101657546B (zh)	2007-09-05	2013-01-02	爱科来株式会社	低密度脂蛋白（ldl）胆固醇测定方法以及ldl胆固醇测定用试验片

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5132086A (en) *	1990-02-06	1992-07-21	Chemtrak Corporation	Non-instrumented cholesterol assay
US5135716A (en) *	1989-07-12	1992-08-04	Kingston Diagnostics, L.P.	Direct measurement of HDL cholesterol via dry chemistry strips
US5460974A (en) *	1992-10-13	1995-10-24	Miles Inc.	Method of assaying whole blood for HDL cholesterol
JP3193634B2 (ja) *	1996-05-29	2001-07-30	第一化学薬品株式会社	Ｌｄｌコレステロールの定量方法
JP3441993B2 (ja) *	1999-01-27	2003-09-02	松下電器産業株式会社	コレステロールセンサ
US6524864B2 (en) *	2000-12-28	2003-02-25	Aurora L. Fernandez Decastro	Test strip for simultaneous detection of a plurality of analytes

2003
- 2003-09-16 WO PCT/US2003/029102 patent/WO2004025265A2/fr not_active Application Discontinuation
- 2003-09-16 AU AU2003272453A patent/AU2003272453A1/en not_active Abandoned
- 2003-09-16 CA CA002499058A patent/CA2499058A1/fr not_active Abandoned
- 2003-09-16 EP EP03754634A patent/EP1540353A4/fr not_active Withdrawn
- 2003-09-16 MX MXPA05002955A patent/MXPA05002955A/es not_active Application Discontinuation
2005
- 2005-03-16 ZA ZA200502214A patent/ZA200502214B/en unknown

Also Published As

Publication number	Publication date
WO2004025265A2 (fr)	2004-03-25
MXPA05002955A (es)	2005-10-18
CA2499058A1 (fr)	2004-03-25
AU2003272453A1 (en)	2004-04-30
EP1540353A2 (fr)	2005-06-15
WO2004025265A3 (fr)	2004-07-01
EP1540353A4 (fr)	2007-01-24

Publication	Publication Date	Title
US20040126830A1 (en)	2004-07-01	Test strip and method for determining LDL cholesterol concentration from whole blood
EP0799896B1 (fr)	2001-09-12	Bandes de test pour la détermination de glucose dans le sang
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MXPA97002503A (en)	1998-04-01	Reagent test stress to determine glucose in the san
MXPA97002502A (en)	1998-04-01	Reagent test for the determination of glucose in the san
EP0759555A2 (fr)	1997-02-26	Bandes de test à lecture directe
EP1792189B1 (fr)	2013-03-13	Dispositif d'essai servant a determiner la concentration en cholesterol ldl dans un echantillon
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JP6055236B2 (ja)	2016-12-27	測定方法
EP0464934A1 (fr)	1992-01-08	Elément pour l'essai de catéchol et des substances qui produisent du catéchol