ZA200407551B - Orally administrable composition for the photoprotection of the skin. - Google Patents
Orally administrable composition for the photoprotection of the skin. Download PDFInfo
- Publication number
- ZA200407551B ZA200407551B ZA200407551A ZA200407551A ZA200407551B ZA 200407551 B ZA200407551 B ZA 200407551B ZA 200407551 A ZA200407551 A ZA 200407551A ZA 200407551 A ZA200407551 A ZA 200407551A ZA 200407551 B ZA200407551 B ZA 200407551B
- Authority
- ZA
- South Africa
- Prior art keywords
- composition
- lactic acid
- bifidobacterium
- acid bacterium
- carotenoid
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims description 76
- 230000003711 photoprotective effect Effects 0.000 title claims description 26
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 54
- 241000894006 Bacteria Species 0.000 claims description 28
- 235000021466 carotenoid Nutrition 0.000 claims description 28
- 150000001747 carotenoids Chemical class 0.000 claims description 28
- 235000014655 lactic acid Nutrition 0.000 claims description 27
- 239000004310 lactic acid Substances 0.000 claims description 27
- LWGJTAZLEJHCPA-UHFFFAOYSA-N n-(2-chloroethyl)-n-nitrosomorpholine-4-carboxamide Chemical group ClCCN(N=O)C(=O)N1CCOCC1 LWGJTAZLEJHCPA-UHFFFAOYSA-N 0.000 claims description 26
- 239000006041 probiotic Substances 0.000 claims description 26
- 235000018291 probiotics Nutrition 0.000 claims description 26
- 230000000529 probiotic effect Effects 0.000 claims description 24
- 238000000034 method Methods 0.000 claims description 20
- 230000005855 radiation Effects 0.000 claims description 16
- 239000012228 culture supernatant Substances 0.000 claims description 15
- 230000000694 effects Effects 0.000 claims description 10
- 239000000843 powder Substances 0.000 claims description 8
- UPYKUZBSLRQECL-UKMVMLAPSA-N Lycopene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1C(=C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=C)CCCC2(C)C UPYKUZBSLRQECL-UKMVMLAPSA-N 0.000 claims description 7
- OAIJSZIZWZSQBC-GYZMGTAESA-N lycopene Chemical compound CC(C)=CCC\C(C)=C\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C=C(/C)CCC=C(C)C OAIJSZIZWZSQBC-GYZMGTAESA-N 0.000 claims description 7
- 229960004999 lycopene Drugs 0.000 claims description 7
- 230000004224 protection Effects 0.000 claims description 7
- JEVVKJMRZMXFBT-XWDZUXABSA-N Lycophyll Natural products OC/C(=C/CC/C(=C\C=C\C(=C/C=C/C(=C\C=C\C=C(/C=C/C=C(\C=C\C=C(/CC/C=C(/CO)\C)\C)/C)\C)/C)\C)/C)/C JEVVKJMRZMXFBT-XWDZUXABSA-N 0.000 claims description 6
- 235000012661 lycopene Nutrition 0.000 claims description 6
- 239000001751 lycopene Substances 0.000 claims description 6
- 235000013336 milk Nutrition 0.000 claims description 6
- 239000008267 milk Substances 0.000 claims description 6
- 210000004080 milk Anatomy 0.000 claims description 6
- 239000000047 product Substances 0.000 claims description 6
- ZCIHMQAPACOQHT-ZGMPDRQDSA-N trans-isorenieratene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/c1c(C)ccc(C)c1C)C=CC=C(/C)C=Cc2c(C)ccc(C)c2C ZCIHMQAPACOQHT-ZGMPDRQDSA-N 0.000 claims description 6
- 241000186018 Bifidobacterium adolescentis Species 0.000 claims description 5
- 241000901050 Bifidobacterium animalis subsp. lactis Species 0.000 claims description 5
- 241001608472 Bifidobacterium longum Species 0.000 claims description 5
- 241000186605 Lactobacillus paracasei Species 0.000 claims description 5
- 229940009289 bifidobacterium lactis Drugs 0.000 claims description 5
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- 208000017520 skin disease Diseases 0.000 claims description 5
- 239000013589 supplement Substances 0.000 claims description 5
- 241000186000 Bifidobacterium Species 0.000 claims description 4
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- 241000186012 Bifidobacterium breve Species 0.000 claims description 4
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- 229940002008 bifidobacterium bifidum Drugs 0.000 claims description 4
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- JKQXZKUSFCKOGQ-LOFNIBRQSA-N all-trans-Zeaxanthin Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2=C(C)CC(O)CC2(C)C JKQXZKUSFCKOGQ-LOFNIBRQSA-N 0.000 claims description 3
- 235000015872 dietary supplement Nutrition 0.000 claims description 3
- JKQXZKUSFCKOGQ-QAYBQHTQSA-N zeaxanthin Chemical compound C([C@H](O)CC=1C)C(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)C[C@@H](O)CC1(C)C JKQXZKUSFCKOGQ-QAYBQHTQSA-N 0.000 claims description 3
- FKUISVKPMQSWTN-UHFFFAOYSA-N Kesselringine Natural products C1CC(C2=C34)N(C)CCC2=CC(O)=C4OC2(OC)C(O)CCC31C2 FKUISVKPMQSWTN-UHFFFAOYSA-N 0.000 claims description 2
- 235000013734 beta-carotene Nutrition 0.000 claims description 2
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- 235000012680 lutein Nutrition 0.000 claims description 2
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- KBPHJBAIARWVSC-XQIHNALSSA-N trans-lutein Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C(=CC(O)CC2(C)C)C KBPHJBAIARWVSC-XQIHNALSSA-N 0.000 claims description 2
- 239000012138 yeast extract Substances 0.000 claims description 2
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- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 claims description 2
- 239000000126 substance Substances 0.000 claims 12
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- NCYCYZXNIZJOKI-UHFFFAOYSA-N vitamin A aldehyde Natural products O=CC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C NCYCYZXNIZJOKI-UHFFFAOYSA-N 0.000 claims 1
- 230000003449 preventive effect Effects 0.000 description 7
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- 229920002774 Maltodextrin Polymers 0.000 description 6
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- DEXFNLNNUZKHNO-UHFFFAOYSA-N 6-[3-[4-[2-(2,3-dihydro-1H-inden-2-ylamino)pyrimidin-5-yl]piperidin-1-yl]-3-oxopropyl]-3H-1,3-benzoxazol-2-one Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)C1CCN(CC1)C(CCC1=CC2=C(NC(O2)=O)C=C1)=O DEXFNLNNUZKHNO-UHFFFAOYSA-N 0.000 description 1
- 241001134770 Bifidobacterium animalis Species 0.000 description 1
- 241000222120 Candida <Saccharomycetales> Species 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
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- 206010020649 Hyperkeratosis Diseases 0.000 description 1
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- 241001406038 Lactobacillus johnsonii NCC 533 Species 0.000 description 1
- CBENFWSGALASAD-UHFFFAOYSA-N Ozone Chemical compound [O-][O+]=O CBENFWSGALASAD-UHFFFAOYSA-N 0.000 description 1
- 208000000453 Skin Neoplasms Diseases 0.000 description 1
- 206010042496 Sunburn Diseases 0.000 description 1
- 229930003316 Vitamin D Natural products 0.000 description 1
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 description 1
- 241000235013 Yarrowia Species 0.000 description 1
- 241000235017 Zygosaccharomyces Species 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
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- 230000032683 aging Effects 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
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- 229940118852 bifidobacterium animalis Drugs 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
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- 230000037406 food intake Effects 0.000 description 1
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- 239000012634 fragment Substances 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
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- 239000002207 metabolite Substances 0.000 description 1
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- 150000004666 short chain fatty acids Chemical class 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/01—Hydrocarbons
- A61K31/015—Hydrocarbons carbocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/07—Retinol compounds, e.g. vitamin A
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/745—Bifidobacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/062—Ascomycota
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/31—Hydrocarbons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/92—Oral administration
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Engineering & Computer Science (AREA)
- Birds (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Dermatology (AREA)
- Alternative & Traditional Medicine (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP02075703 | 2002-02-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200407551B true ZA200407551B (en) | 2005-10-12 |
Family
ID=27741186
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200407551A ZA200407551B (en) | 2002-02-21 | 2004-09-20 | Orally administrable composition for the photoprotection of the skin. |
Country Status (23)
Country | Link |
---|---|
US (2) | US20050069505A1 (da) |
EP (1) | EP1478329B1 (da) |
JP (1) | JP2005526038A (da) |
KR (1) | KR20040096604A (da) |
CN (1) | CN1301708C (da) |
AR (1) | AR038594A1 (da) |
AT (1) | ATE325604T1 (da) |
AU (1) | AU2003232184B2 (da) |
BR (1) | BR0307875B1 (da) |
CA (1) | CA2477144C (da) |
DE (1) | DE60305159T2 (da) |
DK (1) | DK1478329T3 (da) |
ES (1) | ES2263990T3 (da) |
HK (1) | HK1079104A1 (da) |
MX (1) | MXPA04008177A (da) |
NO (1) | NO20043848L (da) |
PL (1) | PL372146A1 (da) |
PT (1) | PT1478329E (da) |
RU (1) | RU2309760C2 (da) |
TW (1) | TWI344845B (da) |
UA (1) | UA77066C2 (da) |
WO (1) | WO2003070203A1 (da) |
ZA (1) | ZA200407551B (da) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050106131A1 (en) * | 2002-02-21 | 2005-05-19 | Lionel Breton | Photoprotective orally administrable composition for skin |
JP2005526038A (ja) * | 2002-02-21 | 2005-09-02 | ソシエテ デ プロデユイ ネツスル ソシエテ アノニム | 皮膚の光防護のための経口投与可能な組成物 |
US8088363B2 (en) | 2002-10-28 | 2012-01-03 | Zeavision Llc | Protection against sunburn and skin problems with orally-ingested high-dosage zeaxanthin |
GB2399752A (en) * | 2003-03-26 | 2004-09-29 | Micap Plc | Pharmaceutical composition comprising a fungal cell or cell fragment as adjuvant |
MXPA06006394A (es) * | 2003-12-04 | 2007-01-25 | Biofilms Strategies Inc | Metodos y composiciones para prevenir formaciones de biopeliculas, reducir biopeliculas existentes y para reducir poblaciones de bacterias. |
MX2007004135A (es) * | 2004-10-04 | 2007-06-15 | Oreal | Composicion cosmetica y/o dermatologica para pieles sensibles. |
FR2876029B1 (fr) * | 2004-10-04 | 2008-11-14 | Oreal | Composition cosmetique et/ou dermatologique pour peaux sensibles. |
US20060269508A1 (en) | 2005-03-29 | 2006-11-30 | Trejo Amy V | Means for regulating the cosmetic appearance and/or health of human keratinous tissue |
CN101155616A (zh) * | 2005-04-08 | 2008-04-02 | 宝洁公司 | 用于人类美容有益效果的口服益生菌双歧杆菌的使用方法 |
AT501919B1 (de) * | 2005-06-14 | 2008-09-15 | Erber Ag | Probiotischer, gesundheits- bzw. leistungsfördernder futtermittel- und/oder trinkwasserzusatz für tiere sowie seine verwendung |
US20110082218A1 (en) * | 2006-06-15 | 2011-04-07 | Karin Wertz | Treatment and modulation of gene expression and skin aging |
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2003
- 2003-02-18 JP JP2003569163A patent/JP2005526038A/ja active Pending
- 2003-02-18 CN CNB038042916A patent/CN1301708C/zh not_active Expired - Fee Related
- 2003-02-18 US US10/505,305 patent/US20050069505A1/en not_active Abandoned
- 2003-02-18 KR KR10-2004-7013096A patent/KR20040096604A/ko not_active Application Discontinuation
- 2003-02-18 DK DK03742550T patent/DK1478329T3/da active
- 2003-02-18 UA UA20040907624A patent/UA77066C2/uk unknown
- 2003-02-18 EP EP03742550A patent/EP1478329B1/en not_active Expired - Lifetime
- 2003-02-18 MX MXPA04008177A patent/MXPA04008177A/es active IP Right Grant
- 2003-02-18 ES ES03742550T patent/ES2263990T3/es not_active Expired - Lifetime
- 2003-02-18 PL PL03372146A patent/PL372146A1/xx not_active Application Discontinuation
- 2003-02-18 RU RU2004127986/15A patent/RU2309760C2/ru not_active IP Right Cessation
- 2003-02-18 WO PCT/EP2003/001685 patent/WO2003070203A1/en active IP Right Grant
- 2003-02-18 AU AU2003232184A patent/AU2003232184B2/en not_active Ceased
- 2003-02-18 AT AT03742550T patent/ATE325604T1/de active
- 2003-02-18 CA CA2477144A patent/CA2477144C/en not_active Expired - Lifetime
- 2003-02-18 BR BRPI0307875-2A patent/BR0307875B1/pt not_active IP Right Cessation
- 2003-02-18 DE DE60305159T patent/DE60305159T2/de not_active Expired - Lifetime
- 2003-02-18 PT PT03742550T patent/PT1478329E/pt unknown
- 2003-02-21 TW TW092103673A patent/TWI344845B/zh not_active IP Right Cessation
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2004
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BR0307875B1 (pt) | 2014-12-23 |
AR038594A1 (es) | 2005-01-19 |
ATE325604T1 (de) | 2006-06-15 |
CA2477144A1 (en) | 2003-08-28 |
DE60305159T2 (de) | 2007-03-15 |
RU2309760C2 (ru) | 2007-11-10 |
EP1478329B1 (en) | 2006-05-10 |
US10688139B2 (en) | 2020-06-23 |
ES2263990T3 (es) | 2006-12-16 |
TW200307555A (en) | 2003-12-16 |
UA77066C2 (en) | 2006-10-16 |
PT1478329E (pt) | 2006-09-29 |
MXPA04008177A (es) | 2005-06-08 |
NO20043848L (no) | 2004-09-14 |
CN1635865A (zh) | 2005-07-06 |
TWI344845B (en) | 2011-07-11 |
CA2477144C (en) | 2011-06-14 |
BR0307875A (pt) | 2004-12-28 |
WO2003070203A1 (en) | 2003-08-28 |
EP1478329A1 (en) | 2004-11-24 |
CN1301708C (zh) | 2007-02-28 |
HK1079104A1 (en) | 2006-03-31 |
DK1478329T3 (da) | 2006-08-28 |
US20070280999A1 (en) | 2007-12-06 |
DE60305159D1 (de) | 2006-06-14 |
PL372146A1 (en) | 2005-07-11 |
RU2004127986A (ru) | 2005-05-10 |
AU2003232184A1 (en) | 2003-09-09 |
JP2005526038A (ja) | 2005-09-02 |
AU2003232184B2 (en) | 2008-11-13 |
US20050069505A1 (en) | 2005-03-31 |
KR20040096604A (ko) | 2004-11-16 |
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