ZA200301082B - Quinazoline derivatives as alpha-1 adrenergic antagonists. - Google Patents

Info

Publication number

ZA200301082B

ZA200301082B ZA200301082A ZA200301082A ZA200301082B ZA 200301082 B ZA200301082 B ZA 200301082B ZA 200301082 A ZA200301082 A ZA 200301082A ZA 200301082 A ZA200301082 A ZA 200301082A ZA 200301082 B ZA200301082 B ZA 200301082B

Authority

ZA

South Africa

Prior art keywords

methyl

amino

phenyl

compound

dimethoxy

Prior art date

2000-08-31

Links

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• 239000000674 adrenergic antagonist Substances 0.000 title claims description 16
• 125000002294 quinazolinyl group Chemical class N1=C(N=CC2=CC=CC=C12)* 0.000 title 1
• 150000001875 compounds Chemical class 0.000 claims description 178
• -1 4-amino-6,7-dimethoxy-quinazolin-2-yl Chemical group 0.000 claims description 118
• 239000000203 mixture Substances 0.000 claims description 53
• 125000003545 alkoxy group Chemical group 0.000 claims description 47
• 125000004093 cyano group Chemical group *C#N 0.000 claims description 45
• 229910052736 halogen Inorganic materials 0.000 claims description 44
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 39
• 150000002367 halogens Chemical class 0.000 claims description 38
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 38
• 125000003118 aryl group Chemical group 0.000 claims description 29
• 201000010099 disease Diseases 0.000 claims description 29
• 150000003839 salts Chemical class 0.000 claims description 26
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 23
• 125000001072 heteroaryl group Chemical group 0.000 claims description 22
• 125000000623 heterocyclic group Chemical group 0.000 claims description 21
• 239000001257 hydrogen Substances 0.000 claims description 21
• 229910052739 hydrogen Inorganic materials 0.000 claims description 21
• 208000002193 Pain Diseases 0.000 claims description 20
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 19
• 125000003282 alkyl amino group Chemical group 0.000 claims description 18
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 18
• 238000011282 treatment Methods 0.000 claims description 18
• 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 17
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• 229940002612 prodrug Drugs 0.000 claims description 17
• 239000012453 solvate Substances 0.000 claims description 17
• 125000004423 acyloxy group Chemical group 0.000 claims description 15
• 125000004466 alkoxycarbonylamino group Chemical group 0.000 claims description 15
• 125000003710 aryl alkyl group Chemical group 0.000 claims description 15
• 125000000753 cycloalkyl group Chemical group 0.000 claims description 15
• 125000000217 alkyl group Chemical group 0.000 claims description 14
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• 125000004446 heteroarylalkyl group Chemical group 0.000 claims description 13
• SYSQUGFVNFXIIT-UHFFFAOYSA-N n-[4-(1,3-benzoxazol-2-yl)phenyl]-4-nitrobenzenesulfonamide Chemical class C1=CC([N+](=O)[O-])=CC=C1S(=O)(=O)NC1=CC=C(C=2OC3=CC=CC=C3N=2)C=C1 SYSQUGFVNFXIIT-UHFFFAOYSA-N 0.000 claims description 12
• 239000008194 pharmaceutical composition Substances 0.000 claims description 12
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• XLXDAWFMQFQZGK-UHFFFAOYSA-N 4-[[(4-amino-6,7-dimethoxyquinazolin-2-yl)-methylamino]methyl]-n,n-dimethyl-4-phenylpiperidine-1-sulfonamide Chemical compound N=1C(N)=C2C=C(OC)C(OC)=CC2=NC=1N(C)CC1(C=2C=CC=CC=2)CCN(S(=O)(=O)N(C)C)CC1 XLXDAWFMQFQZGK-UHFFFAOYSA-N 0.000 claims description 2
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