ZA200200787B - 2-aminotetralin derivatives for the therapy of glaucoma. - Google Patents

2-aminotetralin derivatives for the therapy of glaucoma. Download PDF

Info

Publication number: ZA200200787B
Authority: ZA; South Africa
Prior art keywords: iop; glaucoma; chf; eye; therapy
Prior art date: 1999-07-30

Application number

ZA200200787A

Other languages

English (en)

Inventor

Stefano Bongrani

Roberta Razzetti

Paolo Chiesi

Original Assignee

Chiesi Farma Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-07-30

Filing date

2002-01-29

Publication date

2003-03-26

2002-01-29 Application filed by Chiesi Farma Spa filed Critical Chiesi Farma Spa

2003-03-26 Publication of ZA200200787B publication Critical patent/ZA200200787B/en

Links

208000010412 Glaucoma Diseases 0.000 title claims description 16
238000002560 therapeutic procedure Methods 0.000 title claims description 8
LCGFVWKNXLRFIF-UHFFFAOYSA-N 1,2,3,4-tetrahydronaphthalen-2-amine Chemical class C1=CC=C2CC(N)CCC2=C1 LCGFVWKNXLRFIF-UHFFFAOYSA-N 0.000 title description 2
150000001875 compounds Chemical class 0.000 claims description 14
239000000203 mixture Substances 0.000 claims description 4
238000002360 preparation method Methods 0.000 claims description 4
239000008194 pharmaceutical composition Substances 0.000 claims description 3
150000003839 salts Chemical class 0.000 claims description 3
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 2
239000000546 pharmaceutical excipient Substances 0.000 claims description 2
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 1
OMMYLOLVPCCZQZ-AWEZNQCLSA-N [(6s)-6-(methylamino)-1-(2-methylpropanoyloxy)-5,6,7,8-tetrahydronaphthalen-2-yl] 2-methylpropanoate Chemical compound C1=CC(OC(=O)C(C)C)=C(OC(=O)C(C)C)C2=C1C[C@@H](NC)CC2 OMMYLOLVPCCZQZ-AWEZNQCLSA-N 0.000 claims 1
230000004410 intraocular pressure Effects 0.000 description 42
TWTMQRXNAZGSCE-UHFFFAOYSA-N hydron;[6-(methylamino)-1-(2-methylpropanoyloxy)-5,6,7,8-tetrahydronaphthalen-2-yl] 2-methylpropanoate;chloride Chemical compound Cl.C1=CC(OC(=O)C(C)C)=C(OC(=O)C(C)C)C2=C1CC(NC)CC2 TWTMQRXNAZGSCE-UHFFFAOYSA-N 0.000 description 26
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XYLJNLCSTIOKRM-UHFFFAOYSA-N Alphagan Chemical compound C1=CC2=NC=CN=C2C(Br)=C1NC1=NCCN1 XYLJNLCSTIOKRM-UHFFFAOYSA-N 0.000 description 5
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KBPLFHHGFOOTCA-UHFFFAOYSA-N caprylic alcohol Natural products CCCCCCCCO KBPLFHHGFOOTCA-UHFFFAOYSA-N 0.000 description 4
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239000004480 active ingredient Substances 0.000 description 2
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YCIMNLLNPGFGHC-UHFFFAOYSA-N catechol Chemical group OC1=CC=CC=C1O YCIMNLLNPGFGHC-UHFFFAOYSA-N 0.000 description 2
150000003943 catecholamines Chemical class 0.000 description 2
230000008859 change Effects 0.000 description 2
OSASVXMJTNOKOY-UHFFFAOYSA-N chlorobutanol Chemical compound CC(C)(O)C(Cl)(Cl)Cl OSASVXMJTNOKOY-UHFFFAOYSA-N 0.000 description 2
230000001684 chronic effect Effects 0.000 description 2
229960002376 chymotrypsin Drugs 0.000 description 2
OCUJLLGVOUDECM-UHFFFAOYSA-N dipivefrin Chemical compound CNCC(O)C1=CC=C(OC(=O)C(C)(C)C)C(OC(=O)C(C)(C)C)=C1 OCUJLLGVOUDECM-UHFFFAOYSA-N 0.000 description 2
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BPBUJYBQUBMWDT-VQHVLOKHSA-N (E)-hydroxyimino-[methyl-[3-(methylamino)propyl]amino]-oxidoazanium Chemical compound CNCCCN(C)[N+](\[O-])=N/O BPBUJYBQUBMWDT-VQHVLOKHSA-N 0.000 description 1
150000005206 1,2-dihydroxybenzenes Chemical class 0.000 description 1
ONIKNECPXCLUHT-UHFFFAOYSA-N 2-chlorobenzoyl chloride Chemical compound ClC(=O)C1=CC=CC=C1Cl ONIKNECPXCLUHT-UHFFFAOYSA-N 0.000 description 1
CFYIUBWVKZQDOG-UHFFFAOYSA-N 4-[[2-[[2-[[1-(4-nitroanilino)-1-oxo-3-phenylpropan-2-yl]amino]-2-oxoethyl]amino]-2-oxoethyl]amino]-4-oxobutanoic acid Chemical compound C=1C=C([N+]([O-])=O)C=CC=1NC(=O)C(NC(=O)CNC(=O)CNC(=O)CCC(=O)O)CC1=CC=CC=C1 CFYIUBWVKZQDOG-UHFFFAOYSA-N 0.000 description 1
ASXGAOFCKGHGMF-UHFFFAOYSA-N 6-amino-5,6,7,8-tetrahydronaphthalene-2,3-diol Chemical compound OC1=C(O)C=C2CC(N)CCC2=C1 ASXGAOFCKGHGMF-UHFFFAOYSA-N 0.000 description 1
KFQYTPMOWPVWEJ-UHFFFAOYSA-N 6-{propyl[2-(thiophen-2-yl)ethyl]amino}-5,6,7,8-tetrahydronaphthalen-1-ol Chemical compound C1CC2=C(O)C=CC=C2CC1N(CCC)CCC1=CC=CS1 KFQYTPMOWPVWEJ-UHFFFAOYSA-N 0.000 description 1
QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
108060003345 Adrenergic Receptor Proteins 0.000 description 1
102000017910 Adrenergic receptor Human genes 0.000 description 1
201000002862 Angle-Closure Glaucoma Diseases 0.000 description 1
201000004569 Blindness Diseases 0.000 description 1
208000020446 Cardiac disease Diseases 0.000 description 1
108090000317 Chymotrypsin Proteins 0.000 description 1
KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
GJSURZIOUXUGAL-UHFFFAOYSA-N Clonidine Chemical class ClC1=CC=CC(Cl)=C1NC1=NCCN1 GJSURZIOUXUGAL-UHFFFAOYSA-N 0.000 description 1
206010018325 Congenital glaucomas Diseases 0.000 description 1
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
206010012565 Developmental glaucoma Diseases 0.000 description 1
FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
206010015150 Erythema Diseases 0.000 description 1
206010019280 Heart failures Diseases 0.000 description 1
108010093488 His-His-His-His-His-His Proteins 0.000 description 1
101000713575 Homo sapiens Tubulin beta-3 chain Proteins 0.000 description 1
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 description 1
208000001953 Hypotension Diseases 0.000 description 1
229930195725 Mannitol Natural products 0.000 description 1
229910019142 PO4 Inorganic materials 0.000 description 1
QCHFTSOMWOSFHM-UHFFFAOYSA-N SJ000285536 Natural products C1OC(=O)C(CC)C1CC1=CN=CN1C QCHFTSOMWOSFHM-UHFFFAOYSA-N 0.000 description 1
DWAQJAXMDSEUJJ-UHFFFAOYSA-M Sodium bisulfite Chemical compound [Na+].OS([O-])=O DWAQJAXMDSEUJJ-UHFFFAOYSA-M 0.000 description 1
239000000150 Sympathomimetic Substances 0.000 description 1
102100036790 Tubulin beta-3 chain Human genes 0.000 description 1
XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
OMMYLOLVPCCZQZ-UHFFFAOYSA-N [6-(methylamino)-1-(2-methylpropanoyloxy)-5,6,7,8-tetrahydronaphthalen-2-yl] 2-methylpropanoate Chemical compound C1=CC(OC(=O)C(C)C)=C(OC(=O)C(C)C)C2=C1CC(NC)CC2 OMMYLOLVPCCZQZ-UHFFFAOYSA-N 0.000 description 1
239000002253 acid Substances 0.000 description 1
230000001154 acute effect Effects 0.000 description 1
239000000654 additive Substances 0.000 description 1
230000002411 adverse Effects 0.000 description 1
NDAUXUAQIAJITI-UHFFFAOYSA-N albuterol Chemical compound CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1 NDAUXUAQIAJITI-UHFFFAOYSA-N 0.000 description 1
125000003277 amino group Chemical group 0.000 description 1
238000010171 animal model Methods 0.000 description 1
210000002159 anterior chamber Anatomy 0.000 description 1
230000002562 anti-bronchospastic effect Effects 0.000 description 1
229960002610 apraclonidine Drugs 0.000 description 1
IEJXVRYNEISIKR-UHFFFAOYSA-N apraclonidine Chemical compound ClC1=CC(N)=CC(Cl)=C1NC1=NCCN1 IEJXVRYNEISIKR-UHFFFAOYSA-N 0.000 description 1
230000004509 aqueous humor production Effects 0.000 description 1
239000012736 aqueous medium Substances 0.000 description 1
238000009412 basement excavation Methods 0.000 description 1
229960000686 benzalkonium chloride Drugs 0.000 description 1
CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 1
230000004397 blinking Effects 0.000 description 1
150000001642 boronic acid derivatives Chemical class 0.000 description 1
239000006172 buffering agent Substances 0.000 description 1
239000004202 carbamide Substances 0.000 description 1
150000004649 carbonic acid derivatives Chemical class 0.000 description 1
239000000969 carrier Substances 0.000 description 1
238000005119 centrifugation Methods 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
229960004926 chlorobutanol Drugs 0.000 description 1
239000000544 cholinesterase inhibitor Substances 0.000 description 1
238000002648 combination therapy Methods 0.000 description 1
231100000478 corneal permeability Toxicity 0.000 description 1
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230000007850 degeneration Effects 0.000 description 1
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239000012153 distilled water Substances 0.000 description 1
238000009826 distribution Methods 0.000 description 1
VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical class NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 description 1
230000009977 dual effect Effects 0.000 description 1
210000000981 epithelium Anatomy 0.000 description 1
150000002148 esters Chemical class 0.000 description 1
230000003203 everyday effect Effects 0.000 description 1
238000009472 formulation Methods 0.000 description 1
239000000499 gel Substances 0.000 description 1
208000019622 heart disease Diseases 0.000 description 1
238000004128 high performance liquid chromatography Methods 0.000 description 1
230000036543 hypotension Effects 0.000 description 1
238000001727 in vivo Methods 0.000 description 1
239000003112 inhibitor Substances 0.000 description 1
230000005764 inhibitory process Effects 0.000 description 1
230000002427 irreversible effect Effects 0.000 description 1
230000000622 irritating effect Effects 0.000 description 1
230000005923 long-lasting effect Effects 0.000 description 1
230000007774 longterm Effects 0.000 description 1
239000000594 mannitol Substances 0.000 description 1
235000010355 mannitol Nutrition 0.000 description 1
238000000034 method Methods 0.000 description 1
150000007522 mineralic acids Chemical class 0.000 description 1
TVMXDCGIABBOFY-UHFFFAOYSA-N n-Octanol Natural products CCCCCCCC TVMXDCGIABBOFY-UHFFFAOYSA-N 0.000 description 1
239000013642 negative control Substances 0.000 description 1
210000005036 nerve Anatomy 0.000 description 1
239000002674 ointment Substances 0.000 description 1
150000007524 organic acids Chemical class 0.000 description 1
235000005985 organic acids Nutrition 0.000 description 1
239000002357 osmotic agent Substances 0.000 description 1
230000001499 parasympathomimetic effect Effects 0.000 description 1
230000007170 pathology Effects 0.000 description 1
230000002085 persistent effect Effects 0.000 description 1
230000000144 pharmacologic effect Effects 0.000 description 1
235000021317 phosphate Nutrition 0.000 description 1
150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
229960001416 pilocarpine Drugs 0.000 description 1
230000003389 potentiating effect Effects 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
230000003518 presynaptic effect Effects 0.000 description 1
230000002035 prolonged effect Effects 0.000 description 1
230000009467 reduction Effects 0.000 description 1
238000011160 research Methods 0.000 description 1
102220047090 rs6152 Human genes 0.000 description 1
229960002052 salbutamol Drugs 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
235000010267 sodium hydrogen sulphite Nutrition 0.000 description 1
238000000638 solvent extraction Methods 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
239000007858 starting material Substances 0.000 description 1
230000004936 stimulating effect Effects 0.000 description 1
230000000638 stimulation Effects 0.000 description 1
230000001975 sympathomimetic effect Effects 0.000 description 1
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238000003786 synthesis reaction Methods 0.000 description 1
229940095064 tartrate Drugs 0.000 description 1
239000012085 test solution Substances 0.000 description 1
CXWXQJXEFPUFDZ-UHFFFAOYSA-N tetralin Substances C1=CC=C2CCCCC2=C1 CXWXQJXEFPUFDZ-UHFFFAOYSA-N 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/222—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having aromatic groups, e.g. dipivefrine, ibopamine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics

Landscapes

Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Epidemiology (AREA)
Emergency Medicine (AREA)
Ophthalmology & Optometry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

ZA200200787A 1999-07-30 2002-01-29 2-aminotetralin derivatives for the therapy of glaucoma. ZA200200787B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT1999MI001713A IT1313583B1 (it)	1999-07-30	1999-07-30	Derivati 2-amminotetralinici per la terapia del glaucoma.

Publications (1)

Publication Number	Publication Date
ZA200200787B true ZA200200787B (en)	2003-03-26

Family

ID=11383465

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200200787A ZA200200787B (en)	1999-07-30	2002-01-29	2-aminotetralin derivatives for the therapy of glaucoma.

Country Status (17)

Country	Link
US (1)	US6953813B1 (de)
EP (1)	EP1200079B1 (de)
JP (1)	JP2003505499A (de)
CN (1)	CN1170532C (de)
AT (1)	ATE250413T1 (de)
AU (1)	AU778148B2 (de)
CA (1)	CA2379778A1 (de)
CZ (1)	CZ2002358A3 (de)
DE (1)	DE60005525T2 (de)
ES (1)	ES2207544T3 (de)
HK (1)	HK1048594A1 (de)
HU (1)	HUP0202098A3 (de)
IT (1)	IT1313583B1 (de)
NO (1)	NO20020475L (de)
PL (1)	PL364794A1 (de)
WO (1)	WO2001008667A2 (de)
ZA (1)	ZA200200787B (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL152751A0 (en) *	2000-05-12	2003-06-24	Chiesi Farma Spa	Optically active 2-aminotetralin derivatives, the processes for the preparation thereof and the therapeutical use of pharmaceutical compositions containing them
US20020198209A1 (en) *	2001-05-03	2002-12-26	Allergan Sales Inc.	Compositions having enhanced pharmacokinetic characteristics
CN101355876B (zh)	2005-11-09	2012-09-05	康宾纳特克斯公司	一种适用于眼部给药的组合物
US7829587B2 (en)	2008-01-09	2010-11-09	Allergan, Inc.	Substituted 2-aminotetralin derivatives as selective alpha 2B agonist

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ZA794872B (en) *	1978-09-20	1980-11-26	Schering Corp	A phenylalkylaminoethylsalicylamide,its preparation and pharmaceutical compositions containing it
IT1218322B (it) *	1982-06-10	1990-04-12	Chiesi Farma Spa	Derivati di 1,2,3,4-tetraidronaftalene,procedimento di preparazione e relative composizioni farmaceutiche
US5236907A (en) *	1988-10-01	1993-08-17	R-Tech Ueno Ltd.	Ocular hypotensive agents
US5314916A (en) *	1993-04-19	1994-05-24	Alcon Laboratories, Inc.	B2 adrenegic agonists and use thereof in the treatment of glaucoma
IT1275935B1 (it) *	1995-03-17	1997-10-24	Chiesi Farma Spa	Derivato di aminotetralina per la terapia di malattie cardiovascolari

1999
- 1999-07-30 IT IT1999MI001713A patent/IT1313583B1/it active
2000
- 2000-07-26 CZ CZ2002358A patent/CZ2002358A3/cs unknown
- 2000-07-26 PL PL00364794A patent/PL364794A1/xx not_active Application Discontinuation
- 2000-07-26 DE DE60005525T patent/DE60005525T2/de not_active Expired - Fee Related
- 2000-07-26 AU AU68293/00A patent/AU778148B2/en not_active Ceased
- 2000-07-26 ES ES00956296T patent/ES2207544T3/es not_active Expired - Lifetime
- 2000-07-26 AT AT00956296T patent/ATE250413T1/de not_active IP Right Cessation
- 2000-07-26 CN CNB008108676A patent/CN1170532C/zh not_active Expired - Fee Related
- 2000-07-26 EP EP00956296A patent/EP1200079B1/de not_active Expired - Lifetime
- 2000-07-26 JP JP2001513397A patent/JP2003505499A/ja active Pending
- 2000-07-26 WO PCT/EP2000/007184 patent/WO2001008667A2/en not_active Application Discontinuation
- 2000-07-26 US US10/030,114 patent/US6953813B1/en not_active Expired - Fee Related
- 2000-07-26 HU HU0202098A patent/HUP0202098A3/hu unknown
- 2000-07-26 CA CA002379778A patent/CA2379778A1/en not_active Abandoned
2002
- 2002-01-29 ZA ZA200200787A patent/ZA200200787B/en unknown
- 2002-01-29 NO NO20020475A patent/NO20020475L/no not_active Application Discontinuation
2003
- 2003-01-30 HK HK03100759.8A patent/HK1048594A1/zh unknown

Also Published As

Publication number	Publication date
JP2003505499A (ja)	2003-02-12
IT1313583B1 (it)	2002-09-09
NO20020475L (no)	2002-03-13
ITMI991713A1 (it)	2001-01-30
HK1048594A1 (zh)	2003-04-11
DE60005525D1 (de)	2003-10-30
ITMI991713A0 (it)	1999-07-30
HUP0202098A2 (en)	2002-10-28
PL364794A1 (en)	2004-12-13
CN1364081A (zh)	2002-08-14
DE60005525T2 (de)	2004-04-22
CN1170532C (zh)	2004-10-13
ES2207544T3 (es)	2004-06-01
AU6829300A (en)	2001-02-19
NO20020475D0 (no)	2002-01-29
WO2001008667A2 (en)	2001-02-08
EP1200079B1 (de)	2003-09-24
EP1200079A2 (de)	2002-05-02
ATE250413T1 (de)	2003-10-15
HUP0202098A3 (en)	2003-08-28
CZ2002358A3 (cs)	2002-04-17
US6953813B1 (en)	2005-10-11
CA2379778A1 (en)	2001-02-08
AU778148B2 (en)	2004-11-18
WO2001008667A3 (en)	2001-06-07

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