ZA200109785B - TH2 differentiation inhibitors. - Google Patents

Info

Publication number

ZA200109785B

ZA200109785B ZA200109785A ZA200109785A ZA200109785B ZA 200109785 B ZA200109785 B ZA 200109785B ZA 200109785 A ZA200109785 A ZA 200109785A ZA 200109785 A ZA200109785 A ZA 200109785A ZA 200109785 B ZA200109785 B ZA 200109785B

Authority

ZA

South Africa

Prior art keywords

optionally substituted

ring

compound

lower alkyl

substituted lower

Prior art date

1999-07-23

Links

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• Global Dossier
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• 230000004069 differentiation Effects 0.000 title claims description 61
• 239000003112 inhibitor Substances 0.000 title claims description 42
• 150000001875 compounds Chemical class 0.000 claims description 338
• 125000000217 alkyl group Chemical group 0.000 claims description 118
• 125000003545 alkoxy group Chemical group 0.000 claims description 67
• 229910052736 halogen Inorganic materials 0.000 claims description 65
• 150000002367 halogens Chemical class 0.000 claims description 65
• 229910052739 hydrogen Inorganic materials 0.000 claims description 65
• 239000001257 hydrogen Substances 0.000 claims description 65
• 125000003342 alkenyl group Chemical group 0.000 claims description 53
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 49
• 150000002431 hydrogen Chemical group 0.000 claims description 47
• 239000000203 mixture Substances 0.000 claims description 46
• 125000004453 alkoxycarbonyl group Chemical group 0.000 claims description 40
• 125000004432 carbon atom Chemical group C* 0.000 claims description 37
• 125000002373 5 membered heterocyclic group Chemical group 0.000 claims description 32
• 125000004070 6 membered heterocyclic group Chemical group 0.000 claims description 28
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 28
• 239000008194 pharmaceutical composition Substances 0.000 claims description 27
• 239000000651 prodrug Substances 0.000 claims description 25
• 229940002612 prodrug Drugs 0.000 claims description 25
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 22
• 150000003839 salts Chemical class 0.000 claims description 20
• 125000002252 acyl group Chemical group 0.000 claims description 19
• 125000004390 alkyl sulfonyl group Chemical group 0.000 claims description 19
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 18
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 14
• 125000000623 heterocyclic group Chemical group 0.000 claims description 14
• 239000012453 solvate Substances 0.000 claims description 14
• 125000000304 alkynyl group Chemical group 0.000 claims description 13
• 125000003107 substituted aryl group Chemical group 0.000 claims description 12
• 125000005346 substituted cycloalkyl group Chemical group 0.000 claims description 12
• 125000004414 alkyl thio group Chemical group 0.000 claims description 11
• 125000003302 alkenyloxy group Chemical group 0.000 claims description 9
• 125000005842 heteroatom Chemical group 0.000 claims description 9
• 125000000392 cycloalkenyl group Chemical group 0.000 claims description 6
• 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims description 5
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• 229910052799 carbon Inorganic materials 0.000 claims description 4
• 125000004448 alkyl carbonyl group Chemical group 0.000 claims description 3
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• 229910052717 sulfur Inorganic materials 0.000 claims description 3
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• QAEDZJGFFMLHHQ-UHFFFAOYSA-N trifluoroacetic anhydride Chemical compound FC(F)(F)C(=O)OC(=O)C(F)(F)F QAEDZJGFFMLHHQ-UHFFFAOYSA-N 0.000 description 10
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• 229910052763 palladium Inorganic materials 0.000 description 9
• 235000017557 sodium bicarbonate Nutrition 0.000 description 9
• 229910000030 sodium bicarbonate Inorganic materials 0.000 description 9
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