ZA200109236B - Pharmaceutical compositions of erythropoietin. - Google Patents

Pharmaceutical compositions of erythropoietin.

Info

Publication number: ZA200109236B
Authority: ZA; South Africa
Prior art keywords: erythropoietin; pharmaceutical compositions; pharmaceutical; compositions
Prior art date: 1999-04-09

Application number

ZA200109236A

Other languages

English (en)

Inventor

Wing K Cheung

Marilyn Sanders

Basant Sharma

Jaya Natarajan

Els Vercamen

Selima Begun

Original Assignee

Ortho Mcneil Pharm Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-04-09

Filing date

2001-11-08

Publication date

2003-12-08

2001-11-08 Application filed by Ortho Mcneil Pharm Inc filed Critical Ortho Mcneil Pharm Inc

2003-12-08 Publication of ZA200109236B publication Critical patent/ZA200109236B/xx

Links

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1816—Erythropoietin [EPO]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Oil, Petroleum & Natural Gas (AREA)
Diabetes (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
Endocrinology (AREA)
Hematology (AREA)
Inorganic Chemistry (AREA)
Dermatology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)

ZA200109236A 1999-04-09 2001-11-08 Pharmaceutical compositions of erythropoietin. ZA200109236B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US12859699P	1999-04-09	1999-04-09

Publications (1)

Publication Number	Publication Date
ZA200109236B true ZA200109236B (en)	2003-12-08

Family

ID=22436082

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200109236A ZA200109236B (en)	1999-04-09	2001-11-08	Pharmaceutical compositions of erythropoietin.

Country Status (27)

Country	Link
US (2)	US6696056B1 (zh)
EP (1)	EP1181036B1 (zh)
JP (1)	JP2002541208A (zh)
KR (1)	KR100740794B1 (zh)
CN (1)	CN1165339C (zh)
AR (1)	AR029623A1 (zh)
AT (1)	ATE401908T1 (zh)
AU (1)	AU775041B2 (zh)
BG (1)	BG106046A (zh)
BR (1)	BR0010665A (zh)
CA (1)	CA2369444C (zh)
CY (1)	CY1108418T1 (zh)
DE (1)	DE60039598D1 (zh)
DK (1)	DK1181036T3 (zh)
ES (1)	ES2308978T3 (zh)
HK (1)	HK1041445B (zh)
HU (1)	HUP0201068A3 (zh)
IL (1)	IL145816A0 (zh)
MX (1)	MXPA01010208A (zh)
NO (1)	NO20014893L (zh)
NZ (1)	NZ515380A (zh)
PL (1)	PL203797B1 (zh)
PT (1)	PT1181036E (zh)
RU (1)	RU2225221C2 (zh)
TR (1)	TR200103788T2 (zh)
WO (1)	WO2000061169A1 (zh)
ZA (1)	ZA200109236B (zh)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7304150B1 (en)	1998-10-23	2007-12-04	Amgen Inc.	Methods and compositions for the prevention and treatment of anemia
RU2225221C2 (ru) *	1999-04-09	2004-03-10	Орто-Макнейл Фармасьютикал, Инк.	ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ Эритропоэтина
US7371787B2 (en) *	2000-04-14	2008-05-13	Viance, Llc	Methods of incorporating treatment agents into wood based composite products
BRPI0110914B8 (pt) *	2000-05-15	2021-05-25	Hoffmann La Roche	'composição farmacêutica líquida, processo para preparação da mesma e uso de uma composicão farmacêutica'
US6818613B2 (en) *	2001-11-07	2004-11-16	Ortho-Mcneil Pharmaceutical, Inc.	Aqueous sustained-release formulations of proteins
ATE553747T1 (de) *	2003-06-10	2012-05-15	Lg Life Sciences Ltd	Stabile wässrige lösung von human-erythropoietin, die kein serumalbumin enthält
DE10333317A1 (de) *	2003-07-22	2005-02-17	Biotecon Therapeutics Gmbh	Formulierung für Proteinarzneimittel ohne Zusatz von humanem Serumalbumin (HSA)
JP2007506678A (ja) *	2003-09-23	2007-03-22	アルコン，インコーポレイテッド	注入のためのトリアムシノロンアセトアニドおよび酢酸アネコルタブの処方物
US7141544B2 (en) *	2003-10-10	2006-11-28	Baxter International, Inc.	Stabilization of pharmaceutical protein formulations with small peptides
DE202004020676U1 (de) *	2004-03-10	2005-11-10	Bioceuticals Arzneimittel Ag	Erythropoietin-Flüssigformulierung
US7588745B2 (en) *	2004-04-13	2009-09-15	Si Options, Llc	Silicon-containing products
US20050255112A1 (en) *	2004-05-17	2005-11-17	Lee Jong Y	Compositions and methods for preventing erythropoietin-associated hypertension
KR20070085227A (ko) *	2004-08-09	2007-08-27	앨리오스 바이오파마 인크.	합성 초글리코실화, 프로테아제 저항성 폴리펩티드 변이체,경구 제제 및 이를 이용한 방법
US7597884B2 (en)	2004-08-09	2009-10-06	Alios Biopharma, Inc.	Hyperglycosylated polypeptide variants and methods of use
CA2610839C (en)	2005-06-14	2019-06-25	Amgen Inc.	Self-buffering protein formulations
AU2006295340B2 (en) *	2005-08-05	2010-11-11	Amgen Inc.	Stable aqueous protein or antibody pharmaceutical formulations and their preparation
CN101015684B (zh) *	2006-02-10	2011-08-24	华北制药集团新药研究开发有限责任公司	一种重组人红细胞生成素溶液制剂
US20080050749A1 (en) *	2006-08-17	2008-02-28	Ildiko Amann-Zalan	Use of bnp-type peptides for the stratification of therapy with erythropoietic stimulating agents
WO2009064838A1 (en)	2007-11-15	2009-05-22	Amgen, Inc.	Aqueous formulation of erythropoiesis stimulating protein stablised by antioxidants for parenteral administration
US8883146B2 (en)	2007-11-30	2014-11-11	Abbvie Inc.	Protein formulations and methods of making same
KR100956431B1 (ko)	2007-12-07	2010-05-06	주식회사 제이에스마루	혈장크린접착제 및 이의 제조방법
MX346001B (es)	2008-09-26	2017-03-01	Ambrx Inc	Polipeptidos de eritropoyetina animal modificados y sus usos.
PL2892550T3 (pl)	2012-09-07	2020-07-27	Coherus Biosciences, Inc.	Stabilne wodne formulacje adalimumabu
US11229702B1 (en)	2015-10-28	2022-01-25	Coherus Biosciences, Inc.	High concentration formulations of adalimumab
US11071782B2 (en)	2016-04-20	2021-07-27	Coherus Biosciences, Inc.	Method of filling a container with no headspace
US20180110856A1 (en)	2016-10-21	2018-04-26	Amgen Inc.	Pharmaceutical Formulations and Methods of Making the Same
BR112019025563A2 (pt)	2017-06-06	2020-06-23	Kindred Biosciences, Inc.	Eritropoietina e análogos para uso veterinário
CN111150837B (zh) *	2020-02-11	2022-07-12	中国人民解放军陆军军医大学	Epo在抗金黄色葡萄球菌感染药物中的应用

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JPS6191131A (ja) *	1984-10-09	1986-05-09	Chugai Pharmaceut Co Ltd	医薬品の吸着防止方法および組成物
JPS6197229A (ja) *	1984-10-18	1986-05-15	Chugai Pharmaceut Co Ltd	安定なエリトロポエチン製剤
DK173067B1 (da) *	1986-06-27	1999-12-13	Univ Washington	Humant erythropoietin-gen, fremgangsmåde til ekspression deraf i transficerede cellelinier, de transficerede cellelinier sa
DE3729863A1 (de) *	1987-09-05	1989-03-16	Boehringer Mannheim Gmbh	Stabilisierte erythropoietin-lyophilisate
GB8822857D0 (en)	1988-09-29	1988-11-02	Patralan Ltd	Pharmaceutical formulations
GB9001987D0 (en) *	1990-01-29	1990-03-28	Janssen Pharmaceutica Nv	Improved cyclodextrin based erythropietin formulation
US5543575A (en) *	1990-06-20	1996-08-06	Pioneer-Hi-Bred International, Inc.	Inbred corn line PHK46
DE4126983A1 (de) *	1991-08-15	1993-02-18	Boehringer Mannheim Gmbh	Verfahren zur herstellung von humanprotein-enthaltenden, konservierten arzneimitteln fuer infusions- oder injektionszwecke
DE4126984A1 (de) *	1991-08-15	1993-02-18	Boehringer Mannheim Gmbh	Verfahren zur herstellung von humanprotein-enthaltenden, gut vertraeglichen arzneimitteln fuer infusions- oder injektionszwecke
US5661125A (en) *	1992-08-06	1997-08-26	Amgen, Inc.	Stable and preserved erythropoietin compositions
US5766582A (en)	1994-10-11	1998-06-16	Schering Corporation	Stable, aqueous alfa interferon solution formulations
DE19539574A1 (de) *	1995-10-25	1997-04-30	Boehringer Mannheim Gmbh	Zubereitungen und Verfahren zur Stabilisierung biologischer Materialien mittels Trocknungsverfahren ohne Einfrieren
TWI240627B (en) *	1996-04-26	2005-10-01	Chugai Pharmaceutical Co Ltd	Erythropoietin solution preparation
TW586933B (en)	1996-06-20	2004-05-11	Chugai Pharmaceutical Co Ltd	Compositions for treating liver-complaints using EPO
RU2225221C2 (ru) *	1999-04-09	2004-03-10	Орто-Макнейл Фармасьютикал, Инк.	ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ Эритропоэтина

2000
- 2000-04-07 RU RU2001130142/15A patent/RU2225221C2/ru not_active IP Right Cessation
- 2000-04-07 TR TR2001/03788T patent/TR200103788T2/xx unknown
- 2000-04-07 DE DE60039598T patent/DE60039598D1/de not_active Expired - Lifetime
- 2000-04-07 BR BR0010665-8A patent/BR0010665A/pt not_active Application Discontinuation
- 2000-04-07 NZ NZ515380A patent/NZ515380A/en not_active IP Right Cessation
- 2000-04-07 DK DK00921929T patent/DK1181036T3/da active
- 2000-04-07 KR KR1020017012906A patent/KR100740794B1/ko not_active IP Right Cessation
- 2000-04-07 CN CNB008085048A patent/CN1165339C/zh not_active Expired - Fee Related
- 2000-04-07 HU HU0201068A patent/HUP0201068A3/hu unknown
- 2000-04-07 PL PL351837A patent/PL203797B1/pl unknown
- 2000-04-07 US US09/545,479 patent/US6696056B1/en not_active Expired - Lifetime
- 2000-04-07 CA CA002369444A patent/CA2369444C/en not_active Expired - Fee Related
- 2000-04-07 IL IL14581600A patent/IL145816A0/xx unknown
- 2000-04-07 PT PT00921929T patent/PT1181036E/pt unknown
- 2000-04-07 EP EP00921929A patent/EP1181036B1/en not_active Expired - Lifetime
- 2000-04-07 ES ES00921929T patent/ES2308978T3/es not_active Expired - Lifetime
- 2000-04-07 MX MXPA01010208A patent/MXPA01010208A/es active IP Right Grant
- 2000-04-07 JP JP2000610501A patent/JP2002541208A/ja active Pending
- 2000-04-07 WO PCT/US2000/009414 patent/WO2000061169A1/en active Application Filing
- 2000-04-07 AU AU42186/00A patent/AU775041B2/en not_active Ceased
- 2000-04-07 AT AT00921929T patent/ATE401908T1/de active
- 2000-04-10 AR ARP000101631A patent/AR029623A1/es unknown
2001
- 2001-10-08 NO NO20014893A patent/NO20014893L/no not_active Application Discontinuation
- 2001-10-24 BG BG106046A patent/BG106046A/xx unknown
- 2001-11-08 ZA ZA200109236A patent/ZA200109236B/xx unknown
2002
- 2002-04-19 HK HK02102987.9A patent/HK1041445B/zh not_active IP Right Cessation
2004
- 2004-02-10 US US10/775,928 patent/US20040248797A1/en not_active Abandoned
2008
- 2008-10-16 CY CY20081101147T patent/CY1108418T1/el unknown

Also Published As

Publication number	Publication date
EP1181036A1 (en)	2002-02-27
NO20014893D0 (no)	2001-10-08
ES2308978T3 (es)	2008-12-16
PL351837A1 (en)	2003-06-16
ATE401908T1 (de)	2008-08-15
JP2002541208A (ja)	2002-12-03
HUP0201068A3 (en)	2002-10-28
PL203797B1 (pl)	2009-11-30
WO2000061169A1 (en)	2000-10-19
IL145816A0 (en)	2002-07-25
DE60039598D1 (de)	2008-09-04
CA2369444C (en)	2009-08-18
EP1181036B1 (en)	2008-07-23
CA2369444A1 (en)	2000-10-19
HK1041445B (zh)	2009-07-03
CY1108418T1 (el)	2014-04-09
NZ515380A (en)	2003-10-31
BG106046A (en)	2002-05-31
KR20020016770A (ko)	2002-03-06
PT1181036E (pt)	2008-10-03
MXPA01010208A (es)	2003-07-21
EP1181036A4 (en)	2004-04-21
CN1354669A (zh)	2002-06-19
DK1181036T3 (da)	2008-11-24
KR100740794B1 (ko)	2007-07-20
HK1041445A1 (en)	2002-07-12
RU2225221C2 (ru)	2004-03-10
TR200103788T2 (tr)	2002-05-21
CN1165339C (zh)	2004-09-08
NO20014893L (no)	2001-11-15
BR0010665A (pt)	2004-03-09
US6696056B1 (en)	2004-02-24
US20040248797A1 (en)	2004-12-09
AU775041B2 (en)	2004-07-15
AU4218600A (en)	2000-11-14
HUP0201068A2 (en)	2002-08-28
AR029623A1 (es)	2003-07-10

Publication	Publication Date	Title
ZA200109236B (en)	2003-12-08	Pharmaceutical compositions of erythropoietin.
HUP0202513A3 (en)	2004-06-28	Betha-carboline pharmaceutical compositions
GB0028088D0 (en)	2001-01-03	Pharmaceutical compositions
GB0001662D0 (en)	2000-03-15	Pharmaceutical compositions
HK1045650A1 (en)	2002-12-06	Pharmaceutical composition.
IL148864A0 (en)	2002-09-12	Pharmaceutical compositions containing nimesulide
ZA200203486B (en)	2003-08-04	Novel pharmaceutical compositions.
AU3556400A (en)	2000-10-04	Pharmaceutical compositions
ZA200000857B (en)	2001-05-31	Pharmaceutical composition.
GB9904163D0 (en)	1999-04-14	Pharmaceutical compositions
AU4304400A (en)	2000-11-10	Novel pharmaceutical compositions comprising 2-isoxazole-8-aminotetralin derivatives
AU6460400A (en)	2001-03-13	Pharmaceutical compositions
GB9911017D0 (en)	1999-07-14	Pharmaceutical compositions
IL148725A0 (en)	2002-09-12	Aqueous pharmaceutical compositions containing circlesonide
AU6460200A (en)	2001-03-13	Pharmaceutical compositions
ZA99890B (en)	2000-08-04	Pharmaceutical compositions.
GB9904911D0 (en)	1999-04-28	Pharmaceutical compositions
AU6460300A (en)	2001-03-13	Pharmaceutical compositions
AU6460100A (en)	2001-03-13	Pharmaceutical compositions
IL130325A0 (en)	2000-06-01	Pharmaceutical compositions comprising allicin
AU4914400A (en)	2000-11-21	Novel pharmaceutical composition
GB9902651D0 (en)	1999-03-31	Pharmaceutical compositions
AU4698900A (en)	2000-11-21	Pharmaceutical compositions for treating malaria
GB9902594D0 (en)	1999-03-24	Pharmaceutical compositions
GB9902591D0 (en)	1999-03-24	Pharmaceutical compositions