YU89892A - NEW BIOGRAPHY FOR 7-ADCK MAKING - Google Patents
NEW BIOGRAPHY FOR 7-ADCK MAKINGInfo
- Publication number
- YU89892A YU89892A YU89892A YU89892A YU89892A YU 89892 A YU89892 A YU 89892A YU 89892 A YU89892 A YU 89892A YU 89892 A YU89892 A YU 89892A YU 89892 A YU89892 A YU 89892A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- adipoyl
- adck
- acid
- making
- transformed
- Prior art date
Links
Landscapes
- Cephalosporin Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Važan intermedijer za izradu cefalosporinskih antibiotika, 7-aminodesacetoksi cefalosporanske kiseline (7-ADCK), izradjuje se novim biopostupkom u kome se transformisani soj Penicillium chrysogenum-a gaji u prisustvu adipatne sirovine da se proizvede adipoil-6-APK (6-amino penicilanske kiseline); i ekspresija in situ gena ekspandaze, na pr. iz Streptomyces clavuligerus-a, pomoću koga je P. chrysogenum bio transformisan, preobraća adipoil-6-APK proširenjem prstena u adipoil-7-ADCK. Krajnji proizvod, 7-ADCK, se potom izradjuje ocepljivanjem adipoil bočnog lanca koristeći adipoil acilazu. Sledstveno tome, celokupna sinteza se izvodi upotrebljavajući biopostupak, i delotvorna je i ekonomična.An important intermediate for the manufacture of cephalosporin antibiotics, 7-aminodesacetoxy cephalosporic acid (7-ADCK), is made by a new bio-process in which a transformed Penicillium chrysogenum strain is grown in the presence of an adipate feed to produce adipoyl-6-APIC (acid-penic acid). ); and in situ expression of the expansion gene, e.g. from Streptomyces clavuligerus, by which P. chrysogenum was transformed, converts adipoyl-6-APK by extending the ring into adipoyl-7-ADCK. The final product, 7-ADCK, is then made by cleavage of the adipoyl side chain using adipoyl acylase. Consequently, the entire synthesis is performed using a bioprocess, and is effective and economical.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/933,469 US5318896A (en) | 1991-09-11 | 1992-08-28 | Recombinant expandase bioprocess for preparing 7-aminodesacetoxy cephalosporanic acid (7-ADCA) |
Publications (2)
Publication Number | Publication Date |
---|---|
YU89892A true YU89892A (en) | 1995-10-03 |
YU48769B YU48769B (en) | 1999-12-27 |
Family
ID=47501702
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YU89892A YU48769B (en) | 1992-08-28 | 1992-10-07 | Novel bioprocess for preparing 7-adca |
Country Status (1)
Country | Link |
---|---|
YU (1) | YU48769B (en) |
-
1992
- 1992-10-07 YU YU89892A patent/YU48769B/en unknown
Also Published As
Publication number | Publication date |
---|---|
YU48769B (en) | 1999-12-27 |
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