YU48999A - Process for preparation of pyrazolo(4,3-d)pyrimidin-7-ones and intermediates thereof - Google Patents

Process for preparation of pyrazolo(4,3-d)pyrimidin-7-ones and intermediates thereof

Info

Publication number
YU48999A
YU48999A YU48999A YU48999A YU48999A YU 48999 A YU48999 A YU 48999A YU 48999 A YU48999 A YU 48999A YU 48999 A YU48999 A YU 48999A YU 48999 A YU48999 A YU 48999A
Authority
YU
Yugoslavia
Prior art keywords
pyrazolo
pyrimidin
intermediates
ones
preparation
Prior art date
Application number
YU48999A
Other languages
Serbo-Croatian (sh)
Inventor
Peter James Dunn
Philip Charles Levett
Original Assignee
Pfizer Research & Development Company N.V./S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10840421&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=YU48999(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Research & Development Company N.V./S.A. filed Critical Pfizer Research & Development Company N.V./S.A.
Publication of YU48999A publication Critical patent/YU48999A/en
Publication of RS49762B publication Critical patent/RS49762B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/26—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Abstract

Procedure has been secured for the obtaining of compounds of formulas (IA) sidenafil/viagra TM) and (IB) encompassing reaction of compounds of formula (IIA) and (IIB) respectively in the presence of OR, where R in the case of forming compounds (IA) is CH2CH3 and R in the case of forming compounds (IB) is CH2CH2CH3, where x is the exit group.
YUP-489/99A 1998-10-12 1999-09-27 Process for preparation of pyrazolo (4,3-d) pyramidin-7-ones and intermediates thereof RS49762B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9822238.3A GB9822238D0 (en) 1998-10-12 1998-10-12 Process for preparation of pyrazolo[4,3-D]pyrimidin-7-ones and intermediates thereof

Publications (2)

Publication Number Publication Date
YU48999A true YU48999A (en) 2002-06-19
RS49762B RS49762B (en) 2008-04-04

Family

ID=10840421

Country Status (49)

Country Link
US (3) US6207829B1 (en)
EP (1) EP0994115B1 (en)
JP (1) JP3721021B2 (en)
KR (1) KR100380954B1 (en)
CN (2) CN1207295C (en)
AP (1) AP1233A (en)
AR (1) AR019244A1 (en)
AT (1) ATE290003T1 (en)
AU (1) AU756463B2 (en)
BG (1) BG63205B1 (en)
BR (1) BR9905092A (en)
CA (1) CA2285733C (en)
CO (1) CO5150214A1 (en)
CR (1) CR6118A (en)
CU (1) CU22928A3 (en)
CZ (1) CZ296816B6 (en)
DE (1) DE69923906T2 (en)
DK (1) DK0994115T3 (en)
DZ (1) DZ2912A1 (en)
EA (1) EA003774B1 (en)
EE (1) EE04192B1 (en)
EG (1) EG22630A (en)
ES (1) ES2237049T3 (en)
GB (1) GB9822238D0 (en)
GE (1) GEP20022700B (en)
GT (1) GT199900172A (en)
HK (1) HK1027559A1 (en)
HR (1) HRP990318B1 (en)
HU (1) HU226162B1 (en)
ID (1) ID23351A (en)
IL (11) IL152926A (en)
IS (1) IS1951B (en)
MA (1) MA25007A1 (en)
MY (1) MY124620A (en)
NO (1) NO313700B1 (en)
OA (1) OA11165A (en)
PE (1) PE20001086A1 (en)
PL (1) PL198150B1 (en)
PT (1) PT994115E (en)
RS (1) RS49762B (en)
SG (1) SG118060A1 (en)
SI (1) SI0994115T1 (en)
SK (1) SK285215B6 (en)
TN (1) TNSN99189A1 (en)
TR (1) TR199902541A2 (en)
TW (1) TW589314B (en)
UA (1) UA66787C2 (en)
UY (1) UY25750A1 (en)
ZA (1) ZA996412B (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5204800A (en) * 1999-06-21 2001-01-09 Biochemical Pharmaceutical Factory of Zhuhai Sez, The Process for preparing sildenafil, and troche which comprises sildenafil and apomorphine
US6667398B2 (en) 2000-06-22 2003-12-23 Pfizer Inc Process for the preparation of pyrazolopyrimidinones
JP2004501142A (en) * 2000-06-22 2004-01-15 ファイザー・インク Method for producing pyrazolopyrimidinone
EP1176142A1 (en) * 2000-07-28 2002-01-30 Pfizer Inc. Process for the preparation of pyrazoles
US6407259B1 (en) 2000-07-28 2002-06-18 Pfizer Inc. Process for the preparation of pyrazoles
EP1176147A1 (en) * 2000-07-28 2002-01-30 Pfizer Limited Process for the preparation of pyrazolo[4,3-d]pyrimidin-7-ones and intermediates thereof
PE20020394A1 (en) 2000-08-18 2002-06-21 Agouron Pharma PIRAZOLE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM, MODULATE AND / OR INHIBIT THE ACTIVITY OF ERAB / HADH2
US7335680B2 (en) * 2001-12-20 2008-02-26 Laboratoires Serono Sa Pyrrolidine derivatives as prostaglandin modulators
EP1503986B1 (en) * 2001-12-21 2015-09-30 Cytokinetics, Inc. Compositions and methods for treating heart failure
SI1509525T1 (en) 2002-05-31 2006-12-31 Schering Corp Process for preparing xanthine phosphodiesterase v inhibitors and precursors thereof
WO2004072079A1 (en) * 2003-02-11 2004-08-26 Pfizer Limited Hydrated and anhydrous sildenafil hemi-citrate compound
ES2378620T3 (en) * 2003-03-27 2012-04-16 Cytokinetics, Inc. SULFONAMIDS FOR THE TREATMENT OF CONGESTIVE CARDIAC INSUFFICIENCY, ITS COMPOSITIONS AND USES.
CN100360531C (en) * 2003-12-18 2008-01-09 中国人民解放军军事医学科学院放射与辐射医学研究所 Pyrazolopyrimidine compounds for prevention and cure of impotence and frigidity
US20070010525A1 (en) * 2005-06-27 2007-01-11 Meyer Jackson Method and compositions for modulating neuropeptide hormone secretion
NL2000291C2 (en) * 2005-11-10 2009-02-17 Pfizer Prod Inc 1- (1- (2-ethoxyethyl) -3-ethyl-7- (4-methylpyridin-2-ylamino) -1 H -pyrazole (4,3-d) pyrimidin-5-yl) piperidine-4-carboxylic acid and salts thereof.
EP2024369A4 (en) * 2006-06-05 2010-10-27 Matrix Lab Ltd Novel process for the preparation of sildenafil citrate
CZ308056B6 (en) * 2015-07-20 2019-11-27 Ustav Experimentalni Botaniky Av Cr V V I 5-Substituted-7- [4- (substituted) benzyl] amino-3-isopropylpyrazolo [4,3-d] pyrimidines, their use as antirheumatics, and pharmaceutical preparations
WO2017168174A1 (en) 2016-04-02 2017-10-05 N4 Pharma Uk Limited New pharmaceutical forms of sildenafil
CN107759603B (en) * 2016-08-18 2020-09-01 四川科伦药物研究院有限公司 Preparation method of heterocyclic compound

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3992441A (en) * 1972-12-26 1976-11-16 Pfizer Inc. Sulfamylbenzoic acids
GB9013750D0 (en) * 1990-06-20 1990-08-08 Pfizer Ltd Therapeutic agents
GB9612514D0 (en) * 1996-06-14 1996-08-14 Pfizer Ltd Novel process
PL336586A1 (en) * 1997-04-25 2000-07-03 Pfizer Pyrazoylpyrimidinones inhibiting the cyclic guanosine 3',5'-monophosphate phosphodiesterase of type 5 (cgmp pde5) for treating sexual disorders

Also Published As

Publication number Publication date
TW589314B (en) 2004-06-01
GT199900172A (en) 2001-03-28
BR9905092A (en) 2000-08-08
EA003774B1 (en) 2003-08-28
HK1027559A1 (en) 2001-01-19
PL335959A1 (en) 2000-04-25
CN1207295C (en) 2005-06-22
CA2285733A1 (en) 2000-04-12
GEP20022700B (en) 2002-05-27
IL152923A (en) 2004-02-08
EA199900822A2 (en) 2000-04-24
IS1951B (en) 2004-10-13
CO5150214A1 (en) 2002-04-29
CA2285733C (en) 2004-08-24
UA66787C2 (en) 2004-06-15
EA199900822A3 (en) 2000-08-28
HUP9903469A3 (en) 2000-10-30
IL132273A (en) 2004-06-20
AU5358199A (en) 2000-04-13
US20010009962A1 (en) 2001-07-26
IL152924A0 (en) 2003-06-24
MA25007A1 (en) 2000-07-01
EP0994115B1 (en) 2005-03-02
NO994943D0 (en) 1999-10-11
TR199902541A2 (en) 2000-07-21
IL152926A (en) 2004-02-19
EG22630A (en) 2003-05-31
ATE290003T1 (en) 2005-03-15
PE20001086A1 (en) 2000-10-18
HRP990318B1 (en) 2004-06-30
US20030069422A1 (en) 2003-04-10
AU756463B2 (en) 2003-01-16
IL152927A0 (en) 2003-06-24
HRP990318A2 (en) 2000-06-30
BG103794A (en) 2000-09-29
IL152928A (en) 2007-07-04
CN1473831A (en) 2004-02-11
BG63205B1 (en) 2001-06-29
SK285215B6 (en) 2006-09-07
GB9822238D0 (en) 1998-12-09
EE04192B1 (en) 2003-12-15
KR100380954B1 (en) 2003-04-21
ID23351A (en) 2000-04-13
SG118060A1 (en) 2006-01-27
EP0994115A2 (en) 2000-04-19
AR019244A1 (en) 2001-12-26
SK138599A3 (en) 2000-05-16
NO994943L (en) 2000-04-13
DK0994115T3 (en) 2005-06-20
IL152927A (en) 2004-06-01
PL198150B1 (en) 2008-05-30
EP0994115A3 (en) 2000-05-24
TNSN99189A1 (en) 2005-11-10
OA11165A (en) 2003-04-22
IL152923A0 (en) 2003-06-24
UY25750A1 (en) 2001-08-27
PT994115E (en) 2005-06-30
CN1255497A (en) 2000-06-07
SI0994115T1 (en) 2005-08-31
IL152924A (en) 2004-02-19
AP9901672A0 (en) 1999-12-31
CZ353299A3 (en) 2000-05-17
DE69923906T2 (en) 2006-04-06
CU22928A3 (en) 2004-02-20
IS5209A (en) 2000-04-13
JP2000119273A (en) 2000-04-25
HUP9903469A2 (en) 2000-08-28
DZ2912A1 (en) 2004-03-01
EE9900507A (en) 2000-06-15
ES2237049T3 (en) 2005-07-16
CR6118A (en) 2005-09-16
NO313700B1 (en) 2002-11-18
ZA996412B (en) 2001-04-11
IL132273A0 (en) 2001-03-19
CZ296816B6 (en) 2006-06-14
JP3721021B2 (en) 2005-11-30
DE69923906D1 (en) 2005-04-07
MY124620A (en) 2006-06-30
KR20000028987A (en) 2000-05-25
RS49762B (en) 2008-04-04
HU226162B1 (en) 2008-05-28
US6207829B1 (en) 2001-03-27
AP1233A (en) 2003-12-18
IL152928A0 (en) 2003-06-24
IL152926A0 (en) 2003-06-24
HU9903469D0 (en) 1999-12-28

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