YU45607B - Postupak za dobijanje pirimidintrionskih derivata - Google Patents

Postupak za dobijanje pirimidintrionskih derivata

Info

Publication number
YU45607B
YU45607B YU66484A YU66484A YU45607B YU 45607 B YU45607 B YU 45607B YU 66484 A YU66484 A YU 66484A YU 66484 A YU66484 A YU 66484A YU 45607 B YU45607 B YU 45607B
Authority
YU
Yugoslavia
Prior art keywords
formula
group
alkyl group
temperature
derivatives
Prior art date
Application number
YU66484A
Other languages
English (en)
Other versions
YU66484A (en
Inventor
P. Gold-Aubert
D. Melkonian
J. Vachta
K. Valter
B. Siegfried
S. Hugentobler
Original Assignee
Sapos S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sapos S.A. filed Critical Sapos S.A.
Publication of YU66484A publication Critical patent/YU66484A/xx
Publication of YU45607B publication Critical patent/YU45607B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/60—Three or more oxygen or sulfur atoms
    • C07D239/62—Barbituric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

POSTUPAK ZA DOBIJANJE PIRIMIDINTRIONSKIH DERIVATA, formule (I): u kojoj R1 i R2 koji mogu biti isti ili različiti, predstavljaju C1-5 alkil grupu, C2-5 alkenil grupu, aralkil grupu u kojoj svaka alkil grupa sadrži 1-4 ugljenikova atoma ili karbocikličnu aril grupu, i R3 predstavlja grupu formule -CH2CH(OCONH2)CH2OX, gde je X vodonik ili C1-5 alkil grupa, naznačen time, što obuhvata reakciju približno ekvimolarnih količina natrijumove soli jedinjenja formule (I) u kome je R3 atom vodonika, sa sredstvom za alkilovanje formule R3Hal, gde je R3 definisano kao gore, a Hal predstavlja atom halogena, na povišenoj temperaturi, kao što je temperatura reaktanata, u prisustvu najmanje 0.2 mola kiseline formule (I) gde je R3 atom vodonika na mol natrijumove soli. Postupak prema zahtevima 1-3, na značen time, što se reakcija izvodi u rastopu na temperaturi od 100-110 C. Postupak prema zahtevu 1, naznačen time, što se R1 i R2 svaki posebno biraju medju etil, propil, izopentil, alil, benzil i fenil grupama. Prijava sadrži još 3 patentna zahteva.
YU66484A 1983-04-12 1984-04-11 Postupak za dobijanje pirimidintrionskih derivata YU45607B (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB838309813A GB8309813D0 (en) 1983-04-12 1983-04-12 Pyrimidinetrione derivatives

Publications (2)

Publication Number Publication Date
YU66484A YU66484A (en) 1986-12-31
YU45607B true YU45607B (sh) 1992-07-20

Family

ID=10540932

Family Applications (1)

Application Number Title Priority Date Filing Date
YU66484A YU45607B (sh) 1983-04-12 1984-04-11 Postupak za dobijanje pirimidintrionskih derivata

Country Status (39)

Country Link
US (1) US4611057A (sh)
EP (1) EP0125046B1 (sh)
JP (1) JPS59205370A (sh)
AR (1) AR240317A1 (sh)
AT (1) AT388917B (sh)
AU (1) AU554056B2 (sh)
BE (1) BE899385A (sh)
BG (1) BG65031A (sh)
BR (1) BR8401679A (sh)
CA (1) CA1247619A (sh)
CH (1) CH658653A5 (sh)
CS (1) CS276389B6 (sh)
DD (1) DD222018A5 (sh)
DE (1) DE3464910D1 (sh)
DK (1) DK158726C (sh)
EG (1) EG17794A (sh)
ES (1) ES8505973A1 (sh)
FI (1) FI84348C (sh)
FR (1) FR2544312B1 (sh)
GB (1) GB8309813D0 (sh)
GR (1) GR79890B (sh)
HU (1) HU192548B (sh)
IE (1) IE57321B1 (sh)
IL (1) IL71515A (sh)
IN (1) IN161291B (sh)
IT (1) IT1177658B (sh)
LU (1) LU85296A1 (sh)
MA (1) MA20092A1 (sh)
MX (1) MX159632A (sh)
NO (1) NO170928C (sh)
NZ (1) NZ207802A (sh)
PH (1) PH24131A (sh)
PL (1) PL144481B1 (sh)
PT (1) PT78400B (sh)
RO (1) RO89141A (sh)
SU (1) SU1380611A3 (sh)
UA (1) UA7040A1 (sh)
YU (1) YU45607B (sh)
ZA (1) ZA842687B (sh)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9002890D0 (en) * 1990-02-08 1990-04-04 Sapos Sa Process for preparing pyrimidinetrione derivatives
JPH0436236A (ja) * 1990-05-30 1992-02-06 Mitsui Pharmaceut Inc 脳神経障害及び脳循環代謝障害の改善治療剤
RU2141322C1 (ru) * 1997-08-12 1999-11-20 Голощапов Николай Михайлович Иммуномодулятор с антимикобактериальной активностью "изофон", способ его получения и применения
US7074925B1 (en) * 1998-05-26 2006-07-11 Rimma Lliinichna Ashkinazi N-substituted derivatives of 5-oxyiminobarbituric acid

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA873891A (en) * 1971-06-22 Melkonian Diran Barbituric acid derivatives
US3075983A (en) * 1963-01-29 -oconh
GB1193438A (en) * 1966-10-26 1970-06-03 Phillipe Gold-Aubert Barbituric Acid Derivatives, preparation thereof and Pharmaceutical Compositions containing them
GB1581834A (en) * 1976-11-01 1980-12-31 Sapos Sa Complexes of barbituric acid derivatives
FR2424262A1 (fr) * 1978-04-24 1979-11-23 Sapos Sa Nouveaux complexes tetrameres de derives de la malonyl-uree a action psychotrope et procede de preparation

Also Published As

Publication number Publication date
BR8401679A (pt) 1984-11-20
FI841430A0 (fi) 1984-04-11
YU66484A (en) 1986-12-31
MX159632A (es) 1989-07-20
MA20092A1 (fr) 1984-12-31
FI84348C (fi) 1991-11-25
EP0125046B1 (en) 1987-07-22
DD222018A5 (de) 1985-05-08
LU85296A1 (fr) 1984-10-26
UA7040A1 (uk) 1995-03-31
PH24131A (en) 1990-03-05
EP0125046A1 (en) 1984-11-14
HU192548B (en) 1987-06-29
BE899385A (fr) 1984-07-31
AU2674984A (en) 1984-10-18
ES531498A0 (es) 1985-06-16
DK186784A (da) 1984-10-13
IE840890L (en) 1984-10-12
AR240317A1 (es) 1990-03-30
AU554056B2 (en) 1986-08-07
PL144481B1 (en) 1988-05-31
DK186784D0 (da) 1984-04-11
NO841438L (no) 1984-10-15
CA1247619A (en) 1988-12-28
IN161291B (sh) 1987-11-07
IT8448019A1 (it) 1985-10-11
US4611057A (en) 1986-09-09
IL71515A0 (en) 1984-07-31
ZA842687B (en) 1984-11-28
IT1177658B (it) 1987-08-26
AT388917B (de) 1989-09-25
CH658653A5 (de) 1986-11-28
DK158726B (da) 1990-07-09
CS276389B6 (en) 1992-05-13
PL247174A1 (en) 1985-03-26
EG17794A (en) 1990-10-30
FI841430A (fi) 1984-10-13
FR2544312A1 (fr) 1984-10-19
GR79890B (sh) 1984-10-31
NO170928C (no) 1992-12-30
PT78400B (en) 1986-05-28
IE57321B1 (en) 1992-07-29
PT78400A (en) 1984-05-01
SU1380611A3 (ru) 1988-03-07
BG65031A (en) 1996-09-30
GB8309813D0 (en) 1983-05-18
CS276284A3 (en) 1992-01-15
HUT34168A (en) 1985-02-28
IT8448019A0 (it) 1984-04-11
FR2544312B1 (fr) 1987-02-20
DK158726C (da) 1990-12-03
ATA122084A (de) 1989-02-15
RO89141A (ro) 1986-04-30
NZ207802A (en) 1986-07-11
FI84348B (fi) 1991-08-15
JPS59205370A (ja) 1984-11-20
ES8505973A1 (es) 1985-06-16
DE3464910D1 (de) 1987-08-27
IL71515A (en) 1988-11-15
JPH0432825B2 (sh) 1992-06-01
NO170928B (no) 1992-09-21

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