YU4101A - Novi postupci za identifikovanje liganada i ciljnih biomolekula - Google Patents
Novi postupci za identifikovanje liganada i ciljnih biomolekulaInfo
- Publication number
- YU4101A YU4101A YU4101A YU4101A YU4101A YU 4101 A YU4101 A YU 4101A YU 4101 A YU4101 A YU 4101A YU 4101 A YU4101 A YU 4101A YU 4101 A YU4101 A YU 4101A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- identification
- peptide
- methods
- rna
- identified
- Prior art date
Links
Landscapes
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Pronalazak obezbedjuje postupke za identifikovanje bioloski aktivnih biomolekula. U jednom vidu pronalaska, jedan bioloski aktivan biomolekul kao sto je RNK ili neki peptid identifikovan je ugradnjom nasumice modifikovanih nukleotidnih sekvenci u jednu resetku koju sacinjava jedan modulator delovanja enzima, transformisanjem u sustini identicnih celija domacina napred dobijenim strukturama i pretrazivanjem tansformisanih celija da bi se identifikovale one kod kojih je promenjeno jedno unapred izabrano fenotipsko svojstvo. Potom se nasumice modifikovana DNK izdvaja iz fenotipski promenjenih celija i odredjuje se peptid i/ili RNK kodiran nasumice modifikovanom sekvencom. Sa svoje strane, partneri za medjusobno delovanje koji su moguci ciljni lekovi identifikovani su i izdvojeni koriscenjem peptida i/ili RNK kao dela afinitetnih reagensa. Jedna preporucljiva resetka je izvedena od krompirovog inhibitora I familije proteinskih inhibitora a kao primer prikazan je jecmeni inhibitor 2A (Cl-2A) himotripsina. Drugi vid pronalaska odnosi se na identifikaciju novih enzimskih inhibitora koristeci u sustini isti pristup, ali uz specificno pretrazivanje promena delovanja ciljnih enzima. Takodje su prikazani postupci izvodjenja relevantnih vektora transformacija i izrazavanja kao i postupci za identifikovanje vodecih jedinjenja i ciljnih lekova za primenu u razvoju lekova. Konacno, u opseg pronalaska takodje spada i postupak za pripremanje jednog lekovitog proizvoda.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA199800956 | 1998-07-20 | ||
US9486898P | 1998-07-29 | 1998-07-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
YU4101A true YU4101A (sh) | 2005-06-10 |
Family
ID=27675497
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YU4101A YU4101A (sh) | 1998-07-20 | 1999-07-16 | Novi postupci za identifikovanje liganada i ciljnih biomolekula |
Country Status (2)
Country | Link |
---|---|
YU (1) | YU4101A (sh) |
ZA (1) | ZA200100195B (sh) |
-
1999
- 1999-07-16 YU YU4101A patent/YU4101A/sh unknown
-
2001
- 2001-01-08 ZA ZA200100195A patent/ZA200100195B/en unknown
Also Published As
Publication number | Publication date |
---|---|
ZA200100195B (en) | 2002-01-08 |
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