YU33204A - Sinteza analoga ciklosporina - Google Patents

Sinteza analoga ciklosporina

Info

Publication number
YU33204A
YU33204A YU33204A YUP33204A YU33204A YU 33204 A YU33204 A YU 33204A YU 33204 A YU33204 A YU 33204A YU P33204 A YUP33204 A YU P33204A YU 33204 A YU33204 A YU 33204A
Authority
YU
Yugoslavia
Prior art keywords
isomers
isatx247
cyclosporine
derivatives
mixtures
Prior art date
Application number
YU33204A
Other languages
English (en)
Inventor
Selvaraj Naicker
Randall Yatscoff
Robert Foster
Mark Abel
Seetharaman Jayaraman
Hans-Jurgen Mair
Jean-Michel Adam
Bruno Lohri
Original Assignee
Isotechnika Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Isotechnika Inc. filed Critical Isotechnika Inc.
Publication of YU33204A publication Critical patent/YU33204A/sh

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Pronalazak se bavi smesama izomera analoga ciklosporina koji imaju strukturu slicnu ciklosporinu A. Smese poseduju poboljsanu delotvornost i smanjenu toksicnost u odnosu na pojedinacne izomere, kao i u odnosu na do sada poznate ciklosporine i derivate ciklosporina koji se nalaze u prirodi. Izvodjenja ovog pronalaska se odnose na cis i trans izomere analoga ciklosporina A, pod nazivom ISATX247, i derivata ovih jedinjenja. Smese izomera ISATX247 pokazuju kako poboljsano delovanje, tako i smanjenu toksicnost u odnosu na do sada poznate ciklosporine, i one koji su prisutni u prirodi. Izomeri ISATX247, zatim alkilovani, arilovani i deuterijumom obelezeni derivati su sintetisani preko stereoselektivnih puteva u kojima odredjeni uslovi reakcije odredjuju stepen stereoselektivnosti. U stereoselektivnim putevima sinteze moze da se koristi Wittig-ova reakcija, ili organometalni reagens koji sadrzi neorganske elemente kao sto su bor, silicijum, titanijum i litijum. Odnos izomera u smesi moze da varira od priblizno 10 do 90 masenih procenata izomera (E) do priblizno 90 do 10 masenih procenata izomera (Z), u odnosu na ukupnu masu smese.
YU33204A 2001-10-19 2002-10-17 Sinteza analoga ciklosporina YU33204A (sh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60346201A 2001-10-19 2001-10-19
US37059602P 2002-04-05 2002-04-05

Publications (1)

Publication Number Publication Date
YU33204A true YU33204A (sh) 2006-08-17

Family

ID=47750099

Family Applications (1)

Application Number Title Priority Date Filing Date
YU33204A YU33204A (sh) 2001-10-19 2002-10-17 Sinteza analoga ciklosporina

Country Status (1)

Country Link
YU (1) YU33204A (sh)

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