YU33204A - Sinteza analoga ciklosporina - Google Patents
Sinteza analoga ciklosporinaInfo
- Publication number
- YU33204A YU33204A YU33204A YUP33204A YU33204A YU 33204 A YU33204 A YU 33204A YU 33204 A YU33204 A YU 33204A YU P33204 A YUP33204 A YU P33204A YU 33204 A YU33204 A YU 33204A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- isomers
- isatx247
- cyclosporine
- derivatives
- mixtures
- Prior art date
Links
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Pronalazak se bavi smesama izomera analoga ciklosporina koji imaju strukturu slicnu ciklosporinu A. Smese poseduju poboljsanu delotvornost i smanjenu toksicnost u odnosu na pojedinacne izomere, kao i u odnosu na do sada poznate ciklosporine i derivate ciklosporina koji se nalaze u prirodi. Izvodjenja ovog pronalaska se odnose na cis i trans izomere analoga ciklosporina A, pod nazivom ISATX247, i derivata ovih jedinjenja. Smese izomera ISATX247 pokazuju kako poboljsano delovanje, tako i smanjenu toksicnost u odnosu na do sada poznate ciklosporine, i one koji su prisutni u prirodi. Izomeri ISATX247, zatim alkilovani, arilovani i deuterijumom obelezeni derivati su sintetisani preko stereoselektivnih puteva u kojima odredjeni uslovi reakcije odredjuju stepen stereoselektivnosti. U stereoselektivnim putevima sinteze moze da se koristi Wittig-ova reakcija, ili organometalni reagens koji sadrzi neorganske elemente kao sto su bor, silicijum, titanijum i litijum. Odnos izomera u smesi moze da varira od priblizno 10 do 90 masenih procenata izomera (E) do priblizno 90 do 10 masenih procenata izomera (Z), u odnosu na ukupnu masu smese.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US60346201A | 2001-10-19 | 2001-10-19 | |
US37059602P | 2002-04-05 | 2002-04-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
YU33204A true YU33204A (sh) | 2006-08-17 |
Family
ID=47750099
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YU33204A YU33204A (sh) | 2001-10-19 | 2002-10-17 | Sinteza analoga ciklosporina |
Country Status (1)
Country | Link |
---|---|
YU (1) | YU33204A (sh) |
-
2002
- 2002-10-17 YU YU33204A patent/YU33204A/sh unknown
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MXPA04003625A (es) | Sintesis de analogos de ciclosporina. | |
MY187182A (en) | Cyclosporine analogue mixtures and their use as immunomodulating agents | |
MY145753A (en) | Novel cyclosporin analog formulations | |
JO2034B1 (en) | Isotopes of the hormone peptide its uses and the chemical compounds it contains | |
GB0015601D0 (en) | Novel antidiuretic agents | |
DE60034128D1 (de) | Zusammensetzungen enthaltend ein solubilisiertes säuereangereichtes antischweissmiteel | |
YU33204A (sh) | Sinteza analoga ciklosporina | |
MA27862A1 (fr) | Composition pharmaceutique | |
YU33004A (sh) | Smeša analoga ciklosporina i njihova upotreba u svojstvu imunomodulatornih supstanci | |
WO2001013895A3 (en) | Controlled-release sedative-hypnotic compositions and methods related thereto | |
AU2000265052A1 (en) | Somatostatin analogs for the treatment of cancer | |
NZ506667A (en) | A process for the conversion of echinocandin class of peptides to their c4-homotyrosine monodeoxy analogues | |
MY136393A (en) | Bombesin analogs for treatment of cancer |