YU216188A - Process for obtaining esthers of pharmacologic active carbonic acids - Google Patents

Process for obtaining esthers of pharmacologic active carbonic acids

Info

Publication number
YU216188A
YU216188A YU02161/88A YU216188A YU216188A YU 216188 A YU216188 A YU 216188A YU 02161/88 A YU02161/88 A YU 02161/88A YU 216188 A YU216188 A YU 216188A YU 216188 A YU216188 A YU 216188A
Authority
YU
Yugoslavia
Prior art keywords
esthers
obtaining
carbonic acids
active carbonic
pharmacologic
Prior art date
Application number
YU02161/88A
Other languages
English (en)
Inventor
A Furlenmeier
C Hubschwerlen
M Montavon
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of YU216188A publication Critical patent/YU216188A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D463/10—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D463/14—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
    • C07D463/16—Nitrogen atoms
    • C07D463/18—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof
    • C07D463/20—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D463/22—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen further substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/02—Preparation
    • C07D477/06—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • C07D477/08—Modification of a carboxyl group directly attached in position 2, e.g. esterification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D505/00—Heterocyclic compounds containing 5-oxa-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
YU02161/88A 1987-11-24 1988-11-24 Process for obtaining esthers of pharmacologic active carbonic acids YU216188A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH457087 1987-11-24
CH316588 1988-08-25

Publications (1)

Publication Number Publication Date
YU216188A true YU216188A (en) 1990-04-30

Family

ID=25692354

Family Applications (2)

Application Number Title Priority Date Filing Date
YU02161/88A YU216188A (en) 1987-11-24 1988-11-24 Process for obtaining esthers of pharmacologic active carbonic acids
YU01915/89A YU191589A (en) 1987-11-24 1989-10-03 Esthers of pharmacological active carbonic acids

Family Applications After (1)

Application Number Title Priority Date Filing Date
YU01915/89A YU191589A (en) 1987-11-24 1989-10-03 Esthers of pharmacological active carbonic acids

Country Status (14)

Country Link
EP (1) EP0318767A3 (fr)
JP (1) JPH01165585A (fr)
KR (1) KR890008082A (fr)
AU (1) AU614793B2 (fr)
DK (1) DK637888A (fr)
FI (1) FI885330A (fr)
HU (1) HU207522B (fr)
IL (1) IL88403A0 (fr)
MC (1) MC1991A1 (fr)
NO (1) NO885221L (fr)
NZ (1) NZ226989A (fr)
PT (1) PT89080B (fr)
SU (1) SU1598880A3 (fr)
YU (2) YU216188A (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL113744A (en) * 1990-11-09 1998-06-15 Eisai Co Ltd History of 3-tufts and their preparation
JPH11504912A (ja) * 1995-05-03 1999-05-11 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー カルバペネムのエステル
KR20140064917A (ko) * 2011-08-31 2014-05-28 말린크로트 엘엘씨 H-포스포네이트-엔/-인 히드로포스포닐화 반응을 이용한 표적화된 나노입자의 원격 어셈블리
WO2013036783A2 (fr) 2011-09-09 2013-03-14 Cubist Pharmaceuticals, Inc. Procédés de traitement d'infections intrapulmonaires
US8809314B1 (en) 2012-09-07 2014-08-19 Cubist Pharmacueticals, Inc. Cephalosporin compound
US8476425B1 (en) 2012-09-27 2013-07-02 Cubist Pharmaceuticals, Inc. Tazobactam arginine compositions
KR102329764B1 (ko) 2013-03-15 2021-11-23 머크 샤프 앤드 돔 코포레이션 세프톨로잔 항균성 조성물
US9872906B2 (en) 2013-03-15 2018-01-23 Merck Sharp & Dohme Corp. Ceftolozane antibiotic compositions
US20140274991A1 (en) 2013-03-15 2014-09-18 Cubist Pharmaceuticals, Inc. Ceftolozane pharmaceutical compositions
WO2015035376A2 (fr) 2013-09-09 2015-03-12 Calixa Therapeutics, Inc. Traitement d'infections au moyen de ceftolozane/tazobactam chez des sujets ayant une fonction rénale altérée
US8906898B1 (en) 2013-09-27 2014-12-09 Calixa Therapeutics, Inc. Solid forms of ceftolozane

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2476087A1 (fr) * 1980-02-18 1981-08-21 Roussel Uclaf Nouvelles oximes derivees de l'acide 3-alkyloxy ou 3-alkyl-thiomethyl 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
JPS5984889A (ja) * 1982-11-05 1984-05-16 Sumitomo Chem Co Ltd セフアロスポリン誘導体およびその製造方法

Also Published As

Publication number Publication date
DK637888D0 (da) 1988-11-15
HU207522B (en) 1993-04-28
YU191589A (en) 1991-02-28
EP0318767A2 (fr) 1989-06-07
EP0318767A3 (fr) 1991-03-20
NO885221L (no) 1989-05-25
PT89080B (pt) 1993-04-30
PT89080A (pt) 1988-12-01
JPH01165585A (ja) 1989-06-29
FI885330A (fi) 1989-05-25
IL88403A0 (en) 1989-06-30
KR890008082A (ko) 1989-07-08
NO885221D0 (no) 1988-11-23
HUT48895A (en) 1989-07-28
NZ226989A (en) 1992-05-26
MC1991A1 (fr) 1989-11-30
AU2578588A (en) 1989-05-25
FI885330A0 (fi) 1988-11-17
SU1598880A3 (ru) 1990-10-07
AU614793B2 (en) 1991-09-12
DK637888A (da) 1989-05-25

Similar Documents

Publication Publication Date Title
EP0425197A3 (en) Process for preparing diester of carbonic acid
YU45686A (en) Process for preparation of surface active means made of citronic acid
YU216188A (en) Process for obtaining esthers of pharmacologic active carbonic acids
HUT43832A (en) Process for production of 1,2,3,4-tetrahydro-6-substituated-4-aryl or heterocyclic-3-//substituated amin-carbonil//-2-tiozo or oxo-5-piramidin carbonic acids and esthers
YU146686A (en) Process for preparing derivatives of amino acids
EP0279435A3 (en) Process for the reduction of mono- and dicarbonic acids
EG18001A (en) Process for preparing of 7-amino-3-prophenylcephalosphoranic acid and esters thereof
HUT49452A (en) Herbicides containing phenil-alkenyl carbonic acids and its esthers and process for production of the active substances
GB2182036B (en) Process for producing l-amino acids
EG17868A (en) Process for preparing of 3 - (substituted) propenyla-minothiazolyl cephalosporanic acids and esters thereof
YU150188A (en) Process for preparing new unsaturated compounds of amino acids
YU141488A (en) Process for obtaining derivatives of hydrocimentic acid
HUT34162A (en) Process for preparing esters of pyridyl-n-oxide-carboxylic acids
HUT48560A (en) Process for reduction of metonin-sulphoxid groups
EP0159866A3 (en) Process for production of l-amino acids
CS714586A1 (en) Process for preparing alpha-cyanobenzylesters of alkanoic and cyclopropanoic acids
HU900727D0 (en) Process for preparation of optically active 3-thiolanyl-sulfonat esthers
PL265243A1 (en) Method of obtaining novel surface active compounds
EG18244A (en) Process for preparing esters of dihydrolysergic acid
CS46087A1 (en) Process for preparing esters of n-alkyl-beta-alanine
BG40059A1 (en) Method for preparing of arylsulphonylethanic acids
GB8817427D0 (en) Method of & apparatus for distributing material
BG47346A3 (en) Method for preparing of dialkyldichlorsuccinates
PL268985A1 (en) Method of obtaining -amino-/3-alkylphenyl/alkylacetic acids
PL265686A1 (en) Method of obtaining n-acylaminoalkanophosphonic acids