YU104191A - SUBSTITUTED BENZIMIDAZOLES AND PROCEDURE FOR THEIR OBTAINING - Google Patents

SUBSTITUTED BENZIMIDAZOLES AND PROCEDURE FOR THEIR OBTAINING

Info

Publication number
YU104191A
YU104191A YU104191A YU104191A YU104191A YU 104191 A YU104191 A YU 104191A YU 104191 A YU104191 A YU 104191A YU 104191 A YU104191 A YU 104191A YU 104191 A YU104191 A YU 104191A
Authority
YU
Yugoslavia
Prior art keywords
carbon atoms
substituted benzimidazoles
procedure
obtaining
alkyl containing
Prior art date
Application number
YU104191A
Other languages
Serbo-Croatian (sh)
Inventor
A.E. Braendstroem
P.L. Lindberg
G.E. Sinnden
Original Assignee
Aktiebolaget Astra
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aktiebolaget Astra filed Critical Aktiebolaget Astra
Publication of YU104191A publication Critical patent/YU104191A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

SUPSTITUISANI BENZIMIDAZOLI I POSTUPAK ZA NJIHOVO DOBIJANJE, nova jedinjenja formule: u kojoj su: R1 i R2, koji su različiti, je svaki H, alkil koji sadrži 1-4 ugljevodonikovih atoma ili -C(O)-R6, pri čemu se jedan od R1 i R2 uvek bira od grupe -C(O)-R6; gde je: R6 alkil koji sadrži 1-4 atoma ugljenika ili alkoksi koji sadrži 1-4 atoma ugljenika, R3 je grupa -CH2OCOOR7, gde je R7 alkil koji sadrži 1-6 atoma ugljenika ili benzil; R4 i R5 su isti ili različiti i izabrani su od i R5 formiraju zajednički sa susednim atomima kiseonika spojenim za piridinski prsten i sa ugljenikovim atomima u piridinskom prstenu neki prsten u kojem je deo koji čine R4 i R5-CH2CH2CH2-,-CH2CH2- ili-CH2-.SUBSTITUTED BENZIMIDAZOLES AND PROCESS FOR THEIR PREPARATION, novel compounds of the formula: wherein: R 1 and R 2, which are different, are each H, alkyl containing 1-4 hydrocarbon atoms or -C (O) -R 6, wherein one of R1 and R2 are always selected from the group -C (O) -R6; wherein: R6 is alkyl containing 1-4 carbon atoms or alkoxy containing 1-4 carbon atoms, R3 is a group -CH2OCOOR7, wherein R7 is alkyl containing 1-6 carbon atoms or benzyl; R4 and R5 are the same or different and are selected from and R5 form together with adjacent oxygen atoms attached to the pyridine ring and with the carbon atoms in the pyridine ring a ring in which the part forming R4 and R5 is -CH2CH2CH2 -, - CH2CH2- or- CH2-.

YU104191A 1990-06-20 1991-06-12 SUBSTITUTED BENZIMIDAZOLES AND PROCEDURE FOR THEIR OBTAINING YU104191A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9002206A SE9002206D0 (en) 1990-06-20 1990-06-20 NEW COMPOUNDS

Publications (1)

Publication Number Publication Date
YU104191A true YU104191A (en) 1994-01-20

Family

ID=20379831

Family Applications (1)

Application Number Title Priority Date Filing Date
YU104191A YU104191A (en) 1990-06-20 1991-06-12 SUBSTITUTED BENZIMIDAZOLES AND PROCEDURE FOR THEIR OBTAINING

Country Status (26)

Country Link
EP (1) EP0535081A1 (en)
JP (1) JPH05507713A (en)
CN (1) CN1058212A (en)
AP (1) AP215A (en)
AU (1) AU649453B2 (en)
CA (1) CA2083714A1 (en)
CZ (1) CZ279772B6 (en)
FI (1) FI925766A (en)
HU (1) HUT62881A (en)
IE (1) IE912025A1 (en)
IL (1) IL98470A0 (en)
IS (1) IS3721A7 (en)
LT (2) LT3952B (en)
LV (1) LV10953A (en)
MA (1) MA22199A1 (en)
NO (1) NO924775D0 (en)
NZ (1) NZ238546A (en)
OA (1) OA09682A (en)
PT (1) PT98035A (en)
RO (1) RO110493B1 (en)
SE (1) SE9002206D0 (en)
TN (1) TNSN91049A1 (en)
TW (1) TW216418B (en)
WO (1) WO1991019711A1 (en)
YU (1) YU104191A (en)
ZA (2) ZA914297B (en)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9002043D0 (en) * 1990-06-07 1990-06-07 Astra Ab IMPROVED METHOD FOR SYNTHESIS
SE9103776D0 (en) * 1991-12-19 1991-12-19 Astra Ab NEW COMPOUNDS
IS4232A (en) * 1993-12-06 1995-06-07 Astra Aktiebolag Substituted benzimidazole, its methods of manufacture and pharmacological use
SE9500422D0 (en) * 1995-02-06 1995-02-06 Astra Ab New oral pharmaceutical dosage forms
SE9500478D0 (en) * 1995-02-09 1995-02-09 Astra Ab New pharmaceutical formulation and process
SE9600070D0 (en) 1996-01-08 1996-01-08 Astra Ab New oral pharmaceutical dosage forms
PT1257269E (en) 2000-02-24 2005-03-31 Kopran Res Lab Ltd DERIVATIVES OF BENZIMIDAZOLE ANTI-ULCERA STABLE IN RELATION TO ORAL ADMINISTRATION ACID
SE0101379D0 (en) 2001-04-18 2001-04-18 Diabact Ab Composition that inhibits gastric acid secretion
US8206741B2 (en) 2001-06-01 2012-06-26 Pozen Inc. Pharmaceutical compositions for the coordinated delivery of NSAIDs
CN100553625C (en) 2002-04-09 2009-10-28 弗拉梅技术公司 The oral administration mixed suspension of active principle microcapsules
SE0203065D0 (en) 2002-10-16 2002-10-16 Diabact Ab Gastric acid secretion inhibiting composition
JP4919801B2 (en) 2003-09-26 2012-04-18 アルザ・コーポレーシヨン Drug coating providing high drug loading and method for providing the same
TW200606163A (en) 2004-04-22 2006-02-16 Eisai Co Ltd Imidazopyridine compound
US8541026B2 (en) 2004-09-24 2013-09-24 Abbvie Inc. Sustained release formulations of opioid and nonopioid analgesics
US20070015782A1 (en) 2005-04-15 2007-01-18 Eisai Co., Ltd. Benzimidazole compound
US9040564B2 (en) 2005-04-28 2015-05-26 Eisai R&D Management Co., Ltd. Stabilized composition
US7981908B2 (en) 2005-05-11 2011-07-19 Vecta, Ltd. Compositions and methods for inhibiting gastric acid secretion
US7803817B2 (en) 2005-05-11 2010-09-28 Vecta, Ltd. Composition and methods for inhibiting gastric acid secretion
WO2007122686A1 (en) * 2006-04-14 2007-11-01 Eisai R & D Management Co., Ltd. Benzimidazole compounds
AU2007278986B2 (en) 2006-07-25 2010-09-16 Vecta, Ltd. Compositions and methods for inhibiting gastric acid secretion using derivatives of small dicarboxylic acids in combination with PPI
JP5492417B2 (en) * 2006-10-13 2014-05-14 エーザイ・アール・アンド・ディー・マネジメント株式会社 Benzimidazole compound having gastric acid secretion inhibitory action
KR20110079641A (en) 2008-09-09 2011-07-07 아스트라제네카 아베 Method for delivering a pharmaceutical composition to patient in need thereof
SG176724A1 (en) 2009-06-25 2012-01-30 Astrazeneca Ab Method for treating a patient at risk for developing an nsaid-associated ulcer
WO2011080500A2 (en) 2009-12-29 2011-07-07 Orexo Ab New pharmaceutical dosage form for the treatment of gastric acid-related disorders
WO2011080502A2 (en) 2009-12-29 2011-07-07 Orexo Ab New pharmaceutical dosage form for the treatment of gastric acid-related disorders
US20120294937A1 (en) 2009-12-29 2012-11-22 Novartis Ag New pharmaceutical dosage form for the treatment of gastric acid-related disorders
EP2601947A1 (en) 2011-12-05 2013-06-12 Abo Bakr Mohammed Ali Al-Mehdar Fixed-dose combination for treatment of helicobacter pylori associated diseases
US9539214B2 (en) 2011-12-28 2017-01-10 Pozen Inc. Compositions and methods for delivery of omeprazole plus acetylsalicylic acid
EP4289425A2 (en) * 2016-09-14 2023-12-13 Yufeng Jane Tseng Novel substituted benzimidazole derivatives as d-amino acid oxidase (daao) inhibitors

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE418966B (en) 1974-02-18 1981-07-06 Haessle Ab ANALOGY PROCEDURE FOR THE PREPARATION OF COMPOUNDS WITH Gastric Acid Secretion Inhibitory Effects
SE416649B (en) 1974-05-16 1981-01-26 Haessle Ab PROCEDURE FOR THE PREPARATION OF SUBSTANCES WHICH PREVENT Gastric acid secretion
IN148930B (en) 1977-09-19 1981-07-25 Hoffmann La Roche
SE7804231L (en) 1978-04-14 1979-10-15 Haessle Ab Gastric acid secretion
US4359465A (en) 1980-07-28 1982-11-16 The Upjohn Company Methods for treating gastrointestinal inflammation
CH644116A5 (en) 1980-08-21 1984-07-13 Hoffmann La Roche IMIDAZOLE DERIVATIVES.
SE8300736D0 (en) 1983-02-11 1983-02-11 Haessle Ab NOVEL PHARMACOLOGICALLY ACTIVE COMPOUNDS
SE8301182D0 (en) 1983-03-04 1983-03-04 Haessle Ab NOVEL COMPOUNDS
IL75400A (en) * 1984-06-16 1988-10-31 Byk Gulden Lomberg Chem Fab Dialkoxypyridine methyl(sulfinyl or sulfonyl)benzimidazoles,processes for the preparation thereof and pharmaceutical compositions containing the same
AU568441B2 (en) * 1984-09-24 1987-12-24 Upjohn Company, The 2-(pyridylalkenesulfinyl) benzimidazole derivatives
IL76839A (en) * 1984-10-31 1988-08-31 Byk Gulden Lomberg Chem Fab Picoline derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
US4738975A (en) 1985-07-02 1988-04-19 Takeda Chemical Industries, Ltd. Pyridine derivatives, and use as anti-ulcer agents
SE8505112D0 (en) * 1985-10-29 1985-10-29 Haessle Ab NOVEL PHARMACOLOGICAL COMPOUNDS
NZ222495A (en) 1986-11-21 1991-04-26 Haessle Ab Benzimidazole derivatives and pharmaceutical compositions
DE3722810A1 (en) * 1987-07-10 1989-01-19 Hoechst Ag SUBSTITUTED BENZIMIDAZOLES, METHOD FOR THE PRODUCTION THEREOF, THE PHARMACEUTICAL PREPARATIONS CONTAINING THEM AND THE USE THEREOF
WO1989003830A1 (en) * 1987-10-30 1989-05-05 Aktiebolaget Hässle 2-pyridinylmethyl (sulfinyl or thio)benzimidazoles for treatment of diseases related to bone loss
AU2817989A (en) * 1987-12-11 1989-07-05 Byk Gulden Lomberg Chemische Fabrik Gmbh Novel benzimidazole derivatives
JPH03504497A (en) * 1988-05-25 1991-10-03 ビイク　グルデン　ロンベルク　ヒエーミツシエ　フアブリーク　ゲゼルシヤフト　ミツト　ベシユレンクテル　ハフツング New fluoroalkoxy compound

Also Published As

Publication number Publication date
CS189491A3 (en) 1992-04-15
LT3977B (en) 1996-06-25
CA2083714A1 (en) 1991-12-21
ZA914296B (en) 1992-03-25
PT98035A (en) 1992-03-31
IL98470A0 (en) 1992-07-15
MA22199A1 (en) 1992-04-01
EP0535081A1 (en) 1993-04-07
NO924775L (en) 1992-12-10
FI925766A0 (en) 1992-12-18
AP215A (en) 1992-09-02
WO1991019711A1 (en) 1991-12-26
ZA914297B (en) 1992-03-25
TW216418B (en) 1993-11-21
CN1058212A (en) 1992-01-29
RO110493B1 (en) 1996-01-30
HUT62881A (en) 1993-06-28
SE9002206D0 (en) 1990-06-20
IE912025A1 (en) 1992-01-01
HU9204033D0 (en) 1993-03-29
CZ279772B6 (en) 1995-06-14
AU8009791A (en) 1992-01-07
NO924775D0 (en) 1992-12-10
FI925766A (en) 1992-12-18
IS3721A7 (en) 1991-12-21
AP9100285A0 (en) 1991-07-31
LTIP1712A (en) 1995-08-25
LTIP1713A (en) 1995-08-25
JPH05507713A (en) 1993-11-04
NZ238546A (en) 1994-03-25
LT3952B (en) 1996-05-27
OA09682A (en) 1993-05-15
TNSN91049A1 (en) 1992-10-25
LV10953A (en) 1995-12-20
AU649453B2 (en) 1994-05-26

Similar Documents

Publication Publication Date Title
YU104191A (en) SUBSTITUTED BENZIMIDAZOLES AND PROCEDURE FOR THEIR OBTAINING
TW234116B (en) 2-Cyano-3-hydroxy-enamides and their preparation process
YU24792A (en) NEW CARBIC ACID AMIDES
YU36998A (en) Substituted 4-hydroxy-phenyl alcanoic acid derivatives with agonist activity to ppar gamma
ATE126517T1 (en) USE OF BIS(3,4-DIALKYLBENZYLIDENE)SORBITOLACETALS AND COMPOSITIONS CONTAINING SAME.
US4161584A (en) Cycloamides of nitriloprostacyclins
ES8101536A1 (en) New pleuromutilin derivatives, their production and pharmaceutical compositions containing them.
US4167625A (en) Trans-4,5,13,14-tetradehydro-PGI1 amides
DE69319925T2 (en) INDOL PIPERAZINE DERIVATIVES AS SELECTIVE LIGANDS OF THE 5HT1D AND 5HT1B RECEPTORS CAN BE USED AS MEDICINAL PRODUCTS
US4129726A (en) 9-Deoxy-9-methylene-PGF1 -piperizinylamides
FI834730A0 (en) 1-CARBOXYKANOYLPERHYDRO-INDOL-2-CARBOXYLSYROR OR DERIVATIVES
YU45597B (en) PROCEDURE FOR OBTAINING HISTAMIN H (INDEX 2) -ANTAGONISTS
ES395057A1 (en) Bis-(triazinylamino)-stilbenesulphonic acids
ES2070623T3 (en) OXISULFONILUREAS INHIBIDORAS DE ACAT.
YU44592A (en) DERIVATI 4-ARIL-3- (HETEROARILKARBAMIDO) HINOLINA
FI923492A0 (en) INDOLDERIVAT, DERAS FRAMSTAELLNING OCH ANVAENDNING.
ES8501770A1 (en) Derivatives of orthocondensed pyrrole useful for the preparation of medicines and their preparation.
DE69316392D1 (en) AZANORADAMANTANE
ATE215083T1 (en) BICYCLIC CARBOXAMIDES AS 5-HT1A RECEPTORS LIGANDS
ES442442A1 (en) 1,4-Oxathiino{8 2,3-c{9 pyrrole derivatives
US4198500A (en) Trans-4,5-didehydro-PGI1 amides
YU47562B (en) BENZOTHIAZINE DERIVATIVES AND THE PROCEDURE FOR THEIR PRODUCTION
US4168383A (en) Amides of 6-hydroxy-PGE1 compounds
JO1674B1 (en) Substituted benzimidazoles, process for their preparation and their pharmaceutical use
YU47213B (en) AZAHETEROCYCLIC COMPOUNDS AND THE PROCEDURE FOR OBTAINING THEM