WO2024135350A1 - Dispositif d'analyse automatisé - Google Patents

Dispositif d'analyse automatisé Download PDF

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Publication number
WO2024135350A1
WO2024135350A1 PCT/JP2023/043522 JP2023043522W WO2024135350A1 WO 2024135350 A1 WO2024135350 A1 WO 2024135350A1 JP 2023043522 W JP2023043522 W JP 2023043522W WO 2024135350 A1 WO2024135350 A1 WO 2024135350A1
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WIPO (PCT)
Prior art keywords
reagent
unit
analysis
stirring
biochemical
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PCT/JP2023/043522
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English (en)
Japanese (ja)
Inventor
達也 坂井
由夏 三宅
孝伸 濱崎
マーカス フォルカー
Original Assignee
株式会社日立ハイテク
エフ・ホフマン・ラ・ロッシュ・アー・ゲー
ロッシュ ディアグノスティクス ゲゼルシャフト ミット ベシュレンクテル ハフツング
ロッシュ ディアグノスティクス オペレーションズ インコーポレーテッド
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Application filed by 株式会社日立ハイテク, エフ・ホフマン・ラ・ロッシュ・アー・ゲー, ロッシュ ディアグノスティクス ゲゼルシャフト ミット ベシュレンクテル ハフツング, ロッシュ ディアグノスティクス オペレーションズ インコーポレーテッド filed Critical 株式会社日立ハイテク
Publication of WO2024135350A1 publication Critical patent/WO2024135350A1/fr

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations

Definitions

  • the present invention relates to an automatic analyzer.
  • Automatic analyzers react blood, urine, and other biological samples (specimens) with analytical reagents that react specifically with the components to be measured in the sample, and quantitatively detect the complexes formed by this reaction, thereby automating the process from measuring the components to outputting the results.
  • analytical reagents that react specifically with the components to be measured in the sample, and quantitatively detect the complexes formed by this reaction, thereby automating the process from measuring the components to outputting the results.
  • biochemical analyzers and immunoanalyzers there are also combined automatic analyzers that perform biochemical analysis and immunoanalysis in a single analyzer.
  • Patent Document 1 As a technology related to a combined automatic analyzer, a technology has been disclosed that prevents the previous measurement sample from being carried over to the next measurement via the analysis unit (see Patent Document 1).
  • Some reagents used in biochemical analysis and immunoanalysis require stirring before use.
  • many of the reagents used in immunoanalysis contain magnetic particles, and immunoanalysis devices are equipped with a reagent stirring mechanism to frequently stir the reagents and prevent the magnetic particles from settling.
  • most reagents used in biochemical analysis are stirred as needed before being placed in the device, and devices generally do not have a stirring mechanism for stirring the reagents.
  • Patent Document 1 does not mention or suggest anything about stirring the reagents used in biochemical analysis or immunoanalysis.
  • the present invention was made in consideration of the above, and aims to provide a combined automatic analyzer that can mix multiple reagents used in multiple measurements that operate on different principles while preventing the device from becoming too large.
  • the present application includes multiple means for solving the above problem, and an example thereof includes a first analysis unit that performs an analysis related to a first group of analysis items, a second analysis unit that performs an analysis related to a second group of analysis items using a measurement principle different from that of the first analysis unit, a reagent storage unit that stores at least one first reagent container containing a reagent used in the analysis by the first analysis unit and at least one second reagent container containing a reagent used in the analysis by the second analysis unit, a stirring unit that stirs the solution in the second reagent container, and a control unit that controls the operation of the stirring unit, and the control unit controls the operation of the stirring unit so as to stir the solution in the first reagent container.
  • the present invention makes it possible to mix multiple reagents used in multiple measurements that operate on different principles while preventing the device from becoming too large.
  • FIG. 1 is a diagram illustrating an overall configuration of an automatic analyzer.
  • FIG. 2 is a functional block diagram illustrating the configuration of an analysis unit of the automatic analyzer.
  • FIG. 13 is a diagram showing a state in which the stirring rod has moved to the cleaning section.
  • FIG. 13 is a diagram showing a state in which the stirring rod has been moved to the reagent storage section.
  • FIG. 13 is a diagram showing how a reagent in a reagent container is stirred by a stirring rod.
  • FIG. 2 is a diagram illustrating a reagent storage unit together with related configuration. 13 is a flowchart showing a process of reagent registration and reagent mixing.
  • FIG. 4 is a diagram showing an example of reagent setting information recorded in a control unit.
  • FIG. 1 is a diagram showing the overall configuration of the automatic analyzer according to this embodiment.
  • the automatic analyzer 100 is roughly composed of a sample storage section 101, a reagent storage section 102, a reagent container 103, a reading section 104, a washing section 105, a stirring section 106, an analysis section 107, a control section 108, an input/output section 109, and a memory section 110.
  • the specimen storage unit 101 holds multiple specimen containers that contain biological samples such as blood and urine.
  • the specimen storage unit 101 is, for example, a disk type in which multiple specimen containers are arranged and placed on a specimen disk that can rotate intermittently clockwise and counterclockwise, or a rack type in which the specimen containers are held in a transportable rack and the rack is transported.
  • the reagent storage unit 102 is a disk-type storage unit that places multiple reagent containers 103 in a circumferential arrangement on a reagent disk that can rotate intermittently clockwise and counterclockwise, and multiple reagent containers 103 corresponding to the analysis items of the automatic analyzer 100 are placed on it.
  • the reading unit 104 is a device that reads the reagent code for identifying the reagent container 103, and reads the reagent code written in each of the multiple reagent containers 103 and transmits it to the control unit 108 (see Figure 6 below, etc.).
  • the stirring unit 106 is a device that stirs the reagent filled in the reagent container 103 placed in the reagent storage unit 102, and stirs the reagent by inserting a stirring rod with a paddle at the tip into the reagent container 103 and rotating it (see Figures 3 to 5, etc. below).
  • the cleaning unit 105 is a device that uses cleaning water to clean the stirring unit 106 after stirring the reagent in the reagent container 103, and cleans the stirring unit 106 by rotating the stirring rod and paddle in the stored cleaning water (see Figures 3 to 5, etc., below).
  • the analysis unit 107 is a device that dispenses the sample and a reagent corresponding to the analysis item, and measures the specified components based on their reaction (see Figure 2 below, etc.).
  • the control unit 108 is a device that controls the overall operation of the automatic analyzer 100, and performs functions such as obtaining corresponding information from the memory unit 110 based on signals (reagent codes) sent from the reading unit 104, controlling the mechanical operation of each part of the automatic analyzer 100, and calculating the analysis data obtained by measurement.
  • the input/output unit 109 is a device that allows the operator to input operational commands and displays analysis results, and is composed of, for example, a mouse, keyboard, touch panel, and liquid crystal display.
  • the memory unit 110 stores reagent information, analysis parameters, analysis item requests, analysis results, etc., and is composed of internal/external memory such as a hard disk.
  • FIG. 2 is a functional block diagram showing the schematic configuration of the analysis section of the automatic analyzer.
  • the analysis unit 107 has two analysis units with different measurement principles: a biochemical analysis unit 201 (first analysis unit) that analyzes biochemical items based on absorbance measurement, and an immune analysis unit 202 (second analysis unit) that analyzes immune items based on chemiluminescence (including electrochemiluminescence).
  • first analysis unit that analyzes biochemical items based on absorbance measurement
  • immune analysis unit 202 second analysis unit that analyzes immune items based on chemiluminescence (including electrochemiluminescence).
  • the biochemical analysis section 201 is composed of a biochemical dispensing section 203, a biochemical reaction section 204, a biochemical measurement section 205, and a biochemical washing section 221, and performs analysis using reagents related to biochemical items.
  • the biochemical reaction unit 204 is equipped with multiple reaction vessels for reacting samples with reagents.
  • the biochemical reaction unit 204 is, for example, a disk-type device that can rotate intermittently clockwise and counterclockwise, and multiple reaction vessels are arranged in a circumferential direction.
  • the biochemical dispensing unit 203 is a device that accesses the specimen storage unit 101, the reagent storage unit 102, the biochemical reaction unit 204, and the biochemical washing unit 221 by an operating unit (not shown) to dispense specimens, reagents, etc.
  • the biochemical dispensing unit 203 aspirates a predetermined amount of specimen from the specimen container placed in the specimen storage unit 101, aspirates a predetermined amount of reagent for a biochemical item from the reagent container 103 in the reagent storage unit 102, and discharges the specimen and reagent into a reaction container placed in the biochemical reaction unit 204.
  • the biochemical dispensing unit 203 may also have a function of stirring the reaction liquid, which is a mixture of the specimen and the reagent.
  • the biochemical dispensing unit 203 may have a function of stirring the reaction liquid by a pipetting operation that repeatedly aspirates and discharges the reaction liquid, or a function of stirring the reaction liquid by applying a liquid flow to the reaction liquid using another mechanism such as a stirring rod or ultrasonic waves.
  • the biochemical measurement section 205 has a light source 223 and a spectrophotometer 224.
  • the light source 223 irradiates light onto the reaction liquid in the reaction vessel on the biochemical reaction section 204.
  • the spectrophotometer 224 calculates the absorbance by measuring the luminous intensity of the light irradiated from the light source 223 and transmitted through the reaction liquid at a wavelength set for each test item.
  • the biochemical washing unit 221 is a device that washes the biochemical dispensing unit 203 after dispensing of samples and reagents into reaction vessels has been completed.
  • the biochemical washing unit 221 may also wash multiple reaction vessels after measurement by the spectrophotometer 224 has been completed.
  • the immune analysis section 202 is composed of an immune dispensing section 206, an immune reaction section 207, an immune measurement section 208, and an immune washing section 222, and performs analysis using reagents related to immune items.
  • the immune reaction unit 207 has multiple reaction vessels placed therein for reacting the sample with the reagent.
  • the immune reaction unit 207 is, for example, a disk-type device capable of intermittent rotation clockwise and counterclockwise, with multiple reaction vessels placed therein aligned in the circumferential direction.
  • a reaction unit having the functions of both the biochemical reaction unit 204 and the immune reaction unit 207 may be configured to be shared by the biochemical analysis unit 201 and the immune analysis unit 202.
  • the immune dispensing unit 206 is a device that accesses the specimen storage unit 101, the reagent storage unit 102, the immune reaction unit 207, and the immune cleaning unit 222 by an operating unit (not shown) to dispense specimens, reagents, etc.
  • the immune dispensing unit 206 aspirates a predetermined amount of specimen from the specimen container placed in the specimen storage unit 101, aspirates a predetermined amount of reagent for immune items from the reagent container 103 in the reagent storage unit 102, and discharges the specimen and reagent into a reaction container placed in the immune reaction unit 207.
  • the immune dispensing unit 206 may also have a function of stirring the reaction liquid, which is a mixture of the specimen and the reagent.
  • the immune dispensing unit 206 may have a function of stirring the reaction liquid by a pipetting operation that repeatedly aspirates and discharges the reaction liquid, or a vortex stirring function that rotates the reaction container around its axis to generate a liquid flow such as a vortex in the reaction liquid and stir the reaction liquid.
  • the immunoassay section 208 is composed of an aspiration nozzle 209, an immunoassay cell 210, and a photomultiplier tube 211.
  • the reagent for the immune item contains magnetic particles, and the magnetic particles in the reaction solution form a complex with the substance to be measured and the luminescent label through an antigen-antibody reaction.
  • the immunoassay section 208 quantitatively measures the substance to be measured by measuring the complex of the magnetic particles, the substance to be measured, and the luminescent label.
  • the suction nozzle 209 sucks the reaction liquid in the reaction container in the immune reaction section 207 and introduces it into the immune cell 210.
  • the immune cell 210 is equipped with a measurement electrode inside, and the complex of the substance to be measured, magnetic particles, and luminescent label in the reaction solution introduced into the immune cell is captured on the electrode by the magnetic force of a magnet (not shown).
  • a voltage is applied to the electrode, and the intensity of the electrochemiluminescent light emitted by the luminescent label of the complex captured on the electrode is measured by a photomultiplier tube 211.
  • chemiluminescence it is also possible to use a method such as chemiluminescence, which uses a trigger reagent to cause a luminescent reaction.
  • Figures 3 to 5 are schematic diagrams showing the structure of the stirring unit and the operation of stirring the reagent.
  • Figure 3 shows the stirring rod of the stirring unit moving to the cleaning unit
  • Figure 4 shows the stirring rod of the stirring unit moving to the reagent storage unit
  • Figure 5 shows the stirring rod stirring the reagent in the reagent container.
  • the stirring unit 106 is roughly composed of a stirring rod 301, a motor 302, an arm 304, and an up-down rotating unit 303.
  • the stirring rod 301 is attached to the lower end of one end of the arm 304, and a paddle 306 is provided at its lower end.
  • the upper end of the stirring rod 301 is connected to a motor 302 provided on the arm 304, and the stirring rod 301 and the paddle 306 are rotated integrally around their axis by the motor 302.
  • the other end of the arm 304 is connected to an up-down rotation operation unit 303.
  • the vertical rotation operating part 303 has a two-axis movement mechanism for up and down (vertical direction) and rotation (horizontal direction), and the arm 304 can move up and down and rotate integrally with the stirring rod 301 by the vertical rotation operating part 303.
  • the stirring unit 106 is arranged so that the reagent storage unit 102 and the washing unit 105 are located below the rotational path of the stirring rod 301 during the rotational movement of the arm 304. That is, the stirring rod 301 of the stirring unit 106 can be moved directly above the washing unit 105 (washing tank) (see FIG. 3) and directly above the reagent container 103 placed in the reagent storage unit 102 (see FIG. 4) by the rotational movement of the arm 304 by the up-down rotational movement unit 303.
  • the stirring rod 301 of the stirring unit 106 can be immersed at its lower end (paddle 306, etc.) in the washing water 311 of the washing unit 105 (not shown) and immersed at its lower end (paddle 306, etc.) in the reagent 305 of the reagent container 103 (see FIG. 5) by the up-down movement of the arm 304 by the up-down rotational movement unit 303.
  • the stirring rod 301 (paddle 306) is rotated while immersed in the reagent 305 in the reagent container 103 to stir the reagent 305.
  • the structure related to stirring in the stirring unit 106 and the operation control by the control unit 108 are configured so that the magnetic particles in the reagent related to the immune analysis unit 202 are made more uniform by stirring.
  • the stirring rod 301 is washed by rotating it while immersed in the cleaning water 311 of the cleaning unit 105.
  • the operation of the motor 302 of the stirring unit 106 and the up-down rotation operation unit 303 is controlled by the control unit 108.
  • the cleaning water 311 used in the cleaning unit 105 is sent by a water supply pump 312 or the like through a liquid sending flow path connected to the cleaning tank of the cleaning unit 105, and is also drained through a waste liquid flow path (not shown) connected to the cleaning tank of the cleaning unit 105.
  • Reagents containing magnetic particles of immune items need to be stirred sufficiently at a certain frequency because the magnetic particles may settle and aggregate at the bottom of the reagent container.
  • the reason why the descending position of the stirring rod 301 is near the inner bottom of the reagent container 103 (about 5 mm from the inner bottom) is that the paddle 306 is lowered within a range where it does not come into contact with the inner bottom of the reagent container, and the paddle 306 is rotated near the inner bottom of the reagent container 103 to stir the magnetic particles that have settled to the bottom of the reagent container by the liquid flow.
  • a reagent related to a biochemical item contains latex particles
  • the latex particles that have settled to the bottom of the reagent container must be thoroughly mixed when the reagent is used for the first time; in this embodiment, this is accomplished by using the stirring rod 301 of the stirring unit 106.
  • the stirring unit 106 which can stir the magnetic particles in the reagent related to the immune items, can be used to thoroughly stir the reagent containing latex particles related to the biochemical items.
  • Figure 6 shows the reagent storage section together with the related configuration.
  • Reagent registration is a process in which, when a user places a reagent container 103 in the reagent storage unit 102, the automatic analyzer 100 recognizes information linking the position of the placed reagent container 103 in the reagent storage unit 102 with the reagent information. Note that the reagent information is stored in the automatic analyzer 100 for each type of reagent in advance of reagent registration.
  • the reagent storage unit 102 has a total of eight reagent placement positions, from reagent placement positions P1 to P8, and the example shows a case in which a user can place up to eight reagent containers 103 in the reagent storage unit 102.
  • the multiple reagent containers 103 placed in the reagent storage unit 102 are shown with a distinction between reagent containers 103a related to biochemical items and reagent containers 103b related to immunological items.
  • the number of reagent containers 103 that can be placed in the reagent storage unit 102 is not limited to a maximum of eight, and the reagent storage unit 102 may be configured to be able to place, for example, 36 reagent containers 103.
  • FIG. 7 is a flowchart showing the process of reagent registration and reagent mixing.
  • the control unit 108 acquires the barcodes and two-dimensional codes attached to each reagent container 103, and the reagent codes 401 recorded in identifiers such as RFID via the reading unit 104 (step S100).
  • the reagent storage unit 102 starts intermittent rotational movement, and when the reagent containers 103 (103a, 103b) on the reagent storage unit 102 pass in front of or stop in front of the reading unit 104, the reading unit 104 sequentially acquires the reagent codes 401 from the identifiers attached to the reagent bottles.
  • the reagent codes 401 are numbers assigned to each type of reagent, and the reagent information is linked to the storage unit 110 of the device using the reagent codes 401 as key information.
  • control unit 108 acquires the reagent code 401 for one reagent container 103, it then acquires the reagent information from the memory unit 110 using the acquired reagent code 401 as key information, and records the reagent installation information (step S110).
  • FIG. 8 shows an example of reagent installation information recorded in the control unit.
  • the reagent installation information includes, in addition to the reagent code 401, information such as a reagent bottle icon 402, reagent installation position 403, analysis type 404, reading history 405, necessity for stirring at first installation 406, and whether or not the reagent is stirred 407, and is displayed on the input/output unit 109 as necessary.
  • the reagent bottle icon 402 is used to display information about the reagent on the input/output unit 109 and the like, and is set, for example, corresponding to the analysis type 404.
  • the analysis type 404 is set corresponding to the analysis item (immunology item, biochemistry item, etc.) of the reagent container 103.
  • the read history 405 is information indicating whether the reagent code of the reagent container 103 placed at the reagent placement position has been read, and indicates whether there is history information indicating that the target reagent has been previously read by the automatic analyzer 100.
  • the necessity of stirring at the time of initial placement 406 is information indicating whether the reagent filled in the reagent container 103 needs to be stirred at the time of initial placement.
  • the presence or absence of reagent stirring 407 is information indicating whether the reagent filled in the reagent container 103 has been stirred.
  • the reagent placement information of a reagent placement position where no reagent container 103 is placed is indicated by a symbol "-" indicating that there is no information.
  • step S110 a determination is then made as to whether or not the target reagent needs to be stirred based on the recorded reagent placement information (steps S120 to S140).
  • step S120 it is determined whether a reagent container is installed, i.e., whether a reagent container 103 is installed (step S120), and if the determination result is NO, i.e., if there is no target reagent container 103, it is determined that the reagent does not need to be stirred (step S121), and the determination ends.
  • step S120 determines whether the reagent in the reagent container 103 is for analysis of an immune item or for analysis of a biochemical item (step S130). If the result of the determination is for analysis of a biochemical item (step S131), it is determined whether there is a reading history (step S132), and whether mixing is necessary when performing the first run (step S133).
  • the reagent in the reagent container 103 is determined to be a reagent to be stirred (step S140), and the determination of whether the target reagent needs to be stirred is completed.
  • the reagent in the reagent container 103 is judged to be a reagent that is not subject to stirring (step S121), and the judgment of whether or not the target reagent needs to be stirred is terminated.
  • step S130 If the result of the determination in step S130 is for analysis of an immune item (step S134), the reagent in the reagent container 103 is determined to be a reagent to be stirred (step S140), and the determination of whether or not the target reagent needs to be stirred is completed.
  • step S120 to S140 it is then determined whether the determination of whether the target reagent needs to be stirred is complete for all reagent containers 103 placed in the reagent storage unit 102 (step S150). If the determination result is NO, the processing of steps S100 to S150 is repeated until the determination result becomes YES, that is, until the determination of whether the target reagent needs to be stirred is complete for all reagent containers 103.
  • step S150 If the determination result in step S150 is YES, the reagent in the reagent container 103 determined to be the reagent to be stirred is stirred (step S160), and the process of reagent registration and reagent stirring is terminated.
  • a reagent related to a biochemical item contains latex particles
  • the latex particles that have settled to the bottom of the reagent container 103 must be thoroughly mixed when the reagent containing latex particles is used for the first time (when there is no reading history).
  • the user would manually invert the reagent container to mix the reagent before registering the reagent, and then place the reagent in an automatic analyzer to register and analyze the reagent.
  • the number of times and speed of inversion differ depending on the user, which can lead to insufficient mixing.
  • inversion can cause air to get mixed into the liquid, generating a large amount of bubbles in the reagent. Insufficient mixing and generation of bubbles can lead to poor measurement results.
  • the mixing section that mixes the reagents in the immunoanalysis section related to immune items is configured to mix the reagents in the biochemical analysis section related to biochemical items (analysis section based on absorbance measurement).
  • the mixing section for the reagents of the two analysis item groups, immune items and biochemical items, which have different measurement principles, is shared, eliminating the need to provide a mixing mechanism for each analysis item group, making it possible to simplify the device configuration and reduce the size of the device.
  • the specific gravity of the biochemistry latex reagent is smaller than that of the immunomagnetic particles, by controlling the stirring rod used to stir the immunological items to stir the biochemistry latex reagent, it is possible to sufficiently stir the reagents containing the latex particles related to the biochemistry items.
  • the system is configured to control mixing of reagents related to immune items and reagents related to biochemical items in the same mixing unit, maintenance work such as cleaning the mixing unit and replacing consumables only needs to be performed on one mixing unit, reducing the labor required for maintenance work compared to when separate mixing units for immune items and biochemical items are provided.
  • the system is configured to control mixing of the reagents related to the immune items and the reagents related to the biochemical items in the same mixing unit, eliminating the need for the user to manually mix the latex particles related to the biochemical items by inverting them, reducing the burden on the user and preventing the user from forgetting to mix by inverting them, improving the reliability of the measurement results.
  • the present invention is not limited to the above-described embodiments, and includes various modifications and combinations within the scope of the gist of the present invention.
  • the present invention is not limited to those having all the configurations described in the above-described embodiments, and includes those in which some of the configurations are deleted.
  • the above-described configurations, functions, etc. may be realized by designing some or all of them as an integrated circuit, for example.
  • the above-described configurations, functions, etc. may be realized by software, in which a processor interprets and executes a program that realizes each function.
  • 100...automatic analyzer 101...sample storage section, 102...reagent storage section, 103, 103a, 103b...reagent container, 104...reading section, 105...cleaning section, 106...mixing section, 107...analysis section, 108...control section, 109...input/output section, 110...memory section, 130...reagent container, 201...biochemical analysis section, 202...immunoanalysis section, 203...biochemical dispensing section, 204...biochemical reaction section, 205...biochemical measurement section, 206...immunodispensing section, 207...immunoreaction section, 208...immunomeasurement section, 209...aspiration nozzle, 210...immuno 211...photomultiplier tube, 221...biochemical washing section, 222...immunochemical washing section, 223...light source, 224...spectrophotometer, 301...stirring rod, 302...motor, 303...up-down rotating section, 304...

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  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

Le présent dispositif d'analyse automatisé comprend une première unité d'analyse pour effectuer une analyse associée à un premier groupe d'éléments d'analyse, une seconde unité d'analyse pour effectuer une analyse d'un second groupe d'éléments d'analyse à l'aide d'un principe de mesure différent de la première unité d'analyse, une unité de stockage de réactif permettant de stocker au moins un premier récipient de réactif recevant un réactif utilisé pour l'analyse par la première unité d'analyse et au moins un second récipient de réactif pour recevoir un réactif utilisé pour l'analyse par la seconde unité d'analyse, une unité d'agitation pour agiter une solution dans le second récipient de réactif, et une unité de commande pour commander le fonctionnement de l'unité d'agitation, l'unité de commande commandant l'opération d'agitation de l'unité d'agitation d'une solution dans le premier récipient de réactif. Ceci permet d'agiter une pluralité de réactifs utilisés pour une pluralité de mesures qui utilisent différents principes, tout en supprimant une augmentation de la taille du dispositif.
PCT/JP2023/043522 2022-12-23 2023-12-05 Dispositif d'analyse automatisé WO2024135350A1 (fr)

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JP2022-207581 2022-12-23

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013253826A (ja) * 2012-06-06 2013-12-19 Hitachi High-Technologies Corp 攪拌棒洗浄機構および自動分析装置
WO2020217636A1 (fr) * 2019-04-26 2020-10-29 株式会社日立ハイテク Dispositif d'analyse automatique
WO2022224604A1 (fr) * 2021-04-19 2022-10-27 株式会社日立ハイテク Dispositif d'analyse automatique et procédé d'analyse

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013253826A (ja) * 2012-06-06 2013-12-19 Hitachi High-Technologies Corp 攪拌棒洗浄機構および自動分析装置
WO2020217636A1 (fr) * 2019-04-26 2020-10-29 株式会社日立ハイテク Dispositif d'analyse automatique
WO2022224604A1 (fr) * 2021-04-19 2022-10-27 株式会社日立ハイテク Dispositif d'analyse automatique et procédé d'analyse

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