WO2024126133A1 - Système d'administration de médicament avec reconnaissance de médicament - Google Patents

Système d'administration de médicament avec reconnaissance de médicament Download PDF

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Publication number
WO2024126133A1
WO2024126133A1 PCT/EP2023/084128 EP2023084128W WO2024126133A1 WO 2024126133 A1 WO2024126133 A1 WO 2024126133A1 EP 2023084128 W EP2023084128 W EP 2023084128W WO 2024126133 A1 WO2024126133 A1 WO 2024126133A1
Authority
WO
WIPO (PCT)
Prior art keywords
drug delivery
dose
drug
protective cap
delivery system
Prior art date
Application number
PCT/EP2023/084128
Other languages
English (en)
Inventor
Nikolaj Eusebius Jakobsen
Per Einar Pontus Holm
Jens Aage Munk
Original Assignee
Novo Nordisk A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk A/S filed Critical Novo Nordisk A/S
Publication of WO2024126133A1 publication Critical patent/WO2024126133A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31566—Means improving security or handling thereof
    • A61M5/31568—Means keeping track of the total dose administered, e.g. since the cartridge was inserted
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3202—Devices for protection of the needle before use, e.g. caps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M2005/2403—Ampoule inserted into the ampoule holder
    • A61M2005/2411—Ampoule inserted into the ampoule holder from the front
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/35—Communication
    • A61M2205/3546—Range
    • A61M2205/3569—Range sublocal, e.g. between console and disposable
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/35—Communication
    • A61M2205/3576—Communication with non implanted data transmission devices, e.g. using external transmitter or receiver
    • A61M2205/3584—Communication with non implanted data transmission devices, e.g. using external transmitter or receiver using modem, internet or bluetooth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/60—General characteristics of the apparatus with identification means

Definitions

  • the invention relates to a drug delivery system comprising a housing structure, a reservoir structure and a protective cap in combination.
  • the drug delivery system is suitable for expelling one or more doses of a liquid drug and preferably of the type wherein the liquid drug is contained in an exchangeable container unit. More particular, the invention relates to such drug delivery system which is able to recognize or determine the type of drug contained in the exchangeable container unit and to communicate this information.
  • the invention further relates to a protective cap for such drug delivery system.
  • Another International patent application WO 2013/053695 discloses an injection device with a BGM cap which is provided with a processor which can calculate dose recommendations.
  • the BGM cap is further provided with detection means which can obtain information from an identifier provided on the individual injection device.
  • the identifier is in one embodiment explained as being an RFID tag.
  • the housing part carrying the dose engine As e.g. disclosed in WO 2012/022771 , a rather complicated interface between the reservoir unit and the housing part is required. Further the presence of an identifier on the reservoir unit and a sensor on an inner surface of the housing part requires that a part of the housing part overlaps with the reservoir unit which restricts the design options available for the injection device and further requires the housing part to have a diameter substantial larger than the diameter of the reservoir unit.
  • the housing structure comprises a dose setting and delivery mechanism for setting and expelling doses of a liquid drug and an electronic dose size capture arrangement for capturing the size of the expelled doses together with first communicating means for communicating the size of the expelled doses.
  • the sensor arrangement in the protective cap comprises an elastomeric connector which is in galvanic contact with the electric conductive and non-conductive areas of the identifier carried by the holder unit when the protective cap is mounted on the drug delivery device to at least partly cover the reservoir structure.
  • An elastomeric connector is often referred to a as a zebra connector and usually comprises a plurality of alternating conductive and non-conductive segments. All the segments or alternatively only some of the segments are made from a flexible material such as an elastomer or a silicone rubber making the zebra connector compressible and thus suitable to be pressed against a surface and maintain electric contact.
  • the alternating conductive and non-conductive areas extend in an axial direction along the centre axis (“X”) of the injection device.
  • Pre-filled injection device an injection device in which the cartridge containing the liquid drug is permanently embedded in the injection device such that it cannot be removed without permanent destruction of the injection device.
  • the user normally discards the entire injection device.
  • the cartridge which has been filled by the manufacturer with a specific amount of liquid drug is secured in a cartridge holder which is then permanently connected in a housing structure such that the cartridge cannot be exchanged.
  • Pre-filled injection devices are usually sold in packages containing more than one injection device whereas durable injection devices are usually sold one at a time.
  • pre-filled injection devices an average user might require as many as 50 to 100 injection devices per year whereas when using durable injection devices one single injection device could last for several years, however, the average user would require 50 to 100 new cartridges per year.
  • Figure 1 show an exploded view of the main structures of the injection device according to the invention.
  • Figure 2 show a perspective view of the reservoir structure.
  • Figure 3 show an exploded view of the cap insert.
  • Figure 4 show a view of the elements shown in figure 3 viewed from a distal position.
  • Figure 5B show the injection device with the protective cap visually removed.
  • Figure 5C show the injection device with the protective cap and the cap insert visually removed.
  • Figure 6A-B show two different views of the dose dial button and the electronic dose capture arrangement insertable into the dose dial button.
  • the figures are schematic and simplified for clarity, and they just show details, which are essential to the understanding of the invention, while other details are left out.
  • the same reference numerals are used for identical or corresponding parts.
  • distal end in the appended figures is meant to refer to the end of the injection device supporting the injection needle, whereas the term “proximal end” is meant to refer to the opposite end carrying the injection button as indicated in figure 1.
  • Distal and proximal is meant to be along an axial orientation extending along the longitudinal axis (X) of the injection device as also shown in figure 1.
  • Translational movement is meant to be a strictly linear movement without any rotation.
  • “Rotational movement” is any movement of rotation around a centre which centre can be a centre point i.e. in one planar or a centre axis i.e. having a longitudinal extension.
  • Axial movement means any movement in an axial direction. Such movement can be a strictly translational movement or include a rotational movement which thus makes it a “Helical movement” as this is meant to be an axial movement combined with a rotational movement.
  • Telescopic is meant to cover the situation in which a movable element moves out from, and/or into, a base element.
  • the telescopic movement can be either translational or include a rotation thus making the telescopic movement helical.
  • the injection device 1 comprises a housing structure 10, a reservoir structure 20 and a protective cap 30.
  • the injection device is disclosed as a longitudinal pen-shaped injection device, but other shapes could be contemplated.
  • Both the housing structure 10 and the reservoir structure comprises a Blue Tooth transmitter as indicated by the “BT” in figure 1.
  • the usage of these two Blue Tooth transmitters will be explained in the following.
  • the housing structure 10 contains a delivery mechanism usually referred to as the dose engine.
  • the dose engine can be a manual dose engine wherein the force for expelling the doses is delivered by the user of the injection device, or the dose engine can be spring driven such that the force driving out doses is delivered by a spring. Alternatively, the dose engine can use an electric motor to dispense the doses. Numerous examples of these different dose engines are to be found in the prior art.
  • a well-known commercial injection device based on a torsion spring driven dose engine is the FlexTouch® from Novo Nordisk A/S which is described in detail in WO 2022/013155, and also depicted in the figures 1 to 3 of WO 2022/013155.
  • the spring driven dose engine is actuated by the pressing an injection button 11 provided at the proximal end of the housing structure 10 which releases the torque stored in the torsion spring during dose setting.
  • the user sets the size of the dose to be expelled by rotating the dose setting button 12.
  • the size of the dose is displayed in the window 13.
  • the housing structure 10 is provided with means for releasable engaging a reservoir structure 20. These means are typically a thread or a bayonet interface. However other interfaces could be contemplated
  • a protective cap 30 is provided to cover the reservoir structure 20 when not in use. This protective cap 20 is preferably clicked onto the distal end of the injection device 1.
  • the reservoir structure 20 is disclosed in figure 2 and comprises a container 21 preferably made from glass and containing the liquid drug permanently embedded in a holder unit 22 which is moulded from a suitable polymer.
  • the reservoir structure 20 is distally provided with a needle interface 23 for securing a pen needle 25 to the reservoir structure 20.
  • the proximal end of the needle cannula in the pen needle 25 penetrates into the glass container 21 as it is generally known from such pen-shaped injection devices.
  • the reservoir structure 20 is provided with a bayonet track 24 which engages with an inwardly pointing protrusion 14 provided on an inner surface of the housing structure 10.
  • the inwardly pointing protrusion 14 is indicated with a broken line in figure 1.
  • the holder unit 22 encapsulating the glass container 21 is moulded as two or more different parts which are assembled around the glass container 21 by gluing, welding or by other means which could be a simple mechanical assembly means such as a threaded interlock connection or an irreversible click mechanism.
  • the holder unit 22 can be moulded around the glass container 22. The holder unit 22 together with the glass container 21 hence makes up the reservoir structure 20.
  • the reservoir structures 20 containing the liquid drug are thus made as separate units which are typically sold as such individual units.
  • the same housing structures 10 can thus be used together with a plurality of different reservoir structures 20 depending on which type of liquid drug the user require for the specific treatment.
  • the reservoir structure 20 also carries an identifier 40 which identifies the type of liquid drug contained in the glass container 21 in the specific reservoir structure 20.
  • the identifier 40 can be any kind of electronic of non-electronic element which can be coded with information regarding the type of liquid drug contained in the glass container 21 in the reservoir structure 20.
  • the coding of the identifier 40 is preferably done as an integral part of the production. An example of a suitable identifier 40 will be provided in the following.
  • the identifier 40 comprises a sheet 41 or the like as best seen in figure 3 which sheet 41 is attached to the reservoir structure 20 as disclosed in figure 2 and has a number of separate areas 42 which can be formed either conductive or non-conductive. In the disclosed example twelve (12) such areas 41 are provided. To provided able redundancy, the areas are duplicated such that there actually is provided two sets of areas each having six (6) separate areas 42. As each of these six areas 42 can be either conductive or non-conductive a 6-bit code can be provided.
  • bit-code system based on conductive and non-conductive areas are provided in US2010/0161240 wherein especially figure 7A shows how these conductive and non-conductive areas can be identified by passing an electric current to the areas and measuring if the current is returned or not. This is preferably controlled by a processor.
  • the sheet 41 comprising the conductive and the non-conductive areas 42 disclosed in figure 3 can be attached to the reservoir structure 20 in many different ways such as e.g. by welding or gluing.
  • the conductive and the non-conductive areas 42 can be made as integral parts of the reservoir structure 20.
  • the conductive and the non-conductive areas 42 are preferably located at the distal end of the reservoir structure 20 pointing away from the bayonet track 24 interfacing the housing structure 10.
  • Figure 3 further discloses a cap insert 50 which distally carries a Printed Circuit Board (PCB) 55 and proximally carries an elastomeric connector 52.
  • the cap insert 50 is on the inner surface provided with a plurality of longitudinal conductive strips 51 e.g. made by a 2K moulding in which the conductive strips 51 can be metallic or otherwise conductive. These conductive strips 51 connects the elastomeric connector 52, also often referred to as a Zebra connector, with the PCB 55.
  • a Zebra connector also often referred to as a Zebra connector
  • This PCB 55 carries the processor controlling the current which through the zebra connector 52 is applied to the conductive and non-conductive areas 42 on the reservoir structure 20 and further controls if these areas 42 closes the circuit to generate the bit-code identifying the type of liquid drug contained in the specific reservoir structure 20.
  • a zebra connector usually comprises a plurality of alternating conductive and non-conductive segments. The segments are made from a flexible material such as an elastomer or a silicone rubber making the zebra connector compressible.
  • the zebra connector 52 is shaped as a circle following the circular contour of the protective cap 30 and the conductive segments in the zebra connector 52 are conductive in the axial direction.
  • Figure 4 discloses the cap insert 50 viewed from a proximal end.
  • the PCB 55 is also provided with two (2) sets of six (6) areas 56 which through the conductive strips 51 and the zebra connector 52 identifies the conductive and the non-conductive areas 42 on the reservoir structure 20 to generate the 6 bit-code.
  • the PCB 55 further comprises a Bluetooth unit 57 able to communicate the bit-code to another electronic unit.
  • the Bluetooth unit 57 and the other components of the PCB are disclosed as separated from the PCB 55 in figure 3, however, in use, these parts including the Bluetooth unit 57 are part of the PCB.
  • the bit-code represents information relating to the type of liquid drug contained in the specific reservoir structure 20 as explained.
  • Figure 5A discloses the injection device of figure 1 with the protective cap 30 attached and covering the reservoir structure 20 and abutting the housing structure 10.
  • the cap insert 50 is distally provided with a number of protrusions 53 which secures the cap insert 50 to the protective cap 30 to functionally operate as one element.
  • the cap insert 50 can be secured to the protective cap 30 in a number of different ways including being an integral part of the protective cap 30.
  • FIG 5C both the protective cap 30 and the cap insert 50 has been visually removed thereby disclosing the PCB 55, a battery 58 and the zebra connector 52 provided inside the cap insert 50.
  • the battery 58 is pressed against the PCB 58 by a compression spring 59 inserted between the protective cap 30 and the battery 58.
  • Figure 5D discloses the injection device with the protective cap 30 fully removed and the pen-needle 25 attached the reservoir structure 20.
  • the zebra connector 52 is pressed against the identifier 40 such that a current can be lead from the conductive strips 51 inside the cap insert 50 and onto the conductive and non-conductive areas 42 of the identifier carried by the reservoir structure 20 to generate the specific bit code.
  • the injection device is further provided with an electronic dose capture arrangement for capturing the size of each expelled dose.
  • the dose capture arrangement 60 is disclosed in figure 6A-B and is encapsulated in a shell 61 which is proximally connected to the injection button 11 to form a single dose unit 65 which can be produced away from the remaining part of the injection device.
  • the injection button 11 is provided with a number of distally extending click arms 15 which connects to the shell 61 to form the single dose unit 65.
  • This dose unit 65 comprising the shell 61 , the dose capture arrangement 60 and the injection button 11 is, as best seen in figure 6B, shaped and dimensioned such that it fits inside the dose setting button 12.
  • a compression spring 66 is provided to urge the dose unit 65 in the proximal direction when a dose is not being injected.
  • a flange, a track or the like is provided to prevent the dose unit 65 from falling out from the dose setting button 12.
  • both the dose dial button 12 and the shell 61 and also the injection button 11 of the dose unit 65 do not rotate during dosing.
  • the dose capture arrangement 60 is distally provided with a distal pin 62 which protrudes through a distal opening in the shell 61 to connect with a rotational part inside the injection device.
  • the distal pin 62 connects to the reset tube of the dosing mechanism which rotates during dose expelling.
  • the dose capture arrangement 60 comprises a rotational part connected to rotate together with the distal pin 62 and a stationary part.
  • the stationary part is non-rotationally secured to the shell 61 and the shell 61 is non-rotational secured to the dose setting button 12 which is further rotationally locked to the housing structure 10 during dosing as explained.
  • the dose setting button is released from the rotational reset tube during dose expelling hence the stationary part of the dose capture arrangement 60 is stationary at least during dose expelling whereas the rotational part connected to the distal pin 62 is rotated during does expelling.
  • the dose capture arrangement 60 thus captures the relative rotation which is an expression of the size of the dose being expelled.
  • the dose capture arrangement 60 is further provided with a first communication means such as a first Bluetooth unit such that the size of the expelled dose can be communicated to another electronic unit.
  • a first communication means such as a first Bluetooth unit such that the size of the expelled dose can be communicated to another electronic unit.
  • the protective cap 30 thus has a sensor arrangement e.g. the zebra connector 52 which is able to sense information from the identifier 40 carried by the reservoir structure 20. The information sensed relates to the type of liquid drug contained in the reservoir structure 20.
  • the protective cap 30 is further provided with second communication means such as a second Bluetooth unit 57 which is able to communicate this information to another electronic unit which in one example could be a mobile phone operating a dosing app.
  • the other electronic unit could be the electronic dose capture arrangement 60 provided in the housing structure 10 of the injection device.
  • the electronic dose capture arrangement 60 also comprises a first communication means such as the first Bluetooth unit which is able to communicate the dose size to another electronic unit which in one example could be the same mobile phone also receiving information regarding the type of liquid drug contained in the reservoir structure 20.
  • the communication means in the protective cap 30 could communicate the information regarding the type of liquid drug contained in the reservoir structure 20 to the dose capture arrangement 60 which again could communicate this drug type information together with information regarding the dose size to an external unit such as a mobile phone to be further processed in an app carried on the mobile phone.
  • the two information streams could also be collected in the protective cap 30 and communicated therefrom to the external unit.
  • the two streams of communication arising from the housing structure 10 and from the protective cap 30 is indicated by the “BT” indication in figure 1.
  • the information regarding the size of the dose and the information regarding the type of liquid drug could be stored together in the protective cap 30 which could further be provided with a display to display this information.

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  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

L'invention concerne un système d'administration de médicament qui comprend essentiellement trois composants principaux : une structure de boîtier (10), une structure de réservoir (20) et une structure de capuchon de protection (30). La structure de boîtier comprend un agencement de capture de taille de dose électronique et un premier moyen de communication. La structure de réservoir contient le médicament liquide et peut être fixée amovible à la structure de boîtier. La structure de réservoir comprend en outre un identifiant qui est codé avec des informations relatives au type de médicament contenu dans la structure de réservoir. Le capuchon de protection, qui peut être monté sur le dispositif d'administration de médicament, comprend un agencement de capteur conçu pour détecter les informations codées dans l'identifiant et un second moyen de communication pour communiquer les informations concernant le type de médicament contenu dans la structure de réservoir.
PCT/EP2023/084128 2022-12-14 2023-12-04 Système d'administration de médicament avec reconnaissance de médicament WO2024126133A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP22213325.8 2022-12-14
EP22213325 2022-12-14

Publications (1)

Publication Number Publication Date
WO2024126133A1 true WO2024126133A1 (fr) 2024-06-20

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ID=84536100

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Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100161240A1 (en) 2008-12-24 2010-06-24 Chao-Man Tseng Test strip and device for measuring sample properties and system incorporating the same
WO2012022771A2 (fr) 2010-08-19 2012-02-23 Sanofi-Aventis Deutschland Gmbh Procédé et système pour déterminer des informations concernant un réservoir de médicament utilisant un capteur électronique
WO2013053695A1 (fr) 2011-10-11 2013-04-18 Novo Nordisk A/S Dispositif de consultation à double usage
US20130310756A1 (en) * 2012-05-21 2013-11-21 Common Sensing Inc. Dose measurement system and method
US20140194825A1 (en) 2011-07-07 2014-07-10 Novo Nordisk A/S Drug delivery injection pen with add-on dose capturing and display module
WO2018111776A1 (fr) * 2016-12-13 2018-06-21 Becton, Dickinson And Company Dispositif de capture d'événement pour instruments d'administration de médicament
WO2020068351A1 (fr) * 2018-09-28 2020-04-02 Becton, Dickinson And Company Capuchon intelligent universel pour stylos-injecteurs
WO2022013155A1 (fr) 2020-07-15 2022-01-20 Novo Nordisk A/S Dispositif d'injection entraîné par un ressort de torsion réutilisable
US11318251B2 (en) 2004-10-21 2022-05-03 Novo Nordisk A/S Injection device with a processor for collecting ejection information

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11318251B2 (en) 2004-10-21 2022-05-03 Novo Nordisk A/S Injection device with a processor for collecting ejection information
US20100161240A1 (en) 2008-12-24 2010-06-24 Chao-Man Tseng Test strip and device for measuring sample properties and system incorporating the same
WO2012022771A2 (fr) 2010-08-19 2012-02-23 Sanofi-Aventis Deutschland Gmbh Procédé et système pour déterminer des informations concernant un réservoir de médicament utilisant un capteur électronique
US20140194825A1 (en) 2011-07-07 2014-07-10 Novo Nordisk A/S Drug delivery injection pen with add-on dose capturing and display module
WO2013053695A1 (fr) 2011-10-11 2013-04-18 Novo Nordisk A/S Dispositif de consultation à double usage
US20130310756A1 (en) * 2012-05-21 2013-11-21 Common Sensing Inc. Dose measurement system and method
WO2018111776A1 (fr) * 2016-12-13 2018-06-21 Becton, Dickinson And Company Dispositif de capture d'événement pour instruments d'administration de médicament
WO2020068351A1 (fr) * 2018-09-28 2020-04-02 Becton, Dickinson And Company Capuchon intelligent universel pour stylos-injecteurs
WO2022013155A1 (fr) 2020-07-15 2022-01-20 Novo Nordisk A/S Dispositif d'injection entraîné par un ressort de torsion réutilisable

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