WO2024108278A1 - Dispositif collecteur avec système de montage, pour l'extraction et le mélange d'un greffon autologue - Google Patents
Dispositif collecteur avec système de montage, pour l'extraction et le mélange d'un greffon autologue Download PDFInfo
- Publication number
- WO2024108278A1 WO2024108278A1 PCT/BR2022/050462 BR2022050462W WO2024108278A1 WO 2024108278 A1 WO2024108278 A1 WO 2024108278A1 BR 2022050462 W BR2022050462 W BR 2022050462W WO 2024108278 A1 WO2024108278 A1 WO 2024108278A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- passages
- handle
- collection device
- handle body
- mixing
- Prior art date
Links
- 238000009434 installation Methods 0.000 title abstract 2
- 239000002253 acid Substances 0.000 claims abstract description 13
- 239000000654 additive Substances 0.000 claims abstract description 11
- 230000000996 additive effect Effects 0.000 claims abstract description 11
- 239000000463 material Substances 0.000 claims abstract description 8
- 210000000130 stem cell Anatomy 0.000 claims abstract description 8
- 238000000605 extraction Methods 0.000 claims description 6
- 230000008878 coupling Effects 0.000 claims description 4
- 238000010168 coupling process Methods 0.000 claims description 4
- 238000005859 coupling reaction Methods 0.000 claims description 4
- 238000005553 drilling Methods 0.000 claims description 4
- 238000002347 injection Methods 0.000 claims description 4
- 239000007924 injection Substances 0.000 claims description 4
- 230000004308 accommodation Effects 0.000 claims 1
- 230000037431 insertion Effects 0.000 claims 1
- 238000003780 insertion Methods 0.000 claims 1
- 210000001185 bone marrow Anatomy 0.000 abstract description 8
- 238000000034 method Methods 0.000 abstract description 8
- 210000001519 tissue Anatomy 0.000 abstract description 8
- 239000012141 concentrate Substances 0.000 abstract description 2
- 230000008929 regeneration Effects 0.000 abstract 1
- 238000011069 regeneration method Methods 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 description 4
- 230000035876 healing Effects 0.000 description 3
- 229920004738 ULTEM® Polymers 0.000 description 2
- 230000001133 acceleration Effects 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 230000001172 regenerating effect Effects 0.000 description 2
- 125000006850 spacer group Chemical group 0.000 description 2
- 210000000278 spinal cord Anatomy 0.000 description 2
- 206010002091 Anaesthesia Diseases 0.000 description 1
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 1
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 description 1
- CMWTZPSULFXXJA-UHFFFAOYSA-N Naproxen Natural products C1=C(C(C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-UHFFFAOYSA-N 0.000 description 1
- 229960001138 acetylsalicylic acid Drugs 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 206010003246 arthritis Diseases 0.000 description 1
- 210000002798 bone marrow cell Anatomy 0.000 description 1
- 230000001054 cortical effect Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 210000001624 hip Anatomy 0.000 description 1
- 229960001680 ibuprofen Drugs 0.000 description 1
- 210000003127 knee Anatomy 0.000 description 1
- 238000002483 medication Methods 0.000 description 1
- 229960002009 naproxen Drugs 0.000 description 1
- CMWTZPSULFXXJA-VIFPVBQESA-N naproxen Chemical compound C1=C([C@H](C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-VIFPVBQESA-N 0.000 description 1
- 230000000399 orthopedic effect Effects 0.000 description 1
- 210000004197 pelvis Anatomy 0.000 description 1
- 238000000554 physical therapy Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 208000037974 severe injury Diseases 0.000 description 1
- 230000009528 severe injury Effects 0.000 description 1
- 210000002832 shoulder Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/02—Instruments for taking cell samples or for biopsy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/34—Trocars; Puncturing needles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
- A61M39/22—Valves or arrangement of valves
- A61M39/24—Check- or non-return valves
Definitions
- the collected autologous bone marrow tissue is mixed with the additive acid and is returned to the patient to promote the acceleration of stem cells.
- BMAC Breast Marrow Aspirate Concentrate
- BMAC is obtained during a procedure in which a small amount of the patient's bone marrow is extracted from the pelvis, using anesthesia to minimize any discomfort.
- the marrow is then processed separately in a centrifuge to produce a concentration of stem cells that will be injected into the patient's damaged tissue to promote healing.
- the procedure involves minimal downtime and patients are usually sore for two or three days at the injection site.
- Anti-inflammatory medications such as Ibuprofen, Naproxen and Aspirin should be avoided for at least two weeks after the procedure as they can interrupt the healing process. Patients should follow a short period of physical therapy to speed up recovery. The full benefit of the procedure should be felt within six to eight weeks.
- This collector is shown in an exploded view of its components as Figure 1, just as an example for the order to be described later. As can be seen, it has a main body with the cannula, receiver of the stylet and perforated suction cannula, through which micro aspiration is performed.
- the collector precisely allows, in the handle body of the collection device itself, this mixture of the autologous bone marrow tissue with the addition acid is made, thus avoiding, after microaspiration, its transfer to the centrifuge or to an external container.
- the handle body (sub injected with the external cannula, which is perforated in correspondence with the perforation of the suction cannula), has 4 passages that can be opened or closed by means of a 4-inch valve. routes with torque through an actuator key, in addition to having a fitting for three syringes.
- the handle body With the vertical passage open, the handle body receives the stylet coupling (with a sharp point at l l ° degrees), which is held by its handle and inserted coaxially along the external cannula.
- the handle body is then wielded and moved to drill into the cortical parts of the spinal cord. After perforation, the stylet is removed so that the suction cannula can then be introduced through the open vertical passage.
- This suction cannula when aligned with the perforation of the external cannula, enables the extraction of cells at different levels and with greater aspiration potential in a single perforation.
- the autologous tissue is aspirated and deposited in a syringe, which is connected to the same vertical inlet of the device. Then, the 4-way valve is turned, giving access to the side inlets, for connection with the syringe(s) containing the acid additive. For the mixture, both the material extracted from the marrow and the additive acid are injected into the compartment of the gripping body without the need to remove the collecting device, thus obtaining, in the body itself, the concentration of stem cells, which will be returned to the patient to promote healing.
- Figure 2 - bottom exploded perspective view, showing the stylet with the sharp tip at 11°, aligned with the vertical passage of the grip body and the external cannula aligned with the elongated sub injection neck.
- the 4-way valve, as well as its actuator key, are aligned with the central opening of the handle body;
- Figure 6 schematically shows the handle body of the collecting device and, in alignment with its central opening, the aligned 4-way valve
- Figure 7 - shows, in sequence, the coaxial coupling of the stylet to the perforated external cannula. This view also shows the coupling of the actuator key to the valve, already located in the central opening of the collector device;
- Figure 8 - shows, in section, the assembled collector device
- Figure 9 - shows one of the side entrances of the handle body, open
- Figure 10 - shows the other side entrance of the handle body, open.
- This vertical passage (4) is aligned with the vertical passage (8) with upper nozzle (9), extended from the recessed portion (10) of the opposite edge (11) of the handle body (2), forming, through a hollow central opening (12), an interconnection with two other horizontal passages (13) and (14), which extend perpendicularly and in contraposition, equally equipped with their lateral nozzles (15) and (16), extended to from recessed portions (17) of the edges (18) of rounded corners of the handle body (2).
- the hollow central opening (12) receives, between passages (4) and (8) and (13) and (14), a 4-way valve (29) coupled with its actuator key (30).
- the stylet (28) is introduced coaxially into the external cannula (6), held by its handle (25) in order to couple the projections (23) and (24) and support the spacers (27) of its recessed internal face, respectively in the cavities (21) and (22) and in the recessed portion (10) of the edge (11) of the handle body (2).
- the stylet (28) is removed from the external cannula (6) to be replaced by the suction cannula (not shown), introduced coaxially through the vertical passages (4) and (8) , also from the upper nozzle (9).
- the suction cannula has its conventional perforation aligned with the perforation (7) of the external cannula (6).
- the material extracted from the marrow and the additive acid are injected into the compartments (19) and (20) of the handle body (2) without the need to remove the collecting device, thus obtaining, in the same body, the concentration of stem cells, which will be returned to the patient.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Surgery (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Anesthesiology (AREA)
- Pathology (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- External Artificial Organs (AREA)
Abstract
L'invention concerne un dispositif collecteur avec système de montage, pour l'extraction et le mélange d'un greffon autologue, destiné à permettre le mélange du tissu autologue extrait de la moelle osseuse avec l'acide additif, dans le propre corps de prise (2) du dispositif collecteur (1). À cet effet, le corps de prise (2) est évidé par formation de 4 passages, soit des passages verticaux (4) et (8) entrecroisés avec des passages horizontaux (13) et (14), reliés par une ouverture centrale (12) de réception de vanne à 4 voies (29), actionnée par clé d'actionnement (30). La vanne (29) est positionnée de manière à libérer les passages verticaux (4) et (8), le stylet (28) étant introduit par l'ouverture (9) supérieure du corps de prise (2), dans la canule externe (6), ledit stylet, après la perforation et la mise en mouvement au voisinage de la moelle osseuse du patient, étant retiré en vue d'un remplacement par la canule d'aspiration (non représentée), également à partir de l'ouverture supérieure (9). Par l'intermédiaire d'une seringue, on effectue la micro-aspiration de la matière extraite pendant la perforation à partir de l'ouverture supérieure (9). Ensuite, la rotation de la vanne (29) pour accéder à un ou à deux passages horizontaux (13) et (14) permet d'accoupler, au niveau de leurs ouvertures (15) et (16), une seringue ou deux seringues contenant l'acide additif. Par l'intermédiaire des seringues, la matière extraite de la moelle osseuse et l'acide additif sont injectés dans les compartiments (19) et (20) du corps de prise (2) en vue du mélange sans nécessité de retirer le dispositif collecteur (1), ce qui permet d'obtenir, dans le corps lui-même, la concentration de cellules souches appelées à être réintroduites dans le patient en vue d'un processus régénératif.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/BR2022/050462 WO2024108278A1 (fr) | 2022-11-24 | 2022-11-24 | Dispositif collecteur avec système de montage, pour l'extraction et le mélange d'un greffon autologue |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/BR2022/050462 WO2024108278A1 (fr) | 2022-11-24 | 2022-11-24 | Dispositif collecteur avec système de montage, pour l'extraction et le mélange d'un greffon autologue |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2024108278A1 true WO2024108278A1 (fr) | 2024-05-30 |
Family
ID=91194771
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/BR2022/050462 WO2024108278A1 (fr) | 2022-11-24 | 2022-11-24 | Dispositif collecteur avec système de montage, pour l'extraction et le mélange d'un greffon autologue |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2024108278A1 (fr) |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1994005210A1 (fr) * | 1992-09-09 | 1994-03-17 | Symbiosis Corporation | Biopsie coaxiale medullaire et aiguille d'aspiration |
BRPI0416062A (pt) * | 2003-10-30 | 2007-01-02 | Praxcell | dispositivo de retirada e/ou de injeção de medula óssea e sistema compreendendo tal dispositivo |
US20140114285A1 (en) * | 2012-10-23 | 2014-04-24 | Spinesmith Partners, L.P. | Bone marrow aspiration device |
US20150250929A1 (en) * | 2014-03-09 | 2015-09-10 | Spinesmith Partners, L.P. | Bone marrow aspiration device |
US20190247027A1 (en) * | 2016-10-24 | 2019-08-15 | Yale University | Aspiration device |
-
2022
- 2022-11-24 WO PCT/BR2022/050462 patent/WO2024108278A1/fr unknown
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1994005210A1 (fr) * | 1992-09-09 | 1994-03-17 | Symbiosis Corporation | Biopsie coaxiale medullaire et aiguille d'aspiration |
BRPI0416062A (pt) * | 2003-10-30 | 2007-01-02 | Praxcell | dispositivo de retirada e/ou de injeção de medula óssea e sistema compreendendo tal dispositivo |
US20140114285A1 (en) * | 2012-10-23 | 2014-04-24 | Spinesmith Partners, L.P. | Bone marrow aspiration device |
US20150250929A1 (en) * | 2014-03-09 | 2015-09-10 | Spinesmith Partners, L.P. | Bone marrow aspiration device |
US20190247027A1 (en) * | 2016-10-24 | 2019-08-15 | Yale University | Aspiration device |
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