WO2024108278A1 - Dispositif collecteur avec système de montage, pour l'extraction et le mélange d'un greffon autologue - Google Patents

Dispositif collecteur avec système de montage, pour l'extraction et le mélange d'un greffon autologue Download PDF

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Publication number
WO2024108278A1
WO2024108278A1 PCT/BR2022/050462 BR2022050462W WO2024108278A1 WO 2024108278 A1 WO2024108278 A1 WO 2024108278A1 BR 2022050462 W BR2022050462 W BR 2022050462W WO 2024108278 A1 WO2024108278 A1 WO 2024108278A1
Authority
WO
WIPO (PCT)
Prior art keywords
passages
handle
collection device
handle body
mixing
Prior art date
Application number
PCT/BR2022/050462
Other languages
English (en)
Portuguese (pt)
Inventor
Wilson Gonçalves ROSA
José Fábio Santos Duarte LANA
Original Assignee
Rosa Wilson Goncalves
Lana Jose Fabio Santos Duarte
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rosa Wilson Goncalves, Lana Jose Fabio Santos Duarte filed Critical Rosa Wilson Goncalves
Priority to PCT/BR2022/050462 priority Critical patent/WO2024108278A1/fr
Publication of WO2024108278A1 publication Critical patent/WO2024108278A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/02—Instruments for taking cell samples or for biopsy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/34—Trocars; Puncturing needles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/22—Valves or arrangement of valves
    • A61M39/24—Check- or non-return valves

Definitions

  • the collected autologous bone marrow tissue is mixed with the additive acid and is returned to the patient to promote the acceleration of stem cells.
  • BMAC Breast Marrow Aspirate Concentrate
  • BMAC is obtained during a procedure in which a small amount of the patient's bone marrow is extracted from the pelvis, using anesthesia to minimize any discomfort.
  • the marrow is then processed separately in a centrifuge to produce a concentration of stem cells that will be injected into the patient's damaged tissue to promote healing.
  • the procedure involves minimal downtime and patients are usually sore for two or three days at the injection site.
  • Anti-inflammatory medications such as Ibuprofen, Naproxen and Aspirin should be avoided for at least two weeks after the procedure as they can interrupt the healing process. Patients should follow a short period of physical therapy to speed up recovery. The full benefit of the procedure should be felt within six to eight weeks.
  • This collector is shown in an exploded view of its components as Figure 1, just as an example for the order to be described later. As can be seen, it has a main body with the cannula, receiver of the stylet and perforated suction cannula, through which micro aspiration is performed.
  • the collector precisely allows, in the handle body of the collection device itself, this mixture of the autologous bone marrow tissue with the addition acid is made, thus avoiding, after microaspiration, its transfer to the centrifuge or to an external container.
  • the handle body (sub injected with the external cannula, which is perforated in correspondence with the perforation of the suction cannula), has 4 passages that can be opened or closed by means of a 4-inch valve. routes with torque through an actuator key, in addition to having a fitting for three syringes.
  • the handle body With the vertical passage open, the handle body receives the stylet coupling (with a sharp point at l l ° degrees), which is held by its handle and inserted coaxially along the external cannula.
  • the handle body is then wielded and moved to drill into the cortical parts of the spinal cord. After perforation, the stylet is removed so that the suction cannula can then be introduced through the open vertical passage.
  • This suction cannula when aligned with the perforation of the external cannula, enables the extraction of cells at different levels and with greater aspiration potential in a single perforation.
  • the autologous tissue is aspirated and deposited in a syringe, which is connected to the same vertical inlet of the device. Then, the 4-way valve is turned, giving access to the side inlets, for connection with the syringe(s) containing the acid additive. For the mixture, both the material extracted from the marrow and the additive acid are injected into the compartment of the gripping body without the need to remove the collecting device, thus obtaining, in the body itself, the concentration of stem cells, which will be returned to the patient to promote healing.
  • Figure 2 - bottom exploded perspective view, showing the stylet with the sharp tip at 11°, aligned with the vertical passage of the grip body and the external cannula aligned with the elongated sub injection neck.
  • the 4-way valve, as well as its actuator key, are aligned with the central opening of the handle body;
  • Figure 6 schematically shows the handle body of the collecting device and, in alignment with its central opening, the aligned 4-way valve
  • Figure 7 - shows, in sequence, the coaxial coupling of the stylet to the perforated external cannula. This view also shows the coupling of the actuator key to the valve, already located in the central opening of the collector device;
  • Figure 8 - shows, in section, the assembled collector device
  • Figure 9 - shows one of the side entrances of the handle body, open
  • Figure 10 - shows the other side entrance of the handle body, open.
  • This vertical passage (4) is aligned with the vertical passage (8) with upper nozzle (9), extended from the recessed portion (10) of the opposite edge (11) of the handle body (2), forming, through a hollow central opening (12), an interconnection with two other horizontal passages (13) and (14), which extend perpendicularly and in contraposition, equally equipped with their lateral nozzles (15) and (16), extended to from recessed portions (17) of the edges (18) of rounded corners of the handle body (2).
  • the hollow central opening (12) receives, between passages (4) and (8) and (13) and (14), a 4-way valve (29) coupled with its actuator key (30).
  • the stylet (28) is introduced coaxially into the external cannula (6), held by its handle (25) in order to couple the projections (23) and (24) and support the spacers (27) of its recessed internal face, respectively in the cavities (21) and (22) and in the recessed portion (10) of the edge (11) of the handle body (2).
  • the stylet (28) is removed from the external cannula (6) to be replaced by the suction cannula (not shown), introduced coaxially through the vertical passages (4) and (8) , also from the upper nozzle (9).
  • the suction cannula has its conventional perforation aligned with the perforation (7) of the external cannula (6).
  • the material extracted from the marrow and the additive acid are injected into the compartments (19) and (20) of the handle body (2) without the need to remove the collecting device, thus obtaining, in the same body, the concentration of stem cells, which will be returned to the patient.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Surgery (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Pathology (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • External Artificial Organs (AREA)

Abstract

L'invention concerne un dispositif collecteur avec système de montage, pour l'extraction et le mélange d'un greffon autologue, destiné à permettre le mélange du tissu autologue extrait de la moelle osseuse avec l'acide additif, dans le propre corps de prise (2) du dispositif collecteur (1). À cet effet, le corps de prise (2) est évidé par formation de 4 passages, soit des passages verticaux (4) et (8) entrecroisés avec des passages horizontaux (13) et (14), reliés par une ouverture centrale (12) de réception de vanne à 4 voies (29), actionnée par clé d'actionnement (30). La vanne (29) est positionnée de manière à libérer les passages verticaux (4) et (8), le stylet (28) étant introduit par l'ouverture (9) supérieure du corps de prise (2), dans la canule externe (6), ledit stylet, après la perforation et la mise en mouvement au voisinage de la moelle osseuse du patient, étant retiré en vue d'un remplacement par la canule d'aspiration (non représentée), également à partir de l'ouverture supérieure (9). Par l'intermédiaire d'une seringue, on effectue la micro-aspiration de la matière extraite pendant la perforation à partir de l'ouverture supérieure (9). Ensuite, la rotation de la vanne (29) pour accéder à un ou à deux passages horizontaux (13) et (14) permet d'accoupler, au niveau de leurs ouvertures (15) et (16), une seringue ou deux seringues contenant l'acide additif. Par l'intermédiaire des seringues, la matière extraite de la moelle osseuse et l'acide additif sont injectés dans les compartiments (19) et (20) du corps de prise (2) en vue du mélange sans nécessité de retirer le dispositif collecteur (1), ce qui permet d'obtenir, dans le corps lui-même, la concentration de cellules souches appelées à être réintroduites dans le patient en vue d'un processus régénératif.
PCT/BR2022/050462 2022-11-24 2022-11-24 Dispositif collecteur avec système de montage, pour l'extraction et le mélange d'un greffon autologue WO2024108278A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/BR2022/050462 WO2024108278A1 (fr) 2022-11-24 2022-11-24 Dispositif collecteur avec système de montage, pour l'extraction et le mélange d'un greffon autologue

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/BR2022/050462 WO2024108278A1 (fr) 2022-11-24 2022-11-24 Dispositif collecteur avec système de montage, pour l'extraction et le mélange d'un greffon autologue

Publications (1)

Publication Number Publication Date
WO2024108278A1 true WO2024108278A1 (fr) 2024-05-30

Family

ID=91194771

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/BR2022/050462 WO2024108278A1 (fr) 2022-11-24 2022-11-24 Dispositif collecteur avec système de montage, pour l'extraction et le mélange d'un greffon autologue

Country Status (1)

Country Link
WO (1) WO2024108278A1 (fr)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994005210A1 (fr) * 1992-09-09 1994-03-17 Symbiosis Corporation Biopsie coaxiale medullaire et aiguille d'aspiration
BRPI0416062A (pt) * 2003-10-30 2007-01-02 Praxcell dispositivo de retirada e/ou de injeção de medula óssea e sistema compreendendo tal dispositivo
US20140114285A1 (en) * 2012-10-23 2014-04-24 Spinesmith Partners, L.P. Bone marrow aspiration device
US20150250929A1 (en) * 2014-03-09 2015-09-10 Spinesmith Partners, L.P. Bone marrow aspiration device
US20190247027A1 (en) * 2016-10-24 2019-08-15 Yale University Aspiration device

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994005210A1 (fr) * 1992-09-09 1994-03-17 Symbiosis Corporation Biopsie coaxiale medullaire et aiguille d'aspiration
BRPI0416062A (pt) * 2003-10-30 2007-01-02 Praxcell dispositivo de retirada e/ou de injeção de medula óssea e sistema compreendendo tal dispositivo
US20140114285A1 (en) * 2012-10-23 2014-04-24 Spinesmith Partners, L.P. Bone marrow aspiration device
US20150250929A1 (en) * 2014-03-09 2015-09-10 Spinesmith Partners, L.P. Bone marrow aspiration device
US20190247027A1 (en) * 2016-10-24 2019-08-15 Yale University Aspiration device

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