WO2024030617A3 - Compositions and methods for improving cartilage formation - Google Patents
Compositions and methods for improving cartilage formation Download PDFInfo
- Publication number
- WO2024030617A3 WO2024030617A3 PCT/US2023/029495 US2023029495W WO2024030617A3 WO 2024030617 A3 WO2024030617 A3 WO 2024030617A3 US 2023029495 W US2023029495 W US 2023029495W WO 2024030617 A3 WO2024030617 A3 WO 2024030617A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- methods
- compositions
- cartilage formation
- improving
- improving cartilage
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 2
- 230000022159 cartilage development Effects 0.000 title 1
- 108010039627 Aprotinin Proteins 0.000 abstract 1
- 208000013201 Stress fracture Diseases 0.000 abstract 1
- 108090000190 Thrombin Proteins 0.000 abstract 1
- 102000004887 Transforming Growth Factor beta Human genes 0.000 abstract 1
- 108090001012 Transforming Growth Factor beta Proteins 0.000 abstract 1
- 229960004405 aprotinin Drugs 0.000 abstract 1
- 210000000845 cartilage Anatomy 0.000 abstract 1
- 230000003848 cartilage regeneration Effects 0.000 abstract 1
- NGOGFTYYXHNFQH-UHFFFAOYSA-N fasudil Chemical compound C=1C=CC2=CN=CC=C2C=1S(=O)(=O)N1CCCNCC1 NGOGFTYYXHNFQH-UHFFFAOYSA-N 0.000 abstract 1
- 229960002435 fasudil Drugs 0.000 abstract 1
- ZPNFWUPYTFPOJU-LPYSRVMUSA-N iniprol Chemical compound C([C@H]1C(=O)NCC(=O)NCC(=O)N[C@H]2CSSC[C@H]3C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(N[C@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC=4C=CC=CC=4)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC=4C=CC=CC=4)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC2=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]2N(CCC2)C(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N2[C@@H](CCC2)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N2[C@@H](CCC2)C(=O)N3)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@H](C(=O)N1)C(C)C)[C@@H](C)O)[C@@H](C)CC)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 ZPNFWUPYTFPOJU-LPYSRVMUSA-N 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 230000000638 stimulation Effects 0.000 abstract 1
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 abstract 1
- 229960004072 thrombin Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
Abstract
This disclosure contemplates methods of improving the growth of damaged cartilage. In certain embodiment, this disclosure relates to methods performing microfracture and applying components reported herein to provide marrow stimulation with improved cartilage regeneration. In certain embodiments, compositions and materials comprise fasudil optionally in combination with thrombin, aprotinin, and transforming growth factor-beta.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202263395416P | 2022-08-05 | 2022-08-05 | |
| US63/395,416 | 2022-08-05 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2024030617A2 WO2024030617A2 (en) | 2024-02-08 |
| WO2024030617A3 true WO2024030617A3 (en) | 2024-03-07 |
Family
ID=89849844
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US2023/029495 WO2024030617A2 (en) | 2022-08-05 | 2023-08-04 | Compositions and methods for improving cartilage formation |
Country Status (1)
| Country | Link |
|---|---|
| WO (1) | WO2024030617A2 (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050158301A1 (en) * | 2002-07-02 | 2005-07-21 | The Board Of Regents, The University Of Texas System | Thrombin peptide derivatives |
| US20110130388A1 (en) * | 2008-07-24 | 2011-06-02 | Yasushi Ikuno | Prophylactic or therapeutic agent for axial myopia |
| US20150374694A1 (en) * | 2013-02-22 | 2015-12-31 | Emory University | Tgf-beta enhancing compositions for cartilage repair and methods related thereto |
| US20180055887A1 (en) * | 2016-08-23 | 2018-03-01 | Academia Sinica | Method for preparing induced mesenchymal stem cells and improving mesenchymal stem cell's characters and its applications |
-
2023
- 2023-08-04 WO PCT/US2023/029495 patent/WO2024030617A2/en unknown
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050158301A1 (en) * | 2002-07-02 | 2005-07-21 | The Board Of Regents, The University Of Texas System | Thrombin peptide derivatives |
| US20110130388A1 (en) * | 2008-07-24 | 2011-06-02 | Yasushi Ikuno | Prophylactic or therapeutic agent for axial myopia |
| US20150374694A1 (en) * | 2013-02-22 | 2015-12-31 | Emory University | Tgf-beta enhancing compositions for cartilage repair and methods related thereto |
| US20180055887A1 (en) * | 2016-08-23 | 2018-03-01 | Academia Sinica | Method for preparing induced mesenchymal stem cells and improving mesenchymal stem cell's characters and its applications |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2024030617A2 (en) | 2024-02-08 |
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