WO2024019673A1 - Antibacterial nanomaterial - Google Patents
Antibacterial nanomaterial Download PDFInfo
- Publication number
- WO2024019673A1 WO2024019673A1 PCT/TR2022/051152 TR2022051152W WO2024019673A1 WO 2024019673 A1 WO2024019673 A1 WO 2024019673A1 TR 2022051152 W TR2022051152 W TR 2022051152W WO 2024019673 A1 WO2024019673 A1 WO 2024019673A1
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- WO
- WIPO (PCT)
- Prior art keywords
- antibacterial
- nano
- pvp
- tube
- immersion
- Prior art date
Links
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 22
- 239000002086 nanomaterial Substances 0.000 title claims description 8
- 239000000203 mixture Substances 0.000 claims abstract description 12
- 239000000126 substance Substances 0.000 claims abstract description 8
- 238000000034 method Methods 0.000 claims description 15
- SQGYOTSLMSWVJD-UHFFFAOYSA-N silver(1+) nitrate Chemical compound [Ag+].[O-]N(=O)=O SQGYOTSLMSWVJD-UHFFFAOYSA-N 0.000 claims description 12
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 8
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 8
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 8
- 239000012279 sodium borohydride Substances 0.000 claims description 7
- 229910000033 sodium borohydride Inorganic materials 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims description 6
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims description 6
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims description 6
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims description 6
- 239000005642 Oleic acid Substances 0.000 claims description 6
- 239000008367 deionised water Substances 0.000 claims description 6
- 229910021641 deionized water Inorganic materials 0.000 claims description 6
- 238000007654 immersion Methods 0.000 claims description 6
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims description 6
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims description 6
- 229910001961 silver nitrate Inorganic materials 0.000 claims description 6
- 238000005507 spraying Methods 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 230000008569 process Effects 0.000 claims description 4
- 230000002209 hydrophobic effect Effects 0.000 claims description 3
- 239000002105 nanoparticle Substances 0.000 claims description 3
- 239000004745 nonwoven fabric Substances 0.000 claims description 3
- 238000000576 coating method Methods 0.000 abstract description 5
- 230000000843 anti-fungal effect Effects 0.000 abstract description 4
- 239000011248 coating agent Substances 0.000 abstract description 4
- 238000009472 formulation Methods 0.000 abstract description 3
- 230000036541 health Effects 0.000 abstract description 3
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 10
- 238000011109 contamination Methods 0.000 description 9
- 235000016709 nutrition Nutrition 0.000 description 7
- 241000894006 Bacteria Species 0.000 description 6
- 244000005700 microbiome Species 0.000 description 6
- 230000035764 nutrition Effects 0.000 description 6
- 239000002245 particle Substances 0.000 description 5
- 229920002635 polyurethane Polymers 0.000 description 4
- 239000004814 polyurethane Substances 0.000 description 4
- 230000000694 effects Effects 0.000 description 3
- 210000003238 esophagus Anatomy 0.000 description 3
- 229920000915 polyvinyl chloride Polymers 0.000 description 3
- 239000004800 polyvinyl chloride Substances 0.000 description 3
- 229910052709 silver Inorganic materials 0.000 description 3
- 239000004332 silver Substances 0.000 description 3
- 210000002784 stomach Anatomy 0.000 description 3
- 206010012735 Diarrhoea Diseases 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 239000003638 chemical reducing agent Substances 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 230000002496 gastric effect Effects 0.000 description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 description 2
- 238000003780 insertion Methods 0.000 description 2
- 230000037431 insertion Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000011707 mineral Substances 0.000 description 2
- -1 polypropylene Polymers 0.000 description 2
- 229920001296 polysiloxane Polymers 0.000 description 2
- 230000000451 tissue damage Effects 0.000 description 2
- 231100000827 tissue damage Toxicity 0.000 description 2
- 206010000060 Abdominal distension Diseases 0.000 description 1
- 208000031729 Bacteremia Diseases 0.000 description 1
- ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical compound [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 description 1
- 206010063655 Erosive oesophagitis Diseases 0.000 description 1
- 208000005489 Esophageal Perforation Diseases 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 206010017865 Gastritis erosive Diseases 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- RJQXTJLFIWVMTO-TYNCELHUSA-N Methicillin Chemical compound COC1=CC=CC(OC)=C1C(=O)N[C@@H]1C(=O)N2[C@@H](C(O)=O)C(C)(C)S[C@@H]21 RJQXTJLFIWVMTO-TYNCELHUSA-N 0.000 description 1
- 206010030181 Oesophageal perforation Diseases 0.000 description 1
- 206010068319 Oropharyngeal pain Diseases 0.000 description 1
- 201000007100 Pharyngitis Diseases 0.000 description 1
- 206010035664 Pneumonia Diseases 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 238000005299 abrasion Methods 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 229940121375 antifungal agent Drugs 0.000 description 1
- 229910052796 boron Inorganic materials 0.000 description 1
- 210000003850 cellular structure Anatomy 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000006837 decompression Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000001647 drug administration Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 208000001780 epistaxis Diseases 0.000 description 1
- 210000000416 exudates and transudate Anatomy 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000007917 intracranial administration Methods 0.000 description 1
- 230000002262 irrigation Effects 0.000 description 1
- 238000003973 irrigation Methods 0.000 description 1
- 210000001630 jejunum Anatomy 0.000 description 1
- 239000004816 latex Substances 0.000 description 1
- 229920000126 latex Polymers 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 235000021073 macronutrients Nutrition 0.000 description 1
- 229960003085 meticillin Drugs 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 239000011785 micronutrient Substances 0.000 description 1
- 235000013369 micronutrients Nutrition 0.000 description 1
- 239000002103 nanocoating Substances 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 230000009965 odorless effect Effects 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000010412 perfusion Effects 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 230000002685 pulmonary effect Effects 0.000 description 1
- 230000003252 repetitive effect Effects 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 201000009890 sinusitis Diseases 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/08—Materials for coatings
- A61L29/085—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J15/00—Feeding-tubes for therapeutic purposes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
- A61L29/16—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
- A61L2300/104—Silver, e.g. silver sulfadiazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/12—Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces
Definitions
- the invention relates to a chemical formulation coating to be applied to health apparatus and products such as injectors, especially nasogastric tubes (NGT) to be used in the medical field, in other words to areas where antibacterial/antifungal effect is desired.
- injectors especially nasogastric tubes (NGT) to be used in the medical field, in other words to areas where antibacterial/antifungal effect is desired.
- NTT nasogastric tubes
- Enteral nutrition can be applied directly, with a tube, percutaneous interventions, or by surgical method to different parts of the system from the mouth to the jejunum.
- Enteral nutrition is the continuous or intermittent administration of macro and micronutrients to the patient by nasogastric or nasoenteric, gastrostomy, or jejunostomy in patients with a functional gastrointestinal (GI) system.
- GI gastrointestinal
- NTT nasogastric tube
- NET nasoenteric tube
- gastrostomy or jejunostomy is opened for long-term nutrition.
- Nasogastric tube is applied to hundreds of thousands of hospitalized patients every year for diagnostic, preventive, or therapeutic purposes as a complement to medical and surgical applications.
- Nasogastric tube (NGT) application is the insertion of a plastic catheter into the stomach by inserting it through the nostril and esophagus.
- Nasogastric tube application is an invasive application that is frequently used for enteral nutrition and concomitant drug administration, and stomach decompression and is under the responsibility of healthcare professionals. It is also used for irrigation and diagnostic applications of the stomach.
- NGTs are made of materials such as polypropylene, polyvinylchloride, latex, silicone, or polyurethane. Tubes made of polyvinylchloride are generally suitable for short-term feeding that will last less than seven days. Polyurethane tubes are especially suitable for enteral nutrition. These tubes are made of polyurethane, which can remain soft and flexible, which is a nonreactive substance. When tubes are used for long periods, they may cause esophageal and gastric erosions in patients. The polyvinyl chloride tubes should be replaced every three to five days, and the silicone or polyurethane tubes after eight weeks.
- Microorganisms such as methicillin-resistant Staphylococcus aureus (MRSA), which increase the mortality rate by 2-2.5 times, cause microbial colonization and contamination in NGT and these microorganisms use NGT as a reservoir.
- MRSA methicillin-resistant Staphylococcus aureus
- contamination of NGT with microorganisms leads to the development of many complications such as abdominal distension, bacteremia, diarrhea, pneumonia, and even death. Studies have shown that bacterial contamination develops 15 minutes after NGT placement; biofilm is formed in 60% of the tubes at the end of 24 hours and in all of them at the end of 48 hours, and the microorganisms that cause contamination on the outer surface of the NGT are also located inside the tube.
- Nano-silver particles are known to be used to eliminate undesirable microorganisms and to prevent contamination due to their effective and wide-spectrum antibacterial activities. Even bacteria and viruses remain giant structures alongside nano-silver particles, and as soon as they come into contact with nanosized (0-200 nm) silver particles, their cellular structures deteriorate and die. Nano-silver has been attracting the attention of the scientific community for many years due to its antibacterial potency and the inability of bacteria to develop resistance to antibiotics against silver. Because of its nanoscale, when silver particles are coated on the surface of any material, the surface area increases several million times, providing a very strong antibacterial effect.
- enteral nutrients are ideal environments for reproduction, and when contamination occurs, bacteria proliferate rapidly, and contamination of the gastrointestinal tract may lead to diarrhea.
- wipe the formula box opening cover with an alcoholic cloth change the bedside formula set and bag routinely every 24 hours, to re-prepare the nutritional formulas every four hours, and to store the open formulas in the refrigerator.
- the invention is described as “A nasogastric tube comprising at least one main lumen and at least one vacuum lumen comprising at least one suction port for sealing the inner wall of an esophagus against it, wherein the said at least one suction port includes a unique concave structure that significantly prevents tissue damage.”
- Small complications of NGTs of the present application include nosebleeds, sinusitis, and sore throat.
- the invention is a useful model, and discloses a nasogastric tube with a double tube cavity, including a perfusion tube cavity, wherein a guide wire tube cavity is provided in the tube body to guide the guide wire, the guide wire tube cavity end is a dead end, and the diameter of the pipe cavity of the guide wire is equivalent to that of the guide wire.
- the advantages of the nasogastric tube are as follows: 1 it reduces the possibility of infection contamination by effectively solving the problem of direct contact of guide wire and exudates in vivo; 2 it greatly enhances the strength of the nasogastric tube body to properly place and position the tube into the body by adjusting the diameter of the nasogastric tube equivalent to that of the guide wire, thus finishes the process once with insertion, avoids repetitive procedures, and reduces patients' pain.
- the present application is far from the solution we have presented.
- the present invention relates to an antibacterial nanomaterial-coated nasogastric tube developed to eliminate the above-mentioned disadvantages and to bring new advantages to the related technical field.
- the object of the invention is to provide an effective solution to show antibacterial/antifungal activity against pathogens on the surface of the NGT with the coating developed with the composition containing antibacterial/antifungal nano-silver ions.
- Nano-silver used in the invention does not harm human health, pets, or plants, in other words, multicellular organisms. During its function, nano-silver does not react in any way, is not deformed and the continuity in its function continues. In this way, the antibacterial effect will be provided on the surfaces contacted by NGTs without harming the living organisms, and thus, negative effects that may occur due to the presence of various bacteria during patient treatment will be eliminated.
- Another object of the invention is to expect the antibacterial cover to be applied on the nasogastric tube to show strong activity on different microorganisms such as both bacteria and fungi.
- the fact that it is odorless, stain-free, non-toxic, and washable is one of the innovations that the product will bring.
- “antibacterial coatings” will be obtained by using "Sol-Gel Coating” techniques, which is one of the most important applications of nano-coating technology.
- NGTs will provide an antibacterial effect in the patient treatment process.
- antibacterial effects will be provided on the surfaces contacted by the Nasogastric Tubes, thus, negative effects that may occur due to the presence of various bacteria during patient treatment will be eliminated.
- the nano solution which has been tested for antibacterial activity in accordance with the standards, will be coated directly on the nasogastric tubes with spray, immersion, and brush application techniques and dried.
- production can be carried out in series with a spraying method and subsequent effective drying phase in such a way that nasogastric tubes are homogeneously coated in a production line.
- Sodium borohydride is used for antibacterial nanomaterial-coated NGTs. This compound is made of boron mineral and one of the most important purposes of its use in this invention is that it is a strong reducing agent. Sodium borohydride is used in the range of 30-45% by weight. In this way, it can store hydrogen in nanostructures at the appropriate pressure and temperature ranges and easily store them. Polyvinylpyrrolidone (PVP) is then added to this composition. The nanoparticles prepared by using this will have a homogeneous distribution in the solution. There will be equal concentrations of nano-silver particles everywhere. PVP is added in the range of 0.5-4.0% by weight. 0.5-2.0% oleic acid by weight is also added to the composition.
- deionized water in the invention is that it is completely free of all organic, inorganic components and minerals within its framework.
- deionized water since deionized water has no taste, smell, color, and conductivity, it does not affect the chemicals or solutions it comes into contact with.
- the invention is a formulation applied to the antibacterial nanomaterial-coated nasogastric tube for use in the medical field; it comprises 30-45% Sodium Borohydride, 0.5-4% PVP, 0.5- 2% Oleic Acid, 30-35% Silver Nitrate, and 14-39% Deionized Water in the combination of the whole formula by weight.
- the production method of the invention comprises the process steps; - Dissolving all chemicals separately in deionized water,
- the maximum efficiency is 85 degrees and it can be preferred between 75-100 degrees.
- the nonwoven fabric used is hydrophobic and repels the existing water.
- the PVP and Sodium Borohydride used in the invention were used as reducing agents. While Silver Nitrate provides antibacterial properties, it acts as a stabilizer in oleic acid in the present invention.
Abstract
The invention relates to a chemical formulation coating to be applied to health apparatus and products such as injectors, especially nasogastric tubes (NGT) to be used in the medical field, in other words to areas where antibacterial/antifungal effect is desired.
Description
ANTIBACTERIAL NANOMATERIAL
TECHNICAL FIELD
The invention relates to a chemical formulation coating to be applied to health apparatus and products such as injectors, especially nasogastric tubes (NGT) to be used in the medical field, in other words to areas where antibacterial/antifungal effect is desired.
BACKGROUND
Enteral nutrition (EB) can be applied directly, with a tube, percutaneous interventions, or by surgical method to different parts of the system from the mouth to the jejunum. Enteral nutrition is the continuous or intermittent administration of macro and micronutrients to the patient by nasogastric or nasoenteric, gastrostomy, or jejunostomy in patients with a functional gastrointestinal (GI) system. While nasogastric tube (NGT) and nasoenteric tube (NET) are the most commonly used tools in short-term nutrition such as four to six weeks, gastrostomy or jejunostomy is opened for long-term nutrition.
Nasogastric tube (NGT) is applied to hundreds of thousands of hospitalized patients every year for diagnostic, preventive, or therapeutic purposes as a complement to medical and surgical applications. Nasogastric tube (NGT) application is the insertion of a plastic catheter into the stomach by inserting it through the nostril and esophagus. Nasogastric tube application is an invasive application that is frequently used for enteral nutrition and concomitant drug administration, and stomach decompression and is under the responsibility of healthcare professionals. It is also used for irrigation and diagnostic applications of the stomach.
Today, NGTs are made of materials such as polypropylene, polyvinylchloride, latex, silicone, or polyurethane. Tubes made of polyvinylchloride are generally suitable for short-term feeding that will last less than seven days. Polyurethane tubes are especially suitable for enteral nutrition. These tubes are made of polyurethane, which can remain soft and flexible, which is a nonreactive substance. When tubes are used for long periods, they may cause
esophageal and gastric erosions in patients. The polyvinyl chloride tubes should be replaced every three to five days, and the silicone or polyurethane tubes after eight weeks.
Microorganisms such as methicillin-resistant Staphylococcus aureus (MRSA), which increase the mortality rate by 2-2.5 times, cause microbial colonization and contamination in NGT and these microorganisms use NGT as a reservoir. Contamination of NGT with microorganisms leads to the development of many complications such as abdominal distension, bacteremia, diarrhea, pneumonia, and even death. Studies have shown that bacterial contamination develops 15 minutes after NGT placement; biofilm is formed in 60% of the tubes at the end of 24 hours and in all of them at the end of 48 hours, and the microorganisms that cause contamination on the outer surface of the NGT are also located inside the tube.
Nano-silver particles are known to be used to eliminate undesirable microorganisms and to prevent contamination due to their effective and wide-spectrum antibacterial activities. Even bacteria and viruses remain giant structures alongside nano-silver particles, and as soon as they come into contact with nanosized (0-200 nm) silver particles, their cellular structures deteriorate and die. Nano-silver has been attracting the attention of the scientific community for many years due to its antibacterial potency and the inability of bacteria to develop resistance to antibiotics against silver. Because of its nanoscale, when silver particles are coated on the surface of any material, the surface area increases several million times, providing a very strong antibacterial effect.
As mentioned above, enteral nutrients are ideal environments for reproduction, and when contamination occurs, bacteria proliferate rapidly, and contamination of the gastrointestinal tract may lead to diarrhea. In order to prevent bacterial contamination in patients who are fed enterally, it is recommended to follow hand hygiene, wipe the formula box opening cover with an alcoholic cloth, change the bedside formula set and bag routinely every 24 hours, to re-prepare the nutritional formulas every four hours, and to store the open formulas in the refrigerator. However, all of these are insufficient in solving the problems in the art.
In document numbered “US10695269B2”, the invention is described as “A nasogastric tube comprising at least one main lumen and at least one vacuum lumen comprising at least one suction port for sealing the inner wall of an esophagus against it, wherein the said at least one suction port includes a unique concave structure that significantly prevents tissue damage.”
Small complications of NGTs of the present application include nosebleeds, sinusitis, and sore throat. Sometimes, the emergence of more important complications such as abrasion, esophageal perforation, pulmonary aspiration, intracranial placement of a collapsed lung or tube in the nose where the tube is fixed has addressed the technical problem and it is claimed that there is a need for improved NGTs with suction ports that can pull the inner wall of an esophagus towards themselves without causing tissue damage due to the applied suction force. Therefore, it is far from our current technical problem and the solution we offer.
In the document numbered “CN201329127Y”, the invention is a useful model, and discloses a nasogastric tube with a double tube cavity, including a perfusion tube cavity, wherein a guide wire tube cavity is provided in the tube body to guide the guide wire, the guide wire tube cavity end is a dead end, and the diameter of the pipe cavity of the guide wire is equivalent to that of the guide wire. The advantages of the nasogastric tube are as follows: 1 it reduces the possibility of infection contamination by effectively solving the problem of direct contact of guide wire and exudates in vivo; 2 it greatly enhances the strength of the nasogastric tube body to properly place and position the tube into the body by adjusting the diameter of the nasogastric tube equivalent to that of the guide wire, thus finishes the process once with insertion, avoids repetitive procedures, and reduces patients' pain. However, the present application is far from the solution we have presented.
As a result, the need to eliminate the deficiencies and disadvantages of the embodiments and applications that exist in the current art and are used today makes it necessary to improve in the relevant technical field.
DESCRIPTION OF THE INVENTION
The present invention relates to an antibacterial nanomaterial-coated nasogastric tube developed to eliminate the above-mentioned disadvantages and to bring new advantages to the related technical field.
The object of the invention is to provide an effective solution to show antibacterial/antifungal activity against pathogens on the surface of the NGT with the coating developed with the composition containing antibacterial/antifungal nano-silver ions.
Nano-silver used in the invention does not harm human health, pets, or plants, in other words, multicellular organisms. During its function, nano-silver does not react in any way, is not deformed and the continuity in its function continues. In this way, the antibacterial effect will be provided on the surfaces contacted by NGTs without harming the living organisms, and thus, negative effects that may occur due to the presence of various bacteria during patient treatment will be eliminated.
Another object of the invention is to expect the antibacterial cover to be applied on the nasogastric tube to show strong activity on different microorganisms such as both bacteria and fungi. At the same time, the fact that it is odorless, stain-free, non-toxic, and washable is one of the innovations that the product will bring. With this study, "antibacterial coatings" will be obtained by using "Sol-Gel Coating" techniques, which is one of the most important applications of nano-coating technology.
Thanks to this invention, currently used NGTs will provide an antibacterial effect in the patient treatment process. In this way, antibacterial effects will be provided on the surfaces contacted by the Nasogastric Tubes, thus, negative effects that may occur due to the presence of various bacteria during patient treatment will be eliminated.
DETAILED DESCRIPTION OF THE INVENTION
In this detailed description, the preferred alternatives of the embodiment of the present invention are merely explained for a better understanding of the subject of the present invention, which is not intended to be limiting in any way.
The nano solution, which has been tested for antibacterial activity in accordance with the standards, will be coated directly on the nasogastric tubes with spray, immersion, and brush application techniques and dried. For industrial applications, production can be carried out in series with a spraying method and subsequent effective drying phase in such a way that nasogastric tubes are homogeneously coated in a production line.
Sodium borohydride is used for antibacterial nanomaterial-coated NGTs. This compound is made of boron mineral and one of the most important purposes of its use in this invention is
that it is a strong reducing agent. Sodium borohydride is used in the range of 30-45% by weight. In this way, it can store hydrogen in nanostructures at the appropriate pressure and temperature ranges and easily store them. Polyvinylpyrrolidone (PVP) is then added to this composition. The nanoparticles prepared by using this will have a homogeneous distribution in the solution. There will be equal concentrations of nano-silver particles everywhere. PVP is added in the range of 0.5-4.0% by weight. 0.5-2.0% oleic acid by weight is also added to the composition. With this addition, moisture is provided on the surface in the nano-silver solution. In addition, for antibacterial activity as the most important main compound, silver nitrate, which will be reduced to the nano-size, is added between 30-35% by weight and the nano solution is prepared. The nanosized solution, which is mixed with a mechanical stirrer for 24 hours in an extremely homogeneous manner, is applied on NGTs by spraying, immersion, and brush application methods and allowed to dry. (Parts 1 and 2).
The reason for using deionized water in the invention is that it is completely free of all organic, inorganic components and minerals within its framework. In addition, since deionized water has no taste, smell, color, and conductivity, it does not affect the chemicals or solutions it comes into contact with.
The invention is a formulation applied to the antibacterial nanomaterial-coated nasogastric tube for use in the medical field; it comprises 30-45% Sodium Borohydride, 0.5-4% PVP, 0.5- 2% Oleic Acid, 30-35% Silver Nitrate, and 14-39% Deionized Water in the combination of the whole formula by weight.
The production method of the invention comprises the process steps;
- Dissolving all chemicals separately in deionized water,
- Adding PVP (Polyvinylpyrrolidone) to Sodium Borohydride,
- Adding oleic acid to the resulting chemical mixture,
- Adding silver nitrate to the resulting mixture,
- Mixing the resulting mixture homogeneously preferably with a mechanical stirrer for 24 hours,
- Applying the nano-sized solution on the apparatus to be directly applied by spraying or immersion or brush application methods or preferably on a hydrophobic nonwoven fabric by immersion, spraying or brush application methods,
- Allowing the applied process to dry preferably at 75-100 degrees in the oven.
From the temperature values used in the invention, the maximum efficiency is 85 degrees and it can be preferred between 75-100 degrees.
The nonwoven fabric used is hydrophobic and repels the existing water.
The PVP and Sodium Borohydride used in the invention were used as reducing agents. While Silver Nitrate provides antibacterial properties, it acts as a stabilizer in oleic acid in the present invention.
Claims
CLAIMS Antibacterial nanomaterials for use in the medical field, characterized in that it comprises 30-45% Sodium Borohydride, 0.5-4% PVP, 0.5-2% Oleic Acid, 30-35% Silver Nitrate, and 14-39% Deionized Water by weight in the combination of the whole formula. A method for producing the antibacterial nanomaterial for use in the medical field, characterized in that it comprises the process steps;
- Dissolving all chemicals separately in deionized water,
- Adding PVP (Polyvinylpyrrolidone) to Sodium Borohydride,
- Adding oleic acid to the resulting chemical mixture,
- Adding silver nitrate to the resulting mixture,
- Mixing the resulting mixture homogeneously preferably with a mechanical stirrer for 24 hours,
- Applying the nano-sized solution on the apparatus to be directly applied by spraying or immersion or brush application methods or preferably on a hydrophobic nonwoven fabric by immersion, spraying or brush application methods,
- Allowing the applied process to dry preferably at 75-100 degrees in the oven.
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TR2022/011677 | 2022-07-21 | ||
TR2022/011677A TR2022011677A2 (en) | 2022-07-21 | 2022-07-21 | ANTIBACTERIAL NANO MATERIAL |
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WO (1) | WO2024019673A1 (en) |
Citations (3)
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CN1266761A (en) * | 2000-03-23 | 2000-09-20 | 南京大学 | Process for preparing nm-class silver powder |
CN101731272A (en) * | 2009-12-24 | 2010-06-16 | 中国人民解放军军事医学科学院基础医学研究所 | Method for preparing antibacterial nanometer silver colloid |
CN114734049A (en) * | 2022-03-14 | 2022-07-12 | 上海大学 | Method for preparing ultra-small nano silver by using sodium borohydride |
-
2022
- 2022-07-21 TR TR2022/011677A patent/TR2022011677A2/en unknown
- 2022-10-18 WO PCT/TR2022/051152 patent/WO2024019673A1/en unknown
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
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CN1266761A (en) * | 2000-03-23 | 2000-09-20 | 南京大学 | Process for preparing nm-class silver powder |
CN101731272A (en) * | 2009-12-24 | 2010-06-16 | 中国人民解放军军事医学科学院基础医学研究所 | Method for preparing antibacterial nanometer silver colloid |
CN114734049A (en) * | 2022-03-14 | 2022-07-12 | 上海大学 | Method for preparing ultra-small nano silver by using sodium borohydride |
Non-Patent Citations (1)
Title |
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ALMATROUDI, A.: "Silver nanoparticles: synthesis, characterisation and biomedical applications", OPEN LIFE SCIENCES, vol. 15, no. 1, 19 November 2020 (2020-11-19), pages 819 - 839, XP093132917 * |
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