WO2023215407A3 - Di-isopropyl-phosphinoyl-alkanes as topical agents for the treatment of eye diseases - Google Patents

Di-isopropyl-phosphinoyl-alkanes as topical agents for the treatment of eye diseases Download PDF

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Publication number
WO2023215407A3
WO2023215407A3 PCT/US2023/020878 US2023020878W WO2023215407A3 WO 2023215407 A3 WO2023215407 A3 WO 2023215407A3 US 2023020878 W US2023020878 W US 2023020878W WO 2023215407 A3 WO2023215407 A3 WO 2023215407A3
Authority
WO
WIPO (PCT)
Prior art keywords
dipa
phosphinoyl
isopropyl
treatment
eye diseases
Prior art date
Application number
PCT/US2023/020878
Other languages
French (fr)
Other versions
WO2023215407A2 (en
Inventor
Edward Wei
Original Assignee
Iview Therapeutics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US17/803,311 external-priority patent/US20220265687A1/en
Application filed by Iview Therapeutics, Inc. filed Critical Iview Therapeutics, Inc.
Publication of WO2023215407A2 publication Critical patent/WO2023215407A2/en
Publication of WO2023215407A3 publication Critical patent/WO2023215407A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)

Abstract

The present invention pertains to a method for treating an eye disease in a subject in need of such a treatment. The method includes administering to the subject a composition comprising a therapeutically effective amount of a 1-di-isopropyl-phosphinoyl-alkane (DIPA) compound. The DIPA compound is a compound selected from DIPA-1-7, DIPA-1-8, and DIPA-1-9. The eye diseases include blepharitis and conjunctivitis.
PCT/US2023/020878 2022-05-03 2023-05-26 Di-isopropyl-phosphinoyl-alkanes as topical agents for the treatment of eye diseases WO2023215407A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17/803,311 2022-05-03
US17/803,311 US20220265687A1 (en) 2018-11-30 2022-05-03 Di-Isopropyl-Phosphinoyl -Alkanes as topical agents for the treatment of sensory discomfort

Publications (2)

Publication Number Publication Date
WO2023215407A2 WO2023215407A2 (en) 2023-11-09
WO2023215407A3 true WO2023215407A3 (en) 2024-02-08

Family

ID=88647000

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2023/020878 WO2023215407A2 (en) 2022-05-03 2023-05-26 Di-isopropyl-phosphinoyl-alkanes as topical agents for the treatment of eye diseases

Country Status (1)

Country Link
WO (1) WO2023215407A2 (en)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20180126908A (en) * 2017-05-19 2018-11-28 에드워드 택 웨이 Method for Increasing Light Reflectance from the Eyes
US20190105335A1 (en) * 2014-12-29 2019-04-11 Edward T. Wei Di-isopropyl-phosphinoyl-alkanes as topical agents for the treatment of sensory discomfort
US20210059998A1 (en) * 2014-06-24 2021-03-04 Sydnexis, Inc. Ophthalmic composition
WO2022150730A1 (en) * 2021-01-11 2022-07-14 Iview Therapeutics, Inc. Treatment of neuropathic sensitization disorders
US20220265687A1 (en) * 2018-11-30 2022-08-25 Edward T. Wei Di-Isopropyl-Phosphinoyl -Alkanes as topical agents for the treatment of sensory discomfort

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20210059998A1 (en) * 2014-06-24 2021-03-04 Sydnexis, Inc. Ophthalmic composition
US20190105335A1 (en) * 2014-12-29 2019-04-11 Edward T. Wei Di-isopropyl-phosphinoyl-alkanes as topical agents for the treatment of sensory discomfort
KR20180126908A (en) * 2017-05-19 2018-11-28 에드워드 택 웨이 Method for Increasing Light Reflectance from the Eyes
US20220265687A1 (en) * 2018-11-30 2022-08-25 Edward T. Wei Di-Isopropyl-Phosphinoyl -Alkanes as topical agents for the treatment of sensory discomfort
WO2022150730A1 (en) * 2021-01-11 2022-07-14 Iview Therapeutics, Inc. Treatment of neuropathic sensitization disorders

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DATABASE PUBCHEM SUBSTANCE ANONYMOUS : "1-diisopropylphosphorylheptane", XP093137393, retrieved from PUBCHEM *

Also Published As

Publication number Publication date
WO2023215407A2 (en) 2023-11-09

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