WO2023177841A3 - Combination products to mitigate misuse of central nervous system stimulants - Google Patents
Combination products to mitigate misuse of central nervous system stimulants Download PDFInfo
- Publication number
- WO2023177841A3 WO2023177841A3 PCT/US2023/015455 US2023015455W WO2023177841A3 WO 2023177841 A3 WO2023177841 A3 WO 2023177841A3 US 2023015455 W US2023015455 W US 2023015455W WO 2023177841 A3 WO2023177841 A3 WO 2023177841A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- misuse
- effective amount
- mitigate
- nervous system
- combination products
- Prior art date
Links
- 239000002269 analeptic agent Substances 0.000 title 1
- 229940079593 drug Drugs 0.000 abstract 5
- 239000003814 drug Substances 0.000 abstract 5
- 238000002483 medication Methods 0.000 abstract 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 3
- 239000003187 aldehyde dehydrogenase inhibitor Substances 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 2
- 239000013066 combination product Substances 0.000 abstract 1
- 229940127555 combination product Drugs 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000000047 product Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/145—Amines having sulfur, e.g. thiurams (>N—C(S)—S—C(S)—N< and >N—C(S)—S—S—C(S)—N<), Sulfinylamines (—N=SO), Sulfonylamines (—N=SO2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
Abstract
A method is provided for reducing concurrent use of stimulant medications and alcohol. In an example, the method comprises administering to the subject a combination product that includes an effective amount of one or more stimulant medications, and an effective amount of one or more aldehyde dehydrogenase inhibitors (ALDIs), to provide the desired effects of the stimulant medication in conjunction with a substance that prevents or deters concurrent alcohol consumption, thereby reducing misuse of stimulant medications in combination with alcohol. Also disclosed are the combination products that include the effective amount of one or more stimulant medications and the effective amount of one or more ALDIs.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202263321221P | 2022-03-18 | 2022-03-18 | |
US63/321,221 | 2022-03-18 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2023177841A2 WO2023177841A2 (en) | 2023-09-21 |
WO2023177841A3 true WO2023177841A3 (en) | 2023-10-19 |
Family
ID=88024197
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2023/015455 WO2023177841A2 (en) | 2022-03-18 | 2023-03-17 | Combination products to mitigate misuse of central nervous system stimulants |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2023177841A2 (en) |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20090281112A1 (en) * | 2008-05-08 | 2009-11-12 | Fabre-Kramer Pharmaceuticals, Inc. | Adatanserin and metabolites thereof for treatment of attention deficit disorder, anxiety, depression, sexual dysfunction, and other disorders |
US20100291205A1 (en) * | 2007-01-16 | 2010-11-18 | Egalet A/S | Pharmaceutical compositions and methods for mitigating risk of alcohol induced dose dumping or drug abuse |
US20160213628A1 (en) * | 2013-09-09 | 2016-07-28 | Nova Southeastern University | Deterring abuse of pharmaceutical products and alcohol |
US20190231719A1 (en) * | 2018-01-26 | 2019-08-01 | Michael Presti | Combination treatments for opioid crisis |
-
2023
- 2023-03-17 WO PCT/US2023/015455 patent/WO2023177841A2/en unknown
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20100291205A1 (en) * | 2007-01-16 | 2010-11-18 | Egalet A/S | Pharmaceutical compositions and methods for mitigating risk of alcohol induced dose dumping or drug abuse |
US20090281112A1 (en) * | 2008-05-08 | 2009-11-12 | Fabre-Kramer Pharmaceuticals, Inc. | Adatanserin and metabolites thereof for treatment of attention deficit disorder, anxiety, depression, sexual dysfunction, and other disorders |
US20160213628A1 (en) * | 2013-09-09 | 2016-07-28 | Nova Southeastern University | Deterring abuse of pharmaceutical products and alcohol |
US20190231719A1 (en) * | 2018-01-26 | 2019-08-01 | Michael Presti | Combination treatments for opioid crisis |
Also Published As
Publication number | Publication date |
---|---|
WO2023177841A2 (en) | 2023-09-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Brideau et al. | The effects of phosphodiesterase type 4 inhibitors on tumour necrosis factor‐α and leukotriene B4 in a novel human whole blood assay | |
Dehesa et al. | Treatment of inflammatory nail disorders | |
Song et al. | Involvement of miR-Let7A in inflammatory response and cell survival/apoptosis regulated by resveratrol in THP-1 macrophage | |
McAlindon et al. | Nutritional factors and osteoarthritis: recent developments | |
Kato et al. | Metformin attenuates production of nitric oxide in response to lipopolysaccharide by inhibiting MyD88-independent pathway | |
AU2021469614A1 (en) | Use of composition comprising astilbin and/or isomer thereof in preparation of drug for treating psoriasis | |
Prachanpanich et al. | A comparison of dexmedetomidine and propofol in Patients undergoing electrophysiology study | |
Kelly et al. | Do withdrawal-like symptoms mediate increased marijuana smoking in individuals treated with venlafaxine-XR? | |
WO2023177841A3 (en) | Combination products to mitigate misuse of central nervous system stimulants | |
Penning et al. | Caffeinated drinks, alcohol consumption, and hangover severity | |
Congiu et al. | N-acylethanolamine acid amidase inhibition potentiates morphine analgesia and delays the development of tolerance | |
Hashimoto et al. | Prurigo successfully treated with duloxetine hydrochloride | |
Borja-Oliveira | Alcohol-medication interactions: the acetaldehyde syndrome | |
Ghisalberti et al. | Soft TCPTP Agonism—Novel Target to Rescue Airway Epithelial Integrity by Exogenous Spermidine | |
MX2020007860A (en) | Combination treatments for opioid crisis. | |
Davicino et al. | Different activities of Schinus areira L.: anti-inflammatory or pro-inflammatory effect | |
Nofal et al. | Low‐dose oral isotretinoin for the treatment of warts: A controversial issue. | |
ALSUntangled Group | ALSUntangled no. 16: cannabis | |
Zhang et al. | Metformin induction of fetal hemoglobin | |
Gurguis et al. | Echocardiographic Findings in Patients (pts) Receiving Tyrosine Kinase Inhibitors (TKIs) for the Treatment of Chronic Myeloid Leukemia (CML) | |
Guliani et al. | Type 2 diabetic female with vildagliptin associated eczematous eruption | |
Chen et al. | Ashwagandha and Its Active Ingredient, Withanolide A, Increase Phosphorylation of TrkB in Cultured Hippocampal Neurons | |
Choi et al. | Carbon monoxide-releasing molecule-401, a water-soluble manganese-based metal carbonyl, suppresses Prevotella intermedia lipopolysaccharide-induced production of nitric oxide in murine macrophages | |
Luo et al. | De-Escalation or Discontinuation of TKI in Patients with Chronic Myeloid Leukemia: a Multicentral, Open-Lable, Prospective Trial in China | |
Ferng et al. | RNA Polymerase II Is a Therapeutic Target to Overcome FLT3 Inhibitor Resistance Mediated By the Bone Marrow Microenvironment |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 23771436 Country of ref document: EP Kind code of ref document: A2 |