WO2023159678A1 - Non-invasive renal sympathetic nerve activity detection system and method - Google Patents
Non-invasive renal sympathetic nerve activity detection system and method Download PDFInfo
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- WO2023159678A1 WO2023159678A1 PCT/CN2022/079974 CN2022079974W WO2023159678A1 WO 2023159678 A1 WO2023159678 A1 WO 2023159678A1 CN 2022079974 W CN2022079974 W CN 2022079974W WO 2023159678 A1 WO2023159678 A1 WO 2023159678A1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/06—Measuring blood flow
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/44—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device
- A61B8/4483—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device characterised by features of the ultrasound transducer
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/48—Diagnostic techniques
- A61B8/488—Diagnostic techniques involving Doppler signals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/52—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/5215—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves involving processing of medical diagnostic data
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/54—Control of the diagnostic device
Definitions
- the invention relates to the technical field of medical detection, in particular to a noninvasive renal sympathetic nerve activity detection system and method.
- the visceral motor nervous system regulates visceral and cardiovascular movements and glandular secretions, and is usually not dominated and controlled by the will. It is called the autonomic nervous system, including sympathetic and parasympathetic nerves.
- the renal sympathetic nerve is an important part of the autonomic nervous system and plays an important role in the regulation of autonomic nervous balance. Its excessive activation is one of the important mechanisms for the occurrence and development of various cardiovascular diseases such as hypertension, heart failure, and arrhythmia. .
- Renal sympathetic denervation blocks renal sympathetic nerves and reduces the activity of the sympathetic nervous system, thereby promoting autonomic rebalancing and lowering blood pressure. It is considered to be an important means of treating resistant hypertension.
- the primary problem currently existing in the treatment of hypertension by RDN surgery is that a considerable number of patients have no significant improvement in blood pressure after RDN surgery. Reliable criteria need to be found to select the beneficiaries of RDN surgery, and the ablation effect can be judged immediately during the operation.
- the current detection methods based on electrical stimulation have poor penetration, need to use electrodes to directly contact the nerve, and cannot perform non-contact deep stimulation, and the renal sympathetic nerve is located in the deep part, which can usually only be used during surgery or minimally invasive intervention; and the nerve Activity evaluation indicators are usually invasive femoral artery blood pressure, routine measurement of blood pressure and heart rate, which reflect the overall sympathetic nervous system activity, but can only indirectly represent the activity of renal sympathetic nerve, and the accuracy is poor.
- the renal sympathetic nerve detection technology based on the blood component detection device is also minimally invasive and interventional. The blood component detection device needs to be placed in the renal artery, and the stimulation device is also invasive, and the blood component changes have a hysteresis.
- the current detection method of renal sympathetic nerve activity has certain limitations, and an effective detection method and device for local activity of renal sympathetic nerve is urgently needed.
- the present application provides a noninvasive renal sympathetic nerve activity detection system and method.
- a non-invasive renal sympathetic nerve activity detection system including an ultrasound transmitting module, an ultrasound dual-function transducer, an ultrasound receiving module, an imaging module, a parameter measurement module, an evaluation module and a control module, wherein:
- the ultrasonic transmitting module is used to generate a first pulse transmitting signal and a second pulse transmitting signal, the first pulse transmitting signal is used for imaging, the second pulse transmitting signal is used to stimulate the detection site, and the first pulse transmitting signal
- the energy of a pulse transmission signal is lower than that of the second pulse transmission signal, and the pulse of the first pulse transmission signal is shorter than the pulse of the second pulse transmission signal;
- the ultrasonic dual-function transducer is used to convert the pulsed transmission signal generated by the ultrasonic transmission module into an acoustic signal within the preset ultrasonic frequency range, and to convert the acoustic signal in the external sound field into an electrical signal;
- the ultrasonic receiving module is configured to receive an ultrasonic echo signal corresponding to the ultrasonic transmitting signal, and convert the ultrasonic echo signal into a digital signal;
- the imaging module is used to perform ultrasonic imaging according to the digital signal to obtain a detection image
- the parameter measurement module is used to measure the ultrasonic parameter change value caused by stimulation based on the detection image
- the evaluation module is configured to evaluate the activity of renal sympathetic nerves based on the change value of the ultrasonic parameter, and obtain an evaluation result;
- the control module is used to receive and compile control instructions through the human-computer interaction interface, and transmit the control instructions to corresponding modules so that the modules can realize corresponding control functions.
- a non-invasive renal sympathetic nerve activity detection method which is applied to a non-invasive renal sympathetic nerve activity detection system, and the non-invasive renal sympathetic nerve activity detection system includes an ultrasonic transmitting module, an ultrasonic dual-function transducer, and an ultrasonic receiving module , an imaging module, a parameter measurement module, an evaluation module and a control module; the method includes:
- the ultrasonic transmitting module generates a first pulse transmitting signal and a second pulse transmitting signal, the first pulse transmitting signal is used for imaging, the second pulse transmitting signal is used to stimulate the detection site, and the first pulse transmitting signal
- the energy of the signal is lower than that of the second pulsed transmission signal, and the pulse of the first pulsed transmission signal is shorter than the pulse of the second pulsed transmission signal;
- the ultrasonic dual-function transducer converts the pulsed emission signal generated by the ultrasonic emission module into an acoustic signal within the preset ultrasonic frequency range, and converts the acoustic signal in the external sound field into an electrical signal;
- the ultrasonic receiving module receives the ultrasonic echo signal corresponding to the ultrasonic transmission signal, and converts the ultrasonic echo signal into a digital signal;
- the imaging module performs ultrasonic imaging according to the digital signal to obtain a detection image
- the parameter measurement module measures the ultrasonic parameter change value caused by the stimulus based on the detection image
- the evaluation module evaluates the activity of the renal sympathetic nerve based on the change value of the ultrasonic parameter, and obtains an evaluation result.
- an electronic device including a memory and a processor, the memory stores a computer program, and when the computer program is executed by the processor, the processor performs the process described in the first aspect and any of the above. Steps of one possible implementation.
- a computer storage medium stores one or more instructions, and the one or more instructions are suitable for being loaded and executed by a processor as described in the above first aspect and any one thereof. Steps for a possible implementation.
- the non-invasive renal sympathetic nerve activity detection system includes an ultrasonic transmitting module, an ultrasonic dual-function transducer, an ultrasonic receiving module, an imaging module, a parameter measurement module, an evaluation module and a control module, wherein: the ultrasonic transmitting module , used to generate a first pulse emission signal and a second pulse emission signal, the first pulse emission signal is used for imaging, the second pulse emission signal is used to stimulate the detection site, the first pulse emission signal The energy is lower than the second pulse transmission signal, and the pulse of the first pulse transmission signal is shorter than the pulse of the second pulse transmission signal; the ultrasonic dual-function transducer is used to operate within the preset ultrasonic frequency range Convert the pulse transmission signal generated by the ultrasonic transmission module into an acoustic signal, and convert the acoustic signal in the external sound field into an electrical signal; the ultrasonic receiving module is used to receive the ultrasonic echo corresponding to the ultrasonic transmission signal signal, converting the ultrasonic echo signal into a
- the beneficial effect of the technical solution of the present application is that the mechanical effect of ultrasound can be used for non-invasive deep nerve stimulation, and the wave effect of ultrasound can be used for imaging, and information such as various parameters before and after stimulation can be obtained to non-invasively evaluate the activity of the renal sympathetic nerve of the subject.
- the mechanical effect of ultrasound can be used for non-invasive deep nerve stimulation
- the wave effect of ultrasound can be used for imaging, and information such as various parameters before and after stimulation can be obtained to non-invasively evaluate the activity of the renal sympathetic nerve of the subject.
- direct detection of the local response at the stimulation site as a new evaluation index of renal sympathetic nerve activity is more accurate and effective than indicators that characterize the overall sympathetic system response such as blood pressure and heart rate variability.
- FIG. 1 is a schematic structural diagram of a non-invasive renal sympathetic nerve activity detection system provided in an embodiment of the present application
- FIG. 2 is a schematic diagram of an ultrasound-stimulated renal sympathetic nerve region provided in an embodiment of the present application
- FIG. 3 is a schematic diagram of a signal transmission sequence of an ultrasonic transmission module provided in an embodiment of the present application
- Fig. 4A is a schematic diagram of a renal artery B-mode image provided in the embodiment of the present application.
- Fig. 4B is a schematic diagram of a renal artery Doppler blood flow image provided in the embodiment of the present application.
- Fig. 5 is a structural and functional schematic diagram of a non-invasive renal sympathetic nerve activity detection system provided by the embodiment of the present application.
- Fig. 6 is a schematic flow chart of a non-invasive renal sympathetic nerve activity detection method provided in the embodiment of the present application.
- FIG. 7 is a schematic structural diagram of an electronic device provided by an embodiment of the present application.
- the ultrasonic waves involved in the embodiments of this application are mechanical waves propagating in elastic media (biological tissues), and have complex acoustic effects such as wave effects, thermal effects, and mechanical effects. They have deep penetrating power, good spatial directivity, and can Advantages such as dynamic focus scanning are widely used in the medical field.
- ultrasonic diagnostic imaging technology mainly uses its wave effect
- high-intensity focused ultrasound therapy technology mainly uses its thermal effect.
- the nonlinear effect of ultrasound makes the medium (nerve) in the sound field subject to radiation force.
- FIG. 1 is a schematic structural diagram of a non-invasive renal sympathetic nerve activity detection system provided in an embodiment of the present application.
- the non-invasive renal sympathetic nerve activity detection system 100 includes an ultrasound transmitting module 110, an ultrasound dual-function transducer 120, an ultrasound receiving module 130, an imaging module 140, a parameter measurement module 150, an evaluation module 160 and a control module 170 ,in:
- the ultrasonic transmitting module 110 is configured to generate a first pulse transmitting signal and a second pulse transmitting signal, the first pulse transmitting signal is used for imaging, and the second pulse transmitting signal is used to stimulate the detection site, the The energy of the first pulse transmission signal is lower than that of the second pulse transmission signal, and the pulse of the first pulse transmission signal is shorter than the pulse of the second pulse transmission signal;
- the ultrasonic dual-function transducer 120 is used to convert the pulsed emission signal generated by the ultrasonic emission module 110 into an acoustic signal within the preset ultrasonic frequency range, and to convert the acoustic signal in the external sound field into an electrical signal ;
- the ultrasonic receiving module 130 is configured to receive an ultrasonic echo signal corresponding to the ultrasonic transmitting signal generated by the ultrasonic transmitting module 110, and convert the ultrasonic echo signal into a digital signal;
- the above-mentioned imaging module 140 is used for performing ultrasonic imaging according to the above-mentioned digital signal to obtain a detection image
- the above-mentioned parameter measurement module 150 is used for measuring the change value of the ultrasonic parameter caused by the stimulation based on the above-mentioned detection image;
- the evaluation module 160 is configured to evaluate the renal sympathetic nerve activity based on the above ultrasound parameters, and obtain an evaluation result;
- the above-mentioned control module 170 is configured to receive and compile the control instructions through the human-computer interaction interface, and transmit the above-mentioned control instructions to corresponding modules so that the above-mentioned modules can realize corresponding control functions.
- a non-invasive renal sympathetic nerve activity detection system which utilizes the unique acoustic characteristics and biophysical effects of ultrasound, that is, the ultrasound transmitting module 110 can generate the first pulse transmission signal, and utilize the wave effect of ultrasound Perform imaging; the ultrasound transmitting module 110 can also generate a second pulse transmission signal, and use the mechanical effect of ultrasound to stimulate nerves, so that various parameters and information before and after stimulation can be obtained, and the activity of the renal sympathetic nerve of the subject can be evaluated non-invasively.
- Fig. 2 is a schematic diagram of an ultrasonic stimulation of the renal sympathetic nerve area provided by the embodiment of the present application. As shown in Figure 2, the ultrasonic emission pulses are electronically focused and act on the specific stimulation target area of the renal artery.
- the above-mentioned imaging module 140 can realize multi-mode imaging through the combination of software and hardware, and can perform ultrasonic grayscale imaging and hemodynamic parameter imaging, including but not limited to ultrasonic B-Mode imaging, Doppler blood flow imaging and blood flow vector imaging Functions, etc., are not limited in this embodiment of the present application.
- the B-Mode imaging in the embodiment of this application is also called B-ultrasound, which is to read in the received echo data, after signal modulation and low-pass filtering, data extraction, data logarithmic enhancement, and data line Rearrangement, interpolation reconstruction, etc. complete the reconstruction process of ultrasound imaging.
- the above-mentioned Doppler blood flow imaging is mainly that the received Doppler echo signal is phase-detected by a frequency mixing circuit and a low-pass filter, and then sent all the way to the processing circuit for spectrum analysis to display the Doppler spectrum; All the way to the computer circuit to get color Doppler blood flow information.
- an MTI filter can be used.
- the ultrasonic Doppler signal passed through the MTI filter enters the autocorrelation processor for autocorrelation processing, and the average velocity, dispersion and power calculation are performed respectively to obtain the color Doppler signal.
- DSC digital scan conversion unit
- D/A digital-to-analog conversion
- different imaging methods can be selected according to needs, for example: one method uses B-ultrasound image spots to track the movement of blood scatterers; the other is based on traditional one-dimensional Doppler technology, By transmitting or receiving echo signals from different directions, the blood flow velocity is estimated from two directions, and the final blood flow vector is synthesized by using triangular vectors.
- the ultrasonic dual-function transducer 120 in the embodiment of the present application is an energy conversion device that converts an alternating electrical signal into an acoustic signal or converts an acoustic signal in an external sound field into an electrical signal within a preset ultrasonic frequency range. It has two modes of imaging and stimulation.
- the ultrasonic transmitting module 110 can generate two high-voltage pulsed transmitting signals (imaging and stimulation) to drive the ultrasonic dual-function transducer 120; the ultrasonic receiving module 130 is mainly used to receive ultrasonic echo signals and convert them into digital signals for imaging.
- the aforementioned imaging module 140 can be used to implement one or more of the following three imaging modes: B-Mode imaging, Doppler blood flow imaging, and blood flow vector imaging.
- the above-mentioned ultrasound parameters include the amount and rate of change before and after stimulation of one or more parameters of renal artery diameter, blood velocity, blood flow, and vessel wall shear force.
- the above-mentioned parameter measurement module 150 can measure and obtain various ultrasonic parameters (which may be ultrasonic parameter change values) based on the detection image obtained by the imaging module 140, for example, measure the diameter of the renal artery from the generated B-Mode grayscale image, From the generated Doppler blood flow imaging and blood flow vector images, hemodynamic parameters such as blood flow velocity, blood flow, and wall shear force, as well as their changes before and after stimulation, and the rate of change, etc. can also be measured. Different parameter types on the mode image can be set as required, which is not limited in this embodiment of the present application.
- the above evaluation module 160 can combine the parameters measured by the parameter measurement module 150 and conventional indicators, such as blood pressure, heart rate variability, blood biochemical parameters and physiological parameters, etc., to comprehensively evaluate renal sympathetic nerve activity. No restrictions.
- the above assessment results include the degree of renal sympathetic nerve activity
- the above evaluation module 160 includes a preset evaluation model for:
- the degree of activity of the above-mentioned renal sympathetic nerves is judged.
- the evaluation module 160 may evaluate the renal sympathetic nerve activity based on a preset evaluation model, score the renal sympathetic nerve activity according to the measured ultrasound parameters or their changes, and compare the scoring result with the preset evaluation threshold, To judge the degree of renal sympathetic nerve activity, for example, it can be considered that if it is higher than a certain threshold a, it means that the renal sympathetic nerve activity is high, and this group of people can benefit from RDN surgery; If there is no change in the measured parameters or the rate of change is less than a certain threshold b, the nerve activity is considered to be lost, and the effect of RDN surgery is ideal. Corresponding judgment rules, evaluation models or related thresholds can be set as required.
- the above-mentioned control module 170 is mainly used for the user to control the operation of the system.
- the control module 170 can receive user operations through the human-computer interaction interface, compile the corresponding control instructions, and transmit the control instructions to the corresponding modules to achieve control of the modules. corresponding function.
- the system 100 is first set to the real-time imaging mode, uses B-Mode imaging and Doppler blood flow imaging, combined with anatomical structure information and Doppler blood flow information to effectively locate the renal artery, and obtain renal arteries around the renal artery wall.
- the sympathetic nerve distribution area is used as the stimulation target area;
- A2 Use real-time B-Mode imaging, Doppler blood flow imaging and blood flow vector imaging to measure hemodynamic parameters such as renal artery diameter, blood flow velocity, blood flow, and wall shear force before stimulation;
- the system 100 is set to real-time imaging + stimulation mode, controls the generation of multi-channel pulse signals with different time delays, drives the ultrasonic linear array transducer to emit multi-channel ultrasonic waves, and forms an electronic focus starting from the starting point of the target area, and the focus follows the set
- the scanning trajectory moves at a constant speed until the entire target area is stimulated in sequence, and the stimulation is repeated for 30s to 300s;
- B-Mode imaging Doppler flow imaging or blood flow vector imaging to measure the renal artery diameter, blood flow velocity, blood flow, and wall shear force after stimulation. Hemodynamic parameters; calculate the amount of change and rate of change of the above ultrasound parameters and record them;
- A6 Combine the system 100 to measure ultrasound parameters and conventional indicators, such as blood pressure, heart rate variability, blood biochemical parameters and physiological parameters, etc., to comprehensively evaluate renal sympathetic nerve activity.
- the non-invasive renal sympathetic nerve activity detection system 100 in the embodiment of the present application can make the renal sympathetic nerve in the sound field be subjected to the action of acoustic radiation force through the nonlinear effect of ultrasound, realize non-invasive and deep stimulation of the renal sympathetic nerve, and realize ultrasonic stimulation Integrate with imaging guidance; directly detect the local response at the stimulation site as a new evaluation index of renal sympathetic nerve activity, which is more accurate and effective than indicators that characterize the overall sympathetic system response such as blood pressure and heart rate variability.
- the detection method based on electrical stimulation devices has poor penetration, and electrodes need to be used to directly contact the nerve, and non-contact deep stimulation cannot be performed.
- Intraoperative, or minimally invasive intervention; and nerve activity evaluation indicators are usually invasive femoral artery blood pressure, routine measurement of blood pressure and heart rate, reflecting the overall sympathetic nervous system activity, can only indirectly represent the activity of renal sympathetic nerves, and the accuracy is poor .
- the renal sympathetic nerve detection technology based on the blood component detection device is also minimally invasive and interventional. The blood component detection device needs to be placed in the renal artery, and the stimulation device is also invasive, and the change of the blood component has a hysteresis. Is there any significant change?
- ultrasound-based nerve detection technology is non-invasive, it is mainly used for nerve localization, stimulation, and ablation. Currently, it is not used for the detection of renal sympathetic nerve activity, and the evaluation indicators are usually blood pressure and heart rate, which reflect the overall sympathetic nervous system activity.
- a non-invasive renal sympathetic nerve activity detection system uses the unique acoustic characteristics and biophysical effects of ultrasound to deeply excavate, utilizes the mechanical effects of ultrasound to stimulate nerves, and uses the fluctuations of ultrasound to Perform imaging functions such as B-ultrasound imaging, Doppler blood flow imaging, and blood flow vector imaging to obtain hemodynamic parameters such as renal artery diameter, blood flow velocity, and blood flow before and after stimulation, as well as their variation and rate of change etc., can non-invasively assess the activity of the renal sympathetic nerves of the subjects. It can assist in status assessment before and after surgery. People with high renal sympathetic nerve activity can benefit from RDN surgery, and the ablation effect can also be evaluated after surgery. If the nerve activity is lost, the RDN surgery effect is considered ideal.
- the embodiment of the present application provides a non-invasive and effective clinical new tool for nerve activity assessment, and provides important guiding significance for RDN surgery planning.
- the above-mentioned ultrasonic dual-function transducer 120 includes a multi-layer structure linear array transducer, which may specifically include: a protective layer, a matching layer, a piezoelectric material layer, a backing layer, a heat dissipation layer and Flexible circuit boards, where:
- the above protective layer is used to protect the piezoelectric material layer
- the above-mentioned matching layer is used to enhance the ultrasonic energy propagating into the tissue
- the above-mentioned piezoelectric material layer is used to realize mutual conversion between electrical signals and acoustic signals
- the above-mentioned backing layer is used to connect the above-mentioned piezoelectric material layer and the above-mentioned heat dissipation layer, and conduct heat from the above-mentioned piezoelectric material layer to the above-mentioned heat dissipation layer;
- the above-mentioned flexible circuit board is used for connecting the above-mentioned ultrasonic dual-function transducer and the above-mentioned ultrasonic transmitting module for signal transmission.
- the ultrasonic dual-function transducer 120 may be a multi-layer structure linear array transducer. Electrical material layer, backing layer, heat dissipation layer and flexible circuit board. Through the control of each array element's individual leads, emission sequence and time delay, and the combination of linear electronic focusing, dynamic focusing, real-time dynamic aperture, dynamic apodization and dynamic frequency scanning, it can obtain superior acoustic beam resolution characteristics, very High sidelobe suppression capability and large signal dynamic range.
- its specific structure and functions are introduced as follows:
- Protective layer located on the surface of the ultrasonic dual-function transducer 120, to protect the piezoelectric material layer from being worn or damaged, made of silicone rubber, the acoustic impedance is similar to that of human tissue, low attenuation, used for beam focusing, and to improve lateral resolution.
- the thickness can be set according to the needs; for example, 1/4 wavelength can be taken;
- Matching layer It is made of epoxy resin and dense powder (such as alumina, glass powder, etc.), which solves the acoustic matching between the acoustic impedance of the ultrasonic dual-function transducer 120 and the acoustic impedance of biological tissue, and enhances the ultrasonic energy transmitted to the tissue;
- Piezoelectric material layer it can be prepared by using 1-3 type piezoelectric composite materials, and is composed of one-dimensionally connected piezoelectric ceramic pillars arranged in parallel with three-dimensionally connected epoxy resin. Adding polymers such as epoxy resin effectively reduces the weakness of ceramics in terms of strength and brittleness, reduces the transverse coupling of ceramics, and increases the longitudinal electromechanical conversion efficiency of composite materials; it has low acoustic impedance and is easy to communicate with media such as water and skin. Impedance matching; due to the large attenuation of the polymer and the low Q value, it is suitable for making broadband narrow pulse transducers.
- it can be prepared by a cut-and-fill method.
- the polarized piezoelectric ceramics are cut into evenly arranged columns, poured with epoxy resin, vacuumed, cured, and the uncut parts are ground away.
- the piezoelectric material layer can realize mutual conversion between electrical signals and acoustic signals according to its unique piezoelectric effect. It is the core component of the ultrasonic dual-function transducer 120 , and the two sides are covered with metal layers as electrode layers.
- Backing layer It is made of epoxy resin, tungsten powder, alumina powder and some additives to enhance attenuation. It has the acoustic characteristics of high attenuation and low acoustic impedance, and absorbs the acoustic energy radiated internally by the piezoelectric material layer due to vibration. Prevent the interference caused by the reflection of sound energy, connect the piezoelectric material layer and the heat dissipation layer, and conduct heat from the piezoelectric material layer to the heat dissipation layer;
- Heat dissipation layer made of aluminum alloy, copper, copper alloy and other metals, with high thermal conductivity
- a flexible circuit board with hollow pins can be used for element lead.
- the linear array ultrasonic transducer used in the embodiment of the present application can set parameters such as the number of array elements, center frequency, and bandwidth range according to needs, and there is no limitation here.
- it can include 20-256 array elements, center frequency 4.7MHz, -6dB bandwidth range: 2.95MHz-6.45MHz, percentage bandwidth: 74.4%.
- the system can select other types of ultrasonic transducers according to needs, such as hemispherical array, area array, linear array, ring array, etc., to act on nerves in different parts, such as brain, heart, thyroid , blood vessels, etc., are not limited here.
- stimulation modules can also be used or combined, that is, other energy sources can be selected or combined to generate non-invasive nerve stimulation, such as electrical energy, mechanical energy, sound energy, magnetic energy, light energy and thermal energy, etc., which are not discussed in this embodiment of the application. Do limit.
- the above-mentioned ultrasonic transmitting module 110 includes a pulse waveform generator, a power amplifier and a transducer matching circuit, wherein:
- the above-mentioned pulse waveform generator is completed by a programmable logic device
- the above-mentioned power amplifier includes an imaging transmission power amplifier and a stimulation power amplifier.
- the above-mentioned imaging transmission power amplifier is realized by a field effect tube driver and a field effect counter tube, and is used to generate the above-mentioned first pulse transmission signal.
- the above-mentioned stimulation power amplifier is used for the above-mentioned second Pulse transmission signal for power amplification;
- the above-mentioned transducer matching circuit includes a series resistance and a parallel inductance, the above-mentioned series resistance is used to realize the impedance matching between the pulse generating circuit and the above-mentioned ultrasonic dual-function transducer 120, and the parallel-connected inductance is used to realize the above-mentioned ultrasonic dual-function transducer 120 parallel tuning.
- the above-mentioned pulse waveform generator is completed by a programmable logic device (FPGA), and the chip can be selected according to the needs, for example, the EP4CE115F29C7N chip of Altera Company can be selected.
- the basic parameters of the imaging and stimulation emission pulse sequence include frequency, number, delay, occupation Duty ratio, repetition rate, timing, etc. can be programmed and controlled.
- the imaging transmitting power amplifier can be realized by adopting field effect tube driver MD1711 and field effect tube TC6320.
- MD1711 is a high-performance driver with 2 channels integrated inside the chip, which can generate 5-level waveforms for B-mode and color Doppler imaging systems.
- TC6320 is a high-voltage low-threshold enhanced field-to-tube transistor. It integrates two pairs of push-pull circuits. Each pair of push-pull circuits is composed of a P-channel MOSFET and an N-channel MOSFET.
- the front-end logic control drive gate can conduct up to ⁇ 100V High-voltage excitation, the maximum output current is 3A, which can be used to generate bipolar high-voltage pulse signals; the two tubes are isolated from each other, and each tube is integrated with a gate-source resistor and a clamping gate-source Zener diode, which effectively protects the input terminal; The high breakdown voltage and high output peak current can effectively excite the ultrasonic dual-function transducer 120 .
- the stimulation power amplifier can be selected according to the needs. For example, VRF151G from Microsemi can be used. After power amplification, the waveform amplitude is up to 170V, the maximum continuous leakage current is 36A, the upper limit of the working frequency is 175MHz, and the maximum transmission power can reach 150W.
- the matching circuit can consist of a series resistor and a shunt inductor. Fine-tuning is performed according to the actual frequency spectrum characteristics of the ultrasonic dual-function transducer 120 to achieve matching.
- the resistor realizes the impedance matching between the high-voltage excitation pulse generating circuit and the transducer, and the parallel inductor realizes the parallel tuning of the transducer.
- the signal transmission timing sequence of the ultrasonic transmission module 110 is shown in Figure 3, which shows two different transmission signals, that is, a lower-energy, short-pulse transmission signal for imaging, and a higher one for stimulation. Energy and long-pulse transmission signals, both of which can be switched at high speed. Multi-channel pulsed electrical signals are electronically delayed to achieve electronic focusing.
- the above-mentioned ultrasonic receiving module 130 includes a transceiver isolation circuit, a variable gain amplifier, a filter circuit, and an analog-to-digital conversion circuit, wherein:
- the transceiver isolation circuit is used to isolate the receiving channel of the ultrasonic echo signal from the transmitting channel of the ultrasonic transmitting signal;
- variable gain amplifier is used to amplify the above-mentioned ultrasonic echo signal
- the above-mentioned filter circuit is used to filter the above-mentioned ultrasonic echo signal
- the above-mentioned analog-to-digital conversion circuit is used to perform analog-to-digital conversion on the ultrasonic echo signal, and transmit the converted signal to the buffer of the above-mentioned pulse waveform generator.
- the ultrasonic dual-function transducer 120 is integrated with a transceiver, and the transceiver circuit needs to be isolated to prevent high-voltage transmission pulses from being directly applied to the receiving circuit and damage subsequent devices.
- a transceiver switch is designed at the front end of the receiving circuit, which is disconnected at the moment of exciting the high voltage, and then turned on to receive the echo signal after transmission.
- the transceiver isolation circuit is mainly composed of a PNP switch transistor 3CK2C and the company's high-voltage switch diode array MMBD3004BRM.
- the gate control level signal is directly input to the base of 3CK2C. When the signal is high level, 3CK2C is cut off, and the emitter and collector are in an off state.
- the DC power supply cannot provide effective forward bias to BD3004 through 3CK2C. voltage, the diode is cut off, so that the ultrasonic echo receiving channel is in the off-circuit state, and the isolation from the transmitting channel is realized.
- the gate control signal is low level, 3CK2C is in a saturated state, the switch is turned on, and the DC power supply provides a sufficient forward bias voltage to the diode of the echo channel through the resistor divider of the emitter, so that the diode is turned on. That is, the receiving channel is opened, so that the ultrasonic echo signal can enter the subsequent signal conditioning circuit through the diode without loss.
- the variable gain amplifier can be the ultrasonic front-end analog chip AFE5808 of TI Company.
- AFE5808 is designed with 8 channels inside, and each channel integrates functions such as LNA, VCAT, PGA, LPF, ADC and CW MIXER.
- the original complex and discrete ultrasonic receiving circuit is integrated in one chip, which is more conducive to optimal design and noise control. In low-noise mode, it can achieve a dynamic gain control of up to 54dB.
- the cut-off frequency of the filter circuit can be selected in multiple levels. It can be easily realized by modifying the register through SPI. After the previous signal amplification and analog filtering, the ultrasonic echo can be adjusted. Analog-to-digital conversion, which is transmitted to the FPGA data buffer in the form of a low-voltage differential signal.
- the system adopts an ultrasonic dual-function transducer with two modes of stimulation and imaging.
- Long-pulse transmission mode through structural optimization design, improved probe manufacturing process, so that the flatness of piezoelectric material and adhesive coating reaches micron level, further improves the thermal conductivity of the probe, and solves the problem when the probe conducts high-power ultrasonic transmission. Due to the problem of transducer heating caused by the problem, the design of the drive circuit is optimized, the response time of the transducer is shortened, and the switching speed between the "stimulation-imaging" modes is improved.
- Fig. 4A is a schematic diagram of a renal artery B-mode image provided in the embodiment of the present application
- Fig. 4B is a schematic diagram of a renal artery Doppler blood flow image provided in the embodiment of the present application.
- the ultrasound probe of the system can be placed laterally in the right anterior abdominal intercostal space or under the costal margin, and the right renal vein and inferior vena cava can be found behind the descending liver, and then the long axis of the right renal artery can be found behind these veins section.
- the B-Mode image can be used to obtain the anatomical structure information of the renal artery, and to measure the vascular diameter and variation in the middle segment of the renal artery.
- Doppler blood flow imaging can be used to measure the average velocity, blood flow and variation of blood flow in the middle renal artery.
- the blood flow vector imaging can also be used to measure the wall shear force and its variation. After completing the measurement of one renal artery, switch to the other side and proceed as above.
- various physiological and functional information monitoring may also be used in the embodiment of the present application, such as electromyographic signals, blood pressure, heart rate, temperature, blood oxygen saturation, hemodynamic parameters, hardness, muscle twitching, and the like.
- the system can also be used to detect the activity of other biological tissue nerves that respond to mechanical stimulation, such as vagus nerve, parasympathetic nerve, etc.
- FIG. 5 is a structural and functional schematic diagram of a non-invasive renal sympathetic nerve activity detection system provided by another embodiment of the present application.
- the non-invasive renal sympathetic nerve activity detection system includes: an ultrasonic dual-function linear array transducer, an ultrasonic transmitting module, an ultrasonic receiving module, a multi-mode imaging module, a control module and a parameter measurement module.
- the ultrasonic dual-function linear array transducer is connected with the ultrasonic transmitting module and the ultrasonic receiving module, the ultrasonic receiving module is connected with the multi-mode imaging module, the multi-mode imaging module is connected with the control module, the control module is connected with the ultrasonic transmitting module, the ultrasonic transmitting module,
- the functional units contained in the ultrasonic receiving module, multi-mode imaging module and evaluation module are shown in the figure.
- the specific structure and function of the non-invasive renal sympathetic nerve activity detection system reference may be made to the specific description in the embodiment shown in FIG. 1 , which will not be repeated here.
- FIG. 6 is a schematic flow chart of a method for detecting non-invasive renal sympathetic nerve activity provided by an embodiment of the present application.
- This method can be applied to the non-invasive renal sympathetic nerve activity detection system in the embodiment shown in Figure 1 or Figure 5, and the non-invasive renal sympathetic nerve activity detection system includes an ultrasonic transmitting module, an ultrasonic dual-function transducer, an ultrasonic receiving module, an imaging module, parameter measurement module, evaluation module and control module, which will not be described in detail here; the method includes:
- the ultrasonic transmission module generates a first pulse transmission signal and a second pulse transmission signal, the first pulse transmission signal is used for imaging, and the second pulse transmission signal is used to stimulate the detection site;
- the energy of the first pulse transmission signal is lower than that of the second pulse transmission signal, and the pulse of the first pulse transmission signal is shorter than the pulse of the second pulse transmission signal;
- the ultrasonic dual-function transducer converts the pulse emission signal generated by the above-mentioned ultrasonic emission module into an acoustic signal within the preset ultrasonic frequency range, and converts the acoustic signal in the external sound field into an electrical signal;
- the ultrasonic receiving module receives the ultrasonic echo signal corresponding to the ultrasonic transmission signal, and converts the ultrasonic echo signal into a digital signal;
- the imaging module performs ultrasonic imaging according to the above digital signal to obtain a detection image
- the parameter measurement module measures the ultrasonic parameter change value caused by the stimulus based on the above detection image
- the evaluation module evaluates the renal sympathetic nerve activity based on the change value of the above-mentioned ultrasound parameters, and obtains an evaluation result.
- the system in the embodiment of this application adopts the integration of ultrasonic stimulation and guidance: the complete matching of stimulation coordinates and imaging guidance coordinates, before stimulation, the use of B-ultrasound imaging and Doppler blood flow imaging to effectively position the renal artery
- the distribution area of renal sympathetic nerves around the wall is used as the stimulation target area; after stimulation, B-ultrasound imaging is used to track the diameter changes of renal arteries in real time, and Doppler flow imaging and blood flow vector imaging are used to track the hemodynamics of renal arteries in real time Changes in academic parameters.
- the system utilizes the characteristic that the mechanosensitive ion channel (pressure sensor) on the renal sympathetic neuron can respond to mechanical stimulation, and through the nonlinear effect of ultrasound, the renal sympathetic nerve in the sound field is affected by the acoustic radiation force to achieve non-invasive and deep stimulation. Renal sympathetic nerves, eliciting the purpose of the response.
- pressure sensor pressure sensor
- the system uses ultrasound to non-invasively measure the hemodynamic parameters of the renal artery, such as blood flow velocity changes, blood flow changes, vessel wall shear force changes, etc., to directly detect the local reaction at the stimulation site, as a new indicator of renal sympathetic nerve activity. Evaluation indicators are more accurate and effective than indicators that characterize the overall sympathetic system response such as blood pressure and heart rate variability.
- the system also combines conventional evaluation indicators, such as blood pressure, heart rate, blood biochemical parameters, and physiological parameters of the subject, to make the detection more comprehensive and reliable. It is believed that people with high renal sympathetic nerve activity can benefit from RDN surgery. The effect of ablation can also be evaluated after surgery. If the nerve activity is lost, the RDN surgery is considered to be ideal.
- the invention provides a non-invasive and effective clinical new tool for nerve activity assessment, and provides important guiding significance for RDN operation planning.
- an embodiment of the present application further provides an electronic device.
- the electronic device 700 includes at least a processor 701 , an input device 702 , an output device 703 and a computer storage medium 704 .
- the processor 701, the input device 702, the output device 703, and the computer storage medium 704 in the electronic device may be connected through a bus or in other ways.
- the computer storage medium 704 may be stored in the memory of the electronic device, the computer storage medium 704 is used to store computer programs, the computer programs include program instructions, and the processor 701 is used to execute the program instructions stored in the computer storage medium 704 .
- Processor 701 or called CPU (Central Processing Unit (central processing unit)
- CPU Central Processing Unit
- CPU Central Processing Unit
- the above-mentioned processor 701 in the embodiment of the present application may be used to perform a series of processing, including the method in the embodiment shown in FIG. 6 and so on.
- An embodiment of the present application also provides a computer storage medium (Memory), where the computer storage medium is a memory device in an electronic device and is used to store programs and data.
- the computer storage medium here may include a built-in storage medium in the electronic device, and certainly may include an extended storage medium supported by the electronic device.
- the computer storage medium provides storage space, and the storage space stores the operating system of the electronic device.
- one or more instructions suitable for being loaded and executed by the processor 701 are also stored in the storage space, and these instructions may be one or more computer programs (including program codes).
- the computer storage medium here can be a high-speed RAM memory, or a non-volatile memory (non-volatile memory), such as at least one disk memory; computer storage media.
- one or more instructions stored in the computer storage medium can be loaded and executed by the processor 701 to implement the corresponding steps in the above-mentioned embodiments; in specific implementation, one or more instructions in the computer storage medium can be Any step of the method in FIG. 6 is loaded and executed by the processor 501 , which will not be repeated here.
- the disclosed systems, devices and methods may be implemented in other ways.
- the division of this module is only a logical function division, and there may be other division methods in actual implementation, for example, multiple modules or components can be combined or integrated into another system, or some features can be ignored, or not implement.
- the mutual coupling, or direct coupling, or communication connection shown or discussed may be through some interfaces, and the indirect coupling or communication connection of devices or modules may be in electrical, mechanical or other forms.
- a module described as a separate component may or may not be physically separated, and a component shown as a module may or may not be a physical module, that is, it may be located in one place, or may also be distributed to multiple network modules. Part or all of the modules can be selected according to actual needs to achieve the purpose of the solution of this embodiment.
- all or part of them may be implemented by software, hardware, firmware or any combination thereof.
- software When implemented using software, it may be implemented in whole or in part in the form of a computer program product.
- the computer program product includes one or more computer instructions. When the computer program instructions are loaded and executed on the computer, the processes or functions according to the embodiments of the present application will be generated in whole or in part.
- the computer can be a general purpose computer, a special purpose computer, a computer network, or other programmable device.
- the computer instructions may be stored in or transmitted over a computer-readable storage medium.
- the computer instructions can be sent from a website site, computer, server or data center via wired (such as coaxial cable, optical fiber, digital subscriber line (digital subscriber line) subscriber line, DSL)) or wirelessly (such as infrared, wireless, microwave, etc.) to another website site, computer, server or data center.
- the computer-readable storage medium may be any available medium that can be accessed by a computer, or a data storage device such as a server or a data center integrated with one or more available media.
- the available media can be read-only memory (read-only memory, ROM), or random access memory (random access memory, RAM), or magnetic media such as floppy disks, hard disks, tapes, magnetic disks, or optical media such as digital versatile discs (digital versatile disc, DVD), or semiconductor media, such as solid state drives (solid state disk, SSD), etc.
- ROM read-only memory
- RAM random access memory
- magnetic media such as floppy disks, hard disks, tapes, magnetic disks, or optical media such as digital versatile discs (digital versatile disc, DVD), or semiconductor media, such as solid state drives (solid state disk, SSD), etc.
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Abstract
A non-invasive renal sympathetic nerve activity detection system (100) and method. In the non-invasive renal sympathetic nerve activity detection system (100), an ultrasonic transmitting module (110) generates pulse signals respectively used for stimulation and imaging; an ultrasonic dual-function transducer (120) performs signal conversion; an ultrasonic receiving module (130) receives an ultrasonic echo signal and converts the ultrasonic echo signal into a digital signal; an imaging module (140) performs ultrasonic grayscale imaging and hemodynamic parameter imaging according to the digital signal; a parameter measurement module (150) measures a parameter change value of an image caused by ultrasonic stimulation; an evaluation module (160) evaluates the renal sympathetic nerve activity on the basis of the ultrasonic parameter change value. Non-invasive deep nerve stimulation is carried out by utilizing a mechanical effect of ultrasonic waves, imaging is carried out by utilizing a fluctuation effect of ultrasonic waves, renal sympathetic nerve stimulation is guided, various hemodynamic parameters before and after stimulation, as well as a change amount and a change rate, etc. thereof are obtained, and the activity of the renal sympathetic nerve of a testee can be evaluated in a non-invasive and accurate mode.
Description
本发明涉及医学检测技术领域,尤其涉及一种无创肾交感神经活性检测***及方法。The invention relates to the technical field of medical detection, in particular to a noninvasive renal sympathetic nerve activity detection system and method.
内脏运动神经***调节内脏、心血管的运动和腺体的分泌,通常不受意志支配和控制,称为自主神经,包括交感神经和副交感神经。肾交感神经是自主神经***的重要组成部分,在自主神经平衡的调节中发挥着重要作用,其过度激活是高血压、心力衰竭、心律失常等多种心血管疾病发生和发展的重要机制之一。The visceral motor nervous system regulates visceral and cardiovascular movements and glandular secretions, and is usually not dominated and controlled by the will. It is called the autonomic nervous system, including sympathetic and parasympathetic nerves. The renal sympathetic nerve is an important part of the autonomic nervous system and plays an important role in the regulation of autonomic nervous balance. Its excessive activation is one of the important mechanisms for the occurrence and development of various cardiovascular diseases such as hypertension, heart failure, and arrhythmia. .
肾交感神经消融(Renal sympathetic denervation, RDN)通过阻断肾交感神经,降低交感神经***活性,从而促进自主神经再平衡,达到降低血压的目的,被认为是治疗顽固性高血压的重要手段。RDN手术治疗高血压目前存在的首要问题是:相当部分患者进行RDN手术后血压没有显著改善,需要找到可靠的标准来选择RDN手术获益人群,并在术中可即时判定消融效果。Renal sympathetic denervation (RDN) blocks renal sympathetic nerves and reduces the activity of the sympathetic nervous system, thereby promoting autonomic rebalancing and lowering blood pressure. It is considered to be an important means of treating resistant hypertension. The primary problem currently existing in the treatment of hypertension by RDN surgery is that a considerable number of patients have no significant improvement in blood pressure after RDN surgery. Reliable criteria need to be found to select the beneficiaries of RDN surgery, and the ablation effect can be judged immediately during the operation.
目前基于电刺激的检测方法穿透性较差,需采用电极直接接触神经,不能进行非接触的深部刺激,而肾交感神经位于深部,通常只能在术中,或者微创介入使用;且神经活性评估指标也通常为有创股动脉血压、常规测量血压和心率,反映整体交感神经***活性,只能间接表征肾交感神经的活性,准确性较差。另外基于血液成分检测装置的肾交感神经检测技术同样是微创介入性,需将血液成分检测装置置于肾动脉血管内,刺激装置也是介入性,且血液成分变化有滞后性。The current detection methods based on electrical stimulation have poor penetration, need to use electrodes to directly contact the nerve, and cannot perform non-contact deep stimulation, and the renal sympathetic nerve is located in the deep part, which can usually only be used during surgery or minimally invasive intervention; and the nerve Activity evaluation indicators are usually invasive femoral artery blood pressure, routine measurement of blood pressure and heart rate, which reflect the overall sympathetic nervous system activity, but can only indirectly represent the activity of renal sympathetic nerve, and the accuracy is poor. In addition, the renal sympathetic nerve detection technology based on the blood component detection device is also minimally invasive and interventional. The blood component detection device needs to be placed in the renal artery, and the stimulation device is also invasive, and the blood component changes have a hysteresis.
因此,目前肾交感神经活性检测方法有一定局限性,亟需针对肾交感神经局部活性的有效检测方法和装置。Therefore, the current detection method of renal sympathetic nerve activity has certain limitations, and an effective detection method and device for local activity of renal sympathetic nerve is urgently needed.
本申请提供了一种无创肾交感神经活性检测***及方法。The present application provides a noninvasive renal sympathetic nerve activity detection system and method.
第一方面,提供了一种无创肾交感神经活性检测***,包括超声发射模块、超声双功能换能器、超声接收模块、成像模块、参数测量模块、评估模块和控制模块,其中:In the first aspect, a non-invasive renal sympathetic nerve activity detection system is provided, including an ultrasound transmitting module, an ultrasound dual-function transducer, an ultrasound receiving module, an imaging module, a parameter measurement module, an evaluation module and a control module, wherein:
所述超声发射模块,用于产生第一脉冲发射信号和第二脉冲发射信号,所述第一脉冲发射信号用于成像,所述第二脉冲发射信号用于对检测部位产生刺激,所述第一脉冲发射信号的能量低于所述第二脉冲发射信号,所述第一脉冲发射信号的脉冲短于所述第二脉冲发射信号的脉冲;The ultrasonic transmitting module is used to generate a first pulse transmitting signal and a second pulse transmitting signal, the first pulse transmitting signal is used for imaging, the second pulse transmitting signal is used to stimulate the detection site, and the first pulse transmitting signal The energy of a pulse transmission signal is lower than that of the second pulse transmission signal, and the pulse of the first pulse transmission signal is shorter than the pulse of the second pulse transmission signal;
所述超声双功能换能器,用于在预设超声频率范围内将所述超声发射模块产生的脉冲发射信号转换成声信号,以及用于将外界声场中的声信号转换为电信号;The ultrasonic dual-function transducer is used to convert the pulsed transmission signal generated by the ultrasonic transmission module into an acoustic signal within the preset ultrasonic frequency range, and to convert the acoustic signal in the external sound field into an electrical signal;
所述超声接收模块,用于接收所述超声发射信号对应的超声回波信号,将所述超声回波信号转换成数字信号;The ultrasonic receiving module is configured to receive an ultrasonic echo signal corresponding to the ultrasonic transmitting signal, and convert the ultrasonic echo signal into a digital signal;
所述成像模块,用于根据所述数字信号进行超声成像,获得检测图像;The imaging module is used to perform ultrasonic imaging according to the digital signal to obtain a detection image;
所述参数测量模块,用于基于所述检测图像测量刺激引起的超声参数变化值;The parameter measurement module is used to measure the ultrasonic parameter change value caused by stimulation based on the detection image;
所述评估模块,用于基于所述超声参数变化值,对肾交感神经活性进行评估,获得评估结果;The evaluation module is configured to evaluate the activity of renal sympathetic nerves based on the change value of the ultrasonic parameter, and obtain an evaluation result;
所述控制模块,用于通过人机交互界面接收并编译控制指令,并将所述控制指令传输到对应的模块以使所述模块实现相应控制功能。The control module is used to receive and compile control instructions through the human-computer interaction interface, and transmit the control instructions to corresponding modules so that the modules can realize corresponding control functions.
第二方面,提供了一种无创肾交感神经活性检测方法,应用于无创肾交感神经活性检测***,所述无创肾交感神经活性检测***包括超声发射模块、超声双功能换能器、超声接收模块、成像模块、参数测量模块、评估模块和控制模块;所述方法包括:In the second aspect, a non-invasive renal sympathetic nerve activity detection method is provided, which is applied to a non-invasive renal sympathetic nerve activity detection system, and the non-invasive renal sympathetic nerve activity detection system includes an ultrasonic transmitting module, an ultrasonic dual-function transducer, and an ultrasonic receiving module , an imaging module, a parameter measurement module, an evaluation module and a control module; the method includes:
所述超声发射模块产生第一脉冲发射信号和第二脉冲发射信号,所述第一脉冲发射信号用于成像,所述第二脉冲发射信号用于对检测部位产生刺激,所述第一脉冲发射信号的能量低于所述第二脉冲发射信号,所述第一脉冲发射信号的脉冲短于所述第二脉冲发射信号的脉冲;The ultrasonic transmitting module generates a first pulse transmitting signal and a second pulse transmitting signal, the first pulse transmitting signal is used for imaging, the second pulse transmitting signal is used to stimulate the detection site, and the first pulse transmitting signal The energy of the signal is lower than that of the second pulsed transmission signal, and the pulse of the first pulsed transmission signal is shorter than the pulse of the second pulsed transmission signal;
所述超声双功能换能器在预设超声频率范围内将所述超声发射模块产生的脉冲发射信号转换成声信号,以及将外界声场中的声信号转换为电信号;The ultrasonic dual-function transducer converts the pulsed emission signal generated by the ultrasonic emission module into an acoustic signal within the preset ultrasonic frequency range, and converts the acoustic signal in the external sound field into an electrical signal;
所述超声接收模块接收所述超声发射信号对应的超声回波信号,将所述超声回波信号转换成数字信号;The ultrasonic receiving module receives the ultrasonic echo signal corresponding to the ultrasonic transmission signal, and converts the ultrasonic echo signal into a digital signal;
所述成像模块根据所述数字信号进行超声成像,获得检测图像;The imaging module performs ultrasonic imaging according to the digital signal to obtain a detection image;
所述参数测量模块基于所述检测图像测量刺激引起的超声参数变化值;The parameter measurement module measures the ultrasonic parameter change value caused by the stimulus based on the detection image;
所述评估模块基于所述超声参数变化值,对肾交感神经活性进行评估,获得评估结果。The evaluation module evaluates the activity of the renal sympathetic nerve based on the change value of the ultrasonic parameter, and obtains an evaluation result.
第三方面,提供了一种电子设备,包括存储器和处理器,所述存储器存储有计算机程序,所述计算机程序被所述处理器执行时,使得所述处理器执行如第一方面及其任一种可能的实现方式的步骤。In a third aspect, there is provided an electronic device, including a memory and a processor, the memory stores a computer program, and when the computer program is executed by the processor, the processor performs the process described in the first aspect and any of the above. Steps of one possible implementation.
第四方面,提供了一种计算机存储介质,所述计算机存储介质存储有一条或多条指令,所述一条或多条指令适于由处理器加载并执行如上述第一方面及其任一种可能的实现方式的步骤。In a fourth aspect, a computer storage medium is provided, the computer storage medium stores one or more instructions, and the one or more instructions are suitable for being loaded and executed by a processor as described in the above first aspect and any one thereof. Steps for a possible implementation.
本申请实施例提供的无创肾交感神经活性检测***,包括超声发射模块、超声双功能换能器、超声接收模块、成像模块、参数测量模块、评估模块和控制模块,其中:所述超声发射模块,用于产生第一脉冲发射信号和第二脉冲发射信号,所述第一脉冲发射信号用于成像,所述第二脉冲发射信号用于对检测部位产生刺激,所述第一脉冲发射信号的能量低于所述第二脉冲发射信号,所述第一脉冲发射信号的脉冲短于所述第二脉冲发射信号的脉冲;所述超声双功能换能器,用于在预设超声频率范围内将所述超声发射模块产生的脉冲发射信号转换成声信号,以及用于将外界声场中的声信号转换为电信号;所述超声接收模块,用于接收所述超声发射信号对应的超声回波信号,将所述超声回波信号转换成数字信号;所述成像模块,用于根据所述数字信号进行超声成像,获得检测图像;所述参数测量模块,用于基于所述检测图像测量刺激引起的超声参数变化值;所述评估模块,用于基于所述超声参数变化值,对肾交感神经活性进行评估,获得评估结果;所述控制模块,用于通过人机交互界面接收并编译控制指令,并将所述控制指令传输到对应的模块以使所述模块实现相应控制功能。本申请技术方案的有益效果在于,可以利用超声波的力学效应进行无创深部神经刺激,利用超声波的波动效应进行成像,并获取刺激前后各项参数等信息,无创评估受测人员的肾交感神经的活性,并且实现了超声刺激和成像引导一体化;直接检测刺激部位的局部反应作为肾交感神经活性新的评估指标,相比比血压、心率变异性等表征整体交感***反应的指标,更精确有效。The non-invasive renal sympathetic nerve activity detection system provided in the embodiment of the present application includes an ultrasonic transmitting module, an ultrasonic dual-function transducer, an ultrasonic receiving module, an imaging module, a parameter measurement module, an evaluation module and a control module, wherein: the ultrasonic transmitting module , used to generate a first pulse emission signal and a second pulse emission signal, the first pulse emission signal is used for imaging, the second pulse emission signal is used to stimulate the detection site, the first pulse emission signal The energy is lower than the second pulse transmission signal, and the pulse of the first pulse transmission signal is shorter than the pulse of the second pulse transmission signal; the ultrasonic dual-function transducer is used to operate within the preset ultrasonic frequency range Convert the pulse transmission signal generated by the ultrasonic transmission module into an acoustic signal, and convert the acoustic signal in the external sound field into an electrical signal; the ultrasonic receiving module is used to receive the ultrasonic echo corresponding to the ultrasonic transmission signal signal, converting the ultrasonic echo signal into a digital signal; the imaging module is used to perform ultrasonic imaging according to the digital signal to obtain a detection image; the parameter measurement module is used to measure the stimulation based on the detection image The ultrasonic parameter change value; the evaluation module is used to evaluate the renal sympathetic nerve activity based on the ultrasonic parameter change value, and obtain the evaluation result; the control module is used to receive and compile control instructions through the human-computer interaction interface , and transmit the control instruction to the corresponding module so that the module realizes the corresponding control function. The beneficial effect of the technical solution of the present application is that the mechanical effect of ultrasound can be used for non-invasive deep nerve stimulation, and the wave effect of ultrasound can be used for imaging, and information such as various parameters before and after stimulation can be obtained to non-invasively evaluate the activity of the renal sympathetic nerve of the subject. , and realized the integration of ultrasound stimulation and imaging guidance; direct detection of the local response at the stimulation site as a new evaluation index of renal sympathetic nerve activity is more accurate and effective than indicators that characterize the overall sympathetic system response such as blood pressure and heart rate variability.
为了更清楚地说明本申请实施例或背景技术中的技术方案,下面将对本申请实施例或背景技术中所需要使用的附图进行说明。In order to more clearly illustrate the technical solutions in the embodiment of the present application or the background art, the following will describe the drawings that need to be used in the embodiment of the present application or the background art.
图1为本申请实施例提供的一种无创肾交感神经活性检测***的结构示意图;FIG. 1 is a schematic structural diagram of a non-invasive renal sympathetic nerve activity detection system provided in an embodiment of the present application;
图2为本申请实施例提供的一种超声刺激肾交感神经区域示意图;FIG. 2 is a schematic diagram of an ultrasound-stimulated renal sympathetic nerve region provided in an embodiment of the present application;
图3为本申请实施例提供的一种超声发射模块的信号发射时序示意图;FIG. 3 is a schematic diagram of a signal transmission sequence of an ultrasonic transmission module provided in an embodiment of the present application;
图4A为本申请实施例提供的一种肾动脉B-mode图像示意图;Fig. 4A is a schematic diagram of a renal artery B-mode image provided in the embodiment of the present application;
图4B为本申请实施例提供的一种肾动脉多普勒血流图像示意图;Fig. 4B is a schematic diagram of a renal artery Doppler blood flow image provided in the embodiment of the present application;
图5为本申请实施例提供的一种无创肾交感神经活性检测***的结构功能示意图;Fig. 5 is a structural and functional schematic diagram of a non-invasive renal sympathetic nerve activity detection system provided by the embodiment of the present application;
图6为本申请实施例提供的一种无创肾交感神经活性检测方法的流程示意图;Fig. 6 is a schematic flow chart of a non-invasive renal sympathetic nerve activity detection method provided in the embodiment of the present application;
图7为本申请实施例提供的一种电子设备的结构示意图。FIG. 7 is a schematic structural diagram of an electronic device provided by an embodiment of the present application.
为了使本技术领域的人员更好地理解本申请方案,下面将结合本申请实施例中的附图,对本申请实施例中的技术方案进行清楚、完整地描述,显然,所描述的实施例仅是本申请一部分实施例,而不是全部的实施例。基于本申请中的实施例,本领域普通技术人员在没有作出创造性劳动前提下所获得的所有其他实施例,都属于本申请保护的范围。In order to enable those skilled in the art to better understand the solution of the application, the technical solution in the embodiment of the application will be clearly and completely described below in conjunction with the drawings in the embodiment of the application. Obviously, the described embodiment is only It is a part of the embodiments of this application, not all of them. Based on the embodiments in this application, all other embodiments obtained by persons of ordinary skill in the art without creative efforts fall within the protection scope of this application.
本申请的说明书和权利要求书及上述附图中的术语“第一”、“第二”等是用于区别不同对象,而不是用于描述特定顺序。此外,术语“包括”和“具有”以及它们任何变形,意图在于覆盖不排他的包含。例如包含了一系列步骤或单元的过程、方法、***、产品或设备没有限定于已列出的步骤或单元,而是可选地还包括没有列出的步骤或单元,或可选地还包括对于这些过程、方法、产品或设备固有的其他步骤或单元。The terms "first", "second" and the like in the description and claims of the present application and the above drawings are used to distinguish different objects, rather than to describe a specific order. Furthermore, the terms "include" and "have", as well as any variations thereof, are intended to cover a non-exclusive inclusion. For example, a process, method, system, product or device comprising a series of steps or units is not limited to the listed steps or units, but optionally also includes unlisted steps or units, or optionally further includes For other steps or units inherent in these processes, methods, products or devices.
在本文中提及“实施例”意味着,结合实施例描述的特定特征、结构或特性可以包含在本申请的至少一个实施例中。在说明书中的各个位置出现该短语并不一定均是指相同的实施例,也不是与其它实施例互斥的独立的或备选的实施例。本领域技术人员显式地和隐式地理解的是,本文所描述的实施例可以与其它实施例相结合。Reference herein to an "embodiment" means that a particular feature, structure, or characteristic described in connection with the embodiment can be included in at least one embodiment of the present application. The occurrences of this phrase in various places in the specification are not necessarily all referring to the same embodiment, nor are separate or alternative embodiments mutually exclusive of other embodiments. It is understood explicitly and implicitly by those skilled in the art that the embodiments described herein can be combined with other embodiments.
本申请实施例中涉及到的超声波是一种在弹性介质(生物组织)中传播的机械波,兼具波动效应、热效应、力学效应等复杂声学效应,具有穿透力深、空间指向性好、可动态聚焦扫描等优势在医学领域广泛应用。在传统生物医学超声中,超声诊断成像技术主要利用其波动效应,高强度聚焦超声治疗技术主要利用其热效应。超声波的非线性效应使声场中的介质(神经)会受到辐射力的作用。The ultrasonic waves involved in the embodiments of this application are mechanical waves propagating in elastic media (biological tissues), and have complex acoustic effects such as wave effects, thermal effects, and mechanical effects. They have deep penetrating power, good spatial directivity, and can Advantages such as dynamic focus scanning are widely used in the medical field. In traditional biomedical ultrasound, ultrasonic diagnostic imaging technology mainly uses its wave effect, and high-intensity focused ultrasound therapy technology mainly uses its thermal effect. The nonlinear effect of ultrasound makes the medium (nerve) in the sound field subject to radiation force.
下面结合本申请实施例中的附图对本申请实施例进行描述。Embodiments of the present application are described below with reference to the drawings in the embodiments of the present application.
请参阅图1,图1是本申请实施例提供的一种无创肾交感神经活性检测***的结构示意图。如图1所示,该无创肾交感神经活性检测***100包括超声发射模块110、超声双功能换能器120、超声接收模块130、成像模块140、参数测量模块150、评估模块160和控制模块170,其中:Please refer to FIG. 1 . FIG. 1 is a schematic structural diagram of a non-invasive renal sympathetic nerve activity detection system provided in an embodiment of the present application. As shown in FIG. 1 , the non-invasive renal sympathetic nerve activity detection system 100 includes an ultrasound transmitting module 110, an ultrasound dual-function transducer 120, an ultrasound receiving module 130, an imaging module 140, a parameter measurement module 150, an evaluation module 160 and a control module 170 ,in:
所述超声发射模块110,用于产生第一脉冲发射信号和第二脉冲发射信号,所述第一脉冲发射信号用于成像,所述第二脉冲发射信号用于对检测部位产生刺激,所述第一脉冲发射信号的能量低于所述第二脉冲发射信号,所述第一脉冲发射信号的脉冲短于所述第二脉冲发射信号的脉冲;The ultrasonic transmitting module 110 is configured to generate a first pulse transmitting signal and a second pulse transmitting signal, the first pulse transmitting signal is used for imaging, and the second pulse transmitting signal is used to stimulate the detection site, the The energy of the first pulse transmission signal is lower than that of the second pulse transmission signal, and the pulse of the first pulse transmission signal is shorter than the pulse of the second pulse transmission signal;
所述超声双功能换能器120,用于在预设超声频率范围内将所述超声发射模块110产生的脉冲发射信号转换成声信号,以及用于将外界声场中的声信号转换为电信号;The ultrasonic dual-function transducer 120 is used to convert the pulsed emission signal generated by the ultrasonic emission module 110 into an acoustic signal within the preset ultrasonic frequency range, and to convert the acoustic signal in the external sound field into an electrical signal ;
所述超声接收模块130,用于接收所述超声发射模块110产生的超声发射信号对应的超声回波信号,将所述超声回波信号转换成数字信号;The ultrasonic receiving module 130 is configured to receive an ultrasonic echo signal corresponding to the ultrasonic transmitting signal generated by the ultrasonic transmitting module 110, and convert the ultrasonic echo signal into a digital signal;
上述成像模块140,用于根据上述数字信号进行超声成像,获得检测图像;The above-mentioned imaging module 140 is used for performing ultrasonic imaging according to the above-mentioned digital signal to obtain a detection image;
上述参数测量模块150,用于基于上述检测图像测量刺激引起的超声参数变化值;The above-mentioned parameter measurement module 150 is used for measuring the change value of the ultrasonic parameter caused by the stimulation based on the above-mentioned detection image;
上述评估模块160,用于基于上述超声参数,对肾交感神经活性进行评估,获得评估结果;The evaluation module 160 is configured to evaluate the renal sympathetic nerve activity based on the above ultrasound parameters, and obtain an evaluation result;
上述控制模块170,用于通过人机交互界面接收并编译控制指令,并将上述控制指令传输到对应的模块以使上述模块实现相应控制功能。The above-mentioned control module 170 is configured to receive and compile the control instructions through the human-computer interaction interface, and transmit the above-mentioned control instructions to corresponding modules so that the above-mentioned modules can realize corresponding control functions.
本申请实施例中提供一种无创的肾交感神经活性检测***,深度挖掘利用超声波独特的声学特性和生物物理效应,即其中的超声发射模块110可以产生第一脉冲发射信号,利用超声波的波动效应进行成像;超声发射模块110还可以产生第二脉冲发射信号,利用超声波的力学效应进行神经刺激,从而可以获取刺激前后的各种参数和信息,无创评估受测人员肾交感神经的活性。In the embodiment of this application, a non-invasive renal sympathetic nerve activity detection system is provided, which utilizes the unique acoustic characteristics and biophysical effects of ultrasound, that is, the ultrasound transmitting module 110 can generate the first pulse transmission signal, and utilize the wave effect of ultrasound Perform imaging; the ultrasound transmitting module 110 can also generate a second pulse transmission signal, and use the mechanical effect of ultrasound to stimulate nerves, so that various parameters and information before and after stimulation can be obtained, and the activity of the renal sympathetic nerve of the subject can be evaluated non-invasively.
图2为本申请实施例提供的一种超声刺激肾交感神经区域示意图。如图2所示,超声发射脉冲电子聚焦,作用于肾动脉特定的刺激靶区。Fig. 2 is a schematic diagram of an ultrasonic stimulation of the renal sympathetic nerve area provided by the embodiment of the present application. As shown in Figure 2, the ultrasonic emission pulses are electronically focused and act on the specific stimulation target area of the renal artery.
上述成像模块140可以通过软硬件结合,实现多模式成像,可以进行超声灰阶成像和血流动力学参数成像,包括但不限于超声B-Mode成像、多普勒血流成像和血流向量成像功能等,本申请实施例对此不做限制。The above-mentioned imaging module 140 can realize multi-mode imaging through the combination of software and hardware, and can perform ultrasonic grayscale imaging and hemodynamic parameter imaging, including but not limited to ultrasonic B-Mode imaging, Doppler blood flow imaging and blood flow vector imaging Functions, etc., are not limited in this embodiment of the present application.
具体的,本申请实施例中的B-Mode成像也称B超,是接收到的回波数据读入,经过信号的调制与低通滤波、数据的抽取、数据的对数增强、数据线的重排、插值重建等完成超声成像的重建过程。Specifically, the B-Mode imaging in the embodiment of this application is also called B-ultrasound, which is to read in the received echo data, after signal modulation and low-pass filtering, data extraction, data logarithmic enhancement, and data line Rearrangement, interpolation reconstruction, etc. complete the reconstruction process of ultrasound imaging.
上述多普勒血流成像,主要是接收到的多普勒回波信号经过混频电路和低通滤波器进行相位检波后,一路送到处理电路,进行频谱分析,以显示多普勒频谱;一路送到计算机电路,以得到彩色多普勒血流信息。为了滤除心脏壁、血管壁等反射的信号,以有效地检测超声射线方向的多普勒信号,可以使用MTI滤波器。经过MTI滤波器的超声多普勒信号,进入自相关处理器进行自相关处理,在分别进行平均速度、分散和乘方运算,便得到彩色多普勒信号。将彩色多普勒信号、多普勒频谱信号以及B型信号一起送入数字扫描转换单元(DSC),然后再进行彩色处理,得到红(R)、绿(G)、蓝(B)三基色数字信号,最后经过数模转换(D/A),在彩色显示器上显示和录像机记录。 The above-mentioned Doppler blood flow imaging is mainly that the received Doppler echo signal is phase-detected by a frequency mixing circuit and a low-pass filter, and then sent all the way to the processing circuit for spectrum analysis to display the Doppler spectrum; All the way to the computer circuit to get color Doppler blood flow information. In order to filter out signals reflected by heart walls, blood vessel walls, etc., to effectively detect Doppler signals in the direction of ultrasound rays, an MTI filter can be used. The ultrasonic Doppler signal passed through the MTI filter enters the autocorrelation processor for autocorrelation processing, and the average velocity, dispersion and power calculation are performed respectively to obtain the color Doppler signal. Send the color Doppler signal, Doppler spectrum signal and B-type signal to the digital scan conversion unit (DSC), and then perform color processing to obtain the three primary colors of red (R), green (G) and blue (B) The digital signal, after digital-to-analog conversion (D/A), is displayed on a color monitor and recorded by a video recorder.
上述血流向量成像,可以根据需要选择不同的成像方式,比如:一种方式利用B超图像斑点追踪血液散射子的运动;另一种是在传统的一维多普勒技术的基础之上,通过从不同的方向发射或者接收回波信号,从两个方向估计血流速度,利用三角向量合成最终的血流向量。For the above-mentioned blood flow vector imaging, different imaging methods can be selected according to needs, for example: one method uses B-ultrasound image spots to track the movement of blood scatterers; the other is based on traditional one-dimensional Doppler technology, By transmitting or receiving echo signals from different directions, the blood flow velocity is estimated from two directions, and the final blood flow vector is synthesized by using triangular vectors.
本申请实施例中的超声双功能换能器120,是一种在预设超声频率范围将交变的电信号转换成声信号或者将外界声场中的声信号转换为电信号的能量转换器件 ,具备成像和刺激两种模式。超声发射模块110可产生两种高压脉冲发射信号(成像和刺激)驱动超声双功能换能器120;超声接收模块130主要用于接收超声回波信号转换成数字信号用于成像。The ultrasonic dual-function transducer 120 in the embodiment of the present application is an energy conversion device that converts an alternating electrical signal into an acoustic signal or converts an acoustic signal in an external sound field into an electrical signal within a preset ultrasonic frequency range. It has two modes of imaging and stimulation. The ultrasonic transmitting module 110 can generate two high-voltage pulsed transmitting signals (imaging and stimulation) to drive the ultrasonic dual-function transducer 120; the ultrasonic receiving module 130 is mainly used to receive ultrasonic echo signals and convert them into digital signals for imaging.
可选的,上述成像模块140,可以用于实现以下三种成像模式中的一种或几种:B-Mode成像、多普勒血流成像、血流向量成像。Optionally, the aforementioned imaging module 140 can be used to implement one or more of the following three imaging modes: B-Mode imaging, Doppler blood flow imaging, and blood flow vector imaging.
进一步可选的,上述超声参数包括肾动脉血管管径、血流速度、血流量、管壁剪切力中的一种或几种参数的刺激前后变化量和变化率。Further optionally, the above-mentioned ultrasound parameters include the amount and rate of change before and after stimulation of one or more parameters of renal artery diameter, blood velocity, blood flow, and vessel wall shear force.
上述参数测量模块150,可以基于成像模块140获得的检测图像,测量获得各种超声参数(可以是超声参数变化值),例如,从生成的B-Mode灰阶图像上测量肾动脉血管管径,从从生成的多普勒血流成像和血流向量图像上测量血流速度、血流量、管壁剪切力等血流动力学参数及其刺激前后变化量,变化率等,还可以测量不同模式图像上的不同参数类型,并可以根据需要进行设置,本申请实施例对此不做限制。The above-mentioned parameter measurement module 150 can measure and obtain various ultrasonic parameters (which may be ultrasonic parameter change values) based on the detection image obtained by the imaging module 140, for example, measure the diameter of the renal artery from the generated B-Mode grayscale image, From the generated Doppler blood flow imaging and blood flow vector images, hemodynamic parameters such as blood flow velocity, blood flow, and wall shear force, as well as their changes before and after stimulation, and the rate of change, etc. can also be measured. Different parameter types on the mode image can be set as required, which is not limited in this embodiment of the present application.
上述评估模块160,可以联合参数测量模块150测量出的参数和常规指标,例如血压、心率变异性、血液生化参数和生理参数等,对肾交感神经活性进行综合评估,本申请实施例对评估维度不做限制。The above evaluation module 160 can combine the parameters measured by the parameter measurement module 150 and conventional indicators, such as blood pressure, heart rate variability, blood biochemical parameters and physiological parameters, etc., to comprehensively evaluate renal sympathetic nerve activity. No restrictions.
在一种可选的实施方式中,上述评估结果包括肾交感神经活性程度;In an optional embodiment, the above assessment results include the degree of renal sympathetic nerve activity;
上述评估模块160包括预设评估模型,用于:The above evaluation module 160 includes a preset evaluation model for:
基于上述超声参数变化值,对肾交感神经活性进行评分;Based on the changes in the above ultrasound parameters, the renal sympathetic nerve activity was scored;
通过比较上述评分和预设评估阈值,判断上述肾交感神经活性程度。By comparing the score above with a preset evaluation threshold, the degree of activity of the above-mentioned renal sympathetic nerves is judged.
具体的,评估模块160对肾交感神经活性的评估可以基于预设评估模型,根据测得的超声参数或者其变化值对肾交感神经活性进行评分,并将评分结果和预设评估阈值进行比较,来判断肾交感神经活性程度,比如,可以认为高于某个阈值a,表示肾交感神经活性较高,该人群能从RDN手术中获益;如果RDN手术后,采用***刺激靶区,刺激前后测量参数无变化或变化率小于某个阈值b,认为神经活性丧失,RDN手术效果理想。可以根据需要设置相应的判断规则、评估模型或相关阈值。Specifically, the evaluation module 160 may evaluate the renal sympathetic nerve activity based on a preset evaluation model, score the renal sympathetic nerve activity according to the measured ultrasound parameters or their changes, and compare the scoring result with the preset evaluation threshold, To judge the degree of renal sympathetic nerve activity, for example, it can be considered that if it is higher than a certain threshold a, it means that the renal sympathetic nerve activity is high, and this group of people can benefit from RDN surgery; If there is no change in the measured parameters or the rate of change is less than a certain threshold b, the nerve activity is considered to be lost, and the effect of RDN surgery is ideal. Corresponding judgment rules, evaluation models or related thresholds can be set as required.
上述控制模块170,主要用于用户对***进行操作控制,该控制模块170可以通过人机交互界面接收用户操作,并编译相应的控制指令,将控制指令传输到对应的模块以达到控制该模块实现相应功能。The above-mentioned control module 170 is mainly used for the user to control the operation of the system. The control module 170 can receive user operations through the human-computer interaction interface, compile the corresponding control instructions, and transmit the control instructions to the corresponding modules to achieve control of the modules. corresponding function.
具体的,对实际应用中该无创肾交感神经活性检测***100工作流程的基本内容举例如下:Specifically, the basic content of the workflow of the non-invasive renal sympathetic nerve activity detection system 100 in practical applications is exemplified as follows:
A1、***100首先设置为实时成像模式,利用B-Mode成像和多普勒血流成像,联合解剖结构信息和多普勒血流信息对肾动脉进行有效定位,获取肾动脉血管壁周围的肾交感神经分布区域作为刺激靶区;A1. The system 100 is first set to the real-time imaging mode, uses B-Mode imaging and Doppler blood flow imaging, combined with anatomical structure information and Doppler blood flow information to effectively locate the renal artery, and obtain renal arteries around the renal artery wall. The sympathetic nerve distribution area is used as the stimulation target area;
A2、利用实时B-Mode成像、多普勒血流成像和血流向量成像,分别测量刺激前的肾动脉管径、血流速度、血流量、管壁剪切力等血流动力学参数;A2. Use real-time B-Mode imaging, Doppler blood flow imaging and blood flow vector imaging to measure hemodynamic parameters such as renal artery diameter, blood flow velocity, blood flow, and wall shear force before stimulation;
A3、***100设置为实时成像+刺激模式,控制产生多通道不同时间延迟的脉冲信号,驱动超声线阵换能器发射多路超声波,形成电子聚焦从靶区起始点出发,焦点按照设定的扫描轨迹以恒定速度移动,直到依次遍历刺激整个靶区,重复刺激30s~300s;A3. The system 100 is set to real-time imaging + stimulation mode, controls the generation of multi-channel pulse signals with different time delays, drives the ultrasonic linear array transducer to emit multi-channel ultrasonic waves, and forms an electronic focus starting from the starting point of the target area, and the focus follows the set The scanning trajectory moves at a constant speed until the entire target area is stimulated in sequence, and the stimulation is repeated for 30s to 300s;
A4、刺激结束后,等待5~30s,利用B-Mode成像、多普勒血流成像或血流向量成像分别测量刺激后肾动脉管径、血流速度、血流量、管壁剪切力等血流动力学参数;计算以上超声参数的变化量、变化率并记录;A4. After the stimulation, wait for 5-30 seconds, and use B-Mode imaging, Doppler flow imaging or blood flow vector imaging to measure the renal artery diameter, blood flow velocity, blood flow, and wall shear force after stimulation. Hemodynamic parameters; calculate the amount of change and rate of change of the above ultrasound parameters and record them;
A5、重复以上过程3次以上,超声参数可取平均;A5. Repeat the above process more than 3 times, and the ultrasonic parameters can be averaged;
A6、联合***100测量超声参数和常规指标,例如血压、心率变异性、血液生化参数和生理参数等,对肾交感神经活性进行综合评估。A6. Combine the system 100 to measure ultrasound parameters and conventional indicators, such as blood pressure, heart rate variability, blood biochemical parameters and physiological parameters, etc., to comprehensively evaluate renal sympathetic nerve activity.
本申请实施例中的无创肾交感神经活性检测***100,可以通过超声波的非线性效应使声场中的肾交感神经受到声辐射力的作用,实现无创、深部刺激肾交感神经,并且实现了超声刺激和成像引导一体化;直接检测刺激部位的局部反应作为肾交感神经活性新的评估指标,相比比血压、心率变异性等表征整体交感***反应的指标,更精确有效。The non-invasive renal sympathetic nerve activity detection system 100 in the embodiment of the present application can make the renal sympathetic nerve in the sound field be subjected to the action of acoustic radiation force through the nonlinear effect of ultrasound, realize non-invasive and deep stimulation of the renal sympathetic nerve, and realize ultrasonic stimulation Integrate with imaging guidance; directly detect the local response at the stimulation site as a new evaluation index of renal sympathetic nerve activity, which is more accurate and effective than indicators that characterize the overall sympathetic system response such as blood pressure and heart rate variability.
目前常用的肾交感神经活性检测中,①基于电刺激装置的检测方法穿透性较差,需采用电极直接接触神经,不能进行非接触的深部刺激,而肾交感神经位于深部,通常只能在术中,或者微创介入使用;且神经活性评估指标也通常为有创股动脉血压、常规测量血压和心率,反映整体交感神经***活性,只能间接表征肾交感神经的活性,准确性较差。②基于血液成分检测装置的肾交感神经检测技术同样是微创介入性,需将血液成分检测装置置于肾动脉血管内,刺激装置也是介入性,且血液成分变化有滞后性,是否有显著变化量还有待研究。③基于超声的神经检测技术虽然无创,但主要用于神经定位、刺激和消融,目前没有用于肾交感神经活性的检测,且评估指标也通常为血压和心率,反映整体交感神经***活性。Among the currently commonly used detection methods for renal sympathetic nerve activity, ① the detection method based on electrical stimulation devices has poor penetration, and electrodes need to be used to directly contact the nerve, and non-contact deep stimulation cannot be performed. Intraoperative, or minimally invasive intervention; and nerve activity evaluation indicators are usually invasive femoral artery blood pressure, routine measurement of blood pressure and heart rate, reflecting the overall sympathetic nervous system activity, can only indirectly represent the activity of renal sympathetic nerves, and the accuracy is poor . ②The renal sympathetic nerve detection technology based on the blood component detection device is also minimally invasive and interventional. The blood component detection device needs to be placed in the renal artery, and the stimulation device is also invasive, and the change of the blood component has a hysteresis. Is there any significant change? amount is still under study. ③Although ultrasound-based nerve detection technology is non-invasive, it is mainly used for nerve localization, stimulation, and ablation. Currently, it is not used for the detection of renal sympathetic nerve activity, and the evaluation indicators are usually blood pressure and heart rate, which reflect the overall sympathetic nervous system activity.
针对目前技术方案的局限性,本申请实施例提供的一种无创肾交感神经活性检测***,深度挖掘利用超声波独特的声学特性和生物物理效应,利用超声波的力学效应进行神经刺激,利用超声波的波动效应进行如B超成像、多普勒血流成像和血流矢量成像等成像功能,获取刺激前后肾动脉血管管径、血流速度、血流量等血流动力学参数及其变化量、变化率等,可以无创评估受测人员肾交感神经的活性。可以辅助手术前后的状态评估。肾交感神经活性较高的人群能从RDN手术中获益,术后也可以对消融效果进行评估,如果神经活性丧失,则认为RDN手术效果理想。本申请实施例为神经活性评估提供无创、有效的临床新工具,为RDN手术规划提供了重要的指导意义。Aiming at the limitations of the current technical solutions, a non-invasive renal sympathetic nerve activity detection system provided in the embodiment of the present application uses the unique acoustic characteristics and biophysical effects of ultrasound to deeply excavate, utilizes the mechanical effects of ultrasound to stimulate nerves, and uses the fluctuations of ultrasound to Perform imaging functions such as B-ultrasound imaging, Doppler blood flow imaging, and blood flow vector imaging to obtain hemodynamic parameters such as renal artery diameter, blood flow velocity, and blood flow before and after stimulation, as well as their variation and rate of change etc., can non-invasively assess the activity of the renal sympathetic nerves of the subjects. It can assist in status assessment before and after surgery. People with high renal sympathetic nerve activity can benefit from RDN surgery, and the ablation effect can also be evaluated after surgery. If the nerve activity is lost, the RDN surgery effect is considered ideal. The embodiment of the present application provides a non-invasive and effective clinical new tool for nerve activity assessment, and provides important guiding significance for RDN surgery planning.
在一种可选的实施方式中,上述超声双功能换能器120包括多层叠结构线阵换能器,具体可包括:保护层、匹配层、压电材料层、背衬层、散热层和柔性电路板,其中:In an optional embodiment, the above-mentioned ultrasonic dual-function transducer 120 includes a multi-layer structure linear array transducer, which may specifically include: a protective layer, a matching layer, a piezoelectric material layer, a backing layer, a heat dissipation layer and Flexible circuit boards, where:
上述保护层用于保护压电材料层;The above protective layer is used to protect the piezoelectric material layer;
上述匹配层用于增强传播到组织中的超声波能量;The above-mentioned matching layer is used to enhance the ultrasonic energy propagating into the tissue;
上述压电材料层用于实现电信号与声信号的互相转换;The above-mentioned piezoelectric material layer is used to realize mutual conversion between electrical signals and acoustic signals;
上述背衬层用于连接上述压电材料层和上述散热层,将热量从上述压电材料层传导到上述散热层;The above-mentioned backing layer is used to connect the above-mentioned piezoelectric material layer and the above-mentioned heat dissipation layer, and conduct heat from the above-mentioned piezoelectric material layer to the above-mentioned heat dissipation layer;
上述柔性电路板用于连结上述超声双功能换能器和上述超声发射模块以进行信号传输。The above-mentioned flexible circuit board is used for connecting the above-mentioned ultrasonic dual-function transducer and the above-mentioned ultrasonic transmitting module for signal transmission.
具体的,超声双功能换能器120可以为多层叠结构线阵换能器,在一种实施方式中,该多层叠结构线阵换能器由前至后依次为保护层、匹配层、压电材料层、背衬层、散热层和柔性电路板。通过对每个阵元单独引线、发射顺序和时间延迟控制,利用线性电子聚焦、动态聚焦、实时动态孔径、动态变迹以及动态频率扫描等技术相结合,可获得优越的声束分辨特性、很高的旁瓣抑制能力和较大的信号动态范围。在一种可选实施方式中,其具体结构及作用介绍如下:Specifically, the ultrasonic dual-function transducer 120 may be a multi-layer structure linear array transducer. Electrical material layer, backing layer, heat dissipation layer and flexible circuit board. Through the control of each array element's individual leads, emission sequence and time delay, and the combination of linear electronic focusing, dynamic focusing, real-time dynamic aperture, dynamic apodization and dynamic frequency scanning, it can obtain superior acoustic beam resolution characteristics, very High sidelobe suppression capability and large signal dynamic range. In an optional implementation mode, its specific structure and functions are introduced as follows:
保护层:位于超声双功能换能器120表面,保护压电材料层不被磨损或破坏,用硅橡胶制备,声阻抗与人体组织相近,低衰减,用于波束聚焦,提高横向分辨力,其厚度可以根据需要设置,;例如可取1/4波长;Protective layer: located on the surface of the ultrasonic dual-function transducer 120, to protect the piezoelectric material layer from being worn or damaged, made of silicone rubber, the acoustic impedance is similar to that of human tissue, low attenuation, used for beam focusing, and to improve lateral resolution. The thickness can be set according to the needs; for example, 1/4 wavelength can be taken;
匹配层:采用环氧树脂和致密粉末(如氧化铝、玻璃粉等)制备,解决超声双功能换能器120声阻抗与生物组织声阻抗的声学匹配,增强传播到组织中的超声波能量;Matching layer: It is made of epoxy resin and dense powder (such as alumina, glass powder, etc.), which solves the acoustic matching between the acoustic impedance of the ultrasonic dual-function transducer 120 and the acoustic impedance of biological tissue, and enhances the ultrasonic energy transmitted to the tissue;
压电材料层:可采用1-3型压电复合材料制备,由一维连通的压电陶瓷柱相平行排列于三维连通的环氧树脂组成。加入环氧树脂等聚合物,有效降低了陶瓷在强度脆性方面的弱点,减小了陶瓷的横向耦合,增大了复合材料纵向机电转换效率;具有低声阻抗,易与水和皮肤等介质进行阻抗匹配;由于聚合物衰减较大,Q值较低,适合制作宽带窄脉冲换能器。可选的,可以采用切割填充法制备,将已极化的压电陶瓷切割成均匀排列的立柱,灌注环氧树脂,抽真空、固化,磨去未切通部分而制成。压电材料层根据其特有的压电效应,可实现电信号与声信号的互相转换,是超声双功能换能器120的核心部件,二面被有金属层作为电极层。Piezoelectric material layer: it can be prepared by using 1-3 type piezoelectric composite materials, and is composed of one-dimensionally connected piezoelectric ceramic pillars arranged in parallel with three-dimensionally connected epoxy resin. Adding polymers such as epoxy resin effectively reduces the weakness of ceramics in terms of strength and brittleness, reduces the transverse coupling of ceramics, and increases the longitudinal electromechanical conversion efficiency of composite materials; it has low acoustic impedance and is easy to communicate with media such as water and skin. Impedance matching; due to the large attenuation of the polymer and the low Q value, it is suitable for making broadband narrow pulse transducers. Optionally, it can be prepared by a cut-and-fill method. The polarized piezoelectric ceramics are cut into evenly arranged columns, poured with epoxy resin, vacuumed, cured, and the uncut parts are ground away. The piezoelectric material layer can realize mutual conversion between electrical signals and acoustic signals according to its unique piezoelectric effect. It is the core component of the ultrasonic dual-function transducer 120 , and the two sides are covered with metal layers as electrode layers.
背衬层:使用环氧树脂、钨粉、氧化铝粉和一些增强衰减的添加物制备,具有高衰减、低声阻抗的声学特性,吸收压电材料层因震动而往内部辐射的声能量,防止声能量反射造成干扰,连接压电材料层和散热层,将热量从压电材料层传导到散热层;Backing layer: It is made of epoxy resin, tungsten powder, alumina powder and some additives to enhance attenuation. It has the acoustic characteristics of high attenuation and low acoustic impedance, and absorbs the acoustic energy radiated internally by the piezoelectric material layer due to vibration. Prevent the interference caused by the reflection of sound energy, connect the piezoelectric material layer and the heat dissipation layer, and conduct heat from the piezoelectric material layer to the heat dissipation layer;
散热层:采用铝合金,铜,铜合金和其它金属制备,具有高的热导率;Heat dissipation layer: made of aluminum alloy, copper, copper alloy and other metals, with high thermal conductivity;
柔性电路板:连结超声双功能换能器120和超声发射模块110,可使用具有镂空引脚的柔性线路板进行阵元引线。Flexible circuit board: to connect the ultrasonic dual-function transducer 120 and the ultrasonic transmitting module 110, a flexible circuit board with hollow pins can be used for element lead.
本申请实施例中采用的线阵超声换能器可以根据需要设置其阵元数量、中心频率和带宽范围等参数,此处不做限制。例如,可以包括20-256个阵元,中心频率4.7MHz,-6dB带宽范围:2.95MHz-6.45MHz,百分比带宽:74.4%。The linear array ultrasonic transducer used in the embodiment of the present application can set parameters such as the number of array elements, center frequency, and bandwidth range according to needs, and there is no limitation here. For example, it can include 20-256 array elements, center frequency 4.7MHz, -6dB bandwidth range: 2.95MHz-6.45MHz, percentage bandwidth: 74.4%.
在一种可选的实施方式中,***可根据需要选择其他类型的超声换能器,例如半球阵、面阵、线阵,环阵等,作用于不同部位的神经,例如脑、心脏、甲状腺、血管等,此处不做限制。In an optional embodiment, the system can select other types of ultrasonic transducers according to needs, such as hemispherical array, area array, linear array, ring array, etc., to act on nerves in different parts, such as brain, heart, thyroid , blood vessels, etc., are not limited here.
可选的,还可以采用或结合其他类型的刺激模块,即选择或结合其他能量源产生无创神经刺激,例如电能、机械能、声能、磁能、光能和热能等,本申请实施例对此不做限制。Optionally, other types of stimulation modules can also be used or combined, that is, other energy sources can be selected or combined to generate non-invasive nerve stimulation, such as electrical energy, mechanical energy, sound energy, magnetic energy, light energy and thermal energy, etc., which are not discussed in this embodiment of the application. Do limit.
在一种可选的实施方式中,上述超声发射模块110包括脉冲波形发生器、功率放大器和换能器匹配电路,其中:In an optional implementation manner, the above-mentioned ultrasonic transmitting module 110 includes a pulse waveform generator, a power amplifier and a transducer matching circuit, wherein:
上述脉冲波形发生器由可编程逻辑器件完成;The above-mentioned pulse waveform generator is completed by a programmable logic device;
上述功率放大器包括成像发射功率放大器和刺激功率放大器,上述成像发射功率放大器采用场效应管驱动器及场效应对管实现,用于产生上述第一脉冲发射信号,上述刺激功率放大器用于对上述第二脉冲发射信号进行功率放大;The above-mentioned power amplifier includes an imaging transmission power amplifier and a stimulation power amplifier. The above-mentioned imaging transmission power amplifier is realized by a field effect tube driver and a field effect counter tube, and is used to generate the above-mentioned first pulse transmission signal. The above-mentioned stimulation power amplifier is used for the above-mentioned second Pulse transmission signal for power amplification;
上述换能器匹配电路包含串联电阻和并联电感,上述串联电阻用于实现脉冲产生电路和上述超声双功能换能器120之间的阻抗匹配,并联电感用于实现上述超声双功能换能器120的并联调谐。The above-mentioned transducer matching circuit includes a series resistance and a parallel inductance, the above-mentioned series resistance is used to realize the impedance matching between the pulse generating circuit and the above-mentioned ultrasonic dual-function transducer 120, and the parallel-connected inductance is used to realize the above-mentioned ultrasonic dual-function transducer 120 parallel tuning.
具体的,上述脉冲波形发生器由可编程逻辑器件(FPGA)完成,可以根据需要选择芯片,例如可选用Altera公司EP4CE115F29C7N芯片,成像和刺激发射脉冲序列的基本参数包括频率、个数、延迟、占空比、重复频率、时序等都可以进行编程控制。Specifically, the above-mentioned pulse waveform generator is completed by a programmable logic device (FPGA), and the chip can be selected according to the needs, for example, the EP4CE115F29C7N chip of Altera Company can be selected. The basic parameters of the imaging and stimulation emission pulse sequence include frequency, number, delay, occupation Duty ratio, repetition rate, timing, etc. can be programmed and controlled.
FPGA输出的脉冲波形幅度、功率很小,不足以直接驱动超声双功能换能器120,因此设置成像发射功率放大器。该成像发射功率放大器可采用场效应管驱动器MD1711及场效应对管TC6320来实现。MD1711是一款高性能的驱动器,芯片内部集成了2个通道,可以产生5级波形用于B-mode和彩色多普勒成像***。TC6320是高压低门限增强型场对管,内部集成两对推挽电路,每对推挽电路由一个P沟道MOSFET和一个N沟道MOSFET组成,前端逻辑控制驱动栅极可导通最高±100V的高压激励,最大输出电流3A,可用于产生双极性高压脉冲信号;两管彼此隔离,且每个管都集成有栅源电阻和钳位栅源齐纳二极管,有效保护了输入端;具有高达的击穿电压和的输出峰值电流,可以有效激励超声双功能换能器120。The amplitude and power of the pulse waveform output by the FPGA are too small to directly drive the ultrasonic dual-function transducer 120 , so an imaging transmit power amplifier is set. The imaging transmitting power amplifier can be realized by adopting field effect tube driver MD1711 and field effect tube TC6320. MD1711 is a high-performance driver with 2 channels integrated inside the chip, which can generate 5-level waveforms for B-mode and color Doppler imaging systems. TC6320 is a high-voltage low-threshold enhanced field-to-tube transistor. It integrates two pairs of push-pull circuits. Each pair of push-pull circuits is composed of a P-channel MOSFET and an N-channel MOSFET. The front-end logic control drive gate can conduct up to ±100V High-voltage excitation, the maximum output current is 3A, which can be used to generate bipolar high-voltage pulse signals; the two tubes are isolated from each other, and each tube is integrated with a gate-source resistor and a clamping gate-source Zener diode, which effectively protects the input terminal; The high breakdown voltage and high output peak current can effectively excite the ultrasonic dual-function transducer 120 .
刺激功率放大器可以根据需要选择,例如可选用Microsemi公司的VRF151G,经过功率放大后的波形幅值最高170V,持续漏电流最大36A,可工作的频率上限175MHz,最大发射功率可达150W。The stimulation power amplifier can be selected according to the needs. For example, VRF151G from Microsemi can be used. After power amplification, the waveform amplitude is up to 170V, the maximum continuous leakage current is 36A, the upper limit of the working frequency is 175MHz, and the maximum transmission power can reach 150W.
匹配电路可以由一个串联电阻和一个并联电感组成。根据超声双功能换能器120实际频谱特性进行微调达到匹配。电阻实现高压激励脉冲产生电路和换能器之间的阻抗匹配,并联电感实现换能器的并联调谐。在此基础上,超声发射模块110的信号发射时序如图3所示,其中显示了两种不同的发射信号,即用于成像的较低能量、短脉冲发射信号,和用于刺激的较高能量、长脉冲发射信号,两者可高速切换。多通道脉冲电信号通过电子延迟,实现电子聚焦。The matching circuit can consist of a series resistor and a shunt inductor. Fine-tuning is performed according to the actual frequency spectrum characteristics of the ultrasonic dual-function transducer 120 to achieve matching. The resistor realizes the impedance matching between the high-voltage excitation pulse generating circuit and the transducer, and the parallel inductor realizes the parallel tuning of the transducer. On this basis, the signal transmission timing sequence of the ultrasonic transmission module 110 is shown in Figure 3, which shows two different transmission signals, that is, a lower-energy, short-pulse transmission signal for imaging, and a higher one for stimulation. Energy and long-pulse transmission signals, both of which can be switched at high speed. Multi-channel pulsed electrical signals are electronically delayed to achieve electronic focusing.
在一种可选的实施方式中,上述超声接收模块130包括收发隔离电路、可变增益放大器、滤波电路和模数转换电路,其中:In an optional implementation manner, the above-mentioned ultrasonic receiving module 130 includes a transceiver isolation circuit, a variable gain amplifier, a filter circuit, and an analog-to-digital conversion circuit, wherein:
上述收发隔离电路用于实现上述超声回波信号的接收通道与上述超声发射信号的发射通道的隔离;The transceiver isolation circuit is used to isolate the receiving channel of the ultrasonic echo signal from the transmitting channel of the ultrasonic transmitting signal;
上述可变增益放大器用于对上述超声回波信号进行放大处理;The above-mentioned variable gain amplifier is used to amplify the above-mentioned ultrasonic echo signal;
上述滤波电路用于对上述超声回波信号进行滤波;The above-mentioned filter circuit is used to filter the above-mentioned ultrasonic echo signal;
上述模数转换电路用于对超声回波信号进行模数转换,并将转换后的信号传输给上述脉冲波形发生器缓存。The above-mentioned analog-to-digital conversion circuit is used to perform analog-to-digital conversion on the ultrasonic echo signal, and transmit the converted signal to the buffer of the above-mentioned pulse waveform generator.
具体的,超声双功能换能器120是收发一体的,需要对收发回路进行隔离,以避免高压发射脉冲直接加到接收回路上,损毁后级器件。在接收电路的最前端设计收发切换开关,在激励高压的瞬间断开,发射完再导通接收回波信号。在一种实施方式中,收发隔离电路主要由PNP开关晶体管3CK2C和公司的高压开关二极管阵列MMBD3004BRM构成。门控制电平信号直接输入到3CK2C的基极,当该信号为高电平时,3CK2C截止,发射极与集电极之间处于关断状态,直流电源无法通过3CK2C向BD3004提供有效的正向偏置电压,二极管截止,使得超声回波接收通道处于断路关闭状态,实现与发射通道的隔离。而当门控信号为低电平时,3CK2C处于饱和状态,开关导通,直流电源通过发射极的电阻分压作用向回波通道的二极管提供足够大的正向偏置电压,使二极管导通,即开启了接收通道,使得超声回波信号能够无损的经由二极管进入到后续的信号调理电路。Specifically, the ultrasonic dual-function transducer 120 is integrated with a transceiver, and the transceiver circuit needs to be isolated to prevent high-voltage transmission pulses from being directly applied to the receiving circuit and damage subsequent devices. A transceiver switch is designed at the front end of the receiving circuit, which is disconnected at the moment of exciting the high voltage, and then turned on to receive the echo signal after transmission. In one embodiment, the transceiver isolation circuit is mainly composed of a PNP switch transistor 3CK2C and the company's high-voltage switch diode array MMBD3004BRM. The gate control level signal is directly input to the base of 3CK2C. When the signal is high level, 3CK2C is cut off, and the emitter and collector are in an off state. The DC power supply cannot provide effective forward bias to BD3004 through 3CK2C. voltage, the diode is cut off, so that the ultrasonic echo receiving channel is in the off-circuit state, and the isolation from the transmitting channel is realized. When the gate control signal is low level, 3CK2C is in a saturated state, the switch is turned on, and the DC power supply provides a sufficient forward bias voltage to the diode of the echo channel through the resistor divider of the emitter, so that the diode is turned on. That is, the receiving channel is opened, so that the ultrasonic echo signal can enter the subsequent signal conditioning circuit through the diode without loss.
超声双功能换能器120接收到的回波信号十分微弱,不能直接采样量化,需要对信号进行放大处理。在一种实施方式中,可变增益放大器可选用TI公司的超声前端模拟芯片AFE5808,AFE5808内部是8通道设计,每通道都集成了LNA、VCAT、PGA、LPF、ADC和CW MIXER等功能,将原本复杂分立的超声接收电路整合在一片芯片内,更利于优化设计和控制噪声。在低噪声模式下,可实现最大54dB的动态增益控制,滤波电路的截止频率多档可选,可通过SPI修改寄存器方便的实现,在经过前面的信号放大和模拟滤波之后,对超声回波进行模数转换,以低电压差分信号的形式传输给FPGA数据缓存。The echo signal received by the ultrasonic dual-function transducer 120 is very weak and cannot be directly sampled and quantized, and the signal needs to be amplified. In one embodiment, the variable gain amplifier can be the ultrasonic front-end analog chip AFE5808 of TI Company. AFE5808 is designed with 8 channels inside, and each channel integrates functions such as LNA, VCAT, PGA, LPF, ADC and CW MIXER. The original complex and discrete ultrasonic receiving circuit is integrated in one chip, which is more conducive to optimal design and noise control. In low-noise mode, it can achieve a dynamic gain control of up to 54dB. The cut-off frequency of the filter circuit can be selected in multiple levels. It can be easily realized by modifying the register through SPI. After the previous signal amplification and analog filtering, the ultrasonic echo can be adjusted. Analog-to-digital conversion, which is transmitted to the FPGA data buffer in the form of a low-voltage differential signal.
本申请实施例中,***采用超声双功能换能器,具备刺激和成像两种模式,不仅能实现成像所使用的低能量、短脉冲发射方式,还能实现刺激所使用的较高能量、较长脉冲发射方式,通过结构优化设计,改进探头制作工艺,使压电材料和粘接剂涂层的平整程度达到微米级,进一步改善了探头的热传导性能,解决了探头进行较大功率超声发射时引起的换能器发热问题,优化了驱动电路设计,缩短了换能器响应时间,提高了“刺激-成像”模式之间的切换速度等。In the embodiment of this application, the system adopts an ultrasonic dual-function transducer with two modes of stimulation and imaging. Long-pulse transmission mode, through structural optimization design, improved probe manufacturing process, so that the flatness of piezoelectric material and adhesive coating reaches micron level, further improves the thermal conductivity of the probe, and solves the problem when the probe conducts high-power ultrasonic transmission. Due to the problem of transducer heating caused by the problem, the design of the drive circuit is optimized, the response time of the transducer is shortened, and the switching speed between the "stimulation-imaging" modes is improved.
图4A为本申请实施例提供的一种肾动脉B-mode图像示意图,图4B为本申请实施例提供的一种肾动脉多普勒血流图像示意图。举例来讲,在具体操作中,***的超声探头可横向置于右前腹肋间或肋缘下,在下移的肝后方寻找右肾静脉和下腔静脉,然后在这些静脉后方寻找右肾动脉长轴切面。如图4A所示,可以利用B-Mode图像获取肾动脉解剖结构信息,测量肾动脉中段血管管径及变化量。如图4B所示,可以利用多普勒血流成像(也可利用血流向量成像),测量肾动脉中段血流平均速度、血流量及变化量。可选的,还可以利用血流向量成像测量管壁剪切力及变化量。完成一侧肾动脉测量后,换另一侧按上述方式进行操作。Fig. 4A is a schematic diagram of a renal artery B-mode image provided in the embodiment of the present application, and Fig. 4B is a schematic diagram of a renal artery Doppler blood flow image provided in the embodiment of the present application. For example, in a specific operation, the ultrasound probe of the system can be placed laterally in the right anterior abdominal intercostal space or under the costal margin, and the right renal vein and inferior vena cava can be found behind the descending liver, and then the long axis of the right renal artery can be found behind these veins section. As shown in FIG. 4A , the B-Mode image can be used to obtain the anatomical structure information of the renal artery, and to measure the vascular diameter and variation in the middle segment of the renal artery. As shown in FIG. 4B , Doppler blood flow imaging (blood flow vector imaging can also be used) can be used to measure the average velocity, blood flow and variation of blood flow in the middle renal artery. Optionally, the blood flow vector imaging can also be used to measure the wall shear force and its variation. After completing the measurement of one renal artery, switch to the other side and proceed as above.
可选的,本申请实施例中还可采用多种生理、功能信息监测,例如肌电信号、血压、心率、温度、血氧饱和度、血流动力学参数、硬度、肌肉抽动等。该***还可用于检测其他对机械力刺激有反馈的生物组织神经的活性,例如迷走神经、副交感神经等。Optionally, various physiological and functional information monitoring may also be used in the embodiment of the present application, such as electromyographic signals, blood pressure, heart rate, temperature, blood oxygen saturation, hemodynamic parameters, hardness, muscle twitching, and the like. The system can also be used to detect the activity of other biological tissue nerves that respond to mechanical stimulation, such as vagus nerve, parasympathetic nerve, etc.
请参阅图5,图5是本申请另一实施例提供的一种无创肾交感神经活性检测***的结构功能示意图。具体的,该无创肾交感神经活性检测***包括:超声双功能线阵换能器、超声发射模块、超声接收模块、多模式成像模块、控制模块和参数测量模块。超声双功能线阵换能器与超声发射模块和超声接收模块连接,超声接收模块与多模式成像模块连接,多模式成像模块连接与控制模块连接,控制模块与超声发射模块连接,超声发射模块、超声接收模块、多模式成像模块和评估模块分别所包含的功能单元如图所示。该无创肾交感神经活性检测***具体结构和功能可以参考图1所示实施例中的具体描述,此处不再赘述。Please refer to FIG. 5 . FIG. 5 is a structural and functional schematic diagram of a non-invasive renal sympathetic nerve activity detection system provided by another embodiment of the present application. Specifically, the non-invasive renal sympathetic nerve activity detection system includes: an ultrasonic dual-function linear array transducer, an ultrasonic transmitting module, an ultrasonic receiving module, a multi-mode imaging module, a control module and a parameter measurement module. The ultrasonic dual-function linear array transducer is connected with the ultrasonic transmitting module and the ultrasonic receiving module, the ultrasonic receiving module is connected with the multi-mode imaging module, the multi-mode imaging module is connected with the control module, the control module is connected with the ultrasonic transmitting module, the ultrasonic transmitting module, The functional units contained in the ultrasonic receiving module, multi-mode imaging module and evaluation module are shown in the figure. For the specific structure and function of the non-invasive renal sympathetic nerve activity detection system, reference may be made to the specific description in the embodiment shown in FIG. 1 , which will not be repeated here.
请参阅图6,图6是本申请实施例提供的一种无创肾交感神经活性检测方法的流程示意图。该方法可应用于如图1或图5所示实施例中的无创肾交感神经活性检测***,该无创肾交感神经活性检测***包括超声发射模块、超声双功能换能器、超声接收模块、成像模块、参数测量模块、评估模块和控制模块,此处不再赘述;该方法包括:Please refer to FIG. 6 . FIG. 6 is a schematic flow chart of a method for detecting non-invasive renal sympathetic nerve activity provided by an embodiment of the present application. This method can be applied to the non-invasive renal sympathetic nerve activity detection system in the embodiment shown in Figure 1 or Figure 5, and the non-invasive renal sympathetic nerve activity detection system includes an ultrasonic transmitting module, an ultrasonic dual-function transducer, an ultrasonic receiving module, an imaging module, parameter measurement module, evaluation module and control module, which will not be described in detail here; the method includes:
超声发射模块产生第一脉冲发射信号和第二脉冲发射信号,上述第一脉冲发射信号用于成像,上述第二脉冲发射信号用于对检测部位产生刺激;The ultrasonic transmission module generates a first pulse transmission signal and a second pulse transmission signal, the first pulse transmission signal is used for imaging, and the second pulse transmission signal is used to stimulate the detection site;
其中,第一脉冲发射信号的能量低于第二脉冲发射信号,第一脉冲发射信号的脉冲短于第二脉冲发射信号的脉冲;Wherein, the energy of the first pulse transmission signal is lower than that of the second pulse transmission signal, and the pulse of the first pulse transmission signal is shorter than the pulse of the second pulse transmission signal;
602、超声双功能换能器在预设超声频率范围内将上述超声发射模块产生的脉冲发射信号转换成声信号,以及将外界声场中的声信号转换为电信号;602. The ultrasonic dual-function transducer converts the pulse emission signal generated by the above-mentioned ultrasonic emission module into an acoustic signal within the preset ultrasonic frequency range, and converts the acoustic signal in the external sound field into an electrical signal;
603、超声接收模块接收上述超声发射发射信号对应的超声回波信号,将上述超声回波信号转换成数字信号;603. The ultrasonic receiving module receives the ultrasonic echo signal corresponding to the ultrasonic transmission signal, and converts the ultrasonic echo signal into a digital signal;
604、成像模块根据上述数字信号进行超声成像,获得检测图像;604. The imaging module performs ultrasonic imaging according to the above digital signal to obtain a detection image;
605、参数测量模块基于上述检测图像测量刺激引起的超声参数变化值;605. The parameter measurement module measures the ultrasonic parameter change value caused by the stimulus based on the above detection image;
606、评估模块基于上述超声参数变化值,对肾交感神经活性进行评估,获得评估结果。606. The evaluation module evaluates the renal sympathetic nerve activity based on the change value of the above-mentioned ultrasound parameters, and obtains an evaluation result.
其中,上述方法中的步骤已经在图1-图3所示实施例中进行了相关具体描述,此处不再赘述。Wherein, the steps in the above method have been specifically described in the embodiments shown in FIGS. 1-3 , and will not be repeated here.
本申请实施例中的***采用超声刺激和引导一体化:刺激坐标和成像引导坐标的完全匹配,刺激前,利用B超成像和多普勒血流成像对肾动脉进行有效定位,获取肾动脉血管壁周围的肾交感神经分布区域作为刺激靶区;刺激后,利用B超成像实时跟踪肾动脉血管的管径变化,利用多普勒血流成像和血流向量成像实时跟踪肾动脉的血流动力学参数变化。The system in the embodiment of this application adopts the integration of ultrasonic stimulation and guidance: the complete matching of stimulation coordinates and imaging guidance coordinates, before stimulation, the use of B-ultrasound imaging and Doppler blood flow imaging to effectively position the renal artery The distribution area of renal sympathetic nerves around the wall is used as the stimulation target area; after stimulation, B-ultrasound imaging is used to track the diameter changes of renal arteries in real time, and Doppler flow imaging and blood flow vector imaging are used to track the hemodynamics of renal arteries in real time Changes in academic parameters.
***利用肾交感神经元上的机械敏感性离子通道(压力传感器)能够响应机械力刺激的特性,通过超声波的非线性效应使声场中的肾交感神经受到声辐射力的作用,达到无创、深部刺激肾交感神经,引起反应的目的。The system utilizes the characteristic that the mechanosensitive ion channel (pressure sensor) on the renal sympathetic neuron can respond to mechanical stimulation, and through the nonlinear effect of ultrasound, the renal sympathetic nerve in the sound field is affected by the acoustic radiation force to achieve non-invasive and deep stimulation. Renal sympathetic nerves, eliciting the purpose of the response.
***采用超声无创测量肾动脉的血流动力学参数,例如血流速度变化量,血流量变化量,管壁剪切力变化量等,直接检测刺激部位的局部反应,作为肾交感神经活性新的评估指标,比血压、心率变异性等表征整体交感***反应的指标更精确有效。The system uses ultrasound to non-invasively measure the hemodynamic parameters of the renal artery, such as blood flow velocity changes, blood flow changes, vessel wall shear force changes, etc., to directly detect the local reaction at the stimulation site, as a new indicator of renal sympathetic nerve activity. Evaluation indicators are more accurate and effective than indicators that characterize the overall sympathetic system response such as blood pressure and heart rate variability.
***也结合常规评估指标,例如血压、心率,血液生化参数,受测人员生理参数,检测更全面可靠,认为肾交感神经活性较高的人群能从RDN手术中获益。术后也可以对消融效果进行评估,如果神经活性丧失,则认为RDN手术效果理想。本发明为神经活性评估提供无创、有效的临床新工具,为RDN手术规划提供了重要的指导意义。The system also combines conventional evaluation indicators, such as blood pressure, heart rate, blood biochemical parameters, and physiological parameters of the subject, to make the detection more comprehensive and reliable. It is believed that people with high renal sympathetic nerve activity can benefit from RDN surgery. The effect of ablation can also be evaluated after surgery. If the nerve activity is lost, the RDN surgery is considered to be ideal. The invention provides a non-invasive and effective clinical new tool for nerve activity assessment, and provides important guiding significance for RDN operation planning.
基于上述方法实施例以及***实施例的描述,本申请实施例还提供一种电子设备。请参见图7,该电子设备700至少包括处理器701、输入设备702、输出设备703以及计算机存储介质704。其中,电子设备内的处理器701、输入设备702、输出设备703以及计算机存储介质704可通过总线或其他方式连接。Based on the descriptions of the foregoing method embodiments and system embodiments, an embodiment of the present application further provides an electronic device. Referring to FIG. 7 , the electronic device 700 includes at least a processor 701 , an input device 702 , an output device 703 and a computer storage medium 704 . Wherein, the processor 701, the input device 702, the output device 703, and the computer storage medium 704 in the electronic device may be connected through a bus or in other ways.
计算机存储介质704可以存储在电子设备的存储器中,上述计算机存储介质704用于存储计算机程序,上述计算机程序包括程序指令,上述处理器701 用于执行上述计算机存储介质704存储的程序指令。处理器701(或称CPU(Central
Processing Unit,中央处理器))是电子设备的计算核心以及控制核心,其适于实现一条或多条指令,具体适于加载并执行一条或多条指令从而实现相应方法流程或相应功能;在一个实施例中,本申请实施例上述的处理器701可以用于进行一系列的处理,包括如图6所示实施例中方法等等。The computer storage medium 704 may be stored in the memory of the electronic device, the computer storage medium 704 is used to store computer programs, the computer programs include program instructions, and the processor 701 is used to execute the program instructions stored in the computer storage medium 704 . Processor 701 (or called CPU (Central
Processing Unit (central processing unit)) is the computing core and control core of electronic equipment, which is suitable for implementing one or more instructions, specifically for loading and executing one or more instructions to realize the corresponding method flow or corresponding function; in a In the embodiment, the above-mentioned processor 701 in the embodiment of the present application may be used to perform a series of processing, including the method in the embodiment shown in FIG. 6 and so on.
本申请实施例还提供了一种计算机存储介质(Memory),上述计算机存储介质是电子设备中的记忆设备,用于存放程序和数据。可以理解的是,此处的计算机存储介质既可以包括电子设备中的内置存储介质,当然也可以包括电子设备所支持的扩展存储介质。计算机存储介质提供存储空间,该存储空间存储了电子设备的操作***。并且,在该存储空间中还存放了适于被处理器701加载并执行的一条或多条的指令,这些指令可以是一个或一个以上的计算机程序(包括程序代码)。需要说明的是,此处的计算机存储介质可以是高速RAM存储器,也可以是非不稳定的存储器(non-volatile memory),例如至少一个磁盘存储器;可选的还可以是至少一个位于远离前述处理器的计算机存储介质。An embodiment of the present application also provides a computer storage medium (Memory), where the computer storage medium is a memory device in an electronic device and is used to store programs and data. It can be understood that the computer storage medium here may include a built-in storage medium in the electronic device, and certainly may include an extended storage medium supported by the electronic device. The computer storage medium provides storage space, and the storage space stores the operating system of the electronic device. Moreover, one or more instructions suitable for being loaded and executed by the processor 701 are also stored in the storage space, and these instructions may be one or more computer programs (including program codes). It should be noted that the computer storage medium here can be a high-speed RAM memory, or a non-volatile memory (non-volatile memory), such as at least one disk memory; computer storage media.
在一个实施例中,可由处理器701加载并执行计算机存储介质中存放的一条或多条指令,以实现上述实施例中的相应步骤;具体实现中,计算机存储介质中的一条或多条指令可以由处理器501加载并执行图6中方法的任意步骤,此处不再赘述。
In one embodiment, one or more instructions stored in the computer storage medium can be loaded and executed by the processor 701 to implement the corresponding steps in the above-mentioned embodiments; in specific implementation, one or more instructions in the computer storage medium can be Any step of the method in FIG. 6 is loaded and executed by the processor 501 , which will not be repeated here. the
所属领域的技术人员可以清楚地了解到,为描述的方便和简洁,上述描述的装置和模块的具体工作过程,可以参考前述方法实施例中的对应过程,在此不再赘述。Those skilled in the art can clearly understand that for the convenience and brevity of the description, the specific working process of the above-described devices and modules can refer to the corresponding process in the foregoing method embodiments, which will not be repeated here.
在本申请所提供的几个实施例中,应该理解到,所揭露的***、装置和方法,可以通过其它的方式实现。例如,该模块的划分,仅仅为一种逻辑功能划分,实际实现时可以有另外的划分方式,例如,多个模块或组件可以结合或者可以集成到另一个***,或一些特征可以忽略,或不执行。所显示或讨论的相互之间的耦合、或直接耦合、或通信连接可以是通过一些接口,装置或模块的间接耦合或通信连接,可以是电性,机械或其它的形式。In the several embodiments provided in this application, it should be understood that the disclosed systems, devices and methods may be implemented in other ways. For example, the division of this module is only a logical function division, and there may be other division methods in actual implementation, for example, multiple modules or components can be combined or integrated into another system, or some features can be ignored, or not implement. The mutual coupling, or direct coupling, or communication connection shown or discussed may be through some interfaces, and the indirect coupling or communication connection of devices or modules may be in electrical, mechanical or other forms.
作为分离部件说明的模块可以是或者也可以不是物理上分开的,作为模块显示的部件可以是或者也可以不是物理模块,即可以位于一个地方,或者也可以分布到多个网络模块上。可以根据实际的需要选择其中的部分或者全部模块来实现本实施例方案的目的。A module described as a separate component may or may not be physically separated, and a component shown as a module may or may not be a physical module, that is, it may be located in one place, or may also be distributed to multiple network modules. Part or all of the modules can be selected according to actual needs to achieve the purpose of the solution of this embodiment.
在上述实施例中,可以全部或部分地通过软件、硬件、固件或者其任意组合来实现。当使用软件实现时,可以全部或部分地以计算机程序产品的形式实现。该计算机程序产品包括一个或多个计算机指令。在计算机上加载和执行该计算机程序指令时,全部或部分地产生按照本申请实施例的流程或功能。该计算机可以是通用计算机、专用计算机、计算机网络、或者其他可编程装置。该计算机指令可以存储在计算机可读存储介质中,或者通过该计算机可读存储介质进行传输。该计算机指令可以从一个网站站点、计算机、服务器或数据中心通过有线(例如同轴电缆、光纤、数字用户线(digital
subscriber line,DSL))或无线(例如红外、无线、微波等)方式向另一个网站站点、计算机、服务器或数据中心进行传输。该计算机可读存储介质可以是计算机能够存取的任何可用介质或者是包含一个或多个可用介质集成的服务器、数据中心等数据存储设备。该可用介质可以是只读存储器(read-only
memory,ROM),或随机存储存储器(random
access memory,RAM),或磁性介质,例如,软盘、硬盘、磁带、磁碟、或光介质,例如,数字通用光盘(digital
versatile disc,DVD)、或者半导体介质,例如,固态硬盘(solid
state disk ,SSD)等。In the above embodiments, all or part of them may be implemented by software, hardware, firmware or any combination thereof. When implemented using software, it may be implemented in whole or in part in the form of a computer program product. The computer program product includes one or more computer instructions. When the computer program instructions are loaded and executed on the computer, the processes or functions according to the embodiments of the present application will be generated in whole or in part. The computer can be a general purpose computer, a special purpose computer, a computer network, or other programmable device. The computer instructions may be stored in or transmitted over a computer-readable storage medium. The computer instructions can be sent from a website site, computer, server or data center via wired (such as coaxial cable, optical fiber, digital subscriber line (digital subscriber line)
subscriber line, DSL)) or wirelessly (such as infrared, wireless, microwave, etc.) to another website site, computer, server or data center. The computer-readable storage medium may be any available medium that can be accessed by a computer, or a data storage device such as a server or a data center integrated with one or more available media. The available media can be read-only memory (read-only
memory, ROM), or random access memory (random
access memory, RAM), or magnetic media such as floppy disks, hard disks, tapes, magnetic disks, or optical media such as digital versatile discs (digital
versatile disc, DVD), or semiconductor media, such as solid state drives (solid
state disk, SSD), etc.
Claims (10)
- 一种无创肾交感神经活性检测***,其特征在于,包括超声发射模块、超声双功能换能器、超声接收模块、成像模块、参数测量模块、评估模块和控制模块,其中:A non-invasive renal sympathetic nerve activity detection system, characterized in that it includes an ultrasound transmitting module, an ultrasound dual-function transducer, an ultrasound receiving module, an imaging module, a parameter measurement module, an evaluation module and a control module, wherein:所述超声发射模块,用于产生第一脉冲发射信号和第二脉冲发射信号,所述第一脉冲发射信号用于成像,所述第二脉冲发射信号用于对检测部位产生刺激,所述第一脉冲发射信号的能量低于所述第二脉冲发射信号,所述第一脉冲发射信号的脉冲短于所述第二脉冲发射信号的脉冲;The ultrasonic transmitting module is used to generate a first pulse transmitting signal and a second pulse transmitting signal, the first pulse transmitting signal is used for imaging, the second pulse transmitting signal is used to stimulate the detection site, and the first pulse transmitting signal The energy of a pulse transmission signal is lower than that of the second pulse transmission signal, and the pulse of the first pulse transmission signal is shorter than the pulse of the second pulse transmission signal;所述超声双功能换能器,用于在预设超声频率范围内将所述超声发射模块产生的脉冲发射电信号转换成声信号,以及用于将外界声场中的声信号转换为电信号;The ultrasonic dual-function transducer is used to convert the pulsed emission electrical signal generated by the ultrasonic transmitting module into an acoustic signal within the preset ultrasonic frequency range, and to convert the acoustic signal in the external sound field into an electrical signal;所述超声接收模块,用于接收超声发射信号对应的超声回波信号,将所述超声回波信号转换成数字信号;The ultrasonic receiving module is configured to receive an ultrasonic echo signal corresponding to the ultrasonic transmission signal, and convert the ultrasonic echo signal into a digital signal;所述成像模块,用于根据所述数字信号进行超声灰阶成像和血流动力学参数成像,获得检测图像;The imaging module is configured to perform ultrasonic grayscale imaging and hemodynamic parameter imaging according to the digital signal to obtain a detection image;所述参数测量模块,用于基于所述检测图像测量刺激引起的参数变化值;The parameter measurement module is used to measure the parameter change value caused by the stimulus based on the detection image;所述评估模块,用于基于超声图像参数,对肾交感神经活性进行评估,获得评估结果;The evaluation module is used to evaluate the renal sympathetic nerve activity based on the ultrasound image parameters, and obtain evaluation results;所述控制模块,用于通过人机交互界面接收并编译控制指令,并将所述控制指令传输到对应的模块以使所述模块实现相应控制功能。The control module is used to receive and compile control instructions through the human-computer interaction interface, and transmit the control instructions to corresponding modules so that the modules can realize corresponding control functions.
- 根据权利要求1所述***,其特征在于,所述超声双功能换能器包括多层叠结构线阵换能器,包括:保护层、匹配层、压电材料层、背衬层、散热层和柔性电路板,其中:The system according to claim 1, wherein the ultrasonic dual-function transducer comprises a multi-layer structure linear array transducer, comprising: a protective layer, a matching layer, a piezoelectric material layer, a backing layer, a heat dissipation layer and Flexible circuit boards, where:所述保护层用于保护压电材料层;The protective layer is used to protect the piezoelectric material layer;所述匹配层用于增强传播到组织中的超声波能量;The matching layer is used to enhance the ultrasonic energy propagating into the tissue;所述压电材料层用于实现电信号与声信号的互相转换;The piezoelectric material layer is used to realize mutual conversion of electrical signals and acoustic signals;所述背衬层用于连接所述压电材料层和所述散热层,将热量从所述压电材料层传导到所述散热层;The backing layer is used to connect the piezoelectric material layer and the heat dissipation layer to conduct heat from the piezoelectric material layer to the heat dissipation layer;所述柔性电路板用于连结所述超声双功能换能器和所述超声发射模块以进行信号传输。The flexible circuit board is used to connect the ultrasonic dual-function transducer and the ultrasonic transmitting module for signal transmission.
- 根据权利要求1所述***,其特征在于,所述超声发射模块包括脉冲波形发生器、功率放大器和换能器匹配电路,其中:The system according to claim 1, wherein the ultrasonic transmitting module includes a pulse waveform generator, a power amplifier and a transducer matching circuit, wherein:所述脉冲波形发生器由可编程逻辑器件完成;The pulse waveform generator is completed by a programmable logic device;所述功率放大器包括成像发射功率放大器和刺激功率放大器,所述成像发射功率放大器采用场效应管驱动器及场效应对管实现,用于产生所述第一脉冲发射信号,所述刺激功率放大器用于对所述第二脉冲发射信号进行功率放大;The power amplifier includes an imaging transmission power amplifier and a stimulation power amplifier. The imaging transmission power amplifier is implemented by a field effect tube driver and a field effect counter tube, and is used to generate the first pulse transmission signal. The stimulation power amplifier is used for performing power amplification on the second pulse transmission signal;所述换能器匹配电路包含串联电阻和并联电感,所述串联电阻用于实现脉冲产生电路和所述超声双功能换能器之间的阻抗匹配,并联电感用于实现所述超声双功能换能器的并联调谐。The transducer matching circuit includes a series resistance and a parallel inductance, the series resistance is used to realize impedance matching between the pulse generating circuit and the ultrasonic dual-function transducer, and the parallel inductor is used to realize the ultrasonic dual-function transducer. Parallel tuning of transducers.
- 根据权利要求1所述***,其特征在于,所述超声接收模块包括收发隔离电路、可变增益放大器、滤波电路和模数转换电路,其中:The system according to claim 1, wherein the ultrasonic receiving module includes a transceiver isolation circuit, a variable gain amplifier, a filter circuit and an analog-to-digital conversion circuit, wherein:所述收发隔离电路用于实现所述超声回波信号的接收通道与所述超声发射信号的发射通道的隔离;The transceiver isolation circuit is used to isolate the receiving channel of the ultrasonic echo signal from the transmitting channel of the ultrasonic transmitting signal;所述可变增益放大器用于对所述超声回波信号进行放大处理;The variable gain amplifier is used to amplify the ultrasonic echo signal;所述滤波电路用于对所述超声回波信号进行滤波;The filtering circuit is used to filter the ultrasonic echo signal;所述模数转换电路用于对超声回波信号进行模数转换,并将转换后的信号传输给所述脉冲波形发生器缓存。The analog-to-digital conversion circuit is used to perform analog-to-digital conversion on the ultrasonic echo signal, and transmit the converted signal to the buffer of the pulse waveform generator.
- 根据权利要求1所述***,其特征在于,所述成像模块用于实现以下三种成像模式中的一种或几种:B-Mode成像、多普勒血流成像、血流向量成像。The system according to claim 1, wherein the imaging module is configured to implement one or more of the following three imaging modes: B-Mode imaging, Doppler blood flow imaging, and blood flow vector imaging.
- 根据权利要求1所述***,其特征在于,所述超声图像参数包括但不限于肾动脉血管管径、血流速度、血流量、管壁剪切力中的一种或几种参数的刺激前后变化量和变化率。The system according to claim 1, wherein the ultrasound image parameters include, but are not limited to, one or more parameters of renal artery diameter, blood flow velocity, blood flow, and vessel wall shear force before and after stimulation. Variation and rate of change.
- 根据权利要求6所述***,其特征在于,所述评估结果包括肾交感神经活性程度;The system according to claim 6, wherein the evaluation result includes the degree of renal sympathetic nerve activity;所述评估模块包括预设评估模型,用于:The assessment module includes preset assessment models for:基于所述超声图像参数,对肾交感神经活性进行评分;scoring renal sympathetic nerve activity based on the ultrasound image parameters;通过比较所述评分和预设评估阈值,判断所述肾交感神经活性程度。The degree of renal sympathetic nerve activity is judged by comparing the score with a preset evaluation threshold.
- 一种无创肾交感神经活性检测方法,其特征在于,应用于无创肾交感神经活性检测***,所述无创肾交感神经活性检测***包括超声发射模块、超声双功能换能器、超声接收模块、成像模块、参数测量模块、评估模块和控制模块;所述方法包括:A method for detecting non-invasive renal sympathetic nerve activity, characterized in that it is applied to a non-invasive renal sympathetic nerve activity detection system, and the non-invasive renal sympathetic nerve activity detection system includes an ultrasonic transmitting module, an ultrasonic dual-function transducer, an ultrasonic receiving module, an imaging module, a parameter measurement module, an evaluation module and a control module; the method comprising:所述超声发射模块产生第一脉冲发射信号和第二脉冲发射信号,所述第一脉冲发射信号用于成像,所述第二脉冲发射信号用于对检测部位产生刺激,所述第一脉冲发射信号的能量低于所述第二脉冲发射信号,所述第一脉冲发射信号的脉冲短于所述第二脉冲发射信号的脉冲;The ultrasonic transmitting module generates a first pulse transmitting signal and a second pulse transmitting signal, the first pulse transmitting signal is used for imaging, the second pulse transmitting signal is used to stimulate the detection site, and the first pulse transmitting signal The energy of the signal is lower than that of the second pulsed transmission signal, and the pulse of the first pulsed transmission signal is shorter than the pulse of the second pulsed transmission signal;所述超声双功能换能器在预设超声频率范围内将所述超声发射模块产生的脉冲发射信号转换成声信号,以及将外界声场中的声信号转换为电信号;The ultrasonic dual-function transducer converts the pulsed emission signal generated by the ultrasonic emission module into an acoustic signal within the preset ultrasonic frequency range, and converts the acoustic signal in the external sound field into an electrical signal;所述超声接收模块接收超声发射信号对应的超声回波信号,将所述超声回波信号转换成数字信号;The ultrasonic receiving module receives the ultrasonic echo signal corresponding to the ultrasonic transmission signal, and converts the ultrasonic echo signal into a digital signal;所述成像模块根据所述数字信号进行超声成像,获得检测图像;The imaging module performs ultrasonic imaging according to the digital signal to obtain a detection image;所述参数测量模块基于所述检测图像测量刺激引起的参数变化值;The parameter measurement module measures a stimulus-induced parameter change value based on the detection image;所述评估模块基于超声图像参数,对肾交感神经活性进行评估,获得评估结果。The evaluation module evaluates the renal sympathetic nerve activity based on the ultrasound image parameters, and obtains an evaluation result.
- 一种电子设备,其特征在于,包括存储器和处理器,所述存储器存储有计算机程序,所述计算机程序被所述处理器执行时,使得所述处理器执行如权利要求8所述方法的步骤。An electronic device, characterized by comprising a memory and a processor, the memory stores a computer program, and when the computer program is executed by the processor, the processor executes the steps of the method according to claim 8 .
- 一种计算机可读存储介质,存储有计算机程序,其特征在于,所述计算机程序被处理器执行时,使得所述处理器执行如权利要求8所述方法的步骤。A computer-readable storage medium storing a computer program, wherein when the computer program is executed by a processor, the processor is made to perform the steps of the method as claimed in claim 8 .
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