WO2023120890A1 - Shape-memory wire-braided re-expandable stent - Google Patents

Shape-memory wire-braided re-expandable stent Download PDF

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Publication number
WO2023120890A1
WO2023120890A1 PCT/KR2022/014479 KR2022014479W WO2023120890A1 WO 2023120890 A1 WO2023120890 A1 WO 2023120890A1 KR 2022014479 W KR2022014479 W KR 2022014479W WO 2023120890 A1 WO2023120890 A1 WO 2023120890A1
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Prior art keywords
shape memory
memory wire
shape
braided
wire
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PCT/KR2022/014479
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French (fr)
Korean (ko)
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김철생
장세림
서일원
이정찬
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전북대학교산학협력단
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Publication of WO2023120890A1 publication Critical patent/WO2023120890A1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/844—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents folded prior to deployment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/02—Inorganic materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/02—Inorganic materials
    • A61L31/022—Metals or alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0014—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof using shape memory or superelastic materials, e.g. nitinol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0014—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof using shape memory or superelastic materials, e.g. nitinol
    • A61F2210/0023—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof using shape memory or superelastic materials, e.g. nitinol operated at different temperatures whilst inside or touching the human body, heated or cooled by external energy source or cold supply
    • A61F2210/0033—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof using shape memory or superelastic materials, e.g. nitinol operated at different temperatures whilst inside or touching the human body, heated or cooled by external energy source or cold supply electrically, e.g. heated by resistor
    • A61F2210/0038—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof using shape memory or superelastic materials, e.g. nitinol operated at different temperatures whilst inside or touching the human body, heated or cooled by external energy source or cold supply electrically, e.g. heated by resistor electromagnetically
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0004—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof adjustable
    • A61F2250/001—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof adjustable for adjusting a diameter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/16—Materials with shape-memory or superelastic properties

Definitions

  • the present invention relates to a shape-memory wire braided re-expandable stent, and more particularly, when a plurality of shape memory wires are braided and inserted into the body, when the lumen in the human body is restenosis, it expands again and narrows due to restenosis. It relates to a shape-memory wire-braided re-expandable stent capable of expanding passages such as blood vessels.
  • stent surgery is a representative treatment method of interventional medicine and is a minimally invasive treatment method that maximizes the treatment effect after treatment without drug injection and surgical treatment due to technological advances in advanced imaging equipment and microscopic medical instruments.
  • Stenting is used as the most common surgical method to open obstructed ducts in the human body, and in 2018, more than 60,000 stent insertion procedures were performed in Korea alone.
  • the metal stent When recombination occurs in the human body after stent surgery, the metal stent is heated by an external magnetic field generator, and when the shape memory temperature is reached, the stent is fully deployed due to the force to return to its original shape. It returns to the duct to expand the obstructed tube and facilitate the flow of bodily fluids.
  • shape memory alloys In the case of existing stents, the characteristics of shape memory alloys almost disappear and only have superelastic properties, and for this reason, they are used as self-expanding stents.
  • a stent By reinforcing such a stent, when a stent is fabricated by weaving heterogeneous shape memory alloy wires with different shape memory temperatures, the shape memory alloy wire self-expands only with superelasticity in the human body by body temperature, and then restenosis in the tube When the diameter is reduced, an external magnetic field is applied to heat the shape memory alloy wire to the shape memory temperature so that it can be unfolded again.
  • Patent Document 1 Republic of Korea Patent Registration No. 10-0776686 (registered on November 8, 2007)
  • the present invention was derived to solve the above-mentioned problems, and the present invention is made into a braid of a plurality of shape memory wires and inserted into the body, when the lumen in the human body is restenosis, the blood vessels are expanded again and narrowed due to restenosis. Its purpose is to provide a shape-memory wire-braided re-expandable stent capable of expanding the passage of the back.
  • a shape memory wire braided re-expandable stent comprises a first shape memory wire having a first shape memory temperature range and a second shape memory temperature range higher than the first shape memory temperature range.
  • a wire may be formed by braiding the first shape memory wire and the second shape memory wire into a cylindrical shape.
  • the braiding ratio of the number of first shape memory wires and the number of second shape memory wires that are braided in a cylindrical shape may be one of 1:1, 1:2, and 1:3.
  • the first shape memory temperature range may be 36° C. to 38° C.
  • the second shape memory temperature range may be 39° C. to 48° C.
  • the first shape memory temperature range is 36 ° C. to 38 ° C.
  • the second shape memory temperature range is 39 ° C. to 48 ° C. It may include a 22nd shape memory temperature range of greater than or equal to °C and less than or equal to 48 °C.
  • the second shape memory wire may include a 21st shape memory wire having a 21st shape memory temperature range and a 22nd shape memory wire having a 22nd shape memory temperature range.
  • the first shape memory temperature range is 36 ° C. to 38 ° C.
  • the second shape memory temperature range is 39 ° C. to 48 ° C.
  • 21st shape memory temperature range, 42 A 22nd shape memory temperature range of greater than or equal to °C and less than 45°C and a 23rd shape memory temperature range of greater than or equal to 45°C and less than or equal to 48°C may be included.
  • the second shape memory wire includes a 21st shape memory wire having a 21st shape memory temperature range, a 22nd shape memory wire having a 22nd shape memory temperature range, and a 23rd shape memory wire having a 23rd shape memory temperature range. can do.
  • a treatment device using a shape-memory wire-braided re-expandable stent applies an electromagnetic field to one of the shape-memory wire-braided re-expandable stent and the first shape-memory wire and the second shape-memory wire to treat the shape-memory wire
  • An electromagnetic field generator to re-expand the braided re-expandable stent.
  • the shape memory wire braided re-expandable stent according to an embodiment of the present invention provides the following effects.
  • FIG. 1 is a view for explaining a shape-memory wire braided re-expandable stent according to a first embodiment of the present invention.
  • FIG. 2 is a view for explaining a shape-memory wire braided re-expandable stent according to a second embodiment of the present invention.
  • Figure 3 is a graph for explaining the expansion rate according to temperature of the shape memory wire braided re-expandable stent according to the second embodiment of the present invention.
  • FIG. 4 is a view for explaining a shape-memory wire braided re-expandable stent according to a third embodiment of the present invention.
  • FIG. 5 is a view for explaining a shape-memory wire braided re-expandable stent according to a fourth embodiment of the present invention.
  • FIG. 6 is a view for explaining a treatment device using a shape-memory wire braided re-expandable stent according to a fifth embodiment of the present invention.
  • first and second may be used to describe various components, but the components should not be limited by the terms. These terms are only used for the purpose of distinguishing one component from another.
  • FIG. 1 is a view for explaining a shape-memory wire braided re-expandable stent according to a first embodiment of the present invention.
  • the shape memory wire braided re-expandable stent 10 may be formed by braiding a first shape memory wire 11 and a second shape memory wire 12 into a cylindrical shape.
  • the shape memory wire braided re-expandable stent 10 is braided through a braiding device (not shown), the first shape memory wire 11 and the second shape memory wire 12 are closed except for the respective start and end ends. It may have a cylindrical structure joined to form a loop shape.
  • the extension direction of each strand of the first shape memory wire 11 and the second shape memory wire 12 may be reversed. Therefore, since both ends of the shape-memory wire-braided re-expandable stent 10 have a round structure, damage to the treatment site can be prevented.
  • the shape memory wire braided re-expandable stent 10 may include a first shape memory wire 11 and a second shape memory wire 12 .
  • the first shape memory wire 11 may be made of a shape memory alloy and have a first shape memory temperature range.
  • the first shape memory wire 11 may be restored to its original shape at the first shape memory temperature.
  • the first shape memory wire 11 may be made of a nitinol shape memory alloy that is restored to its original shape at a first shape memory temperature.
  • the process of forming the first shape memory wire 11 is not shown in the drawing, it can be formed by braiding the first shape memory wire 11 so as to cross the second shape memory wire 12 using a conventional jig. there is.
  • the second shape memory wire 12 is made of a shape memory alloy and may have a second shape memory temperature range higher than the first shape memory temperature.
  • the second shape memory wire 12 may be restored to its original shape at the second shape memory temperature.
  • the second shape memory wire 12 may be made of a nitinol shape memory alloy that is restored to its original shape at a second shape memory temperature.
  • the process of forming the second shape memory wire 12 is not shown in the drawing, it can be formed by braiding the second shape memory wire 12 so as to cross the first shape memory wire 11 using a conventional jig. there is.
  • Nitinol shape memory alloy is a mixture of nickel (Ni) and titanium (Ti), and even if it is deformed, it is restored to its original shape when heated above a certain temperature.
  • the first shape memory wire 11 is a nitinol shape memory alloy that is restored to its original shape at a first shape memory temperature
  • the second shape memory wire 12 has a second shape memory temperature higher than the first shape memory temperature. Since it is a nitinol shape memory alloy that is restored to a circular shape in the human body, it may have a property of maintaining a circular shape within the lumen of the human body.
  • the shape-memory wire-braided re-expandable stent 10 when the shape-memory wire-braided re-expandable stent 10 is raised to the first shape-memory temperature by applying heat to the shape-memory wire-braided re-expandable stent 10, the first shape memory wire 11 After expansion, when the shape memory wire braided re-expandable stent 10 is raised to the second shape memory temperature, the second shape memory wire 12 expands to re-expand the shape memory wire braided re-expandable stent 10 be able to
  • the braiding ratio of the number of first shape memory wires 11 and the number of second shape memory wires 12 that are braided in a cylindrical shape may be one of 1:1, 1:2 and 1:3.
  • FIG. 2 is a view for explaining a shape-memory wire braided re-expandable stent according to a second embodiment of the present invention.
  • the shape memory wire braided re-expandable stent 20 may include a first shape memory wire 21 and a second shape memory wire 22 .
  • the braiding ratio of the number of first shape memory wires 21 and the number of second shape memory wires 22 that are braided in a cylindrical shape may be 1:1.
  • the braiding may be made by crossing the first shape memory wire 21 and the second shape memory wire 22 one by one.
  • the first shape memory temperature range of the first shape memory wire 21 may be 36° C. to 38° C. or less. Since the first shape memory temperature range of 36° C. to 38° C. is similar to a human body temperature, the first shape memory wire 21 can maintain a certain shape in blood vessels.
  • the shape memory wire braided re-expandable stent 20 when the human body temperature is less than 36 ° C., heat is applied to the shape memory wire braided re-expandable stent 20 to raise the temperature to 36 ° C. to 38 ° C., and the first shape memory wire 21 is formed into a circular shape It can be inflated to recover.
  • the second shape memory temperature range of the second shape memory wire 22 may be 39° C. to 48° C. or less.
  • the shape memory wire braided re-expandable stent 20 is heated to raise the temperature to 39° C. or higher and 48° C. or lower, the second shape memory wire 22 may expand to restore its original shape.
  • the first shape-memory wire 21 at a temperature of 36° C. to 38° C. can maintain a certain shape according to a person's body temperature.
  • the shape memory wire braided re-expandable stent 20 is heated by an external electromagnetic field, and the second shape memory wire 22 expands at a temperature of 39 ° C. to 48 ° C. It is possible to secure the passage of the blood vessel by pushing out the obstruction.
  • the expansion rate of the shape memory wire braided re-expandable stent 10 is increased at a temperature of 45° C. rather than at a temperature of 36° C.
  • FIG. 4 is a view for explaining a shape-memory wire braided re-expandable stent according to a third embodiment of the present invention.
  • the shape memory wire braided re-expandable stent 30 may include a first shape memory wire 31 and a second shape memory wire 32 .
  • the second shape memory wire 32 may include a 21 shape memory wire 321 having a 21st shape memory temperature range and a 22nd shape memory wire 322 having a 22nd shape memory temperature range.
  • the braiding ratio of the number of first shape memory wires 31 and the number of second shape memory wires 32 that are braided in a cylindrical shape may be 1:2.
  • the braiding may be performed in order of the first shape memory wire 31 , the twenty-first shape memory wire 321 and the twenty-second shape memory wire 322 .
  • the first shape memory wire 31, the twenty-first shape memory wire 321, and the twenty-second shape memory wire 322 are shown as being braided at regular intervals, but are not limited thereto, and the first embodiment
  • the 21st shape memory wire 321 and the 22nd shape memory wire 322 may be more densely braided between the first shape memory wires 31 while maintaining the distance between the first shape memory wires 21 according to .
  • the first shape memory temperature range of the first shape memory wire 31 may be 36° C. to 38° C. or less. Since the first shape memory temperature range of 36° C. to 38° C. is similar to the human body temperature, the first shape memory wire 31 can maintain a certain shape in blood vessels.
  • the 21st shape memory temperature range of the 21st shape memory wire 321 may be 39°C or more and 48°C or less.
  • the 22nd shape memory temperature range of the 22nd shape memory wire 322 may be 44 degrees C or more and 48 degrees C or less.
  • both the 21st shape memory wire 321 and the 22nd shape memory wire 322 may expand to restore their original shape.
  • the shape memory wire braided re-expandable stent 30 when the shape memory wire braided re-expandable stent 30 is inserted into the blood vessel, the first shape memory wire 31 at 36° C. to 38° C. can maintain a certain shape according to the body temperature of the person. .
  • the shape memory wire braided re-expandable stent 30 is heated by an external electromagnetic field and the 21st shape memory wire 321 expands at a temperature of 39 ° C or more to less than 44 ° C. It is possible to secure the passage of the blood vessel by pushing out the obstruction.
  • the state of the blood vessel is monitored, and when the obstruction in the blood vessel is less pushed, that is, when more blood vessel passage is required, shape memory wire braided re-expandable stent by external electromagnetic field As the 21st shape memory wire 321 and the 22nd shape memory wire 322 expand at a temperature of 44 ° C. to 48 ° C. due to heat generation of the 30, the obstruction is pushed out to secure the passage of the blood vessel. .
  • the shape memory wire braided re-expandable stent 30 can be expanded in stages according to the size of the blood vessel passage.
  • FIG. 5 is a view for explaining a shape-memory wire braided re-expandable stent according to a fourth embodiment of the present invention.
  • the shape memory wire braided re-expandable stent 40 may include a first shape memory wire 41 and a second shape memory wire 42 .
  • the second shape memory wire 42 includes a 21st shape memory wire 421 having a 21st shape memory temperature range, a 22nd shape memory wire 422 having a 22nd shape memory temperature range, and a 23rd shape memory temperature range. It may include a 23rd shape memory wire 423 having a.
  • the braiding ratio of the number of first shape memory wires 41 and the number of second shape memory wires 42 that are braided in a cylindrical shape may be 1:3.
  • the braiding may be performed in order of the first shape memory wire 41, the 22nd shape memory wire 422, the 21st shape memory wire 421 and the 23rd shape memory wire 423.
  • the first shape memory wire 41, the 22nd shape memory wire 422, the 21st shape memory wire 421 and the 23rd shape memory wire 423 are shown as being braided at regular intervals, but are limited thereto.
  • the 22nd shape memory wire 422 and the 21st shape memory wire 421 are interposed between the first shape memory wires 41 while maintaining the distance between the first shape memory wires 21 according to the first embodiment.
  • the 23rd shape memory wire 423 may be braided more densely.
  • the first shape memory temperature range of the first shape memory wire 41 may be 36° C. to 38° C. or less. Since the first shape memory temperature range of 36° C. to 38° C. is similar to a human body temperature, the first shape memory wire 41 can maintain a certain shape in blood vessels.
  • the shape memory wire braided re-expandable stent 40 when the human body temperature is less than 36 ° C., heat is applied to the shape memory wire braided re-expandable stent 40 to raise the temperature to 36 ° C. to 38 ° C., and the first shape memory wire 41 is circular. It can be inflated to recover.
  • the 21st shape memory temperature range of the 21st shape memory wire 421 may be 39°C or higher and 48°C or lower.
  • the 22nd shape memory temperature range of the 22nd shape memory wire 422 may be 42 degrees C or more and less than 45 degrees C.
  • the 23rd shape memory temperature range of the 23rd shape memory wire 423 may be 45°C or more and 48°C or less.
  • the 21st shape memory wire 421 When heat is applied to the shape memory wire-braided re-expandable stent 40 to raise the temperature to 39° C. or more and less than 42° C., only the 21st shape memory wire 421 can be expanded to restore the original shape. Then, when the temperature is raised to 42° C. or more and less than 45° C., the 21st shape memory wire 421 and the 22nd shape memory wire 422 may expand to restore their original shape. In addition, when the temperature is raised to 45° C. or higher and 48° C. or lower, the 21st shape memory wire 421 and the 23rd shape memory wire 423 may expand to restore their original shape.
  • the 21st shape memory wire 421 is shown as being braided between the 22nd shape memory wire 422 and the 23rd shape memory wire 423, which is the first shape of the 21st shape memory wire 421. This is because the 21st shape memory temperature range includes the 22nd shape memory temperature range and the 23rd shape memory temperature range.
  • the 21st shape memory wire 421 expands in the 21st shape memory temperature range of 39° C. to 48° C.
  • the 22nd shape memory wire 422 is between the 21st shape memory temperature range and the 22nd shape memory It expands in the temperature range of 42 ° C. to less than 45 ° C.
  • the 23rd shape memory wire 423 may expand in the 23rd shape memory temperature range of 45 ° C. to 48 ° C., which is between the 21st shape memory temperature range. Accordingly, the 21st shape memory wire 421 can be stably expanded between the 22nd shape memory wire 422 and the 23rd shape memory wire 423 without being biased towards the first shape memory wire 41 .
  • the braided position of the second shape memory wire 42 may vary depending on the region where the shape memory wire braided re-expandable stent 40 is used.
  • the first shape-memory wire 41 at a temperature of 36° C. to 38° C. can maintain a certain shape according to a person's body temperature.
  • the shape-memory wire braided re-expandable stent 40 is heated by an external electromagnetic field, and the 21st shape memory wire 421 expands at a temperature of 39 ° C or more to less than 42 ° C. It is possible to secure the passage of the blood vessel by pushing out the obstruction.
  • the state of the blood vessel is monitored, and when the obstruction in the blood vessel is less pushed, that is, when more blood vessel passage is required, shape memory wire braided re-expandable stent by external electromagnetic field As (40) generates heat and the 21st shape memory wire 421 and the 22nd shape memory wire 422 expand at a temperature of 42 ° C. to less than 45 ° C., the obstruction can be pushed out to secure the passage of blood vessels. .
  • the state of the blood vessel is monitored, and when the obstruction in the blood vessel is less pushed, that is, when it is necessary to secure the passage of the blood vessel, it is not exposed to external electromagnetic fields.
  • the shape memory wire braided re-expandable stent 40 generates heat and the 21st shape memory wire 421 and the 23rd shape memory wire 423 expand at a temperature of 45 ° C or more to 48 ° C or less, the obstruction is pushed to secure the passage of blood vessels.
  • the shape memory wire braided re-expandable stent 40 can be expanded in stages according to the size of the blood vessel passage.
  • FIG. 6 is a view for explaining a treatment device using a shape-memory wire braided re-expandable stent according to a fifth embodiment of the present invention.
  • a treatment device using a shape-memory wire-braided re-expandable stent may include a shape-memory wire-braided re-expandable stent 10 and an electromagnetic field generator 50 .
  • the treatment device using the shape-memory wire-braided re-expandable stent includes the shape-memory wire-braided re-expandable stent 10 according to the first embodiment, the shape-memory wire-braided re-expandable stent 20 according to the second embodiment, It may include both the shape-memory wire-braided re-expandable stent 30 according to the third embodiment and the shape-memory wire-braided re-expandable stent 40 according to the fourth embodiment. Only the shape-memory wire braided re-expandable stent 10 will be described.
  • the shape-memory wire-braided re-expandable stent 10 can be inserted into the blood vessel 1. After being inserted into the blood vessel 1, the shape-memory wire-braided re-expandable stent 10 may generate heat according to the electromagnetic field applied by the electromagnetic field generator 50.
  • At least one of the first shape memory wire 11 and the second shape memory wire 12 may expand according to an exothermic temperature.
  • the electromagnetic field generator 50 may re-expand the shape memory wire braided re-expandable stent 10 by applying an electromagnetic field M to at least one of the first shape memory wire 11 and the second shape memory wire 12. .
  • the shape-memory wire-braided re-expandable stent is applied to the blood vessel (1). (10) is inserted to secure the passage of the blood vessel (1).
  • restenosis of the blood vessel 1 may occur when the obstruction 2 proliferates again in the blood vessel 1 over time.
  • an electromagnetic field (M) is applied to the shape memory wire braided re-expandable stent 10 from the electromagnetic field generator 50 to reach the first shape memory temperature, the first shape memory wire 11 expands and the inside of the blood vessel 1 The obstruction (2) can be pushed out.
  • the electromagnetic field (M) when the electromagnetic field (M) is applied to the shape memory wire braided re-expandable stent 10 from the electromagnetic field generator 50 to reach the second shape memory temperature, the second shape memory wire 12 expands and the inside of the blood vessel 1 The obstruction 2 can be further pushed out.
  • the first shape memory wire 11 and the second shape memory wire 11 and the second shape memory wire 11 are not re-operated on the shape memory wire braided re-expandable stent 10.
  • the shape-memory wire-braided re-expandable stent 10 by applying heat to the wire 12, the narrowed passage of the blood vessel 1 can be expanded.

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Abstract

The present invention relates to a shape-memory wire-braided re-expandable stent, which re-expands, when a lumen in a human body has undergone restenosis after a plurality of shape-memory wires are braided and inserted into the body, and thus can expand the passage of a blood vessel that has narrowed due to restenosis. In the present invention are included a first shape memory wire having a first shape memory temperature range and a second shape memory wire having a second shape memory temperature range higher than the first shape memory temperature range, and the first shape memory wire and the second shape memory wire may be formed by being braided into a cylindrical shape.

Description

형상기억 와이어 편조형 재팽창 스텐트Shape-memory wire-braided re-expandable stent
본 발명은 형상기억 와이어 편조형 재팽창 스텐트에 관한 것으로, 더욱 상세하게는 복수의 형상기억 와이어를 편조로 제작하여 체내에 삽입 후에 인체 내의 내강이 재협착된 경우, 다시 팽창되어 재협착으로 인해 좁아진 혈관 등의 통로를 확장시킬 수 있는 형상기억 와이어 편조형 재팽창 스텐트에 관한 것이다.The present invention relates to a shape-memory wire braided re-expandable stent, and more particularly, when a plurality of shape memory wires are braided and inserted into the body, when the lumen in the human body is restenosis, it expands again and narrows due to restenosis. It relates to a shape-memory wire-braided re-expandable stent capable of expanding passages such as blood vessels.
일반적으로, 스텐트 시술은 중재의학의 대표적인 시술법으로 첨단 영상장비와 미세 의료기구의 기술적인 발전으로 약물 주입과 외과적 시술을 하지 않고 시술 후 치료 효과를 극대화하는 최소 침습적 시술 방법이다.In general, stent surgery is a representative treatment method of interventional medicine and is a minimally invasive treatment method that maximizes the treatment effect after treatment without drug injection and surgical treatment due to technological advances in advanced imaging equipment and microscopic medical instruments.
스텐트 시술은 인체 내 폐색된 도관을 개통할 수 있는 가장 일반적인 수술법으로 사용되고 있으며, 2018년 한 해 동안 국내에서만 6만 건 이상의 스텐트 삽입 시술이 진행되었다.Stenting is used as the most common surgical method to open obstructed ducts in the human body, and in 2018, more than 60,000 stent insertion procedures were performed in Korea alone.
스텐트 시술 이후 인체 관내 재폐색이 발생했을 때 외부 자기장 발생장치에 의해 금속 스텐트를 발열시키게 되고, 이로 인해 형상기억 온도에 도달하게 되면 스텐트는 원래의 모습으로 돌아가려는 힘으로 인해 완전히 전개된 상태의 모습으로 돌아가게 되어 폐색된 관을 확장시켜 체액의 흐름을 원활하게 할 수 있다.When recombination occurs in the human body after stent surgery, the metal stent is heated by an external magnetic field generator, and when the shape memory temperature is reached, the stent is fully deployed due to the force to return to its original shape. It returns to the duct to expand the obstructed tube and facilitate the flow of bodily fluids.
기존 스텐트의 경우 형상기억합금의 특성이 거의 사라져 초탄성의 특성만을 가지게 되며, 이로 인해 자가 팽창형 스텐트로 사용되고 있다. 이러한 스텐트를 보강하여, 형상기억 온도가 다른 이종의 형상기억합금 와이어를 엮어 스텐트를 제작하게 되면 사람의 체내에서는 체온에 의해 형상기억합금 와이어가 초탄성만으로 자가 팽창하게 되고, 이후 재협착에 의해 관내 직경이 줄어들었을 때 외부의 자기장을 걸어주어 형상기억합금 와이어를 형상기억 온도까지 발열시키면 다시 전개시킬 수 있도록 하고 있다.In the case of existing stents, the characteristics of shape memory alloys almost disappear and only have superelastic properties, and for this reason, they are used as self-expanding stents. By reinforcing such a stent, when a stent is fabricated by weaving heterogeneous shape memory alloy wires with different shape memory temperatures, the shape memory alloy wire self-expands only with superelasticity in the human body by body temperature, and then restenosis in the tube When the diameter is reduced, an external magnetic field is applied to heat the shape memory alloy wire to the shape memory temperature so that it can be unfolded again.
본 발명에서는 이러한 이종의 형상기억합금 와이어를 엮어 스텐트를 제작하는 방법 중 편조를 이용하여 제작된 스텐트에 대하여 제안하고자 한다.In the present invention, it is intended to propose a stent manufactured using braiding among methods for manufacturing a stent by weaving these heterogeneous shape memory alloy wires.
[참고문헌][references]
(특허문헌1) 대한민국 등록특허 제10-0776686호(2007.11.08 등록)(Patent Document 1) Republic of Korea Patent Registration No. 10-0776686 (registered on November 8, 2007)
따라서 본 발명은 상술한 문제점을 해결하기 위해 도출된 것으로서, 본 발명은 복수의 형상기억 와이어를 편조로 제작하여 체내에 삽입 후에 인체 내의 내강이 재협착된 경우, 다시 팽창되어 재협착으로 인해 좁아진 혈관 등의 통로를 확장시킬 수 있는 형상기억 와이어 편조형 재팽창 스텐트를 제공하는데 그 목적이 있다.Therefore, the present invention was derived to solve the above-mentioned problems, and the present invention is made into a braid of a plurality of shape memory wires and inserted into the body, when the lumen in the human body is restenosis, the blood vessels are expanded again and narrowed due to restenosis. Its purpose is to provide a shape-memory wire-braided re-expandable stent capable of expanding the passage of the back.
본 발명의 다른 목적들은 이하에 서술되는 실시예를 통하여 더욱 명확해질 것이다.Other objects of the present invention will become clearer through the examples described below.
본 발명의 일 측면에 따른 형상기억 와이어 편조형 재팽창 스텐트는 제1 형상기억 온도 범위를 가지는 제1 형상기억 와이어 및 제1 형상기억 온도 범위 보다 높은 제2 형상기억 온도 범위를 가지는 제2 형상기억 와이어를 포함하고, 제1 형상기억 와이어와 제2 형상기억 와이어가 원통형으로 편조되어 형성될 수 있다.A shape memory wire braided re-expandable stent according to an aspect of the present invention comprises a first shape memory wire having a first shape memory temperature range and a second shape memory temperature range higher than the first shape memory temperature range. A wire may be formed by braiding the first shape memory wire and the second shape memory wire into a cylindrical shape.
또한, 원통형으로 편조되는 제1 형상기억 와이어의 수와 제2 형상기억 와이어의 수의 편조비는 1:1, 1:2 및 1:3 중 하나일 수 있다.In addition, the braiding ratio of the number of first shape memory wires and the number of second shape memory wires that are braided in a cylindrical shape may be one of 1:1, 1:2, and 1:3.
또한, 편조비가 1:1 일 때, 제1 형상기억 온도 범위는 36℃ 이상 ~ 38℃ 이하이고, 제2 형상기억 온도 범위는, 39℃ 이상 ~ 48℃ 이하일 수 있다.In addition, when the braiding ratio is 1:1, the first shape memory temperature range may be 36° C. to 38° C., and the second shape memory temperature range may be 39° C. to 48° C.
또한, 편조비가 1:2 일 때, 제1 형상기억 온도 범위는 36℃ 이상 ~ 38℃ 이하이고, 제2 형상기억 온도 범위는, 39℃ 이상 ~ 48℃ 이하의 제21 형상기억 온도 범위 및 44℃ 이상 ~ 48℃ 이하의 제22 형상기억 온도 범위를 포함할 수 있다.In addition, when the braiding ratio is 1:2, the first shape memory temperature range is 36 ° C. to 38 ° C., and the second shape memory temperature range is 39 ° C. to 48 ° C. It may include a 22nd shape memory temperature range of greater than or equal to °C and less than or equal to 48 °C.
또한, 제2 형상기억 와이어는, 제21 형상기억 온도 범위를 가지는 제21 형상기억 와이어 및 제22 형상기억 온도 범위를 가지는 제22 형상기억 와이어를 포함할 수 있다.In addition, the second shape memory wire may include a 21st shape memory wire having a 21st shape memory temperature range and a 22nd shape memory wire having a 22nd shape memory temperature range.
또한, 편조비가 1:3 일 때, 제1 형상기억 온도 범위는 36℃ 이상 ~ 38℃ 이하이고, 제2 형상기억 온도 범위는, 39℃ 이상 ~ 48℃ 이하의 제21 형상기억 온도 범위, 42℃ 이상 ~ 45℃ 미만의 제22 형상기억 온도 범위 및 45℃ 이상 ~ 48℃ 이하의 제23 형상기억 온도 범위를 포함할 수 있다.In addition, when the braiding ratio is 1:3, the first shape memory temperature range is 36 ° C. to 38 ° C., and the second shape memory temperature range is 39 ° C. to 48 ° C. 21st shape memory temperature range, 42 A 22nd shape memory temperature range of greater than or equal to ℃ and less than 45°C and a 23rd shape memory temperature range of greater than or equal to 45°C and less than or equal to 48°C may be included.
제2 형상기억 와이어는, 제21 형상기억 온도 범위를 가지는 제21 형상기억 와이어, 제22 형상기억 온도 범위를 가지는 제22 형상기억 와이어 및 제23 형상기억 온도 범위를 가지는 제23 형상기억 와이어를 포함할 수 있다.The second shape memory wire includes a 21st shape memory wire having a 21st shape memory temperature range, a 22nd shape memory wire having a 22nd shape memory temperature range, and a 23rd shape memory wire having a 23rd shape memory temperature range. can do.
본 발명의 다른 일 측면에 따른 형상기억 와이어 편조형 재팽창 스텐트를 이용한 치료 장치는 형상기억 와이어 편조형 재팽창 스텐트 및 제1 형상기억 와이어 및 제2 형상기억 와이어 중 하나에 전자기장을 가해 형상기억 와이어 편조형 재팽창 스텐트를 재팽창시키는 전자기장 발생기를 포함할 수 있다.A treatment device using a shape-memory wire-braided re-expandable stent according to another aspect of the present invention applies an electromagnetic field to one of the shape-memory wire-braided re-expandable stent and the first shape-memory wire and the second shape-memory wire to treat the shape-memory wire An electromagnetic field generator to re-expand the braided re-expandable stent.
본 발명의 실시예에 따른 형상기억 와이어 편조형 재팽창 스텐트는 다음과 같은 효과를 제공한다.The shape memory wire braided re-expandable stent according to an embodiment of the present invention provides the following effects.
본 발명은 복수의 형상기억 와이어를 편조로 제작하여 체내에 삽입 후에 인체 내의 내강이 재협착된 경우, 다시 팽창되어 재협착으로 인해 좁아진 혈관 등의 통로를 확장시킬 수 있는 효과가 있다.According to the present invention, when a plurality of shape-memory wires are braided and inserted into the body and the lumen in the human body is restenosis, it expands again to expand passages such as blood vessels narrowed due to restenosis.
본 발명의 효과는 이상에서 언급된 것들에 한정되지 않으며, 언급되지 아니한 다른 효과들은 아래의 기재로부터 당업자에게 명확하게 이해될 수 있을 것이다.The effects of the present invention are not limited to those mentioned above, and other effects not mentioned will be clearly understood by those skilled in the art from the description below.
도 1은 본 발명의 제1 실시예에 따른 형상기억 와이어 편조형 재팽창 스텐트를 설명하기 위한 도면이다.1 is a view for explaining a shape-memory wire braided re-expandable stent according to a first embodiment of the present invention.
도 2는 본 발명의 제2 실시예에 따른 형상기억 와이어 편조형 재팽창 스텐트를 설명하기 위한 도면이다.2 is a view for explaining a shape-memory wire braided re-expandable stent according to a second embodiment of the present invention.
도 3은 본 발명의 제2 실시예에 따른 형상기억 와이어 편조형 재팽창 스텐트의 온도별 팽창률을 설명하기 위한 그래프이다.Figure 3 is a graph for explaining the expansion rate according to temperature of the shape memory wire braided re-expandable stent according to the second embodiment of the present invention.
도 4는 본 발명의 제3 실시예에 따른 형상기억 와이어 편조형 재팽창 스텐트를 설명하기 위한 도면이다.4 is a view for explaining a shape-memory wire braided re-expandable stent according to a third embodiment of the present invention.
도 5는 본 발명의 제4 실시예에 따른 형상기억 와이어 편조형 재팽창 스텐트를 설명하기 위한 도면이다.5 is a view for explaining a shape-memory wire braided re-expandable stent according to a fourth embodiment of the present invention.
도 6은 본 발명의 제5 실시예에 따른 형상기억 와이어 편조형 재팽창 스텐트를 이용한 치료 장치를 설명하기 위한 도면이다.6 is a view for explaining a treatment device using a shape-memory wire braided re-expandable stent according to a fifth embodiment of the present invention.
본 발명은 다양한 변환을 가할 수 있고 여러 가지 실시 예를 가질 수 있는 바, 특정 실시 예들을 도면에 예시하고 상세한 설명에서 상세하게 설명하고자 한다. 그러나, 이는 본 발명을 특정한 실시 형태에 대해 한정하려는 것이 아니며, 본 발명의 사상 및 기술 범위에 포함되는 모든 변환, 균등물 내지 대체물을 포함하는 것으로 이해되어야 한다. 본 발명을 설명함에 있어서 관련된 공지 기술에 대한 구체적인 설명이 본 발명의 요지를 흐릴 수 있다고 판단되는 경우 그 상세한 설명을 생략한다.Since the present invention can apply various transformations and have various embodiments, specific embodiments will be illustrated in the drawings and described in detail in the detailed description. However, it should be understood that this is not intended to limit the present invention to specific embodiments, and includes all transformations, equivalents, and substitutes included in the spirit and scope of the present invention. In describing the present invention, if it is determined that a detailed description of related known technologies may obscure the gist of the present invention, the detailed description will be omitted.
본 출원에서 사용한 용어는 단지 특정한 실시예를 설명하기 위해 사용된 것으로, 본 발명을 한정하려는 의도가 아니다. 단수의 표현은 문맥상 명백하게 다르게 뜻하지 않는 한, 복수의 표현을 포함한다. 본 출원에서, "포함하다" 또는 "가지다" 등의 용어는 명세서상에 기재된 특징, 숫자, 단계, 동작, 구성요소, 부품 또는 이들을 조합한 것이 존재함을 지정하려는 것이지, 하나 또는 그 이상의 다른 특징들이나 숫자, 단계, 동작, 구성요소, 부품 또는 이들을 조합한 것들의 존재 또는 부가 가능성을 미리 배제하지 않는 것으로 이해되어야 한다.Terms used in this application are only used to describe specific embodiments, and are not intended to limit the present invention. Singular expressions include plural expressions unless the context clearly dictates otherwise. In this application, the terms "include" or "have" are intended to designate that there is a feature, number, step, operation, component, part, or combination thereof described in the specification, but one or more other features It should be understood that the presence or addition of numbers, steps, operations, components, parts, or combinations thereof is not precluded.
제1, 제2 등의 용어는 다양한 구성요소들을 설명하는데 사용될 수 있지만, 상기 구성요소들은 상기 용어들에 의해 한정되어서는 안 된다. 상기 용어들은 하나의 구성요소를 다른 구성요소로부터 구별하는 목적으로만 사용된다. Terms such as first and second may be used to describe various components, but the components should not be limited by the terms. These terms are only used for the purpose of distinguishing one component from another.
이하, 첨부한 도면들을 참조하여 본 발명에 따른 실시예들을 상세히 설명하기로 하며, 첨부 도면을 참조하여 설명함에 있어 도면 부호에 상관없이 동일하거나 대응하는 구성 요소는 동일한 참조번호를 부여하고 이에 대한 중복되는 설명은 생략하기로 한다.Hereinafter, embodiments according to the present invention will be described in detail with reference to the accompanying drawings. description is omitted.
이하 본 발명의 실시예들에 따른 형상기억 와이어 편조형 재팽창 스텐트에 대하여 도 1 내지 도 6을 참조하여 상세히 설명한다.Hereinafter, a shape memory wire braided re-expandable stent according to embodiments of the present invention will be described in detail with reference to FIGS. 1 to 6 .
도 1은 본 발명의 제1 실시예에 따른 형상기억 와이어 편조형 재팽창 스텐트를 설명하기 위한 도면이다.1 is a view for explaining a shape-memory wire braided re-expandable stent according to a first embodiment of the present invention.
도 1을 참조하면, 본 실시예에 따른 형상기억 와이어 편조형 재팽창 스텐트(10)는 제1 형상기억 와이어(11) 및 제2 형상기억 와이어(12)가 원통형으로 편조되어 형성될 수 있다.Referring to FIG. 1 , the shape memory wire braided re-expandable stent 10 according to the present embodiment may be formed by braiding a first shape memory wire 11 and a second shape memory wire 12 into a cylindrical shape.
형상기억 와이어 편조형 재팽창 스텐트(10)는 편조 장치(미도시됨)를 통해 편조되므로 제1 형상기억 와이어(11)와 제2 형상기억 와이어(12) 각각의 시작단 및 끝단을 제외하고 폐루프 형태를 이루도록 접합된 원통형 구조를 가질 수 있다.Since the shape memory wire braided re-expandable stent 10 is braided through a braiding device (not shown), the first shape memory wire 11 and the second shape memory wire 12 are closed except for the respective start and end ends. It may have a cylindrical structure joined to form a loop shape.
즉, 형상기억 와이어 편조형 재팽창 스텐트(10)의 양 끝단에서는 제1 형상기억 와이어(11) 및 제2 형상기억 와이어(12) 각각의 가닥의 연장 방향이 반대로 전환될 수 있다. 따라서 형상기억 와이어 편조형 재팽창 스텐트(10)의 양 끝단은 라운드 구조를 가지므로 시술 부위에 대한 손상을 방지할 수 있는 효과가 있다.That is, at both ends of the shape-memory wire braided re-expandable stent 10, the extension direction of each strand of the first shape memory wire 11 and the second shape memory wire 12 may be reversed. Therefore, since both ends of the shape-memory wire-braided re-expandable stent 10 have a round structure, damage to the treatment site can be prevented.
이러한 형상기억 와이어 편조형 재팽창 스텐트(10)는 제1 형상기억 와이어(11) 및 제2 형상기억 와이어(12)를 포함할 수 있다.The shape memory wire braided re-expandable stent 10 may include a first shape memory wire 11 and a second shape memory wire 12 .
제1 형상기억 와이어(11)는 형상기억합금으로 이루어지고, 제1 형상기억 온도 범위를 가질 수 있다. 제1 형상기억 와이어(11)는 제1 형상기억 온도에서 원래의 형상으로 복원될 수 있다. 예를 들어, 제1 형상기억 와이어(11)는 제1 형상기억 온도에서 원 형상으로 복원되는 니티놀(nitinol) 형상기억합금으로 이루어질 수 있다.The first shape memory wire 11 may be made of a shape memory alloy and have a first shape memory temperature range. The first shape memory wire 11 may be restored to its original shape at the first shape memory temperature. For example, the first shape memory wire 11 may be made of a nitinol shape memory alloy that is restored to its original shape at a first shape memory temperature.
제1 형상기억 와이어(11)를 형성하는 과정은 도면에 도시하지 않았으나, 통상의 지그를 이용하여 제1 형상기억 와이어(11)를 제2 형상기억 와이어(12)와 교차하도록 편조하여 형성할 수 있다.Although the process of forming the first shape memory wire 11 is not shown in the drawing, it can be formed by braiding the first shape memory wire 11 so as to cross the second shape memory wire 12 using a conventional jig. there is.
제2 형상기억 와이어(12)는 형상기억합금으로 이루어지고, 제1 형상기억 온도보다 높은 제2 형상기억 온도 범위를 가질 수 있다. 제2 형상기억 와이어(12)는 제2 형상기억 온도에서 원래의 형상으로 복원될 수 있다. 예를 들어, 제2 형상기억 와이어(12)는 제2 형상기억 온도에서 원 형상으로 복원되는 니티놀(nitinol) 형상기억합금으로 이루어질 수 있다.The second shape memory wire 12 is made of a shape memory alloy and may have a second shape memory temperature range higher than the first shape memory temperature. The second shape memory wire 12 may be restored to its original shape at the second shape memory temperature. For example, the second shape memory wire 12 may be made of a nitinol shape memory alloy that is restored to its original shape at a second shape memory temperature.
제2 형상기억 와이어(12)를 형성하는 과정은 도면에 도시하지 않았으나, 통상의 지그를 이용하여 제2 형상기억 와이어(12)를 제1 형상기억 와이어(11)와 교차하도록 편조하여 형성할 수 있다.Although the process of forming the second shape memory wire 12 is not shown in the drawing, it can be formed by braiding the second shape memory wire 12 so as to cross the first shape memory wire 11 using a conventional jig. there is.
니티놀(nitinol) 형상기억합금은 니켈(Ni)과 티타늄(Ti)을 섞은 합금으로써, 변형되어도 일정한 온도 이상으로 가열하면 원래의 형상으로 복원된다. 제1 형상기억 와이어(11)는 제1 형상기억 온도에서 원 형상으로 복원되는 니티놀(nitinol) 형상기억합금이고, 제2 형상기억 와이어(12)는 제1 형상기억 온도보다 높은 제2 형상기억 온도에서 원 형상으로 복원되는 니티놀(nitinol) 형상기억합금이므로, 인체의 내강 내에서 원 형상을 유지하려는 성질을 가질 수 있다.Nitinol shape memory alloy is a mixture of nickel (Ni) and titanium (Ti), and even if it is deformed, it is restored to its original shape when heated above a certain temperature. The first shape memory wire 11 is a nitinol shape memory alloy that is restored to its original shape at a first shape memory temperature, and the second shape memory wire 12 has a second shape memory temperature higher than the first shape memory temperature. Since it is a nitinol shape memory alloy that is restored to a circular shape in the human body, it may have a property of maintaining a circular shape within the lumen of the human body.
즉, 본 실시예에서는 형상기억 와이어 편조형 재팽창 스텐트(10)에 열을 가하여 형상기억 와이어 편조형 재팽창 스텐트(10)를 제1 형상기억 온도로 상승시키면 제1 형상기억 와이어(11)가 팽창하고, 이후 형상기억 와이어 편조형 재팽창 스텐트(10)를 제2 형상기억 온도로 상승시키면 제2 형상기억 와이어(12)가 팽창하여 형상기억 와이어 편조형 재팽창 스텐트(10)를 재팽창시킬 수 있게 된다.That is, in the present embodiment, when the shape-memory wire-braided re-expandable stent 10 is raised to the first shape-memory temperature by applying heat to the shape-memory wire-braided re-expandable stent 10, the first shape memory wire 11 After expansion, when the shape memory wire braided re-expandable stent 10 is raised to the second shape memory temperature, the second shape memory wire 12 expands to re-expand the shape memory wire braided re-expandable stent 10 be able to
또한, 원통형으로 편조되는 제1 형상기억 와이어(11)의 수와 제2 형상기억 와이어(12)의 수의 편조비는 1:1, 1:2 및 1:3 중 하나일 수 있다.In addition, the braiding ratio of the number of first shape memory wires 11 and the number of second shape memory wires 12 that are braided in a cylindrical shape may be one of 1:1, 1:2 and 1:3.
이하, 도 2 내지 도 5를 참조하여 제1 형상기억 와이어(11)의 수와 제2 형상기억 와이어(12)의 수의 편조비 1:1, 1:2 및 1:3 각각에 대하여 설명한다.Hereinafter, with reference to FIGS. 2 to 5, the number of first shape memory wires 11 and the number of second shape memory wires 12 at a braiding ratio of 1:1, 1:2, and 1:3 will be described, respectively. .
도 2는 본 발명의 제2 실시예에 따른 형상기억 와이어 편조형 재팽창 스텐트를 설명하기 위한 도면이다.2 is a view for explaining a shape-memory wire braided re-expandable stent according to a second embodiment of the present invention.
도 2를 참조하면, 본 실시예에 따른 형상기억 와이어 편조형 재팽창 스텐트(20)는 제1 형상기억 와이어(21) 및 제2 형상기억 와이어(22)를 포함할 수 있다. Referring to FIG. 2 , the shape memory wire braided re-expandable stent 20 according to the present embodiment may include a first shape memory wire 21 and a second shape memory wire 22 .
원통형으로 편조되는 제1 형상기억 와이어(21)의 수와 제2 형상기억 와이어(22)의 수의 편조비는 1:1일 수 있다. 여기서 편조는 제1 형상기억 와이어(21)와 제2 형상기억 와이어(22)가 하나씩 교차로 이루어질 수 있다.The braiding ratio of the number of first shape memory wires 21 and the number of second shape memory wires 22 that are braided in a cylindrical shape may be 1:1. Here, the braiding may be made by crossing the first shape memory wire 21 and the second shape memory wire 22 one by one.
편조비가 1:1 일 때, 제1 형상기억 와이어(21)의 제1 형상기억 온도 범위는 36℃ 이상 ~ 38℃ 이하일 수 있다. 제1 형상기억 온도 범위 36℃ 이상 ~ 38℃ 이하는 사람의 신체 온도와 유사하므로 혈관 내에서 제1 형상기억 와이어(21)가 일정 형상을 유지할 수 있다.When the braiding ratio is 1:1, the first shape memory temperature range of the first shape memory wire 21 may be 36° C. to 38° C. or less. Since the first shape memory temperature range of 36° C. to 38° C. is similar to a human body temperature, the first shape memory wire 21 can maintain a certain shape in blood vessels.
다만, 사람의 신체 온도가 36℃ 미만인 경우 형상기억 와이어 편조형 재팽창 스텐트(20)에 열을 가하여 온도를 36℃ 이상 ~ 38℃ 이하로 상승시키면 제1 형상기억 와이어(21)는 원 형상으로 복원되기 위해 팽창할 수 있다.However, when the human body temperature is less than 36 ° C., heat is applied to the shape memory wire braided re-expandable stent 20 to raise the temperature to 36 ° C. to 38 ° C., and the first shape memory wire 21 is formed into a circular shape It can be inflated to recover.
또한, 편조비가 1:1 일 때, 제2 형상기억 와이어(22)의 제2 형상기억 온도 범위는 39℃ 이상 ~ 48℃ 이하일 수 있다. 형상기억 와이어 편조형 재팽창 스텐트(20)에 열을 가하여 온도를 39℃ 이상 ~ 48℃ 이하로 상승시키면 제2 형상기억 와이어(22)는 원 형상으로 복원되기 위해 팽창할 수 있다.In addition, when the braiding ratio is 1:1, the second shape memory temperature range of the second shape memory wire 22 may be 39° C. to 48° C. or less. When the shape memory wire braided re-expandable stent 20 is heated to raise the temperature to 39° C. or higher and 48° C. or lower, the second shape memory wire 22 may expand to restore its original shape.
본 실시예에 따르면, 혈관 내에 형상기억 와이어 편조형 재팽창 스텐트(20)가 삽입되면 36℃ 이상 ~ 38℃ 이하인 제1 형상기억 와이어(21)가 사람의 체온에 따라 일정 형상을 유지할 수 있다. 폐색물에 의해 혈관이 폐색된 경우 외부의 전자기장에 의해 형상기억 와이어 편조형 재팽창 스텐트(20)가 발열되어 39℃ 이상 ~ 48℃ 이하의 온도에서 제2 형상기억 와이어(22)가 팽창함에 따라 폐색물을 밀어내어 혈관의 통로를 확보할 수 있다.According to this embodiment, when the shape-memory wire braided re-expandable stent 20 is inserted into a blood vessel, the first shape-memory wire 21 at a temperature of 36° C. to 38° C. can maintain a certain shape according to a person's body temperature. When a blood vessel is occluded by an obstruction, the shape memory wire braided re-expandable stent 20 is heated by an external electromagnetic field, and the second shape memory wire 22 expands at a temperature of 39 ° C. to 48 ° C. It is possible to secure the passage of the blood vessel by pushing out the obstruction.
도 3을 참조하면, 형상기억 와이어 편조형 재팽창 스텐트(10)는 36℃의 온도보다 45℃의 온도에서 팽창률이 증가된 것을 확인할 수 있다.Referring to FIG. 3 , it can be seen that the expansion rate of the shape memory wire braided re-expandable stent 10 is increased at a temperature of 45° C. rather than at a temperature of 36° C.
도 4는 본 발명의 제3 실시예에 따른 형상기억 와이어 편조형 재팽창 스텐트를 설명하기 위한 도면이다.4 is a view for explaining a shape-memory wire braided re-expandable stent according to a third embodiment of the present invention.
도 4를 참조하면, 본 실시예에 따른 형상기억 와이어 편조형 재팽창 스텐트(30)는 제1 형상기억 와이어(31) 및 제2 형상기억 와이어(32)를 포함할 수 있다.Referring to FIG. 4 , the shape memory wire braided re-expandable stent 30 according to the present embodiment may include a first shape memory wire 31 and a second shape memory wire 32 .
이때 제2 형상기억 와이어(32)는 제21 형상기억 온도 범위를 가지는 제21 형상기억 와이어(321) 및 제22 형상기억 온도 범위를 가지는 제22 형상기억 와이어(322)를 포함할 수 있다.In this case, the second shape memory wire 32 may include a 21 shape memory wire 321 having a 21st shape memory temperature range and a 22nd shape memory wire 322 having a 22nd shape memory temperature range.
원통형으로 편조되는 제1 형상기억 와이어(31)의 수와 제2 형상기억 와이어(32)의 수의 편조비는 1:2일 수 있다. 여기서 편조는 제1 형상기억 와이어(31), 제21 형상기억 와이어(321) 및 제22 형상기억 와이어(322)의 순서대로 이루어질 수 있다.The braiding ratio of the number of first shape memory wires 31 and the number of second shape memory wires 32 that are braided in a cylindrical shape may be 1:2. Here, the braiding may be performed in order of the first shape memory wire 31 , the twenty-first shape memory wire 321 and the twenty-second shape memory wire 322 .
도 4에서는 제1 형상기억 와이어(31), 제21 형상기억 와이어(321) 및 제22 형상기억 와이어(322)가 일정 간격으로 편조되는 것으로 도시하였으나, 이에 한정하고자 하는 것은 아니며, 제1 실시예에 따른 제1 형상기억 와이어(21)의 간격을 유지하면서 제1 형상기억 와이어(31) 사이에 제21 형상기억 와이어(321) 및 제22 형상기억 와이어(322)가 보다 조밀하게 편조될 수도 있다.In FIG. 4, the first shape memory wire 31, the twenty-first shape memory wire 321, and the twenty-second shape memory wire 322 are shown as being braided at regular intervals, but are not limited thereto, and the first embodiment The 21st shape memory wire 321 and the 22nd shape memory wire 322 may be more densely braided between the first shape memory wires 31 while maintaining the distance between the first shape memory wires 21 according to .
이 경우에는 제1 형상기억 와이어(31)의 간격이 넓어짐에 따라 제1 형상기억 온도에서 제1 형상기억 와이어(31)가 제 역할을 하지 못하는 상황을 방지할 수 있다.In this case, as the interval between the first shape memory wires 31 is widened, a situation in which the first shape memory wires 31 do not function properly at the first shape memory temperature can be prevented.
편조비가 1:2일 때 제1 형상기억 와이어(31)의 제1 형상기억 온도 범위는 36℃ 이상 ~ 38℃ 이하일 수 있다. 제1 형상기억 온도 범위 36℃ 이상 ~ 38℃ 이하는 사람의 신체 온도와 유사하므로 혈관 내에서 제1 형상기억 와이어(31)가 일정 형상을 유지할 수 있다.When the braid ratio is 1:2, the first shape memory temperature range of the first shape memory wire 31 may be 36° C. to 38° C. or less. Since the first shape memory temperature range of 36° C. to 38° C. is similar to the human body temperature, the first shape memory wire 31 can maintain a certain shape in blood vessels.
다만, 사람의 신체 온도가 36℃ 미만인 경우 형상기억 와이어 편조형 재팽창 스텐트(30)에 열을 가하여 온도를 36℃ 이상 ~ 38℃ 이하로 상승시키면 제1 형상기억 와이어(31)는 원 형상으로 복원되기 위해 팽창할 수 있다.However, when the human body temperature is less than 36 ° C., heat is applied to the shape-memory wire braided re-expandable stent 30 to raise the temperature to 36 ° C. to 38 ° C. It can be inflated to recover.
또한, 편조비가 1:2일 때 제21 형상기억 와이어(321)의 제21 형상기억 온도 범위는 39℃ 이상 ~ 48℃ 이하일 수 있다. 그리고 제22 형상기억 와이어(322)의 제22 형상기억 온도 범위는 44℃ 이상 ~ 48℃ 이하일 수 있다.In addition, when the braiding ratio is 1:2, the 21st shape memory temperature range of the 21st shape memory wire 321 may be 39°C or more and 48°C or less. And the 22nd shape memory temperature range of the 22nd shape memory wire 322 may be 44 degrees C or more and 48 degrees C or less.
형상기억 와이어 편조형 재팽창 스텐트(30)에 열을 가하여 온도를 39℃ 이상 ~ 44℃ 미만으로 상승시키면 제21 형상기억 와이어(321)만 원 형상으로 복원되기 위해 팽창할 수 있다. 이후 온도를 44℃ 이상 ~ 48℃ 이하로 상승시키면 제21 형상기억 와이어(321)와 제22 형상기억 와이어(322)가 모두 원 형상으로 복원되기 위해 팽창할 수 있다.When the shape memory wire braided re-expandable stent 30 is heated to raise the temperature to 39° C. or more and less than 44° C., only the 21st shape memory wire 321 can be expanded to restore the original shape. Then, when the temperature is raised to 44° C. or higher and 48° C. or lower, both the 21st shape memory wire 321 and the 22nd shape memory wire 322 may expand to restore their original shape.
*본 실시예에 따르면, 혈관 내에 형상기억 와이어 편조형 재팽창 스텐트(30)가 삽입되면 36℃ 이상 ~ 38℃ 이하인 제1 형상기억 와이어(31)가 사람의 체온에 따라 일정 형상을 유지할 수 있다. 폐색물에 의해 혈관이 폐색된 경우 외부의 전자기장에 의해 형상기억 와이어 편조형 재팽창 스텐트(30)가 발열되어 39℃ 이상 ~ 44℃ 미만의 온도에서 제21 형상기억 와이어(321)가 팽창함에 따라 폐색물을 밀어내어 혈관의 통로를 확보할 수 있다.*According to this embodiment, when the shape memory wire braided re-expandable stent 30 is inserted into the blood vessel, the first shape memory wire 31 at 36° C. to 38° C. can maintain a certain shape according to the body temperature of the person. . When a blood vessel is occluded by an obstruction, the shape memory wire braided re-expandable stent 30 is heated by an external electromagnetic field and the 21st shape memory wire 321 expands at a temperature of 39 ° C or more to less than 44 ° C. It is possible to secure the passage of the blood vessel by pushing out the obstruction.
제21 형상기억 와이어(321)가 팽창한 이후 혈관의 상태를 모니터링하고, 혈관 내의 폐색물이 덜 밀린 경우, 즉 혈관의 통로 확보가 더 필요한 경우 외부의 전자기장에 의해 형상기억 와이어 편조형 재팽창 스텐트(30)가 발열되어 44℃ 이상 ~ 48℃ 이하의 온도에서 제21 형상기억 와이어(321)와 제22 형상기억 와이어(322)가 팽창함에 따라 폐색물을 밀어내어 혈관의 통로를 확보할 수 있다.After the 21st shape memory wire 321 is inflated, the state of the blood vessel is monitored, and when the obstruction in the blood vessel is less pushed, that is, when more blood vessel passage is required, shape memory wire braided re-expandable stent by external electromagnetic field As the 21st shape memory wire 321 and the 22nd shape memory wire 322 expand at a temperature of 44 ° C. to 48 ° C. due to heat generation of the 30, the obstruction is pushed out to secure the passage of the blood vessel. .
따라서 본 실시예에서는 혈관의 통로 확보 크기에 따라 형상기억 와이어 편조형 재팽창 스텐트(30)를 단계적으로 팽창시킬 수 있는 특징이 있다.Therefore, in the present embodiment, there is a feature in that the shape memory wire braided re-expandable stent 30 can be expanded in stages according to the size of the blood vessel passage.
도 5는 본 발명의 제4 실시예에 따른 형상기억 와이어 편조형 재팽창 스텐트를 설명하기 위한 도면이다.5 is a view for explaining a shape-memory wire braided re-expandable stent according to a fourth embodiment of the present invention.
도 5를 참조하면, 본 실시예에 따른 형상기억 와이어 편조형 재팽창 스텐트(40)는 제1 형상기억 와이어(41) 및 제2 형상기억 와이어(42)를 포함할 수 있다.Referring to FIG. 5 , the shape memory wire braided re-expandable stent 40 according to the present embodiment may include a first shape memory wire 41 and a second shape memory wire 42 .
이때 제2 형상기억 와이어(42)는 제21 형상기억 온도 범위를 가지는 제21 형상기억 와이어(421), 제22 형상기억 온도 범위를 가지는 제22 형상기억 와이어(422) 및 제23 형상기억 온도 범위를 가지는 제23 형상기억 와이어(423)를 포함할 수 있다.At this time, the second shape memory wire 42 includes a 21st shape memory wire 421 having a 21st shape memory temperature range, a 22nd shape memory wire 422 having a 22nd shape memory temperature range, and a 23rd shape memory temperature range. It may include a 23rd shape memory wire 423 having a.
원통형으로 편조되는 제1 형상기억 와이어(41)의 수와 제2 형상기억 와이어(42)의 수의 편조비는 1:3일 수 있다. 여기서 편조는 제1 형상기억 와이어(41), 제22 형상기억 와이어(422), 제21 형상기억 와이어(421) 및 제23 형상기억 와이어(423)의 순서대로 이루어질 수 있다.The braiding ratio of the number of first shape memory wires 41 and the number of second shape memory wires 42 that are braided in a cylindrical shape may be 1:3. Here, the braiding may be performed in order of the first shape memory wire 41, the 22nd shape memory wire 422, the 21st shape memory wire 421 and the 23rd shape memory wire 423.
도 5에서는 제1 형상기억 와이어(41), 제22 형상기억 와이어(422), 제21 형상기억 와이어(421) 및 제23 형상기억 와이어(423)가 일정 간격으로 편조되는 것으로 도시하였으나, 이에 한정하고자 하는 것은 아니며, 제1 실시예에 따른 제1 형상기억 와이어(21)의 간격을 유지하면서 제1 형상기억 와이어(41) 사이에 제22 형상기억 와이어(422), 제21 형상기억 와이어(421) 및 제23 형상기억 와이어(423)가 보다 조밀하게 편조될 수도 있다.In FIG. 5, the first shape memory wire 41, the 22nd shape memory wire 422, the 21st shape memory wire 421 and the 23rd shape memory wire 423 are shown as being braided at regular intervals, but are limited thereto. The 22nd shape memory wire 422 and the 21st shape memory wire 421 are interposed between the first shape memory wires 41 while maintaining the distance between the first shape memory wires 21 according to the first embodiment. ) and the 23rd shape memory wire 423 may be braided more densely.
편조비가 1:3일 때 제1 형상기억 와이어(41)의 제1 형상기억 온도 범위는 36℃ 이상 ~ 38℃ 이하일 수 있다. 제1 형상기억 온도 범위 36℃ 이상 ~ 38℃ 이하는 사람의 신체 온도와 유사하므로 혈관 내에서 제1 형상기억 와이어(41)가 일정 형상을 유지할 수 있다.When the braid ratio is 1:3, the first shape memory temperature range of the first shape memory wire 41 may be 36° C. to 38° C. or less. Since the first shape memory temperature range of 36° C. to 38° C. is similar to a human body temperature, the first shape memory wire 41 can maintain a certain shape in blood vessels.
다만, 사람의 신체 온도가 36℃ 미만인 경우 형상기억 와이어 편조형 재팽창 스텐트(40)에 열을 가하여 온도를 36℃ 이상 ~ 38℃ 이하로 상승시키면 제1 형상기억 와이어(41)는 원 형상으로 복원되기 위해 팽창할 수 있다.However, when the human body temperature is less than 36 ° C., heat is applied to the shape memory wire braided re-expandable stent 40 to raise the temperature to 36 ° C. to 38 ° C., and the first shape memory wire 41 is circular. It can be inflated to recover.
또한, 편조비가 1:3일 때 제21 형상기억 와이어(421)의 제21 형상기억 온도 범위는 39℃ 이상 ~ 48℃ 이하일 수 있다. 그리고 제22 형상기억 와이어(422)의 제22 형상기억 온도 범위는 42℃ 이상 ~ 45℃ 미만일 수 있다. 마지막으로 제23 형상기억 와이어(423)의 제23 형상기억 온도 범위는 45℃ 이상 ~ 48℃ 이하일 수 있다.In addition, when the braiding ratio is 1:3, the 21st shape memory temperature range of the 21st shape memory wire 421 may be 39°C or higher and 48°C or lower. And the 22nd shape memory temperature range of the 22nd shape memory wire 422 may be 42 degrees C or more and less than 45 degrees C. Finally, the 23rd shape memory temperature range of the 23rd shape memory wire 423 may be 45°C or more and 48°C or less.
형상기억 와이어 편조형 재팽창 스텐트(40)에 열을 가하여 온도를 39℃ 이상 ~ 42℃ 미만으로 상승시키면 제21 형상기억 와이어(421)만 원 형상으로 복원되기 위해 팽창할 수 있다. 이후 온도를 42℃ 이상 ~ 45℃ 미만으로 상승시키면 제21 형상기억 와이어(421)와 제22 형상기억 와이어(422)가 원 형상으로 복원되기 위해 팽창할 수 있다. 또한, 온도를 45℃ 이상 ~ 48℃ 이하로 상승시키면 제21 형상기억 와이어(421)와 제23 형상기억 와이어(423)가 원 형상으로 복원되기 위해 팽창할 수 있다.When heat is applied to the shape memory wire-braided re-expandable stent 40 to raise the temperature to 39° C. or more and less than 42° C., only the 21st shape memory wire 421 can be expanded to restore the original shape. Then, when the temperature is raised to 42° C. or more and less than 45° C., the 21st shape memory wire 421 and the 22nd shape memory wire 422 may expand to restore their original shape. In addition, when the temperature is raised to 45° C. or higher and 48° C. or lower, the 21st shape memory wire 421 and the 23rd shape memory wire 423 may expand to restore their original shape.
한편, 도 5에서는 제21 형상기억 와이어(421)를 제22 형상기억 와이어(422)와 제23 형상기억 와이어(423) 사이에 편조하는 것으로 도시하였고, 이는 제21 형상기억 와이어(421)의 제21 형상기억 온도 범위가 제22 형상기억 온도 범위와 제23 형상기억 온도 범위를 포함하고 있기 때문이다.On the other hand, in FIG. 5, the 21st shape memory wire 421 is shown as being braided between the 22nd shape memory wire 422 and the 23rd shape memory wire 423, which is the first shape of the 21st shape memory wire 421. This is because the 21st shape memory temperature range includes the 22nd shape memory temperature range and the 23rd shape memory temperature range.
즉, 제21 형상기억 와이어(421)는 제21 형상기억 온도 범위인 39℃ 이상 ~ 48℃ 이하에서 팽창하고, 제22 형상기억 와이어(422)는 제21 형상기억 온도 범위 사이인 제22 형상기억 온도 범위 42℃ 이상 ~ 45℃ 미만에서 팽창하며, 제23 형상기억 와이어(423)는 제21 형상기억 온도 범위 사이인 제23 형상기억 온도 범위 45℃ 이상 ~ 48℃ 이하에서 팽창할 수 있다. 이에 제21 형상기억 와이어(421)는 제1 형상기억 와이어(41)로 편중되지 않고 제22 형상기억 와이어(422)와 제23 형상기억 와이어(423)의 사이에서 안정적으로 팽창할 수 있다.That is, the 21st shape memory wire 421 expands in the 21st shape memory temperature range of 39° C. to 48° C., and the 22nd shape memory wire 422 is between the 21st shape memory temperature range and the 22nd shape memory It expands in the temperature range of 42 ° C. to less than 45 ° C., and the 23rd shape memory wire 423 may expand in the 23rd shape memory temperature range of 45 ° C. to 48 ° C., which is between the 21st shape memory temperature range. Accordingly, the 21st shape memory wire 421 can be stably expanded between the 22nd shape memory wire 422 and the 23rd shape memory wire 423 without being biased towards the first shape memory wire 41 .
다만, 이에 한정하고자 하는 것은 아니며 형상기억 와이어 편조형 재팽창 스텐트(40)의 사용 부위에 따라 제2 형상기억 와이어(42)의 편조 위치는 달라질 수 있다.However, it is not intended to be limited thereto, and the braided position of the second shape memory wire 42 may vary depending on the region where the shape memory wire braided re-expandable stent 40 is used.
본 실시예에 따르면, 혈관 내에 형상기억 와이어 편조형 재팽창 스텐트(40)가 삽입되면 36℃ 이상 ~ 38℃ 이하인 제1 형상기억 와이어(41)가 사람의 체온에 따라 일정 형상을 유지할 수 있다. 폐색물에 의해 혈관이 폐색된 경우 외부의 전자기장에 의해 형상기억 와이어 편조형 재팽창 스텐트(40)가 발열되어 39℃ 이상 ~ 42℃ 미만의 온도에서 제21 형상기억 와이어(421)가 팽창함에 따라 폐색물을 밀어내어 혈관의 통로를 확보할 수 있다.According to the present embodiment, when the shape-memory wire braided re-expandable stent 40 is inserted into a blood vessel, the first shape-memory wire 41 at a temperature of 36° C. to 38° C. can maintain a certain shape according to a person's body temperature. When a blood vessel is occluded by an obstruction, the shape-memory wire braided re-expandable stent 40 is heated by an external electromagnetic field, and the 21st shape memory wire 421 expands at a temperature of 39 ° C or more to less than 42 ° C. It is possible to secure the passage of the blood vessel by pushing out the obstruction.
제21 형상기억 와이어(421)가 팽창한 이후 혈관의 상태를 모니터링하고, 혈관 내의 폐색물이 덜 밀린 경우, 즉 혈관의 통로 확보가 더 필요한 경우 외부의 전자기장에 의해 형상기억 와이어 편조형 재팽창 스텐트(40)가 발열되어 42℃ 이상 ~ 45℃ 미만의 온도에서 제21 형상기억 와이어(421)와 제22 형상기억 와이어(422)가 팽창함에 따라 폐색물을 밀어내어 혈관의 통로를 확보할 수 있다.After the 21st shape memory wire 421 is inflated, the state of the blood vessel is monitored, and when the obstruction in the blood vessel is less pushed, that is, when more blood vessel passage is required, shape memory wire braided re-expandable stent by external electromagnetic field As (40) generates heat and the 21st shape memory wire 421 and the 22nd shape memory wire 422 expand at a temperature of 42 ° C. to less than 45 ° C., the obstruction can be pushed out to secure the passage of blood vessels. .
제21 형상기억 와이어(421)와 제22 형상기억 와이어(422)가 팽창한 이후 혈관의 상태를 모니터링하고, 혈관 내의 폐색물이 덜 밀린 경우, 즉 혈관의 통로 확보가 더 필요한 경우 외부의 전자기장에 의해 형상기억 와이어 편조형 재팽창 스텐트(40)가 발열되어 45℃ 이상 ~ 48℃ 이하의 온도에서 제21 형상기억 와이어(421)와 제23 형상기억 와이어(423)가 팽창함에 따라 폐색물을 밀어내어 혈관의 통로를 확보할 수 있다.After the 21st shape memory wire 421 and the 22nd shape memory wire 422 are inflated, the state of the blood vessel is monitored, and when the obstruction in the blood vessel is less pushed, that is, when it is necessary to secure the passage of the blood vessel, it is not exposed to external electromagnetic fields. As the shape memory wire braided re-expandable stent 40 generates heat and the 21st shape memory wire 421 and the 23rd shape memory wire 423 expand at a temperature of 45 ° C or more to 48 ° C or less, the obstruction is pushed to secure the passage of blood vessels.
따라서 본 실시예에서는 혈관의 통로 확보 크기에 따라 형상기억 와이어 편조형 재팽창 스텐트(40)를 단계적으로 팽창시킬 수 있는 특징이 있다.Therefore, in this embodiment, there is a feature that the shape memory wire braided re-expandable stent 40 can be expanded in stages according to the size of the blood vessel passage.
도 6은 본 발명의 제5 실시예에 따른 형상기억 와이어 편조형 재팽창 스텐트를 이용한 치료 장치를 설명하기 위한 도면이다.6 is a view for explaining a treatment device using a shape-memory wire braided re-expandable stent according to a fifth embodiment of the present invention.
도 6을 참조하면, 형상기억 와이어 편조형 재팽창 스텐트를 이용한 치료 장치는 형상기억 와이어 편조형 재팽창 스텐트(10) 및 전자기장 발생기(50)를 포함할 수 있다. 여기서 형상기억 와이어 편조형 재팽창 스텐트를 이용한 치료 장치는 제1 실시예에 따른 형상기억 와이어 편조형 재팽창 스텐트(10), 제2 실시예에 따른 형상기억 와이어 편조형 재팽창 스텐트(20), 제3 실시예에 따른 형상기억 와이어 편조형 재팽창 스텐트(30) 및 제4 실시예에 따른 형상기억 와이어 편조형 재팽창 스텐트(40) 모두를 포함할 수 있고, 아래에서는 제1 실시예에 따른 형상기억 와이어 편조형 재팽창 스텐트(10)에 대해서만 설명한다.Referring to FIG. 6 , a treatment device using a shape-memory wire-braided re-expandable stent may include a shape-memory wire-braided re-expandable stent 10 and an electromagnetic field generator 50 . Here, the treatment device using the shape-memory wire-braided re-expandable stent includes the shape-memory wire-braided re-expandable stent 10 according to the first embodiment, the shape-memory wire-braided re-expandable stent 20 according to the second embodiment, It may include both the shape-memory wire-braided re-expandable stent 30 according to the third embodiment and the shape-memory wire-braided re-expandable stent 40 according to the fourth embodiment. Only the shape-memory wire braided re-expandable stent 10 will be described.
형상기억 와이어 편조형 재팽창 스텐트(10)는 혈관(1)내에 삽입될 수 있다. 형상기억 와이어 편조형 재팽창 스텐트(10)는 혈관(1) 내에 삽입된 후 전자기장 발생기(50)에서 가해지는 전자기장에 따라 발열할 수 있다.The shape-memory wire-braided re-expandable stent 10 can be inserted into the blood vessel 1. After being inserted into the blood vessel 1, the shape-memory wire-braided re-expandable stent 10 may generate heat according to the electromagnetic field applied by the electromagnetic field generator 50.
형상기억 와이어 편조형 재팽창 스텐트(10)는 발열 온도에 따라 제1 형상기억 와이어(11) 및 제2 형상기억 와이어(12) 중 적어도 하나가 팽창할 수 있다.In the shape memory wire braided re-expandable stent 10 , at least one of the first shape memory wire 11 and the second shape memory wire 12 may expand according to an exothermic temperature.
전자기장 발생기(50)는 제1 형상기억 와이어(11) 및 제2 형상기억 와이어(12) 중 적어도 하나에 전자기장(M)을 가해 형상기억 와이어 편조형 재팽창 스텐트(10)를 재팽창시킬 수 있다.The electromagnetic field generator 50 may re-expand the shape memory wire braided re-expandable stent 10 by applying an electromagnetic field M to at least one of the first shape memory wire 11 and the second shape memory wire 12. .
형상기억 와이어 편조형 재팽창 스텐트를 이용한 치료 장치를 사용하는 과정을 설명하면, 혈관(1) 내에 종양과 같은 폐색물(2)이 발생한 경우, 혈관(1)에 형상기억 와이어 편조형 재팽창 스텐트(10)를 삽입하여 혈관(1)의 통로를 확보하게 된다.Describing the process of using the treatment device using the shape-memory wire-braided re-expandable stent, when an obstruction (2) such as a tumor occurs in the blood vessel (1), the shape-memory wire-braided re-expandable stent is applied to the blood vessel (1). (10) is inserted to secure the passage of the blood vessel (1).
다만, 시간이 흘러 혈관(1) 내에서 폐색물(2)이 다시 증식하게 되면 혈관(1)의 재협착이 발생할 수 있다. 이때, 전자기장 발생기(50)에서 형상기억 와이어 편조형 재팽창 스텐트(10)에 전자기장(M)을 가하여 제1 형상기억 온도에 도달하면 제1 형상기억 와이어(11)가 팽창하여 혈관(1) 내의 폐색물(2)을 밀어낼 수 있다.However, restenosis of the blood vessel 1 may occur when the obstruction 2 proliferates again in the blood vessel 1 over time. At this time, when an electromagnetic field (M) is applied to the shape memory wire braided re-expandable stent 10 from the electromagnetic field generator 50 to reach the first shape memory temperature, the first shape memory wire 11 expands and the inside of the blood vessel 1 The obstruction (2) can be pushed out.
또한, 전자기장 발생기(50)에서 형상기억 와이어 편조형 재팽창 스텐트(10)에 전자기장(M)을 가하여 제2 형상기억 온도에 도달하면 제2 형상기억 와이어(12)가 팽창하여 혈관(1) 내의 폐색물(2)을 더 밀어낼 수 있다.In addition, when the electromagnetic field (M) is applied to the shape memory wire braided re-expandable stent 10 from the electromagnetic field generator 50 to reach the second shape memory temperature, the second shape memory wire 12 expands and the inside of the blood vessel 1 The obstruction 2 can be further pushed out.
이에 따라 폐색물(2)이 다시 증식하여 혈관(1)이 재협착되더라도, 형상기억 와이어 편조형 재팽창 스텐트(10)를 재시술하지 않고, 제1 형상기억 와이어(11) 및 제2 형상기억 와이어(12)에 열을 가하여 간단하게 형상기억 와이어 편조형 재팽창 스텐트(10)를 재팽창시킴으로써, 혈관(1)의 좁혀진 통로를 확대시킬 수 있다.Accordingly, even if the obstruction 2 proliferates again and the blood vessel 1 is restenosis, the first shape memory wire 11 and the second shape memory wire 11 and the second shape memory wire 11 are not re-operated on the shape memory wire braided re-expandable stent 10. By simply re-expanding the shape-memory wire-braided re-expandable stent 10 by applying heat to the wire 12, the narrowed passage of the blood vessel 1 can be expanded.
상기에서는 본 발명의 일 실시예를 참조하여 설명하였지만, 해당 기술 분야에서 통상의 지식을 가진 자라면 하기의 특허 청구의 범위에 기재된 본 발명의 사상 및 영역으로부터 벗어나지 않는 범위 내에서 본 발명을 다양하게 수정 및 변경시킬 수 있음을 이해할 수 있을 것이다.Although the above has been described with reference to an embodiment of the present invention, those skilled in the art can make various modifications to the present invention within the scope not departing from the spirit and scope of the present invention described in the claims below. It will be appreciated that modifications and changes may be made.

Claims (8)

  1. 제1 형상기억 온도 범위를 가지는 제1 형상기억 와이어; 및a first shape memory wire having a first shape memory temperature range; and
    상기 제1 형상기억 온도 범위 보다 높은 제2 형상기억 온도 범위를 가지는 제2 형상기억 와이어; 를 포함하고,a second shape memory wire having a second shape memory temperature range higher than the first shape memory temperature range; including,
    상기 제1 형상기억 와이어와 상기 제2 형상기억 와이어가 원통형으로 편조되어 형성되는 형상기억 와이어 편조형 재팽창 스텐트.A shape memory wire braided re-expandable stent formed by braiding the first shape memory wire and the second shape memory wire into a cylindrical shape.
  2. 제1 항에 있어서,According to claim 1,
    상기 원통형으로 편조되는 상기 제1 형상기억 와이어의 수와 상기 제2 형상기억 와이어의 수의 편조비는 1:1, 1:2 및 1:3 중 하나인 형상기억 와이어 편조형 재팽창 스텐트.The braiding ratio of the number of the first shape memory wires and the number of the second shape memory wires braided in the cylindrical shape is one of 1: 1, 1: 2 and 1: 3 shape memory wire braided re-expandable stent.
  3. 제2 항에 있어서,According to claim 2,
    상기 편조비가 1:1 일 때,When the braiding ratio is 1: 1,
    상기 제1 형상기억 온도 범위는 36℃ 이상 ~ 38℃ 이하이고,The first shape memory temperature range is 36 ° C or more to 38 ° C or less,
    상기 제2 형상기억 온도 범위는, The second shape memory temperature range,
    39℃ 이상 ~ 48℃ 이하인 형상기억 와이어 편조형 재팽창 스텐트.A shape-memory wire-braided re-expandable stent that is above 39℃ and below 48℃.
  4. 제2 항에 있어서,According to claim 2,
    상기 편조비가 1:2 일 때,When the braiding ratio is 1:2,
    상기 제1 형상기억 온도 범위는 36℃ 이상 ~ 38℃ 이하이고,The first shape memory temperature range is 36 ° C or more to 38 ° C or less,
    상기 제2 형상기억 온도 범위는, The second shape memory temperature range,
    39℃ 이상 ~ 48℃ 이하의 제21 형상기억 온도 범위 및 44℃ 이상 ~ 48℃ 이하의 제22 형상기억 온도 범위를 포함하는 형상기억 와이어 편조형 재팽창 스텐트.A shape memory wire braided re-expandable stent comprising a 21st shape memory temperature range of 39° C. to 48° C. and a 22nd shape memory temperature range of 44° C. to 48° C.
  5. 제4 항에 있어서,According to claim 4,
    상기 제2 형상기억 와이어는, The second shape memory wire,
    상기 제21 형상기억 온도 범위를 가지는 제21 형상기억 와이어 및 상기 제22 형상기억 온도 범위를 가지는 제22 형상기억 와이어를 포함하는 형상기억 와이어 편조형 재팽창 스텐트.A shape memory wire braided re-expandable stent comprising a 21st shape memory wire having the 21st shape memory temperature range and a 22nd shape memory wire having the 22nd shape memory temperature range.
  6. 제2 항에 있어서,According to claim 2,
    상기 편조비가 1:3 일 때,When the braiding ratio is 1:3,
    상기 제1 형상기억 온도 범위는 36℃ 이상 ~ 38℃ 이하이고,The first shape memory temperature range is 36 ° C or more to 38 ° C or less,
    상기 제2 형상기억 온도 범위는, The second shape memory temperature range,
    39℃ 이상 ~ 48℃ 이하의 제21 형상기억 온도 범위, 42℃ 이상 ~ 45℃ 미만의 제22 형상기억 온도 범위 및 45℃ 이상 ~ 48℃ 이하의 제23 형상기억 온도 범위를 포함하는 형상기억 와이어 편조형 재팽창 스텐트.A shape memory wire comprising a 21st shape memory temperature range of 39° C. to 48° C., a 22nd shape memory temperature range of 42° C. to less than 45° C., and a 23rd shape memory temperature range of 45° C. to 48° C. Braided re-expandable stent.
  7. 제6 항에 있어서,According to claim 6,
    상기 제2 형상기억 와이어는,The second shape memory wire,
    상기 제21 형상기억 온도 범위를 가지는 제21 형상기억 와이어, 상기 제22 형상기억 온도 범위를 가지는 제22 형상기억 와이어 및 상기 제23 형상기억 온도 범위를 가지는 제23 형상기억 와이어를 포함하는 형상기억 와이어 편조형 재팽창 스텐트.A shape memory wire including a 21st shape memory wire having the 21st shape memory temperature range, a 22nd shape memory wire having the 22nd shape memory temperature range, and a 23rd shape memory wire having the 23rd shape memory temperature range Braided re-expandable stent.
  8. 제1 항 내지 제7 항 중 어느 한 항의 형상기억 와이어 편조형 재팽창 스텐트; 및The shape memory wire-braided re-expandable stent according to any one of claims 1 to 7; and
    상기 제1 형상기억 와이어 및 상기 제2 형상기억 와이어 중 하나에 전자기장을 가해 상기 형상기억 와이어 편조형 재팽창 스텐트를 재팽창시키는 전자기장 발생기를 포함하는 형상기억 와이어 편조형 재팽창 스텐트를 이용한 치료 장치.A treatment device using a shape-memory wire-braided re-expandable stent comprising an electromagnetic field generator for re-expanding the shape-memory wire-braided re-expandable stent by applying an electromagnetic field to one of the first shape-memory wire and the second shape-memory wire.
PCT/KR2022/014479 2021-12-24 2022-09-27 Shape-memory wire-braided re-expandable stent WO2023120890A1 (en)

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