WO2023076418A3 - Platforms, compositions, and methods for therapeutic delivery - Google Patents
Platforms, compositions, and methods for therapeutic delivery Download PDFInfo
- Publication number
- WO2023076418A3 WO2023076418A3 PCT/US2022/047925 US2022047925W WO2023076418A3 WO 2023076418 A3 WO2023076418 A3 WO 2023076418A3 US 2022047925 W US2022047925 W US 2022047925W WO 2023076418 A3 WO2023076418 A3 WO 2023076418A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- extracellular vesicle
- methods
- compositions
- platforms
- therapeutic delivery
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 2
- 230000001225 therapeutic effect Effects 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
- A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
- A61K48/0041—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid the non-active part being polymeric
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/12—Animals modified by administration of exogenous cells
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/035—Animal model for multifactorial diseases
- A01K2267/0387—Animal model for diseases of the immune system
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Wood Science & Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Immunology (AREA)
- Virology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Disclosed herein is an engineered extracellular vesicle and compositions containing the engineered extracellular vesicle. Further disclosed are methods of manufacturing and administering the engineered extracellular vesicle and compositions containing said engineered extracellular vesicle. Further, wherein a composition comprises an extracellular vesicle, wherein the extracellular vesicle comprises a transmembrane moiety bound to an affinity receiver.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202163272059P | 2021-10-26 | 2021-10-26 | |
US63/272,059 | 2021-10-26 | ||
US202263354613P | 2022-06-22 | 2022-06-22 | |
US63/354,613 | 2022-06-22 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2023076418A2 WO2023076418A2 (en) | 2023-05-04 |
WO2023076418A3 true WO2023076418A3 (en) | 2023-11-02 |
Family
ID=86158728
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2022/047925 WO2023076418A2 (en) | 2021-10-26 | 2022-10-26 | Platforms, compositions, and methods for therapeutic delivery |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2023076418A2 (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2023076418A2 (en) * | 2021-10-26 | 2023-05-04 | Entelexo Biotherapeutics, Inc. | Platforms, compositions, and methods for therapeutic delivery |
WO2023250440A1 (en) * | 2022-06-22 | 2023-12-28 | Entelexo Biotherapeutics, Inc. | Engineered extracellular vesicles for therapeutic delivery |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2017160884A1 (en) * | 2016-03-14 | 2017-09-21 | Capricor, Inc. | Methods of treating ocular inflammation and chemical injuries of the eye with extracellular vesicles |
US10527609B2 (en) * | 2010-02-11 | 2020-01-07 | Oxford University Innovation Limited | Peptide tag systems that spontaneously form an irreversible link to protein partners via isopeptide bonds |
WO2020257710A1 (en) * | 2019-06-21 | 2020-12-24 | Entelexo Biotherapeutics Inc. | Platforms, compositions, and methods for therapeutics delivery |
WO2021154888A1 (en) * | 2020-01-27 | 2021-08-05 | Mantra Bio. Inc. | Non-naturally occurring vesicles comprising a chimeric vesicle localization moiety, methods of making and uses thereof |
WO2023076418A2 (en) * | 2021-10-26 | 2023-05-04 | Entelexo Biotherapeutics, Inc. | Platforms, compositions, and methods for therapeutic delivery |
-
2022
- 2022-10-26 WO PCT/US2022/047925 patent/WO2023076418A2/en unknown
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10527609B2 (en) * | 2010-02-11 | 2020-01-07 | Oxford University Innovation Limited | Peptide tag systems that spontaneously form an irreversible link to protein partners via isopeptide bonds |
WO2017160884A1 (en) * | 2016-03-14 | 2017-09-21 | Capricor, Inc. | Methods of treating ocular inflammation and chemical injuries of the eye with extracellular vesicles |
WO2020257710A1 (en) * | 2019-06-21 | 2020-12-24 | Entelexo Biotherapeutics Inc. | Platforms, compositions, and methods for therapeutics delivery |
WO2021154888A1 (en) * | 2020-01-27 | 2021-08-05 | Mantra Bio. Inc. | Non-naturally occurring vesicles comprising a chimeric vesicle localization moiety, methods of making and uses thereof |
WO2023076418A2 (en) * | 2021-10-26 | 2023-05-04 | Entelexo Biotherapeutics, Inc. | Platforms, compositions, and methods for therapeutic delivery |
Non-Patent Citations (4)
Title |
---|
ANTHONY H. KEEBLE, PAULA TURKKI, SAMUEL STOKES, IRSYAD N. A. KHAIRIL ANUAR, ROLLE RAHIKAINEN, VESA P. HYTöNEN, MARK HOWARTH: "Approaching infinite affinity through engineering of peptide–protein interaction", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, vol. 116, no. 52, 26 December 2019 (2019-12-26), pages 26523 - 26533, XP055723018, ISSN: 0027-8424, DOI: 10.1073/pnas.1909653116 * |
CHAUHAN VEEREN M.; ZHANG HONGYU; DALBY PAUL A.; AYLOTT JONATHAN W.: "Advancements in the co-formulation of biologic therapeutics", JOURNAL OF CONTROLLED RELEASE, ELSEVIER, AMSTERDAM, NL, vol. 327, 14 August 2020 (2020-08-14), AMSTERDAM, NL , pages 397 - 405, XP086327830, ISSN: 0168-3659, DOI: 10.1016/j.jconrel.2020.08.013 * |
KANG HAE JOO, PATERSON NEIL G., GASPAR ANDREW H., TON-THAT HUNG, BAKER EDWARD N.: "The Corynebacterium diphtheriae shaft pilin SpaA is built of tandem Ig-like modules with stabilizing isopeptide and disulfide bonds", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, vol. 106, no. 40, 6 October 2009 (2009-10-06), pages 16967 - 16971, XP093107520, ISSN: 0027-8424, DOI: 10.1073/pnas.0906826106 * |
WENDY FITZGERALD, GOMEZ-LOPEZ NARDHY, EREZ OFFER, ROMERO ROBERTO, MARGOLIS LEONID: "Extracellular vesicles generated by placental tissues ex vivo: A transport system for immune mediators and growth factors", AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, WILEY-BLACKWELL PUBLISHING, INC., US, vol. 80, no. 1, 1 July 2018 (2018-07-01), US , pages e12860, XP055547900, ISSN: 1046-7408, DOI: 10.1111/aji.12860 * |
Also Published As
Publication number | Publication date |
---|---|
WO2023076418A2 (en) | 2023-05-04 |
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