WO2023070349A1 - 一种血栓弹力图仪 - Google Patents

一种血栓弹力图仪 Download PDF

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Publication number
WO2023070349A1
WO2023070349A1 PCT/CN2021/126582 CN2021126582W WO2023070349A1 WO 2023070349 A1 WO2023070349 A1 WO 2023070349A1 CN 2021126582 W CN2021126582 W CN 2021126582W WO 2023070349 A1 WO2023070349 A1 WO 2023070349A1
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module
thromboelastography
pipetting
sampling
needle
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PCT/CN2021/126582
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English (en)
French (fr)
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唐宇阳
孙亚威
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阳普医疗科技股份有限公司
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Priority to PCT/CN2021/126582 priority Critical patent/WO2023070349A1/zh
Publication of WO2023070349A1 publication Critical patent/WO2023070349A1/zh

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices

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  • the invention relates to the technical field of medical instruments, and more specifically, relates to a thromboelastography instrument.
  • thrombelastographs There are three types of traditional thrombelastographs: the first is a manual instrument, almost no automation, complicated operation, and the doctor’s labor intensity is extremely high; the second is a semi-automatic thrombelastograph, which is currently on the market, and the operation is slightly more than manual. Simple, but there are still problems such as high labor intensity and inconvenient operation for large sample size detection; the third type is fully automatic thromboelastography. Although this type of instrument on the market solves the trouble of manual operation, the structure setting It is more complicated, the number of detection channels is small, and the volume is too large to be placed in the laboratory department of the hospital.
  • the technical problem to be solved by the present invention is to provide a thromboelastography instrument for the above-mentioned defects of the prior art.
  • a thromboelastography instrument which includes a thromboelastography detection module for detecting thromboelastography items, an activation tube tray for placing activation tubes, a cup tray for placing reaction cups, a reagent bottle module, and a sampling module for blood sampling , a pipetting module for pipetting and moving the cuvette, and a cleaning module;
  • the sampling module includes a sampling needle
  • the liquid pipetting module includes a pipetting needle
  • the cleaning module includes a cleaning module for the sampling needle
  • the sampling needle cleaning module for cleaning, the liquid pipetting needle cleaning module for cleaning the pipetting needle, and the liquid circuit module, the sampling needle cleaning module and the liquid pipetting needle cleaning module are both connected to the liquid circuit module and are controlled by the liquid circuit module. control.
  • the thromboelastography apparatus wherein the thromboelastography apparatus further includes a frame, the thromboelastography detection module is arranged on the rear side of the frame, the activation tube tray and the cup tray They are all arranged on the front side of the frame; the pipetting module is arranged above the cups and trays.
  • the thromboelastography apparatus of the present invention wherein, the frame is divided into upper and lower layers, the upper layer of the frame is installed with the thromboelastography detection module, the activation tube tray and the cup tray, the The lower layer of the frame is installed with the liquid circuit module.
  • a plurality of the thromboelastography detection modules are arranged side by side on the frame.
  • the sampling module further includes a sampling manipulator driving the sampling needle to move and a first plunger pump communicating with the sampling needle.
  • the thromboelastography apparatus according to the present invention, wherein, the thromboelastography apparatus further includes a waste cuvette discard port.
  • the pipetting module further includes a pipetting manipulator and a gripper for holding a cuvette, and both the gripper and the pipetting needle are driven by the pipetting manipulator move.
  • the movable end of the pipetting manipulator is further provided with a second plunger pump communicating with the pipetting needle.
  • the thromboelastography apparatus of the present invention wherein, the thromboelastography apparatus further includes a traverse unit that drives the activation tube disk to traverse.
  • a refrigerating unit for refrigerating the cuvette is arranged on the cup tray.
  • the beneficial effects of the present invention are: during detection, after the sampling module quantitatively collects blood from the blood test tube, the blood is added to the activation tube on the activation tube plate for activation, and the pipetting module clamps the cuvette from the cup plate and places it on the On the detection station of the thromboelastography detection module, the pipetting module drives the pipetting needle to quantitatively absorb the blood in the activation tube, the reagent in the reagent cup on the cup tray, or the reagent in the reagent bottle on the reagent bottle module to add to the thromboelastometry
  • the thromboelastography detection module detects the thromboelastography items, and the sampling needle and the pipetting needle are automatically cleaned by the cleaning module after each use;
  • the modularity of each function is high, and the combination and assembly are more concise. Different numbers of detection modules can be matched according to actual needs to meet the needs of different hospitals, which is conducive to saving space and realizing automatic detection.
  • Fig. 1 is the schematic diagram of the structure of the thrombelastography apparatus of the preferred embodiment of the present invention
  • Fig. 2 is a top view of the thromboelastography apparatus in a preferred embodiment of the present invention.
  • the thromboelastography apparatus of the preferred embodiment of the present invention includes a thromboelastography detection module 1 for performing thromboelastography item detection, an activation tube plate 2 for placing an activation tube, and a cuvette for placing Cup tray 3, reagent bottle module 4, sampling module 5 for blood sampling, pipetting module 6 for pipetting and moving cuvette, and cleaning module 7; sampling module 5 includes sampling needle 50, pipetting The module 6 includes a pipetting needle 60, the cleaning module 7 includes a sampling needle 50 cleaning module 70 for cleaning the sampling needle, a pipetting needle cleaning module 71 for cleaning the pipetting needle 60, and a liquid circuit module 72, and the sampling needle cleaning module 70 and the pipetting needle cleaning module 71 are all communicated with and controlled by the liquid circuit module 72;
  • the pipetting module 6 drives the pipetting needle 60 to quantitatively absorb the blood in the activation tube, the reagent in the reaction cup on the cup tray 3 or the reagent in the reagent bottle module 4 to the thromboelastography detection
  • the thromboelastography detection module 1 performs the detection of thromboelastography items
  • the cleaning module 7 performs automatic corresponding cleaning after each use of the sampling needle 50 and the pipetting needle 60. cleaning;
  • the application of the thromboelastograph of the present application has good integrity, high degree of modularization of each function, and simpler combination and assembly. It can be matched with different numbers of detection channels according to actual needs to meet the needs of different hospitals, which is conducive to saving space and realizing automatic detection;
  • the thromboelastograph of this application does not include a (blood test tube) sampling device, and can be used with a sampling platform or manual sampling.
  • the reagent bottle module 4 is arranged between the activation tube tray 2 and the cup tray 3;
  • the thromboelastography instrument also includes a frame 8, the thromboelastography detection module 1 is arranged on the rear side of the frame 8, and the activation tube tray 2 and the cup tray 3 are all arranged on the front side of the frame 8; the pipetting module 6 is arranged above the cup and tray 3; the layout is reasonable and compact, which is convenient for human intervention and status monitoring.
  • the frame 8 is divided into upper and lower layers, the upper layer of the frame 8 is equipped with a thromboelastography detection module 1, the activation tube plate 2 and the cup plate 3, and the lower layer of the frame 8 is equipped with a liquid circuit module 72; the layout is reasonable, Overall good.
  • multiple thromboelastography detection modules 1 are arranged side by side on the frame 8; it is convenient for multi-station thrombus detection.
  • the sampling module 5 also includes a sampling manipulator 51 that drives the sampling needle 50 to move and a first plunger pump 52 that communicates with the sampling needle 50; it is easy to control, and the sampling manipulator 51 and the first plunger pump can use existing equipment .
  • the thromboelastography instrument also includes a waste cuvette discarding port 9; it is convenient to discard the cuvettes on the thromboelastography detection module 1 after the detection is completed; preferably, the cuvette discarding port 9 is set on the activation tube plate 2 and the position between the cup and plate 3.
  • the pipetting module 6 also includes a pipetting manipulator 61 and a gripper 62 for clamping the cuvette, the gripper 62 and the pipetting needle 60 are driven to move by the pipetting manipulator 61; the pipetting manipulator 61 and the gripper 62 sample Existing equipment is sufficient; during installation, one or both of the jaws 62 and the pipetting needle 60 can be driven by means of a lifting cylinder on the manipulator to avoid interference, or by controlling the jaws 62 and The lateral spacing of the pipette needles 60 is done in such a way as to avoid interference.
  • the movable end of the pipetting robot 61 is further provided with a second plunger pump 63 communicating with the pipetting needle 60 .
  • the thromboelastography instrument further includes a traverse unit 10 that drives the activation tube plate 2 to traverse; it is convenient to cooperate with the sampling manipulator for sampling and improve sampling efficiency.
  • a refrigerating unit for refrigerating the cuvette is arranged on the cup tray 3; it is convenient for storing the reagent for a long time.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Analytical Chemistry (AREA)
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  • General Health & Medical Sciences (AREA)
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Abstract

血栓弹力图仪，包括进行血栓弹力图项目检测的血栓弹力图检测模块(1)、放置激活管的激活管盘(2)、放置反应杯的杯盘(3)、试剂瓶模块(4)、进行血液采样的采样模组(5)、进行移液以及移动反应杯的移液模组(6)，和清洗模组(7)；采样模组(5)包括采样针(50)，移液模组(6)包括移液针(60)，清洗模组(7)包括对采样针(50)清洗的采样针清洗模块(70)、对移液针(60)清洗的移液针清洗模块(71)和液路模块(72)，采样针清洗模块(70)和移液针清洗模块(71)均与液路模块(72)联通并受其控制。该血栓弹力图仪整体性好，各功能模块化程度高，组合装配更加简洁，可以根据实际需求搭配不同数量的检测模块(1)对应不同医院的需求，有利于节省空间以及实现自动化检测。

Description

一种血栓弹力图仪 技术领域
本发明涉及医疗器械技术领域，更具体地说，涉及一种血栓弹力图仪。
背景技术
传统的血栓弹力图仪有三种：第一种是手动仪器，几乎没有自动化，操作复杂，医生的劳动强度极高；第二种是半自动血栓弹力图仪，目前市面上较多，操作比手动稍微简单，但进行大样本量检测依然存在劳动轻度高，操作不便等问题；第三类是全自动血栓弹力图仪，目前市场上的该类仪器，虽然解决了人工操作的麻烦，但结构设置较为复杂，检测通道数较少，体积较大不便于医院检验科摆放。
发明内容
本发明要解决的技术问题在于，针对现有技术的上述缺陷，提供一种血栓弹力图仪。
本发明解决其技术问题所采用的技术方案是：
构造一种血栓弹力图仪，其中，包括进行血栓弹力图项目检测的血栓弹力图检测模块、放置激活管的激活管盘、放置反应杯的杯盘、试剂瓶模块、进行血液采样的采样模组、进行移液以及移动反应杯的移液模组，和清洗模组；所述采样模组包括采样针，所述移液模组包括移液针，所述清洗模组包括对所述采样针清洗的采样针清洗模块、对所述移液针清洗的移液针清洗模块和液路模 块，所述采样针清洗模块和所述移液针清洗模块均与所述液路模块联通并受其控制。
本发明所述的血栓弹力图仪，其中，所述血栓弹力图仪还包括机架，所述血栓弹力图检测模块设置在所述机架的后侧，所述激活管盘和所述杯盘均设置在所述机架的前侧；所述移液模组设置在所述杯盘的上方。
本发明所述的血栓弹力图仪，其中，所述机架分为上下两层，所述机架的上层安装有所述血栓弹力图检测模块、所述激活管盘和所述杯盘，所述机架的下层安装有所述液路模块。
本发明所述的血栓弹力图仪，其中，所述血栓弹力图检测模块在所述机架上并排设置有多个。
本发明所述的血栓弹力图仪，其中，所述采样模组还包括带动所述采样针移动的采样机械手以及与所述采样针联通的第一柱塞泵。
本发明所述的血栓弹力图仪，其中，所述血栓弹力图仪还包括废弃反应杯抛弃口。
本发明所述的血栓弹力图仪，其中，所述移液模组还包括移液机械手和夹持反应杯的夹爪，所述夹爪和所述移液针均由所述移液机械手带动移动。
本发明所述的血栓弹力图仪，其中，所述移液机械手的活动端还设置有与所述移液针联通的第二柱塞泵。
本发明所述的血栓弹力图仪，其中，所述血栓弹力图仪还包括带动所述激活管盘横移的横移单元。
本发明所述的血栓弹力图仪，其中，所述杯盘上设置有对反应杯制冷的制冷单元。
本发明的有益效果在于：检测时，采样模组从血液试管定量采集血液后， 将血液添加到激活管盘上的激活管内进行激活，移液模组从杯盘处夹取反应杯后放置在血栓弹力图检测模块的检测工位上，然后移液模组分别带动移液针定量吸取激活管中血液、杯盘上试剂杯内的试剂或试剂瓶模块上试剂瓶内的试剂添加到血栓弹力图检测模块的反应杯内，血栓弹力图检测模块进行血栓弹力图项目检测，采样针和移液针每次使用后由清洗模组对应进行自动清洗；应用本申请的血栓弹力图仪，整体性好，各功能模块化程度高，组合装配更加简洁，可以根据实际需求搭配不同数量的检测模块对应不同医院的需求，有利于节省空间以及实现自动化检测。
附图说明
为了更清楚地说明本发明实施例或现有技术中的技术方案，下面将结合附图及实施例对本发明作进一步说明，下面描述中的附图仅仅是本发明的部分实施例，对于本领域普通技术人员来讲，在不付出创造性劳动的前提下，还可以根据这些附图获得其他附图：
图1是本发明较佳实施例的血栓弹力图仪结构示意图；
图2是本发明较佳实施例的血栓弹力图仪俯视图。
具体实施方式
为了使本发明实施例的目的、技术方案和优点更加清楚，下面将结合本发明实施例中的技术方案进行清楚、完整的描述，显然，所描述的实施例是本发明的部分实施例，而不是全部实施例。基于本发明的实施例，本领域普通技术人员在没有付出创造性劳动的前提下所获得的所有其他实施例，都属于本发明 的保护范围。
本发明较佳实施例的血栓弹力图仪，如图1所示，同时参阅图2，包括进行血栓弹力图项目检测的血栓弹力图检测模块1、放置激活管的激活管盘2、放置反应杯的杯盘3、试剂瓶模块4、进行血液采样的采样模组5、进行移液以及移动反应杯的移液模组6，和清洗模组7；采样模组5包括采样针50，移液模组6包括移液针60，清洗模组7包括对采样针清洗的采样针50清洗模块70、对移液针60清洗的移液针清洗模块71和液路模块72，采样针清洗模块70和移液针清洗模块71均与液路模块72联通并受其控制；
检测时，采样模组5从血液试管定量采集血液后，将血液添加到激活管盘2上的激活管内进行激活，移液模组6从杯盘3处夹取反应杯后放置在血栓弹力图检测模块1的检测工位上，然后移液模组6分别带动移液针60定量吸取激活管中血液、杯盘3上反应杯内的试剂或试剂瓶模块4内的试剂到血栓弹力图检测模块1的反应杯上(每吸取一次后需要进行对应清洗)，血栓弹力图检测模块1进行血栓弹力图项目检测，采样针50和移液针60每次使用后由清洗模组7对应进行自动清洗；
应用本申请的血栓弹力图仪，整体性好，各功能模块化程度高，组合装配更加简洁，可以根据实际需求搭配不同数量的检测通道对应不同医院的需求，有利于节省空间以及实现自动化检测；
需要说明的是，本申请的血栓弹力图仪不包含(血液试管)进样装置，使用时可以选择搭配进样台或者手动进样。
较佳的，试剂瓶模块4设置在激活管盘2和杯盘3之间位置；
优选的，血栓弹力图仪还包括机架8，血栓弹力图检测模块1设置在机架8的后侧，激活管盘2和杯盘3均设置在机架8的前侧；移液模组6设置在杯 盘3的上方；布局合理且紧凑，便于人为干预和状态监测。
优选的，机架8分为上下两层，机架8的上层安装有血栓弹力图检测模块1、激活管盘2和杯盘3，机架8的下层安装有液路模块72；布局合理，整体性好。
优选的，血栓弹力图检测模块1在机架8上并排设置有多个；便于进行多工位的血栓检测。
优选的，采样模组5还包括带动采样针50移动的采样机械手51以及与采样针50联通的第一柱塞泵52；易于控制，采样机械手51和第一柱塞泵采用现有设备即可。
优选的，血栓弹力图仪还包括废弃反应杯抛弃口9；便于对检测完成后的血栓弹力图检测模块1上的反应杯进行丢弃；较佳的，反应杯抛弃口9设置在激活管盘2和杯盘3之间位置。
优选的，移液模组6还包括移液机械手61和夹持反应杯的夹爪62，夹爪62和移液针60均由移液机械手61带动移动；移液机械手61和夹爪62采样现有的设备即可；安装时，可以由机械手上设置升降气缸等方式来带动夹爪62和移液针60其中一个或两个的方式来进行避免干涉，也可以是通过控制夹爪62和移液针60的横向间距的方式来进行避免干涉。
优选的，移液机械手61的活动端还设置有与移液针60联通的第二柱塞泵63。
优选的，血栓弹力图仪还包括带动激活管盘2横移的横移单元10；便于配合采样机械手采样，提升采样效率。
优选的，杯盘3上设置有对反应杯制冷的制冷单元；便于对试剂进行较长时间的保存。
应当理解的是，对本领域普通技术人员来说，可以根据上述说明加以改进或变换，而所有这些改进和变换都应属于本发明所附权利要求的保护范围。

Claims (10)

  1. 一种血栓弹力图仪，其特征在于，包括进行血栓弹力图项目检测的血栓弹力图检测模块、放置激活管的激活管盘、放置反应杯的杯盘、试剂瓶模块、进行血液采样的采样模组、进行移液以及移动反应杯的移液模组，和清洗模组；所述采样模组包括采样针，所述移液模组包括移液针，所述清洗模组包括对所述采样针清洗的采样针清洗模块、对所述移液针清洗的移液针清洗模块和液路模块，所述采样针清洗模块和所述移液针清洗模块均与所述液路模块联通并受其控制。
  2. 根据权利要求1所述的血栓弹力图仪，其特征在于，所述血栓弹力图仪还包括机架，所述血栓弹力图检测模块设置在所述机架的后侧，所述激活管盘和所述杯盘均设置在所述机架的前侧；所述移液模组设置在所述杯盘的上方。
  3. 根据权利要求2所述的血栓弹力图仪，其特征在于，所述机架分为上下两层，所述机架的上层安装有所述血栓弹力图检测模块、所述激活管盘和所述杯盘，所述机架的下层安装有所述液路模块。
  4. 根据权利要求2所述的血栓弹力图仪，其特征在于，所述血栓弹力图检测模块在所述机架上并排设置有多个。
  5. 根据权利要求1所述的血栓弹力图仪，其特征在于，所述采样模组还包括带动所述采样针移动的采样机械手以及与所述采样针联通的第一柱塞泵。
  6. 根据权利要求1所述的血栓弹力图仪，其特征在于，所述血栓弹力图仪还包括废弃反应杯抛弃口。
  7. 根据权利要求1所述的血栓弹力图仪，其特征在于，所述移液模组还 包括移液机械手和夹持反应杯的夹爪，所述夹爪和所述移液针均由所述移液机械手带动移动。
  8. 根据权利要求7所述的血栓弹力图仪，其特征在于，所述移液机械手的活动端还设置有与所述移液针联通的第二柱塞泵。
  9. 根据权利要求1所述的血栓弹力图仪，其特征在于，所述血栓弹力图仪还包括带动所述激活管盘横移的横移单元。
  10. 根据权利要求1所述的血栓弹力图仪，其特征在于，所述杯盘上设置有对反应杯制冷的制冷单元。
PCT/CN2021/126582 2021-10-27 2021-10-27 一种血栓弹力图仪 WO2023070349A1 (zh)

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