WO2023035278A1 - 用于电活动感测的*** - Google Patents
用于电活动感测的*** Download PDFInfo
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- WO2023035278A1 WO2023035278A1 PCT/CN2021/118191 CN2021118191W WO2023035278A1 WO 2023035278 A1 WO2023035278 A1 WO 2023035278A1 CN 2021118191 W CN2021118191 W CN 2021118191W WO 2023035278 A1 WO2023035278 A1 WO 2023035278A1
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- electrodes
- patient
- therapy
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- electrical activity
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- 230000000694 effects Effects 0.000 title claims abstract description 61
- 238000002560 therapeutic procedure Methods 0.000 claims abstract description 126
- 210000004556 brain Anatomy 0.000 claims abstract description 16
- 210000005013 brain tissue Anatomy 0.000 claims description 23
- 230000009467 reduction Effects 0.000 claims description 7
- 230000003321 amplification Effects 0.000 claims description 4
- 238000003199 nucleic acid amplification method Methods 0.000 claims description 4
- 230000004044 response Effects 0.000 claims description 3
- 230000001225 therapeutic effect Effects 0.000 claims description 2
- 238000000034 method Methods 0.000 abstract description 4
- 230000000638 stimulation Effects 0.000 abstract description 4
- 230000008569 process Effects 0.000 abstract description 2
- 230000006870 function Effects 0.000 description 3
- 210000005036 nerve Anatomy 0.000 description 2
- 230000000747 cardiac effect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000007383 nerve stimulation Effects 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/316—Modalities, i.e. specific diagnostic methods
- A61B5/369—Electroencephalography [EEG]
- A61B5/377—Electroencephalography [EEG] using evoked responses
- A61B5/383—Somatosensory stimuli, e.g. electric stimulation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/36125—Details of circuitry or electric components
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/36128—Control systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/36128—Control systems
- A61N1/36132—Control systems using patient feedback
Definitions
- the present application relates to the field of implantable medical systems technology, and more particularly to systems for electrical activity sensing, particularly electrical activity sensing while delivering therapy.
- Implantable medical systems generally include implantable nerve electrical stimulation systems, implantable cardiac electrical stimulation systems, and implantable drug infusion systems.
- the implanted electrical nerve stimulation system mainly includes a pulse generator implanted in the body, electrodes and external control devices.
- the pulse generator is connected with the electrode, so that the pulse generated by the pulse generator is transmitted to the electrode, and the pulse signal generated by the pulse generator is transmitted from the electrode to a specific nerve part for electrical stimulation, so that the human body function can be restored to normal operation. state.
- the deep brain electrical signals of patients are collected, the patients are not stimulated, and the collected electrical signals cannot reflect the brain conditions of the patients when they are stimulated.
- a system for sensing electrical activity comprising: a plurality of electrodes positionable within the brain of a patient to deliver therapy to the patient or sense electrical activity a therapy delivery circuit operably coupled to the plurality of electrodes to deliver therapy to the patient; a sensing circuit operably coupled to the plurality of electrodes to sensing electrical activity; and a controller comprising processing circuitry operably coupled to the therapy delivery circuit and the sensing circuit, the controller configured to: , controlling one or more of the plurality of electrodes to deliver therapy to the patient, during the delivery of therapy, through the sensing circuit, sensing the potential of the plurality of electrodes, and based on the plurality of The potential of the electrodes is calculated by calculating the difference between the potentials of any two electrodes to obtain the voltage between the two electrodes.
- controller is further configured to: via the therapy delivery circuit, control one of the plurality of electrodes to deliver therapy to the patient, and based on the relationship between the one electrode and the Voltages between other electrodes of the plurality of electrodes, obtaining a voltage decay curve of the one of the electrodes delivering therapy to the patient and brain tissue between the one of the electrodes and other electrodes of the plurality of electrodes One or more of the impedances.
- said obtaining a voltage decay curve of said one electrode delivering therapy to said patient based on the voltage between said one electrode and other electrodes in said plurality of electrodes comprises: The distance between one of the electrodes and the other electrodes in the plurality of electrodes is the horizontal axis, and the voltage between the one electrode and the other electrodes in the plurality of electrodes is the vertical axis, and the wherein One electrode delivers a voltage decay profile of therapy to the patient.
- controller is further configured to: deliver therapy to the patient based on a voltage decay profile of the one of the electrodes and a difference between the one of the electrodes and the other electrodes of the plurality of electrodes One or more of the impedances of the brain tissue, determining a first electrode combination comprising the one of the electrodes, and controlling the first electrode combination to deliver therapy to the patient via the therapy delivery circuitry.
- controller is further configured to: determine a second electrode combination that decays the slowest based on a voltage decay profile for each of the plurality of electrodes delivering therapy to the patient, and by The therapy delivery circuitry controls the second electrode combination to deliver therapy to the patient.
- the electrical activity sensed by the plurality of electrodes includes electrical activity for delivering therapy to the patient and the patient's own bioelectrical activity.
- a filter operatively coupled between the sensing circuit and the controller to filter out the patient's self sensed by the plurality of electrodes The bioelectric activity of the patient or the electrical activity of delivering therapy to the patient.
- a signal amplification circuit is further included, the signal amplification circuit is operatively coupled between the sensing circuit and the controller to amplify the patient signal sensed by the plurality of electrodes. own bioelectric activity.
- it further includes a signal reduction circuit, the signal reduction circuit is operatively coupled between the sensing circuit and the controller, to reduce the signals sensed by the plurality of electrodes to the The electrical activity of the patient to deliver therapy.
- the patient's own bioelectrical activity is the electrical activity of a single cell, the electrical activity of a nucleus, or the electrical activity of a local nucleus.
- a system comprising: means for receiving electrical potentials of one or more of a plurality of electrodes in response to delivering therapy to a patient from the plurality of electrodes; The electric potential of a plurality of electrodes, calculating the difference between the potentials of any two electrodes, and obtaining the voltage between the two electrodes; wherein, the plurality of electrodes can be positioned in the brain of the patient to provide the The patient delivers therapy or senses electrical activity.
- said means for calculating a voltage decay curve for said one of the electrodes to deliver therapy to said patient based on a voltage between said one of said electrodes and other electrodes of said plurality of electrodes and said The means for one or more of the impedance of brain tissue between one of the electrodes and other electrodes of the plurality of electrodes is further configured to: The distance between them is the horizontal axis, and the voltage between the one of the electrodes and other electrodes in the plurality of electrodes is taken as the vertical axis to draw the voltage decay curve of the treatment delivered by the one of the electrodes to the patient.
- a voltage decay profile for delivering therapy to said patient based on said one of the electrodes and an impedance of brain tissue between said one of the electrodes and other electrodes of said plurality of electrodes
- a voltage decay profile for delivering therapy to said patient based on said one of the electrodes and an impedance of brain tissue between said one of the electrodes and other electrodes of said plurality of electrodes
- Fig. 1 is a schematic illustration of a simplified block diagram of a system provided by an embodiment of the present application.
- an embodiment of the present application provides a system 40, including: a plurality of electrodes that can be positioned in the brain of a patient to deliver therapy or sense electrical activity to the patient; a therapy delivery circuit 10 , the therapy delivery circuit 10 is operatively coupled to the plurality of electrodes to deliver therapy to the patient; a sensing circuit 20 is operatively coupled to the plurality of electrodes to sense electrometric activity; and a controller 30 comprising processing circuitry 40 operatively coupled to the therapy delivery circuit 10 and the sensing circuit 20, the controller 30 being configured to:
- the therapy delivery circuit 10 controls one or more of the plurality of electrodes to deliver therapy to the patient, and during the process of delivering therapy, the potential of the plurality of electrodes is sensed by the sensing circuit 20 , and based on the potentials of the plurality of electrodes, calculate the difference between the potentials of any two electrodes, and obtain the voltage between the two electrodes.
- the treatment delivery circuit 10 may include a pulse generator and an extension wire connected to the pulse generator, one end of the extension wire is connected to the pulse generator, and the other end is connected to the electrode, so as to transmit the pulse generated by the pulse generator to the electrode , using electrodes to deliver therapy to a patient.
- a pulse generator may be coupled to controller 30 .
- Controller 30 may include memory and a processor.
- the application does not limit the size, shape and position of the controller 30 .
- the control function of the controller 30 can be realized by MPU, MCU, DSP, FPGA or any combination thereof, adopting the way of integrated chip, supporting wireless upgrading of embedded programs.
- the system 40 of the present application controls one or more of the plurality of electrodes to deliver therapy to the patient through the treatment delivery circuit 10, and at the same time senses the potential of the plurality of electrodes through the sensing circuit 20, and based on multiple Calculate the potential of any two electrodes, and calculate the difference between the potentials of any two electrodes to obtain the voltage between any two electrodes.
- the measured voltage can reflect the brain condition of the patient when receiving the therapy to a certain extent, and has a great influence on the follow-up therapy of the patient. reference value.
- the controller 30 may be further configured to: through the therapy delivery circuit 10, control one of the plurality of electrodes to deliver therapy to the patient, and based on the one of the electrodes and other electrodes in the plurality of electrodes, obtaining a voltage decay curve of the one of the electrodes delivering therapy to the patient and a voltage between the one of the electrodes and other electrodes in the plurality of electrodes One or more of the impedance of brain tissue.
- the brain condition of the patient when receiving the therapy can be more intuitively reflected;
- One or more of the impedance of the brain tissue may reflect, to some extent, the state of the brain tissue of the patient while receiving the delivered therapy.
- the obtaining the voltage decay curve of the one of the electrodes delivering therapy to the patient based on the voltage between the one of the electrodes and other electrodes in the plurality of electrodes may include: The distance between one of the electrodes and the other electrodes in the plurality of electrodes is the horizontal axis, and the voltage between the one electrode and the other electrodes in the plurality of electrodes is the vertical axis, and the wherein One electrode delivers a voltage decay profile of therapy to the patient.
- the voltage decay curve of the delivery therapy can reflect the brain condition of the treatment site where one of the electrodes is located and the corresponding parts of the other electrodes when the patient receives the delivery therapy.
- the controller 30 may be further configured to: deliver therapy to the patient based on the voltage decay profile of the one of the electrodes and the relationship between the one of the electrodes and the other electrodes of the plurality of electrodes. One or more of the impedances of the brain tissue therebetween, determine a first electrode combination comprising the one of the electrodes, and through the therapy delivery circuit 10, control the first electrode combination to deliver therapy to the patient.
- the voltage decay curve and the brain tissue can be combined.
- the impedance of the tissue is used as a reference by the therapy delivery circuit 10 to control the first electrode combination to deliver therapy to the patient.
- the controller 30 may be further configured to: determine a second electrode combination that decays the slowest based on a voltage decay curve for each of the plurality of electrodes delivering therapy to the patient, and Via the therapy delivery circuit 10, the second electrode combination is controlled to deliver therapy to the patient.
- the second electrode combination that decays the slowest can be determined, and the second electrode combination is controlled to deliver therapy to the patient through the therapy delivery circuit 10, Generally speaking, the slower the electrode voltage decays, the better the therapeutic effect.
- the electrical activity senseable by the plurality of electrodes may include electrical activity for delivering therapy to the patient and the patient's own bioelectrical activity.
- the signal intensity of the electrical activity delivering treatment to the patient is relatively high, while the patient's own bioelectrical activity signal is relatively weak, usually on the order of microvolts.
- the system 40 may further include a filter, the filter is operatively coupled between the sensing circuit 20 and the controller 30 to filter out the plurality of electrode senses.
- the filter by setting the filter, the patient's own bioelectric activity can be filtered out, and the voltage between the electrodes thus calculated can reflect the intensity of the treatment delivered to the patient; on the other hand, the filter can be used to filter out the The electrical activity of the treatment, and thus the calculated voltage between the electrodes can reflect the strength of the patient's EEG signal.
- the system 40 may further include a signal amplifying circuit, the signal amplifying circuit is operatively coupled between the sensing circuit 20 and the controller 30 to amplify the signals of the plurality of electrodes.
- the magnification can be 10 times, 100 times or 1000 times.
- the patient's own bioelectric activity sensed by multiple electrodes can be amplified to facilitate subsequent calculation.
- the system 40 may further include a signal reduction circuit, the signal reduction circuit is operatively coupled between the sensing circuit 20 and the controller 30, to reduce the number of electrodes
- the sensed electrical activity delivers therapy to the patient.
- the reduction factor can be 2 times, 3 times or 5 times.
- the electrical activity sensed by the plurality of electrodes to deliver therapy to the patient can be reduced.
- the instrument for measuring electrode potential is more precise and has a smaller range.
- the measured potential value can be prevented from exceeding the range.
- the patient's own bioelectric activity is the electrical activity of a single cell, the electrical activity of a nucleus, or the electrical activity of a local nucleus.
- the electrodes required to acquire single-cell electrical signals are not the same as those required to acquire local field potentials.
- Single cells require small electrodes or microelectrodes, and the signals collected from single cells have high amplitude and high frequency.
- Local field potential requires normal electrodes or macro electrodes, and the collected signals have low amplitude and low frequency.
- the size of the normal electrode is, for example, 6 square millimeters.
- the system of the present application can use multiple electrodes to sense the electrical activity of a single cell, the electrical activity of nuclei, or the local electrical activity of nuclei.
- An embodiment of the present application also provides a system, including: a device for receiving the potentials of a plurality of electrodes in response to one or more of the plurality of electrodes delivering treatment to a patient; The potential of the electrodes, wherein the difference between the potentials of any two electrodes is calculated to obtain the voltage between any two electrodes; wherein the plurality of electrodes can be positioned in the patient's brain to deliver to the patient therapy or sensing electrical activity.
- the electrical activity can be sensed while the treatment is being delivered to the patient, and the measured voltage can reflect the brain condition of the patient when receiving the treatment to a certain extent, which has great reference value for the follow-up treatment of the patient.
- the system may further comprise: means for controlling one of the plurality of electrodes to deliver therapy to the patient; the voltage between the other electrodes of the plurality of electrodes, calculating the voltage decay curve for the one of the electrodes to deliver therapy to the patient and the impedance of the brain tissue between the one of the electrodes and the other electrodes of the plurality of electrodes one or more devices.
- the brain condition of the patient when receiving the therapy can be more intuitively reflected;
- One or more of the impedance of the brain tissue may reflect, to some extent, the state of the brain tissue of the patient while receiving the delivered therapy.
- said means for calculating a voltage decay curve for said one of the electrodes to deliver therapy to said patient based on a voltage between said one of the electrodes and other electrodes of said plurality of electrodes and said The means for one or more of the impedance of brain tissue between one of the electrodes and other electrodes of the plurality of electrodes may be further configured to: The distance between them is the horizontal axis, and the voltage between the one of the electrodes and other electrodes in the plurality of electrodes is taken as the vertical axis to draw the voltage decay curve of the treatment delivered by the one of the electrodes to the patient.
- the voltage decay curve of the delivery therapy can reflect the brain condition of the treatment site where one of the electrodes is located and the corresponding parts of the other electrodes when the patient receives the delivery therapy.
- the system may further include: a voltage decay profile for delivering therapy to the patient based on the one of the electrodes and the voltage between the one of the electrodes and the other electrodes of the plurality of electrodes. one or more of the impedance of brain tissue, means for determining a first electrode combination comprising said one of the electrodes; and means for controlling said first electrode combination to deliver therapy to said patient.
- the degree of attenuation and the brain tissue is used as a reference to control the first electrode combination to deliver therapy to the patient.
- system may further comprise: means for determining a second slowest decaying electrode combination based on a voltage decay curve for each of the plurality of electrodes delivering therapy to the patient; and means for controlling the delivery of therapy to the patient by the second electrode combination.
- the second electrode combination that decays the slowest can be determined, and the second electrode combination can be controlled to deliver therapy to the patient.
- the electrode voltage The slower the decay, the better its healing.
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Abstract
一种***(40),包括:多个电极,多个电极能够定位于患者脑内以向患者递送治疗或者感测电活动;治疗递送电路(10),该治疗递送电路(10)可操作地耦接到多个电极以向患者递送治疗;感测电路(20),该感测电路(20)可操作地耦接到多个电极以感测电活动;以及控制器(30),该控制器(30)包括可操作地耦接到该治疗递送电路(10)和该感测电路(20)的处理电路***,该控制器(30)被配置成:通过该治疗递送电路(10),控制多个电极中的一个或多个向该患者递送治疗,在递送治疗的过程中,通过该感测电路(20),感测该多个电极的电位,并且基于该多个电极的电位,计算其中任意两个电极的电位的差值,得到该任意两个电极之间的电压。该***(40)能够实现在患者接受刺激的情况下,采集其脑深部电信号。
Description
本申请涉及植入式医疗***技术领域,尤其涉及用于电活动感测的***,特别是在递送治疗的同时进行电活动感测。
植入式医疗***通常包括植入式神经电刺激***、植入式心脏电刺激***、植入式药物输注***。
以植入式神经电刺激***为例,主要包括植入体内的脉冲发生器、电极以及体外的控制装置。其中,脉冲发生器与电极相连接,从而将脉冲发生器所产生的脉冲传输到电极,脉冲发生器产生的脉冲信号由电极传输至特定神经部位进行电刺激,从而使人体机能恢复到正常运作的状态。
目前在采集患者的脑深部电信号时,是在患者未接受刺激的情况下进行的,采集到的电信号并不能反映患者在接受刺激时的脑部状况。
发明内容
根据本申请公开的实施例,提供一种用于电活动感测的***,包括:多个电极,所述多个电极能够定位于患者脑内,以向所述患者递送治疗或者感测电活动;治疗递送电路,所述治疗递送电路可操作地耦接到所述多个电极以向所述患者递送治疗;感测电路,所述感测电路可操作地耦接到所述多个电极以感测电活动;以及控制器,所述控制器包括可操作地耦接到所述治疗递送电路和所述感测电路的处理电路***,所述控制器被配置成:通过所述治疗递送电路,控制所述多个电极中的一个或多个向所述患者递送治疗,在递送治疗的过程中,通过所述感测电路,感测所述多个电极的电位,并且基于所述多个电极的电位,计算其中任意两个电极的电位的差值,得到所述任意两个电极之间的电压。
在一实施例中,其中所述控制器被进一步配置成:通过所述治疗递送电路,控制所述多个电极中的其中一个电极向所述患者递送治疗,并且基于所述其中一个电极与所述多个电极中的其他电极之间的电压,获取所述其中一个电极向所述患者递送治疗的电压衰减曲线和所述其中一个电极与所述多个电极中的其他电极之间的脑组织的阻抗中的一个或多个。
在一实施例中,其中所述基于所述其中一个电极与所述多个电极中的其他电 极之间的电压,获取所述其中一个电极向所述患者递送治疗的电压衰减曲线包括:以所述其中一个电极与所述多个电极中的其他电极之间的距离为横轴,以所述其中一个电极与所述多个电极中的其他电极之间的电压为纵轴,绘制所述其中一个电极向所述患者递送治疗的电压衰减曲线。
在一实施例中,其中所述控制器被进一步配置成:基于所述其中一个电极向所述患者递送治疗的电压衰减曲线和所述其中一个电极与所述多个电极中的其他电极之间的脑组织的阻抗中的一个或多个,确定包含所述其中一个电极的第一电极组合,并且通过所述治疗递送电路,控制所述第一电极组合向所述患者递送治疗。
在一实施例中,其中所述控制器被进一步配置成:基于所述多个电极中的每个电极向所述患者递送治疗的电压衰减曲线,确定衰减最慢的第二电极组合,并且通过所述治疗递送电路,控制所述第二电极组合向所述患者递送治疗。
在一实施例中,其中所述多个电极能够感测的电活动包括向所述患者递送治疗的电活动和所述患者自身的生物电活动。
在一实施例中,还包括滤波器,所述滤波器可操作地耦接在所述感测电路和所述控制器之间,以滤除所述多个电极感测到的所述患者自身的生物电活动或者向所述患者递送治疗的电活动。
在一实施例中,还包括信号放大电路,所述信号放大电路可操作地耦接在所述感测电路和所述控制器之间,以放大所述多个电极感测到的所述患者自身的生物电活动。
在一实施例中,还包括信号缩小电路,所述信号缩小电路可操作地耦接在所述感测电路和所述控制器之间,以缩小所述多个电极感测到的向所述患者递送治疗的电活动。
在一实施例中,其中所述患者自身的生物电活动是单细胞的电活动、核团的电活动或者核团局部的电活动。
根据本申请公开的实施例,提供一种***,包括:用于响应于多个电极中的一个或多个向患者递送治疗,接收所述多个电极的电位的装置;以及用于基于所述多个电极的电位,计算其中任意两个电极的电位的差值,得到所述任意两个电极之间的电压的装置;其中,所述多个电极能够定位于患者脑内,以向所述患者 递送治疗或者感测电活动。
在一实施例中,还包括:用于控制所述多个电极中的其中一个电极向所述患者递送治疗的装置;以及用于基于所述其中一个电极与所述多个电极中的其他电极之间的电压,计算所述其中一个电极向所述患者递送治疗的电压衰减曲线和所述其中一个电极与所述多个电极中的其他电极之间的脑组织的阻抗中的一个或多个的装置。
在一实施例中,其中所述用于基于所述其中一个电极与所述多个电极中的其他电极之间的电压,计算所述其中一个电极向所述患者递送治疗的电压衰减曲线和所述其中一个电极与所述多个电极中的其他电极之间的脑组织的阻抗中的一个或多个的装置被进一步配置成:以所述其中一个电极与所述多个电极中的其他电极之间的距离为横轴,以所述其中一个电极与所述多个电极中的其他电极之间的电压为纵轴,绘制所述其中一个电极向所述患者递送治疗的电压衰减曲线。
在一实施例中,还包括:用于基于所述其中一个电极向所述患者递送治疗的电压衰减曲线和所述其中一个电极与所述多个电极中的其他电极之间的脑组织的阻抗中的一个或多个,确定包含所述其中一个电极的第一电极组合的装置;以及用于控制所述第一电极组合向所述患者递送治疗的装置。
在一实施例中,还包括:用于基于所述多个电极中的每个电极向所述患者递送治疗的电压衰减曲线,确定衰减最慢的第二电极组合的装置;以及用于控制所述第二电极组合向所述患者递送治疗的装置。
根据下面的具体实施方式及附图,本申请公开的主题的进一步特征、性质及各种优点将更显而易见,其中,
图1是本申请实施例提供的一***的简化框图的示意性示出。
下面,结合附图以及具体实施方式,对本申请做进一步描述,需要说明的是,在不相冲突的前提下,以下描述的各实施例之间或各技术特征之间可以任意组合形成新的实施例。
参见图1,本申请实施例提供了一种***40,包括:多个电极,所述多个电极能够定位于患者脑内,以向所述患者递送治疗或者感测电活动;治疗递送电路 10,所述治疗递送电路10可操作地耦接到所述多个电极以向所述患者递送治疗;感测电路20,所述感测电路20可操作地耦接到所述多个电极以感测电活动;以及控制器30,所述控制器30包括可操作地耦接到所述治疗递送电路10和所述感测电路20的处理电路***40,所述控制器30被配置成:通过所述治疗递送电路10,控制所述多个电极中的一个或多个向所述患者递送治疗,在递送治疗的过程中,通过所述感测电路20,感测所述多个电极的电位,并且基于所述多个电极的电位,计算其中任意两个电极的电位的差值,得到所述任意两个电极之间的电压。
其中,治疗递送电路10可以包括脉冲发生器以及连接在脉冲发生器上的延伸导线,延伸导线的一端连接至脉冲发生器,另一端连接至电极,从而将脉冲发生器所产生的脉冲传输到电极,利用电极向患者递送治疗。脉冲发生器可以与控制器30耦接。
控制器30可以包括存储器和处理器。本申请对控制器30的大小、形状和位置不做限定。控制器30的控制功能可以由MPU、MCU、DSP、FPGA或其任意组合来实现,采用集成芯片的方式,支持无线升级嵌入式程序。
本申请的***40在感测电活动时,通过治疗递送电路10控制多个电极中的一个或多个向患者递送治疗,同时,通过感测电路20感测多个电极的电位,并且基于多个电极的电位,计算其中任意两个电极的电位的差值,得到任意两个电极之间的电压。
由于感测电活动是在对患者进行递送治疗的情况下同步进行的,因此测得的电压可以在一定程度上反映患者在接受递送治疗时的脑部状况,对患者的后续治疗有着较大的参考价值。
在一实施例中,所述控制器30可以被进一步配置成:通过所述治疗递送电路10,控制所述多个电极中的其中一个电极向所述患者递送治疗,并且基于所述其中一个电极与所述多个电极中的其他电极之间的电压,获取所述其中一个电极向所述患者递送治疗的电压衰减曲线和所述其中一个电极与所述多个电极中的其他电极之间的脑组织的阻抗中的一个或多个。
由此,通过获取其中一个电极向患者递送治疗的电压衰减曲线,可以更为直观地反映患者在接受递送治疗时的脑部状况,通过获取其中一个电极与多个电极 中的其他电极之间的脑组织的阻抗中的一个或多个,可以在一定程度上反映患者在接受递送治疗时脑组织的状态。
在一实施例中,所述基于所述其中一个电极与所述多个电极中的其他电极之间的电压,获取所述其中一个电极向所述患者递送治疗的电压衰减曲线可以包括:以所述其中一个电极与所述多个电极中的其他电极之间的距离为横轴,以所述其中一个电极与所述多个电极中的其他电极之间的电压为纵轴,绘制所述其中一个电极向所述患者递送治疗的电压衰减曲线。
由此,通过以其中一个电极与多个电极中的其他电极之间的距离为横轴,以其中一个电极与多个电极中的其他电极之间的电压为纵轴,绘制其中一个电极向患者递送治疗的电压衰减曲线,可以反映患者在接受递送治疗时,该其中一个电极所在的治疗部位以及其他电极对应的部位的脑部状况。
在一实施例中,所述控制器30可以被进一步配置成:基于所述其中一个电极向所述患者递送治疗的电压衰减曲线和所述其中一个电极与所述多个电极中的其他电极之间的脑组织的阻抗中的一个或多个,确定包含所述其中一个电极的第一电极组合,并且通过所述治疗递送电路10,控制所述第一电极组合向所述患者递送治疗。
由此,在得到其中一个电极向患者递送治疗的电压衰减曲线和其中一个电极与多个电极中的其他电极之间的脑组织的阻抗中的一个或多个之后,可以将电压衰减曲线和脑组织的阻抗作为参考,通过治疗递送电路10,控制第一电极组合向患者递送治疗。
在一实施例中,所述控制器30可以被进一步配置成:基于所述多个电极中的每个电极向所述患者递送治疗的电压衰减曲线,确定衰减最慢的第二电极组合,并且通过所述治疗递送电路10,控制所述第二电极组合向所述患者递送治疗。
由此,可以基于多个电极中的每个电极向所述患者递送治疗的电压衰减曲线,确定衰减最慢的第二电极组合,通过治疗递送电路10,控制第二电极组合向患者递送治疗,一般而言,电极电压衰减越慢,其治疗效果越好。
在一实施例中,所述多个电极能够感测的电活动可以包括向所述患者递送治疗的电活动和所述患者自身的生物电活动。
一般而言,向患者递送治疗的电活动的信号强度较大,患者自身的生物电活 动信号较为微弱,通常为微伏数量级。
在一实施例中,所述***40还可以包括滤波器,所述滤波器可操作地耦接在所述感测电路20和所述控制器30之间,以滤除所述多个电极感测到的所述患者自身的生物电活动或者向所述患者递送治疗的电活动。
一方面,通过设置滤波器,可以滤除患者自身的生物电活动,由此计算得到的电极之间的电压可以反映向患者递送治疗的强度;另一方面,利用滤波器可以滤除向患者递送治疗的电活动,由此计算得到的电极之间的电压可以反映患者的脑电信号强度。
在一实施例中,所述***40还可以包括信号放大电路,所述信号放大电路可操作地耦接在所述感测电路20和所述控制器30之间,以放大所述多个电极感测到的所述患者自身的生物电活动。放大倍数可以是10倍、100倍或者1000倍。
通过设置信号放大电路,可以放大多个电极感测到的患者自身的生物电活动,便于后续的计算。
在一实施例中,所述***40还可以包括信号缩小电路,所述信号缩小电路可操作地耦接在所述感测电路20和所述控制器30之间,以缩小所述多个电极感测到的向所述患者递送治疗的电活动。缩小倍数可以是2倍、3倍或者5倍。
通过设置信号缩小电路,可以缩小多个电极感测到的向所述患者递送治疗的电活动。一般而言,测量电极电位的仪器较为精密,量程较小,通过缩小多个电极感测到的向患者递送治疗的电活动,可以避免测量的电位值超出量程。
在一实施例中,所述患者自身的生物电活动是单细胞的电活动、核团的电活动或者核团局部的电活动。
一般而言,采集单细胞电信号所需的电极和采集局部场电位所需的电极不一样。单细胞需要小电极或微电极,单细胞采集出来的信号幅值高,频率高。局部场电位需要正常电极或宏电极,采集出来的信号幅值低,频率低。其中,正常电极的尺寸例如是6个平方毫米。
本申请的***可以利用多个电极感测单细胞的电活动、核团的电活动或者核团局部的电活动。
本申请实施例还提供了一种***,包括:用于响应于多个电极中的一个或多个向患者递送治疗,接收所述多个电极的电位的装置;以及用于基于所述多个电 极的电位,计算其中任意两个电极的电位的差值,得到所述任意两个电极之间的电压的装置;其中,所述多个电极能够定位于患者脑内,以向所述患者递送治疗或者感测电活动。
由此,可以在对患者进行递送治疗的同时感测电活动,测得的电压可以在一定程度上反映患者在接受递送治疗时的脑部状况,对患者的后续治疗有着较大的参考价值。
在一实施例中,所述***还可以包括:用于控制所述多个电极中的其中一个电极向所述患者递送治疗的装置;以及用于基于所述其中一个电极与所述多个电极中的其他电极之间的电压,计算所述其中一个电极向所述患者递送治疗的电压衰减曲线和所述其中一个电极与所述多个电极中的其他电极之间的脑组织的阻抗中的一个或多个的装置。
由此,通过获取其中一个电极向患者递送治疗的电压衰减曲线,可以更为直观地反映患者在接受递送治疗时的脑部状况,通过获取其中一个电极与多个电极中的其他电极之间的脑组织的阻抗中的一个或多个,可以在一定程度上反映患者在接受递送治疗时脑组织的状态。
在一实施例中,所述用于基于所述其中一个电极与所述多个电极中的其他电极之间的电压,计算所述其中一个电极向所述患者递送治疗的电压衰减曲线和所述其中一个电极与所述多个电极中的其他电极之间的脑组织的阻抗中的一个或多个的装置可以被进一步配置成:以所述其中一个电极与所述多个电极中的其他电极之间的距离为横轴,以所述其中一个电极与所述多个电极中的其他电极之间的电压为纵轴,绘制所述其中一个电极向所述患者递送治疗的电压衰减曲线。
由此,通过以其中一个电极与多个电极中的其他电极之间的距离为横轴,以其中一个电极与多个电极中的其他电极之间的电压为纵轴,绘制其中一个电极向患者递送治疗的电压衰减曲线,可以反映患者在接受递送治疗时,该其中一个电极所在的治疗部位以及其他电极对应的部位的脑部状况。
在一实施例中,所述***还可以包括:用于基于所述其中一个电极向所述患者递送治疗的电压衰减曲线和所述其中一个电极与所述多个电极中的其他电极之间的脑组织的阻抗中的一个或多个,确定包含所述其中一个电极的第一电极组合的装置;以及用于控制所述第一电极组合向所述患者递送治疗的装置。
由此,在得到其中一个电极向患者递送治疗的电压衰减曲线和其中一个电极与多个电极中的其他电极之间的脑组织的阻抗中的一个或多个之后,可以将衰减度和脑组织的阻抗作为参考,控制第一电极组合向患者递送治疗。
在一实施例中,所述***还可以包括:用于基于所述多个电极中的每个电极向所述患者递送治疗的电压衰减曲线,确定衰减最慢的第二电极组合的装置;以及用于控制所述第二电极组合向所述患者递送治疗的装置。
由此,可以基于多个电极中的每个电极向所述患者递送治疗的电压衰减曲线,确定衰减最慢的第二电极组合,控制第二电极组合向患者递送治疗,一般而言,电极电压衰减越慢,其治疗效果越好。
本申请从使用目的上,效能上,进步及新颖性等观点进行阐述,已符合专利法所强调的功能增进及使用要件,本申请以上的说明书及说明书附图,仅为本申请的较佳实施例而已,并非以此局限本申请,因此,凡一切与本申请构造,装置,特征等近似、雷同的,即凡依本申请专利申请范围所作的等同替换或修饰等,皆应属本申请的专利申请保护的范围之内。
Claims (15)
- 一种***,包括:多个电极,所述多个电极能够定位于患者脑内,以向所述患者递送治疗或者感测电活动;治疗递送电路,所述治疗递送电路可操作地耦接到所述多个电极以向所述患者递送治疗;感测电路,所述感测电路可操作地耦接到所述多个电极以感测电活动;以及控制器,所述控制器包括可操作地耦接到所述治疗递送电路和所述感测电路的处理电路***,所述控制器被配置成:通过所述治疗递送电路,控制所述多个电极中的一个或多个向所述患者递送治疗,在递送治疗的过程中,通过所述感测电路,感测所述多个电极的电位,并且基于所述多个电极的电位,计算其中任意两个电极的电位的差值,得到所述任意两个电极之间的电压。
- 根据权利要求1所述的***,其中所述控制器被进一步配置成:通过所述治疗递送电路,控制所述多个电极中的其中一个电极向所述患者递送治疗,并且基于所述其中一个电极与所述多个电极中的其他电极之间的电压,获取所述其中一个电极向所述患者递送治疗的电压衰减曲线和所述其中一个电极与所述多个电极中的其他电极之间的脑组织的阻抗中的一个或多个。
- 根据权利要求2所述的***,其中所述基于所述其中一个电极与所述多个电极中的其他电极之间的电压,获取所述其中一个电极向所述患者递送治疗的电压衰减曲线包括:以所述其中一个电极与所述多个电极中的其他电极之间的距离为横轴,以所述其中一个电极与所述多个电极中的其他电极之间的电压为纵轴,绘制所述其中一个电极向所述患者递送治疗的电压衰减曲线。
- 根据权利要求2所述的***,其中所述控制器被进一步配置成:基于所述其中一个电极向所述患者递送治疗的电压衰减曲线和所述其中一个电极与所述多个电极中的其他电极之间的脑组织的阻抗中的一个或多个,确定 包含所述其中一个电极的第一电极组合,并且通过所述治疗递送电路,控制所述第一电极组合向所述患者递送治疗。
- 根据权利要求2所述的***,其中所述控制器被进一步配置成:基于所述多个电极中的每个电极向所述患者递送治疗的电压衰减曲线,确定衰减最慢的第二电极组合,并且通过所述治疗递送电路,控制所述第二电极组合向所述患者递送治疗。
- 根据前述权利要求中任一项所述的***,其中所述多个电极能够感测的电活动包括向所述患者递送治疗的电活动和所述患者自身的生物电活动。
- 根据权利要求6所述的***,还包括滤波器,所述滤波器可操作地耦接在所述感测电路和所述控制器之间,以滤除所述多个电极感测到的所述患者自身的生物电活动或者向所述患者递送治疗的电活动。
- 根据权利要求6所述的***,还包括信号放大电路,所述信号放大电路可操作地耦接在所述感测电路和所述控制器之间,以放大所述多个电极感测到的所述患者自身的生物电活动。
- 根据权利要求6所述的***,还包括信号缩小电路,所述信号缩小电路可操作地耦接在所述感测电路和所述控制器之间,以缩小所述多个电极感测到的向所述患者递送治疗的电活动。
- 根据权利要求6所述的***,其中所述患者自身的生物电活动是单细胞的电活动、核团的电活动或者核团局部的电活动。
- 一种***,包括:用于响应于多个电极中的一个或多个向患者递送治疗,接收所述多个电极的电位的装置;以及用于基于所述多个电极的电位,计算其中任意两个电极的电位的差值,得到所述任意两个电极之间的电压的装置;其中,所述多个电极能够定位于患者脑内,以向所述患者递送治疗或者感测电活动。
- 根据权利要求11所述的***,还包括:用于控制所述多个电极中的其中一个电极向所述患者递送治疗的装置;以及用于基于所述其中一个电极与所述多个电极中的其他电极之间的电压,计算 所述其中一个电极向所述患者递送治疗的电压衰减曲线和所述其中一个电极与所述多个电极中的其他电极之间的脑组织的阻抗中的一个或多个的装置。
- 根据权利要求12所述的***,其中所述用于基于所述其中一个电极与所述多个电极中的其他电极之间的电压,计算所述其中一个电极向所述患者递送治疗的电压衰减曲线和所述其中一个电极与所述多个电极中的其他电极之间的脑组织的阻抗中的一个或多个的装置被进一步配置成:以所述其中一个电极与所述多个电极中的其他电极之间的距离为横轴,以所述其中一个电极与所述多个电极中的其他电极之间的电压为纵轴,绘制所述其中一个电极向所述患者递送治疗的电压衰减曲线。
- 根据权利要求12所述的***,还包括:用于基于所述其中一个电极向所述患者递送治疗的电压衰减曲线和所述其中一个电极与所述多个电极中的其他电极之间的脑组织的阻抗中的一个或多个,确定包含所述其中一个电极的第一电极组合的装置;以及用于控制所述第一电极组合向所述患者递送治疗的装置。
- 根据权利要求12所述的***,还包括:用于基于所述多个电极中的每个电极向所述患者递送治疗的电压衰减曲线,确定衰减最慢的第二电极组合的装置;以及用于控制所述第二电极组合向所述患者递送治疗的装置。
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