WO2023026711A1 - 搬送装置、搬送装置を備えた検体分析システム、および、搬送装置を備えた検体前処理装置 - Google Patents
搬送装置、搬送装置を備えた検体分析システム、および、搬送装置を備えた検体前処理装置 Download PDFInfo
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- WO2023026711A1 WO2023026711A1 PCT/JP2022/027301 JP2022027301W WO2023026711A1 WO 2023026711 A1 WO2023026711 A1 WO 2023026711A1 JP 2022027301 W JP2022027301 W JP 2022027301W WO 2023026711 A1 WO2023026711 A1 WO 2023026711A1
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- electromagnetic actuators
- sample
- magnetic circuit
- adjacent
- transport
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- 238000004458 analytical method Methods 0.000 title claims description 57
- 238000004804 winding Methods 0.000 claims description 35
- 239000000696 magnetic material Substances 0.000 claims description 9
- 230000014759 maintenance of location Effects 0.000 claims description 2
- 239000000523 sample Substances 0.000 description 144
- 230000032258 transport Effects 0.000 description 54
- 239000003153 chemical reaction reagent Substances 0.000 description 34
- 238000012546 transfer Methods 0.000 description 14
- 238000010586 diagram Methods 0.000 description 11
- 239000007788 liquid Substances 0.000 description 8
- 230000004907 flux Effects 0.000 description 7
- 210000004369 blood Anatomy 0.000 description 6
- 239000008280 blood Substances 0.000 description 6
- 230000007246 mechanism Effects 0.000 description 6
- 210000002700 urine Anatomy 0.000 description 6
- 238000001514 detection method Methods 0.000 description 5
- 238000012545 processing Methods 0.000 description 5
- 238000000034 method Methods 0.000 description 4
- 238000004364 calculation method Methods 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 230000006866 deterioration Effects 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 238000000926 separation method Methods 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 239000012472 biological sample Substances 0.000 description 2
- 239000000969 carrier Substances 0.000 description 2
- 239000012295 chemical reaction liquid Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 230000010349 pulsation Effects 0.000 description 2
- 229910052779 Neodymium Inorganic materials 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 230000001133 acceleration Effects 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 238000012742 biochemical analysis Methods 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
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- 210000002966 serum Anatomy 0.000 description 1
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Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65G—TRANSPORT OR STORAGE DEVICES, e.g. CONVEYORS FOR LOADING OR TIPPING, SHOP CONVEYOR SYSTEMS OR PNEUMATIC TUBE CONVEYORS
- B65G54/00—Non-mechanical conveyors not otherwise provided for
- B65G54/02—Non-mechanical conveyors not otherwise provided for electrostatic, electric, or magnetic
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
- G01N2035/0474—Details of actuating means for conveyors or pipettes
- G01N2035/0477—Magnetic
Definitions
- the present invention includes, for example, a transport device suitable for a sample analysis system that analyzes a biological sample (hereinafter referred to as a sample) such as blood and urine, and a sample pretreatment device that performs pretreatment necessary for analysis, and a transport device.
- a sample such as blood and urine
- a sample pretreatment device that performs pretreatment necessary for analysis
- the present invention relates to a sample analysis system and a sample pretreatment device.
- Patent Document 1 discloses a delivery system that transports a plurality of container carriers on a transport plane.
- a plurality of electromagnetic actuators are arranged below the transport plane, and a control device drives the electromagnetic actuators so that the container carriers are transported in the desired direction in the transport plane.
- the specified analysis items are tested for samples such as blood, plasma, serum, urine, and other body fluids.
- devices with multiple functions can be connected to automatically process each step.
- the analysis units for multiple analysis fields such as biochemistry and immunology, and the pretreatment unit that performs the pretreatment necessary for analysis, are connected by a transport line and operated as a single system.
- the transport line used in conventional sample analysis systems is mainly belt-driven.
- a belt drive system there is a problem that if the transport is stopped due to some kind of abnormality in the middle of the transport, the sample cannot be supplied to the downstream apparatus. Therefore, it is necessary to pay sufficient attention to wear of the belt.
- Patent Document 1 discloses that a plurality of lower planes are combined to form a transport plane, but does not disclose how the lower planes are connected. If the lower planes are connected so that the locations where the electromagnetic actuators on the lower planes are dense are adjacent, or if the lower planes are connected so that the locations where the electromagnetic actuators are sparse are adjacent, the inductance characteristics of the connection area will change. It will differ from the inductance characteristics of other locations. As a result, there is a problem that the thrust force applied to the transported object varies and the accuracy of estimating the position of the transported object deteriorates, making it impossible to transport the transported object stably.
- the present invention includes a plurality of means for solving the above-described problems.
- One example is a magnetic circuit in which electromagnetic actuators having teeth made of a magnetic material and windings wound around the teeth are arranged in a grid pattern.
- Each of the substantially quadrilateral magnetic circuit sections includes a plurality of first electromagnetic actuators arranged along one of the opposing sides and the other side of the opposing sides.
- a plurality of magnetic circuit units are connected so that a side with a large number of magnetic actuators and a side with a small number of electromagnetic actuators are adjacent to each other.
- the inductance characteristic in the connection area is changed to the inductance of another part. It is possible to suppress different characteristics. As a result, it is possible to suppress variations in the thrust force applied to the transported object and deterioration in the accuracy of estimating the position of the transported object in the connection area, thereby stably transporting the transported object. can.
- FIG. 1 is a diagram showing the configuration of a conveying device according to Embodiment 1;
- FIG. 4 is a perspective view showing a magnetic circuit section of the conveying device of Embodiment 1.
- FIG. It is the figure which showed the connection example of the magnetic circuit part of the conveying apparatus of the past and Example 1.
- FIG. FIG. 11 is a diagram showing an example of connection of magnetic circuit units of the conveying apparatus of Example 2; It is a figure which shows the structure of a conveying system.
- 1 is a diagram showing the configuration of a sample analysis system;
- FIG. It is a figure which shows the structure of a sample pretreatment apparatus.
- FIG. 1 is a diagram showing the configuration of a conveying device according to the first embodiment.
- the conveying device 1 is a conveying device that conveys the object to be conveyed 10 in the X direction and the Y direction.
- FIG. 2 is a perspective view showing the magnetic circuit section of the conveying device of the first embodiment.
- a plurality of conveying devices 1 shown in FIG. A conveying surface 15 is provided on the magnetic circuit unit 2 , and a magnetic permanent magnet 11 (see FIG. 8 ) embedded in the conveyed object 10 moves on the conveying surface 15 .
- the 2A has three transport lines for transporting the transported object 10 in the X direction and three transport lines for transporting the transported object 10 in the Y direction.
- a winding 30 is wound around each of the plurality of magnetic cylindrical teeth 20 .
- the tooth 20 is a generic term for the teeth 20a to 20d.
- a plurality of teeth 20 are magnetically coupled by a magnetic yoke 40 on the opposite side ( ⁇ Z side) of the conveying surface 15 .
- the teeth 20 wound with windings are called an electromagnetic actuator 70 .
- the plurality of electromagnetic actuators 70 are arranged in a grid.
- the yoke 40 is formed corresponding to three transfer lines formed along the X direction and three transfer lines formed along the Y direction, and has a lattice shape.
- the yoke 40 is made of a magnetic material and is magnetically coupled with a plurality of teeth. Yoke 40 supports multiple teeth 20 so that multiple teeth 20 extend in the Z direction.
- the teeth 20 include a tooth 20a with one adjacent tooth, a tooth 20b with two adjacent teeth, a tooth 20c with three adjacent teeth, and a tooth 20d with four adjacent teeth.
- Teeth 20a are teeth arranged on the outermost side. Teeth 20a are adjacent to teeth only on one side in the X direction or the Y direction.
- the teeth 20b are adjacent to the teeth on both sides in the X direction or the Y direction.
- the teeth 20c are adjacent to the teeth on both sides in the X or Y direction and on one side in the Y or X direction.
- the teeth 20c are adjacent to the teeth on both sides in the X direction and both sides in the Y direction.
- the above teeth 20a, 20b, 20c and 20d have different characteristics in terms of magnetic circuits.
- Each tooth has different inductance characteristics due to the difference in the number of teeth adjacent to each other.
- tooth 20a has fewer adjacent teeth than teeth 20b-20d. Therefore, the amount of magnetic flux generated when a constant current is passed through the winding 30 is smaller than that of the teeth 20b to 20d. Therefore, the thrust acting on the transported object 10 from the teeth 20a is reduced.
- the winding 30 of the tooth 20a and the winding 30 of the teeth 20b to 20d change in current value when a constant voltage is applied, so the degree of magnetic saturation also changes. For this reason, there also arises a problem that the accuracy of the position detection of the transported object using magnetic saturation deteriorates.
- the magnetic circuit section 2 is substantially quadrilateral, with sides X1 and X2 forming the substantially quadrilateral facing each other, and sides Y1 and Y2 forming the substantially quadrilateral facing each other.
- the number of the plurality of electromagnetic actuators 70 arranged along one side X1 (6 in the first embodiment) corresponds to the number of the plurality of electromagnetic actuators 70 arranged along the other side X2 (the number , three). Further, the number of the plurality of electromagnetic actuators 70 arranged along one side Y1 (six in the first embodiment) is the number of the plurality of electromagnetic actuators 70 arranged along the other side Y2 (the number of the plurality of electromagnetic actuators 70 arranged along the other side Y2). 1, more than 3).
- a plurality of electromagnetic actuators 70 arranged along side X1 are arranged adjacent to each other. Also, the plurality of electromagnetic actuators 70 arranged along the side X2 are arranged at intervals. That is, the pitch between the electromagnetic actuators 70 arranged along the side X1 is smaller than the pitch between the electromagnetic actuators 70 arranged along the side X2. Similarly, the plurality of electromagnetic actuators 70 arranged along side Y1 are arranged adjacent to each other. Also, the plurality of electromagnetic actuators 70 arranged along the side Y2 are arranged at intervals. That is, the pitch between the electromagnetic actuators 70 arranged along the side Y1 is smaller than the pitch between the electromagnetic actuators 70 arranged along the side Y2.
- FIG. 3 is a diagram showing an example of connection of the magnetic circuit units of the conventional conveying apparatus and the first embodiment.
- FIG. 3(a) is a diagram showing a connection example of a magnetic circuit unit of a conventional conveying device.
- FIG. 3(b) is a diagram showing a connection example of the magnetic circuit section of the conveying apparatus of the first embodiment.
- the conventional conveying device 1000 in FIG. 3(a) includes three magnetic circuit units 2000.
- the three magnetic circuit units 2000 are connected in an L shape. If the conventional magnetic circuit section 2000 is formed into a desired shape, the density of the electromagnetic actuators 70 becomes sparse in the connection region 4000 between the magnetic circuit sections 2000 . For this reason, in the connection area 4000 of the conventional transport apparatus 1000, the thrust applied to the transported object 10 varies, and the position estimation accuracy of the transported object 10 deteriorates. As a result, the transported object 10 shakes during transport, deviates from the transport surface of the transport apparatus 1000, or damages the transport surface.
- the conveying device 1 of Example 1 includes the three magnetic circuit units 2 described with reference to FIG.
- the three magnetic circuit sections 2 are connected in an L shape.
- the magnetic circuit unit 2 is arranged such that a portion of the magnetic circuit unit 2 where the electromagnetic actuators 70 are densely arranged and a portion of the magnetic circuit unit 2 where the electromagnetic actuators 70 are sparsely arranged are adjacent to each other. to connect.
- the density of the electromagnetic actuators 70 is alternately dense, sparse, dense, and sparse along the X and Y directions.
- connection area 4 of the magnetic circuit unit 2 it is possible to suppress the variation in the thrust force applied to the transported object 10, and to reduce the deterioration of the estimation accuracy of the position of the transported object 10. can. As a result, it is possible to prevent the object 10 from swinging, deviating from the conveying surface of the conveying apparatus 1000, and damaging the conveying surface while the object 10 is being conveyed.
- FIG. 4 is a diagram showing a connection example of the magnetic circuit section of the conveying apparatus of the second embodiment.
- the three magnetic circuit units 2 are linearly connected along the Y direction.
- the magnetic circuit unit 2 is arranged such that a portion of the magnetic circuit unit 2 where the electromagnetic actuators 70 are densely arranged and a portion of the magnetic circuit unit 2 where the electromagnetic actuators 70 are sparsely arranged are adjacent to each other. to connect.
- the density of the electromagnetic actuators 70 is alternately dense, sparse, dense, and sparse along the Y direction.
- the connection area 4 of the magnetic circuit section 2 it is possible to suppress the variation in the thrust force applied to the transported object 10, and to reduce the deterioration of the estimation accuracy of the position of the transported object 10. can.
- Example 2 the specimen loading device 35 is arranged so as to be adjacent to the left side of the magnetic circuit section 2 at the bottom of FIG.
- the area a where the number of electromagnetic actuators 70 is small serves as the carry-in port for the transported object 10 .
- the pitch between the electromagnetic actuators 70 is large.
- a transported object 10 having a permanent magnet is attracted to an electromagnetic actuator 70 that constitutes a transport line. That is, the range B in which the transported object 10 can be stably carried in is widened.
- the object to be transported 10 can be attracted to the target position by the attraction force of the electromagnetic actuator 70, so that the object to be transported 10 can be stably transported. can do.
- Example 2 the sample analyzer 36 is arranged so as to be adjacent to the left side of the uppermost magnetic circuit section 2 in FIG. In other words, the region c where the number of electromagnetic actuators 70 is small serves as the outlet for the transported object 10 . In this area c, the pitch between the electromagnetic actuators 70 is large. Since the transported object 10 having a permanent magnet is less likely to be affected by the electromagnetic actuators 70 constituting other transport lines, the transported object 10 can be carried out stably.
- the transport line on the left side of FIG. 4 is the shortest route.
- the left transport line is the most efficient route for transporting the transported object 10 from the sample loading device 35 to the sample analyzer 36 . Therefore, the transport line on the left side is used as a high-speed transport line to transport the transported object 10 from the sample loading device 35 to the sample analyzer 36 at high speed.
- Example 2 the dispensing device 37 is arranged so as to be adjacent to the right side of the magnetic circuit section 2 in FIG. In the region b where the electromagnetic actuators 70 are densely arranged, the pitch of the electromagnetic actuators 70 in the Y direction is narrow, and the position of the transported object 10 can be finely controlled. It becomes possible to place the transported object 10 .
- the number of the electromagnetic actuators 70 differs in the horizontal direction ( ⁇ X direction) with respect to the position of the area b. That is, the electromagnetic actuator 70 exists on the left side of the region b, but the electromagnetic actuator 70 does not exist on the right side of the region b. Therefore, when the object to be conveyed 10 is conveyed in the Y direction in the area b, a thrust force acts on the object to be conveyed 10 in the left direction for each pitch of the electromagnetic actuator 70, and the speed pulsation occurs when the object to be conveyed 10 is conveyed. occurs.
- the area b where the electromagnetic actuators 70 are densely arranged is not the transfer line but the holding area of the objects to be transferred 10 .
- the area b where the electromagnetic actuators 70 are densely arranged is used as the low-speed transfer line.
- FIG. 5 is a diagram showing an example of the configuration of a transport system that transports the object to be transported 10.
- the permanent magnet 11 of the transported object 10 is transported on the transport surface 15 installed on the magnetic circuit section 2 .
- the transport system shown in FIG. 5 is a system for estimating the position of the transported object 10 on the transport surface from the relationship between the voltage applied to the windings and the current flowing through the windings.
- a current detector 55 is connected to each of the windings 30 and the position of the carried object 10 is estimated based on the information from the plurality of current detectors 55 .
- the drive circuit 50 applies a voltage to the coil to generate a thrust applied to the transported object 10 .
- the calculation unit 53 controls the drive circuit 50 based on the detected current value.
- a permanent magnet 11 such as neodymium or ferrite is used.
- Other magnets or soft magnetic bodies may be used instead of the permanent magnets 11 .
- a combination of the permanent magnet 11 and a soft magnetic material may be used instead of the permanent magnet 11, a combination of the permanent magnet 11 and a soft magnetic material may be used.
- the term "magnetic material” means the permanent magnet 11, other magnets or soft magnetic materials, or a combination of the permanent magnet 11 and soft magnetic materials.
- a permanent magnet 11 is used as an example of the magnetic material.
- the transport system requires relative positional information between the transported object 10 and the winding 30 . This is to allow the electromagnetic force generated in the teeth 20 to efficiently act on the carried object 10 by applying current to the windings 30, and to move the carried object 10 in a desired direction. . For example, it is assumed that the transported object 10 is above (immediately above) one of the two windings 30 . Even if a voltage is applied to the windings 30 directly under the transported body 10, no force (thrust force) is generated in the transported body 10 in the transport direction.
- Position detection of the transported object 10 will be described.
- the magnitude of the acting magnetic field differs between the winding 30 closer to the transported object 10 and the winding 30 farther.
- the magnitude of the magnetic field acting on the winding 30 changes depending on the relative position between the transported object 10 and the winding 30 .
- the teeth 20 are made of a magnetic material, and have the property that the magnetic flux passing through the teeth 20 becomes difficult to pass as the magnetic flux increases.
- a magnetic flux (magnetic field) generated by the current is generated in the teeth 20 . Therefore, a magnetic flux (magnetic field) generated by the permanent magnet 11 and a magnetic flux (magnetic field) generated by the current flowing through the winding 30 are generated in the tooth 20 .
- a current is passed through the winding 30, a magnetic field is generated around it, and the generated magnetic flux is proportional to the current value. This proportionality constant is called inductance.
- magnetic saturation occurs in the winding 30 and the magnetic permeability decreases, so that the current flowing through the winding 30 changes.
- the inductance L can be calculated by detecting the current flowing through the winding 30 and how it flows. That is, by detecting the inductance L of the winding 30, which varies depending on the position of the permanent magnet 11, the position of the permanent magnet 11 that affects the inductance L can be obtained. Therefore, the driving circuit 50 is connected to the winding 30, and a current detection unit 55 (for example, a resistor is arranged) for detecting the value of the current flowing through the winding 30 is provided. A voltage is applied to the winding 30 by the drive circuit 50 , the current value generated by the voltage is detected by the current detection unit 55 , and the value is read by the calculation unit 53 .
- a current detection unit 55 for example, a resistor is arranged
- the inductance characteristics are different between areas where the electromagnetic actuators 70 are dense and areas where they are sparse, which affects the estimation of the position of the permanent magnets 11 and the generation of thrust. In other words, it affects stable transportation of the object to be transported 10 and operation requirements (for example, transportation speed, unevenness of transportation speed, acceleration/deceleration characteristics, etc.). Therefore, in the above-described embodiment, the arrangement and connection method of the electromagnetic actuators 70 of the magnetic circuit section 2 are devised. In a transport system, reducing the difference in inductance characteristics and thrust characteristics of each tooth is an important point for realizing stable transport. Therefore, devising the arrangement and connection method of the electromagnetic actuators 70 of the magnetic circuit section 2 will lead to the realization of a high-performance conveying apparatus.
- FIG. 6 is a diagram schematically showing the overall configuration of sample analysis system 100. As shown in FIG.
- the specimen analysis system 100 is a device that dispenses specimens and reagents into reaction containers, reacts them, and measures the reacted liquids.
- the sample analysis system 100 includes a carry-in section 101 , an emergency rack inlet 113 , a transport line 102 , a buffer 104 , an analysis section 105 , a storage section 103 , a display section 118 and a control section 120 .
- the carry-in section 101 is a place where a sample rack 111 containing a plurality of sample containers 122 containing biological samples such as blood and urine is installed.
- the emergency rack loading port 113 is a place for loading a sample rack (calibration rack) loaded with a standard solution or a sample rack 111 containing a sample container 122 containing a sample requiring urgent analysis into the apparatus. .
- the buffer 104 holds a plurality of sample racks 111 transported by the transport line 102 so that the sample dispensing order in the sample racks 111 can be changed.
- the analysis unit 105 analyzes the sample conveyed from the buffer 104 via the conveyor line 106 .
- the storage unit 103 holds a sample rack 111 in which sample containers 122 containing samples that have been analyzed by the analysis unit 105 are stored.
- the transport line 102 is a line that transports the sample racks 111 installed in the carry-in section 101, and has the same configuration as any of the transport apparatuses described in the first and second embodiments.
- permanent magnet 11 is provided on the back side of sample rack 111 . That is, the sample rack 111 is the transported object 10 .
- Analysis unit 105 includes conveyor line 106 , reaction disk 108 , sample dispensing nozzle 107 , reagent disk 110 , reagent dispensing nozzle 109 , cleaning mechanism 112 , reagent tray 114 , reagent ID reader 115 , reagent loader 116 , spectrophotometer 121 .
- the conveyor line 106 is a line that carries the sample racks 111 in the buffer 104 to the analysis section 105 .
- the reaction disk 108 has a plurality of reaction containers.
- the sample dispensing nozzle 107 dispenses the sample from the sample container 122 to the reaction container of the reaction disk 108 by rotational driving or vertical driving.
- Reagent disk 110 holds a plurality of reagent bottles.
- Reagent dispensing nozzles 109 dispense reagents from reagent bottles in reagent disk 110 to reaction containers in reaction disk 108 .
- the cleaning mechanism 112 cleans the reaction container of the reaction disk 108 .
- the spectrophotometer 121 measures the absorbance of the reaction liquid by measuring transmitted light obtained from a light source (not shown) through the reaction liquid in the reaction container.
- the reagent tray 114 is a member for placing reagents when registering the reagents in the sample analysis system 100 .
- the reagent ID reader 115 is a device for acquiring reagent information by reading the reagent ID attached to the reagent placed on the reagent tray 114 .
- the reagent loader 116 is a device that loads reagents onto the reagent disk 110 .
- the display unit 118 is a display device for displaying the analysis result of the concentration of a predetermined component in a liquid sample such as blood or urine.
- the control unit 120 is a computer having a CPU, ROM, RAM, storage, etc., and controls the operation of each mechanism within the sample analysis system 100 .
- the control unit 120 performs arithmetic processing to obtain the concentration of a predetermined component in a specimen such as blood or urine.
- the sample analysis processing by the sample analysis system 100 is as follows. First, the sample rack 111 is installed in the loading section 101 or the emergency rack input port 113, and is loaded into the random-accessible buffer 104 by the transport line 102. FIG. The sample analysis system 100 carries the sample rack 111 with the highest priority among the racks stored in the buffer 104 to the analysis unit 105 via the conveyor line 106 according to the priority rule.
- the sample rack 111 that has arrived at the analysis unit 105 is transported by the conveyor line 106 to a sample collection position near the reaction disk 108 .
- the sample pipetting nozzle 107 dispenses the sample from the sample container 122 of the sample rack 111 into the reaction container of the reaction disk 108 .
- the specimen pipetting nozzle 107 aliquots the specimen the required number of times according to the requested analysis items for the specimen.
- the sample dispensing nozzle 107 dispenses samples from all the sample containers 122 mounted on the sample rack 111 .
- the sample rack 111 for which all the sample containers 122 have undergone sorting processing is transferred to the buffer 104 .
- the sample rack 111 for which all sample sorting processes including automatic retesting have been completed is transferred to the storage unit 103 by the conveyor line 106 and the transfer line 102 .
- the reagent used for analysis is dispensed from the reagent bottle on the reagent disk 110 by the reagent dispensing nozzle 109 . Then, the sampled reagent is dispensed into the reaction container into which the sample was previously dispensed. Subsequently, a stirring mechanism (not shown) stirs the mixture of the sample and the reagent in the reaction vessel.
- the light generated from the light source is transmitted through the reaction vessel containing the mixed liquid after stirring, and the light intensity of the transmitted light is measured by the spectrophotometer 121 .
- the light intensity measured by spectrophotometer 121 is transmitted to control section 120 via an A/D converter and an interface. Then, the control unit 120 performs calculations, obtains the concentration of a predetermined component in a liquid sample such as blood or urine, and displays the result on the display unit 118 or the like or stores it in a storage unit (not shown). do.
- sample analysis system 100 does not need to have all the configurations shown in FIG. 6, and pretreatment units can be added as appropriate, and some units and some configurations can be deleted. .
- analysis unit 105 is not limited to the one for biochemical analysis, and may be for immunological analysis.
- FIG. 7 is a diagram showing the overall configuration of the sample pretreatment device 150.
- a sample pretreatment device 150 is a device that performs various pretreatments necessary for sample analysis.
- the sample pretreatment apparatus 150 includes a plugging unit 152, a sample storage unit 153, an empty holder stacker 154, a sample loading unit 155, a centrifugal separation unit 156, a liquid volume measurement unit 157, a plug opening unit 158, a secondary sample container preparation unit 159, a It has a note unit 160, a transfer unit 161, and an operation unit PC 163 that controls the operations of these units.
- the sample pretreatment device 150 is connected to the sample analysis system 100 for qualitative and quantitative analysis of the components of the sample as a transfer destination of the sample processed by the sample pretreatment device 150 .
- the specimen loading unit 155 is a unit for loading the specimen container 122 containing the specimen into the specimen pretreatment apparatus 150 .
- the centrifugal separation unit 156 is a unit for centrifuging the loaded specimen container 122 .
- the liquid volume measurement unit 157 is a unit that measures the liquid volume of the sample contained in the sample container 122 .
- the unplugging unit 158 is a unit that unplugs the sample container 122 that has been put in.
- the secondary sample container preparation unit 159 is a unit that makes necessary preparations for dispensing the sample contained in the loaded sample container 122 in the next dispensing unit 160 .
- the dispensing unit 160 subdivides the centrifuged sample for analysis by a sample analysis system or the like, and subdivides the sample container 122 (hereinafter, the subdivided sample container 122 is referred to as the secondary sample container 122). It is a unit that affixes barcodes, etc.
- the transfer unit 161 is a unit that sorts the dispensed secondary sample containers 122 and prepares for transfer to the sample analysis system 100 .
- the capping unit 152 is a unit that caps the sample container 122 and secondary sample container 122 .
- the sample storage unit 153 is a unit that stores the closed sample container 122 .
- the transport apparatus of either the first embodiment or the second embodiment is used.
- the sample pretreatment apparatus 150 does not need to have all the configurations described above, and some units and some configurations can be omitted. Also, the sample pretreatment apparatus 150 may include units other than the units described above.
- sample analysis system of this embodiment may be a sample analysis system 200 including a sample pretreatment device 150 and a sample analysis system 100 as shown in FIG.
- sample analysis system 200 may be connected by the transport apparatus 1 of the first and second embodiments described above.
- the sample analysis systems 100 and 200 and the sample pretreatment device 150 are equipped with the transport device 1 of the first and second embodiments. As a result, it is possible to reduce the magnitude of the thrust force when the sample rack 111 and the sample holder are transported and stopped depending on the positions of the sample rack 111 and the sample holder. Further, it is possible to provide the transport apparatus 1 in which the detected value and change value of the current required for detecting the positions of the sample rack 111 and the sample holder are stable. In other words, it is possible to realize the transport apparatus 1 with high controllability of the sample rack 111 and the sample holder, and with high estimated positional accuracy of the sample rack 111 and the sample holder.
- Embodiments 1 and 2 the case where the object to be transported by the transport apparatus is the sample rack 111 or the sample holder has been described.
- Objects to be transported are not limited to racks, holders, and the like that hold sample containers 122, and various objects that are required to be transported on a large scale can be objects to be transported.
- Reagent Dispensing nozzle 110 Reagent disk 111
- Sample rack 112 Cleaning mechanism 113
- Emergency rack inlet 114 Reagent tray 115
- Reagent ID reader 116 Reagent loader 118
- Display unit 120 Control unit 121
- Spectrophotometer 122 Specimen Container
- secondary sample container 150 sample pretreatment device 152 plugging unit 153 sample storage unit 154 holder stacker 155 sample loading unit 156 centrifugal separation unit 157 liquid volume measurement unit 158 plugging unit 159 secondary sample container Preparing unit 160 Dispensing unit 161 Transfer unit 163 Operation unit PC 200
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Abstract
Description
実施例1の搬送装置について説明する。図1は、実施例1の搬送装置の構成を示す図である。搬送装置1は、被搬送体10をX方向及びY方向に搬送する搬送装置である。図2は、実施例1の搬送装置の磁気回路部を示す斜視図である。長い距離を搬送する場合、図1に示した搬送装置1をX方向及び/又はY方向に複数接続して、被搬送体10の長距離搬送を実現する。磁気回路部2の上には、搬送面15が設置されており、搬送面15の上を被搬送体10に埋め込まれた磁性体の永久磁石11(図8参照)が移動する。図2(a)に示した磁気回路部2は、X方向に被搬送体10を搬送する3つの搬送ラインと、Y方向に被搬送体10を搬送する3つの搬送ラインと、を有する。磁性体の円筒形の複数のティース20の各々には、巻線30が巻かれている。なお、ティース20は、ティース20a~dの総称である。複数のティース20は、搬送面15と反対側(-Z側)で磁性体のヨーク40によって磁気的に結合されている。ティース20に巻線が巻かれたものを電磁アクチュエータ70と呼ぶ。複数の電磁アクチュエータ70は、格子状に配列されている。
実施例2の搬送装置について、図4を用いて説明する。実施例1と同様の部分の説明は省略する。図4は、実施例2の搬送装置の磁気回路部の接続例を示す図である。3つの磁気回路部2は、Y方向に沿って直線状に接続されている。磁気回路部2を所望の形状にする場合、磁気回路部2の電磁アクチュエータ70が密となる箇所と磁気回路部2の電磁アクチュエータ70が疎となる箇所とが隣接するように、磁気回路部2を接続する。このように構成することによって、Y方向に沿って、電磁アクチュエータ70の密度が密、疎、密、疎と交互に繰り返す。その結果、磁気回路部2の接続領域4において、被搬送体10に加わる推力がばらつくのを抑制することができ、また、被搬送体10の位置の推定精度が悪化するのを低減することができる。その結果、被搬送体10の搬送中に被搬送体10が、揺れたり、搬送装置1000の搬送面から逸脱したり、搬送面を損傷させたりするのを抑制することができる。
図5は、被搬送体10を搬送する搬送システムの構成の一例を示す図である。被搬送体10の永久磁石11は、磁気回路部2上に設置された搬送面15の上で搬送される。図5に示した搬送システムは、巻線に印加した電圧と巻線に流れる電流との関係から被搬送体10の搬送面上の場所を推定するシステムである。本システムでは、巻線30の各々に電流検出部55を接続し、複数の電流検出部55からの情報に基づいて、被搬送体10の位置を推定する。駆動回路50は、コイルに電圧を印加して、被搬送体10に加わる推力を発生させる。演算部53は、検出した電流値に基づいて、駆動回路50を制御する。
被搬送体10の位置検出について説明する。図5の手前側の巻線30の上に被搬送体10があった場合、永久磁石11が作る磁場が巻線30に作用する。ここで、被搬送体10に近い側の巻線30と、遠い側の巻線30とでは、作用する磁場の大きさが異なる。つまり、被搬送体10と巻線30の相対位置によって巻線30に作用する磁場の大きさが変わることになる。
検体分析システム100の全体構成について、図6を用いて説明する。図6は、検体分析システム100の全体構成を概略的に示す図である。
2…磁気回路部
4…接続領域
10…被搬送体
11…永久磁石
15…搬送面
20、20a、20b、20c、20d…ティース
30…巻線
35…検体投入装置
36…検体分析装置
37…分注装置
40…ヨーク
100…検体分析システム
101…搬入部
102…搬送ライン
103…収納部
104…バッファ
105…分析部
106…コンベアライン
107…検体分注ノズル
108…反応ディスク
109…試薬分注ノズル
110…試薬ディスク
111…検体ラック
112…洗浄機構
113…緊急ラック投入口
114…試薬トレイ
115…試薬IDリーダー
116…試薬ローダ
118…表示部
120…制御部
121…分光光度計
122…検体容器、子検体容器
150…検体前処理装置
152…閉栓ユニット
153…検体収納ユニット
154…ホルダスタッカー
155…検体投入ユニット
156…遠心分離ユニット
157…液量測定ユニット
158…開栓ユニット
159…子検体容器準備ユニット
160…分注ユニット
161…移載ユニット
163…操作部PC
200…検体分析システム
Claims (10)
- 磁性体からなるティース及び前記ティースに巻かれた巻線を有する電磁アクチュエータが格子状に配列された磁気回路部を複数接続した搬送装置であって、
略四辺形の前記磁気回路部の各々は、
対向する辺の一方の辺に沿って配置された複数の第1電磁アクチュエータと、
前記対向する辺の他方の辺に沿って配置された複数の第2電磁アクチュエータと、
他の対向する辺の一方の辺に沿って配置された複数の第3電磁アクチュエータと、
前記他の対向する辺の他方の辺に沿って配置された複数の第4電磁アクチュエータと、を有し、
前記第1電磁アクチュエータの数は、前記第2電磁アクチュエータの数より多く、
前記第3電磁アクチュエータの数は、前記第4電磁アクチュエータの数より多く、
前記電磁アクチュエータの数が多い辺と前記電磁アクチュエータの数が少ない辺とが隣接するように前記複数の磁気回路部を接続する、搬送装置。 - 請求項1記載の搬送装置であって、前記電磁アクチュエータの数が少ない辺に隣接するように被搬送体の搬入口が設けられる、搬送装置。
- 請求項1記載の搬送装置であって、前記電磁アクチュエータの数が少ない辺に隣接するように被搬送体の搬出口が設けられる、搬送装置。
- 請求項1記載の搬送装置であって、前記磁気回路部の前記電磁アクチュエータの数が少ない辺に隣接するように被搬送体の搬入口が設けられ、且つ、前記磁気回路部とは異なる前記磁気回路部の前記電磁アクチュエータの数が少ない辺に隣接するように前記被搬送体の搬出口が設けられる、搬送装置。
- 請求項1記載の搬送装置であって、前記電磁アクチュエータの数が多い辺に隣接するように、検体容器から検体を分取する又は分取した検体を分注する分注装置が配置される、搬送装置。
- 請求項1記載の搬送装置であって、前記電磁アクチュエータの数が少ない側を被搬送体の高速搬送ラインとし、前記電磁アクチュエータの数が多い側を前記被搬送体の低速搬送ライン又は滞留領域とする、搬送装置。
- 請求項2記載の搬送装置と、前記電磁アクチュエータの数が少ない辺に隣接するように配置された検体投入装置と、を備える検体分析システム。
- 請求項3記載の搬送装置と、前記電磁アクチュエータの数が少ない辺に隣接するように配置された検体分析装置と、を備える検体分析システム。
- 請求項5記載の搬送装置と、前記電磁アクチュエータの数が多い辺に隣接するように配置された前記分注装置と、を備える検体分析システム。
- 請求項1乃至請求項6の何れか1項に記載の搬送装置を備える、検体前処理装置。
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JP2020201167A (ja) * | 2019-06-12 | 2020-12-17 | 株式会社日立ハイテク | 搬送装置 |
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JP2020201167A (ja) * | 2019-06-12 | 2020-12-17 | 株式会社日立ハイテク | 搬送装置 |
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