WO2023009080A1 - Anti-viral, anti-bacterial herbal medicine to prevent the transmission and spread of diseases transmitted by respiratory tract and surface contact - Google Patents

Anti-viral, anti-bacterial herbal medicine to prevent the transmission and spread of diseases transmitted by respiratory tract and surface contact Download PDF

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Publication number
WO2023009080A1
WO2023009080A1 PCT/TR2021/050828 TR2021050828W WO2023009080A1 WO 2023009080 A1 WO2023009080 A1 WO 2023009080A1 TR 2021050828 W TR2021050828 W TR 2021050828W WO 2023009080 A1 WO2023009080 A1 WO 2023009080A1
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Prior art keywords
bacteria
viruses
triacetin
feature
accordance
Prior art date
Application number
PCT/TR2021/050828
Other languages
French (fr)
Inventor
Mehmet Serhan KURTULMUS
Original Assignee
Kurtulmus Mehmet Serhan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
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Application filed by Kurtulmus Mehmet Serhan filed Critical Kurtulmus Mehmet Serhan
Publication of WO2023009080A1 publication Critical patent/WO2023009080A1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays

Definitions

  • the invention is related to an active substance used in the form of nasal and mouth spray, inhaler, cream, gel, lozenge, mouthwash, toothpaste, hand disinfectant, and surface disinfectant, in order to prevent the transmission and spread of viruses and bacteria that are transmitted by the respiratory tract and surface contact and that may threaten human and animal health, especially Sars Cov-2 virus and its variants.
  • the invention is related to the active substance called Triacetin, which forms a layer on the mucosal surfaces such as the nasal and mouth mucosa without disturbing the user, thus preventing the entry of viruses and bacteria into the body by contacting these surfaces, which further with its solvent effect, a natural feature of the active substance, ensures the rapid deterioration of protein and lipid structures of the viruses and bacteria that come into contact with itself.
  • Triacetin the active substance called Triacetin
  • the outer walls of viruses and bacteria transmitted through the upper respiratory tract are composed of various protein and lipid structures. These structures can be of different shapes and sizes, depending on the type of virus and bacteria. Thanks to these structures, viruses and bacteria attach to some special cells especially in the nasal and oral mucosa, such as Goblet Cells, and enter the body. Therefore, in order to prevent transmission, either these protein and lipid structures of viruses and bacteria must be disrupted or these structures must be detached from the body. Although current applications include many active substances that can slow the spread and reduce the number of viruses, the number of products that will not harm the human body and can even be used as a nasal spray is low.
  • the objective of the invention is mainly related to the active substance used to reduce the rate of transmission and prevent the spread of infectious diseases such as Covid-19 and the use of this active substance.
  • One objective of the invention is that the ingredient does not harm human health and can be used on all living organisms and surfaces, particularly because it is obtained from a tropical tree called Papaya and is suitable for use in food products.
  • Another objective of the invention is that it can be obtained by chemical means in line with the need.
  • Another objective of the invention is that the active substance in question prevents transmission by exerting two different features.
  • One of the features is that it creates a layer that will not disturb the user, especially on the mucous surfaces of the nose and mouth, thus preventing viruses and bacteria from entering the body by contacting these surfaces, while the other and the main feature is that, with the solvent effect, which is a natural feature of the active substance, it causes rapid deterioration of protein and lipid structures of viruses and bacteria that come into contact with itself.
  • Another objective of the invention is to use the active ingredient in various forms such as nasal and mouth spray, cream, gel, lozenge, mouthwash, hand disinfectant, and surface disinfectant. In this way, it can be applied to all living organisms and surfaces at the desired dose.
  • Another important objective of the invention is to allow its use as an inhaler and its effect to spread to the lung tissues, disrupting the protein and lipid structures of viruses and bacteria it encounters.
  • Another objective of the invention is being highly advantageous since it does not contain alcohol, considering the irritations caused by other alcohol-containing hand and surface disinfectants on the skin.
  • the invention is related to the use of an active substance called Triacetin in the form of nasal and mouth spray, inhaler, cream, gel, lozenge, mouthwash, toothpaste, hand disinfectant, and surface disinfectant, in order to prevent the transmission and spread of viruses and bacteria that are transmitted by the respiratory tract and surface contact and that may threaten human and animal health, especially Sars Cov-2 virus and its variants.
  • an active substance called Triacetin
  • Triacetin the subject of the invention, is an active ingredient obtained from the tree called Papaya, which especially grows in tropical regions.
  • the solvent effect of the active ingredient Triacetin which denatures the protein and lipid layers as determined in the literature, is utilized.
  • the CAS number of the active ingredient Triacetin is 102-76-1, its chemical formula is C9H14O6, and its linear formula is (CH3COOCH2)2CHOCOCH3 .
  • Triacetin is used in different doses by diluting according to its usage (Depending on the usage area, it can be diluted with distilled water and used at rates that can vary between 1% - 99.9%).
  • the outer walls of viruses and bacteria transmitted through the upper respiratory tract are composed of various protein and lipid structures. These structures can be of different shapes and sizes, depending on the type of virus and bacteria. Thanks to these structures, viruses and bacteria attach to some special cells especially in the nasal and oral mucosa, such as Goblet Cells, and enter the body. Therefore, in order to prevent transmission, either these protein and lipid structures of viruses and bacteria must be disrupted or these structures must be detached from the body.
  • Triacetin prevents transmission via two separate features: One of them is that it forms a layer that will not disturb the user, especially on mucous surfaces such as the nose and mouth mucosa. For a longer-lasting effect of this layer, triacetin can be used with low rates of CMC (carboxymethyl cellulose), etc. gelling agents. In this way, it prevents viruses and bacteria from entering the body by contacting these surfaces.
  • the other and the main feature of Triacetin is that, with its solvent effect, which is a natural feature of Triacetin, it rapidly degrades the protein and lipid structures of viruses and bacteria that come into contact with it. Viruses and bacteria with impaired protein and lipid structures lose their ability to transmit disease and die. In this way, viruses and bacteria on the surfaces that Triacetin comes into contact with lose their effects as a result of the deterioration of protein and lipid structures after contact.
  • the active ingredient Triacetin can be prepared in various forms such as nasal and mouth spray, cream, gel, inhaler, lozenge, mouthwash, toothpaste, hand disinfectant, and surface disinfectant, and can be used in line with the needs of the users.
  • Triacetin When used as an inhaler, its effect is to spread to the lung tissues and disrupt the protein and lipid structures of viruses and bacteria it encounters.
  • Triacetin When Triacetin is used as a hand and surface disinfectant, it provides long-term protection on the surfaces it is used on. Its mechanism of action is that it destroys the structures of viruses and bacteria that come into contact with it and thus renders them ineffective.
  • the invention is particularly related to the use of the active ingredient Triacetin (C9H14O6), which can be obtained from the tree called papaya or produced chemically, to prevent the transmission and spread of the virus and bacterial species that may threaten human and animal health, especially Sars Cov-2 virus and its variants, which are transmitted by the respiratory tract and surface contact.
  • the active ingredient Triacetin can be used together with carboxymethyl cellulose or gelling agent to form a layer that will not disturb the user on mucous surfaces such as the nasal and mouth mucosa, thus preventing viruses and bacteria from entering the body by contacting these surfaces and increasing the duration of protection.
  • Triacetin can be used as an inhaler in order to spread the effect of the triacetin ingredient to the lung tissues and disrupt the protein and lipid structures of the viruses and bacteria it encounters.
  • the subject of the invention, Triacetin can be used as nasal and mouth spray, inhaler, cream, gel, lozenge, mouthwash, toothpaste, gum, hand disinfectant, and surface disinfectant.
  • aromatizing the active ingredient Triacetin facilitates its use and increases its preferability.

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Otolaryngology (AREA)
  • Inorganic Chemistry (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)

Abstract

The invention is related to an active substance used in the form of nasal and mouth spray, inhaler, cream, gel, lozenge, mouthwash, toothpaste, hand disinfectant, and surface disinfectant, in order to prevent the transmission and spread of viruses and bacteria that are transmitted by the respiratory tract and surface contact and that may threaten human and animal health, especially Sars Cov-2 virus and its variants. In particular, the invention is related to the active substance called Triacetin, which forms a layer on the mucosal surfaces such as the nasal and mouth mucosa without disturbing the user, thus preventing the entry of viruses and bacteria into the body by contacting these surfaces, which further with its solvent effect, a natural feature of the active substance, ensures the rapid deterioration of protein and lipid structures of the viruses and bacteria that come into contact with itself.

Description

ANTI-VIRAL, ANTI-BACTERIAL HERBAL MEDICINE TO PREVENT THE TRANSMISSION AND SPREAD OF DISEASES TRANSMITTED BY RESPIRATORY TRACT AND SURFACE
CONTACT
TECHNICAL FIELD
The invention is related to an active substance used in the form of nasal and mouth spray, inhaler, cream, gel, lozenge, mouthwash, toothpaste, hand disinfectant, and surface disinfectant, in order to prevent the transmission and spread of viruses and bacteria that are transmitted by the respiratory tract and surface contact and that may threaten human and animal health, especially Sars Cov-2 virus and its variants.
In particular, the invention is related to the active substance called Triacetin, which forms a layer on the mucosal surfaces such as the nasal and mouth mucosa without disturbing the user, thus preventing the entry of viruses and bacteria into the body by contacting these surfaces, which further with its solvent effect, a natural feature of the active substance, ensures the rapid deterioration of protein and lipid structures of the viruses and bacteria that come into contact with itself.
PRIOR ART
The increasing population of living organisms in the world causes epidemic diseases to be more effective, and the epidemic threatens human life. The sudden emergence of epidemics and the very high transmission rate have revealed the need for new studies to take precautions against the epidemics. In the current state of the art, there are some active ingredients produced to prevent the transmission of infectious diseases, such as Sars Cov-2. However, these active ingredients cannot give the desired result.
The outer walls of viruses and bacteria transmitted through the upper respiratory tract are composed of various protein and lipid structures. These structures can be of different shapes and sizes, depending on the type of virus and bacteria. Thanks to these structures, viruses and bacteria attach to some special cells especially in the nasal and oral mucosa, such as Goblet Cells, and enter the body. Therefore, in order to prevent transmission, either these protein and lipid structures of viruses and bacteria must be disrupted or these structures must be detached from the body. Although current applications include many active substances that can slow the spread and reduce the number of viruses, the number of products that will not harm the human body and can even be used as a nasal spray is low.
In the current technique, most of the products cannot be used as nasal sprays, etc., and the ones that can be used are not effective due to their active ingredients, and therefore increase the risk of transmission and cannot defend against viruses that are rapidly transmitted through respiration.
In conclusion, the negativities described above and the inadequacy of the existing solutions on the subject render it necessary to make an improvement in the relevant field. OBJECTIVE OF THE INVENTION
The objective of the invention is mainly related to the active substance used to reduce the rate of transmission and prevent the spread of infectious diseases such as Covid-19 and the use of this active substance.
One objective of the invention is that the ingredient does not harm human health and can be used on all living organisms and surfaces, particularly because it is obtained from a tropical tree called Papaya and is suitable for use in food products.
Another objective of the invention is that it can be obtained by chemical means in line with the need.
Another objective of the invention is that the active substance in question prevents transmission by exerting two different features. One of the features is that it creates a layer that will not disturb the user, especially on the mucous surfaces of the nose and mouth, thus preventing viruses and bacteria from entering the body by contacting these surfaces, while the other and the main feature is that, with the solvent effect, which is a natural feature of the active substance, it causes rapid deterioration of protein and lipid structures of viruses and bacteria that come into contact with itself. Another objective of the invention is to use the active ingredient in various forms such as nasal and mouth spray, cream, gel, lozenge, mouthwash, hand disinfectant, and surface disinfectant. In this way, it can be applied to all living organisms and surfaces at the desired dose.
Another important objective of the invention is to allow its use as an inhaler and its effect to spread to the lung tissues, disrupting the protein and lipid structures of viruses and bacteria it encounters.
Another objective of the invention is being highly advantageous since it does not contain alcohol, considering the irritations caused by other alcohol-containing hand and surface disinfectants on the skin.
DETAILED DESCRIPTION OF THE INVENTION
The invention is related to the use of an active substance called Triacetin in the form of nasal and mouth spray, inhaler, cream, gel, lozenge, mouthwash, toothpaste, hand disinfectant, and surface disinfectant, in order to prevent the transmission and spread of viruses and bacteria that are transmitted by the respiratory tract and surface contact and that may threaten human and animal health, especially Sars Cov-2 virus and its variants. In these areas of use, optionally, aromatization of the product can also be performed. Triacetin, the subject of the invention, is an active ingredient obtained from the tree called Papaya, which especially grows in tropical regions. In the said invention, the solvent effect of the active ingredient Triacetin, which denatures the protein and lipid layers as determined in the literature, is utilized. The CAS number of the active ingredient Triacetin is 102-76-1, its chemical formula is C9H14O6, and its linear formula is (CH3COOCH2)2CHOCOCH3 .
Synonyms under the same CAS number are: Enzactin, 1,2,3-Triacetylglycerol, Glyceryl triacetate, 1,2,3-Triacetoxypropane.
It is obtained particularly from a tropical tree called Papaya and is suitable for use in food products. It can also be obtained by chemical means in line with the need.
In the invention in question, Triacetin is used in different doses by diluting according to its usage (Depending on the usage area, it can be diluted with distilled water and used at rates that can vary between 1% - 99.9%). The outer walls of viruses and bacteria transmitted through the upper respiratory tract are composed of various protein and lipid structures. These structures can be of different shapes and sizes, depending on the type of virus and bacteria. Thanks to these structures, viruses and bacteria attach to some special cells especially in the nasal and oral mucosa, such as Goblet Cells, and enter the body. Therefore, in order to prevent transmission, either these protein and lipid structures of viruses and bacteria must be disrupted or these structures must be detached from the body.
In the invention in question, Triacetin prevents transmission via two separate features: One of them is that it forms a layer that will not disturb the user, especially on mucous surfaces such as the nose and mouth mucosa. For a longer-lasting effect of this layer, triacetin can be used with low rates of CMC (carboxymethyl cellulose), etc. gelling agents. In this way, it prevents viruses and bacteria from entering the body by contacting these surfaces. The other and the main feature of Triacetin is that, with its solvent effect, which is a natural feature of Triacetin, it rapidly degrades the protein and lipid structures of viruses and bacteria that come into contact with it. Viruses and bacteria with impaired protein and lipid structures lose their ability to transmit disease and die. In this way, viruses and bacteria on the surfaces that Triacetin comes into contact with lose their effects as a result of the deterioration of protein and lipid structures after contact.
For this reason, the active ingredient Triacetin can be prepared in various forms such as nasal and mouth spray, cream, gel, inhaler, lozenge, mouthwash, toothpaste, hand disinfectant, and surface disinfectant, and can be used in line with the needs of the users. When used as an inhaler, its effect is to spread to the lung tissues and disrupt the protein and lipid structures of viruses and bacteria it encounters. When Triacetin is used as a hand and surface disinfectant, it provides long-term protection on the surfaces it is used on. Its mechanism of action is that it destroys the structures of viruses and bacteria that come into contact with it and thus renders them ineffective.
The invention is particularly related to the use of the active ingredient Triacetin (C9H14O6), which can be obtained from the tree called papaya or produced chemically, to prevent the transmission and spread of the virus and bacterial species that may threaten human and animal health, especially Sars Cov-2 virus and its variants, which are transmitted by the respiratory tract and surface contact. In the invention, the active ingredient Triacetin can be used together with carboxymethyl cellulose or gelling agent to form a layer that will not disturb the user on mucous surfaces such as the nasal and mouth mucosa, thus preventing viruses and bacteria from entering the body by contacting these surfaces and increasing the duration of protection. With the solvent effect, which is a natural feature of Triacetin, it is possible to use it together with distilled water to rapidly degrade the protein and lipid structures of viruses and bacteria that come into contact with it and hence to cause viruses and bacteria with impaired protein and lipid structures to lose their disease-transmitting properties.
It can be used as an inhaler in order to spread the effect of the triacetin ingredient to the lung tissues and disrupt the protein and lipid structures of the viruses and bacteria it encounters. The subject of the invention, Triacetin; can be used as nasal and mouth spray, inhaler, cream, gel, lozenge, mouthwash, toothpaste, gum, hand disinfectant, and surface disinfectant. In addition, in these usage areas, aromatizing the active ingredient Triacetin facilitates its use and increases its preferability.

Claims

1. The invention is related to the use of the active ingredient Triacetin (C9H14O6), which can be obtained from the tree called papaya or produced chemically, to prevent the transmission and spread of the virus and bacterial species that may threaten human and animal health, especially Sars Cov-2 virus and its variants, which are transmitted by the respiratory tract and surface contact.
2. It is used in accordance with Claim-1 and its feature is; the use of the active ingredient of triacetin together with carboxymethyl cellulose to form a layer that will not disturb the user on mucous surfaces such as the nasal and mouth mucosa, thus preventing viruses and bacteria from entering the body by contacting these surfaces and increasing the duration of protection.
3. It is used in accordance with Claim-1 and its feature is; the use of the active ingredient of triacetin together with a gelling agent to form a layer that will not disturb the user on mucous surfaces such as the nasal and mouth mucosa, thus preventing viruses and bacteria from entering the body by contacting these surfaces and increasing the duration of protection.
4. It is used in accordance with Claim-1 and its feature is; with the solvent effect, which is a natural feature of Triacetin, it is used together with distilled water to rapidly degrade the protein and lipid structures of viruses and bacteria that come into contact with it and to cause viruses and bacteria with deteriorated protein and lipid structures to lose their disease-transmitting properties.
5. It is used in accordance with Claim-1 and its feature is; to be used as an inhaler to spread its effect to the lung tissues and disrupt the protein and lipid structures of viruses and bacteria it encounters.
6. It is used in accordance with Claim-1 and its feature is; it can be used as nasal and mouth spray, inhaler, cream, gel, lozenge, mouthwash, toothpaste, hand disinfectant, and surface disinfectant.
7. It is used in accordance with Claim-1 and its feature is; aromatizing the active ingredient Triacetin to facilitate its use and increase its preferability.
PCT/TR2021/050828 2021-07-29 2021-08-18 Anti-viral, anti-bacterial herbal medicine to prevent the transmission and spread of diseases transmitted by respiratory tract and surface contact WO2023009080A1 (en)

Applications Claiming Priority (2)

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TRTR2021012040 2021-07-29
TR2021012040 2021-07-29

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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20190060378A (en) * 2017-11-24 2019-06-03 (주)아모레퍼시픽 Cosmetic Composition Containing High-Content of Urea

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20190060378A (en) * 2017-11-24 2019-06-03 (주)아모레퍼시픽 Cosmetic Composition Containing High-Content of Urea

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CARLSON T L, LOCK J Y, CARRIER R L: "Annual Review of Biomedical Engineering; Engineering the Mucus Barrier", ANNU. REV. BIOMED. ENG, vol. 20, 30 June 2018 (2018-06-30), pages 197 - 220, XP093030754, DOI: 10.1146/annurev-bioeng-062117-121156 *
ROSATO, A. ET AL.: "Antibacterial effect of some essential oils administered alone or in combination with Norfloxacin", PHYTOMEDICINE, vol. 14, no. 11, 2007, pages 727 - 732, XP022294012, DOI: 10.1016/j.phymed.2007.01.005 *

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