WO2022263172A1 - Composition en comprimé monodose - Google Patents
Composition en comprimé monodose Download PDFInfo
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- WO2022263172A1 WO2022263172A1 PCT/EP2022/064898 EP2022064898W WO2022263172A1 WO 2022263172 A1 WO2022263172 A1 WO 2022263172A1 EP 2022064898 W EP2022064898 W EP 2022064898W WO 2022263172 A1 WO2022263172 A1 WO 2022263172A1
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- WO
- WIPO (PCT)
- Prior art keywords
- unit
- tablet composition
- dose tablet
- water
- composition according
- Prior art date
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- 239000007916 tablet composition Substances 0.000 title claims description 42
- 239000000203 mixture Substances 0.000 claims abstract description 70
- 238000004140 cleaning Methods 0.000 claims abstract description 33
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 33
- 239000007884 disintegrant Substances 0.000 claims abstract description 31
- 150000003839 salts Chemical class 0.000 claims abstract description 26
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims abstract description 14
- 239000004094 surface-active agent Substances 0.000 claims abstract description 13
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims abstract description 8
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims abstract description 8
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims abstract description 8
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims abstract description 8
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims abstract description 8
- 229920002472 Starch Polymers 0.000 claims abstract description 7
- 239000000378 calcium silicate Substances 0.000 claims abstract description 7
- 229910052918 calcium silicate Inorganic materials 0.000 claims abstract description 7
- 235000012241 calcium silicate Nutrition 0.000 claims abstract description 7
- OYACROKNLOSFPA-UHFFFAOYSA-N calcium;dioxido(oxo)silane Chemical compound [Ca+2].[O-][Si]([O-])=O OYACROKNLOSFPA-UHFFFAOYSA-N 0.000 claims abstract description 7
- 239000012153 distilled water Substances 0.000 claims abstract description 7
- 235000019359 magnesium stearate Nutrition 0.000 claims abstract description 7
- 239000008108 microcrystalline cellulose Substances 0.000 claims abstract description 7
- 229940016286 microcrystalline cellulose Drugs 0.000 claims abstract description 7
- 239000008109 sodium starch glycolate Substances 0.000 claims abstract description 7
- 229940079832 sodium starch glycolate Drugs 0.000 claims abstract description 7
- 229920003109 sodium starch glycolate Polymers 0.000 claims abstract description 7
- 239000008107 starch Substances 0.000 claims abstract description 7
- 229940032147 starch Drugs 0.000 claims abstract description 7
- 235000019698 starch Nutrition 0.000 claims abstract description 7
- 235000002639 sodium chloride Nutrition 0.000 claims description 27
- 238000000034 method Methods 0.000 claims description 14
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 10
- 229910052783 alkali metal Inorganic materials 0.000 claims description 9
- 150000001340 alkali metals Chemical class 0.000 claims description 9
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 6
- 150000004677 hydrates Chemical class 0.000 claims description 6
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 5
- 235000010216 calcium carbonate Nutrition 0.000 claims description 5
- 229910052708 sodium Inorganic materials 0.000 claims description 5
- 239000011734 sodium Substances 0.000 claims description 5
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims description 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 4
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims description 4
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 4
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 claims description 4
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 4
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 claims description 4
- 239000011736 potassium bicarbonate Substances 0.000 claims description 4
- 235000015497 potassium bicarbonate Nutrition 0.000 claims description 4
- 229910000028 potassium bicarbonate Inorganic materials 0.000 claims description 4
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 claims description 4
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 claims description 4
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 3
- 150000005323 carbonate salts Chemical class 0.000 claims description 3
- 229910052700 potassium Inorganic materials 0.000 claims description 3
- 239000011591 potassium Substances 0.000 claims description 3
- 229960003975 potassium Drugs 0.000 claims description 3
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims description 2
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 2
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 claims description 2
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims description 2
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims description 2
- 239000001361 adipic acid Substances 0.000 claims description 2
- 235000011037 adipic acid Nutrition 0.000 claims description 2
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims description 2
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 claims description 2
- NKWPZUCBCARRDP-UHFFFAOYSA-L calcium bicarbonate Chemical compound [Ca+2].OC([O-])=O.OC([O-])=O NKWPZUCBCARRDP-UHFFFAOYSA-L 0.000 claims description 2
- 229910000020 calcium bicarbonate Inorganic materials 0.000 claims description 2
- 235000015165 citric acid Nutrition 0.000 claims description 2
- 239000001530 fumaric acid Substances 0.000 claims description 2
- 235000011087 fumaric acid Nutrition 0.000 claims description 2
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 claims description 2
- 239000001095 magnesium carbonate Substances 0.000 claims description 2
- 229910000021 magnesium carbonate Inorganic materials 0.000 claims description 2
- 239000001630 malic acid Substances 0.000 claims description 2
- 235000011090 malic acid Nutrition 0.000 claims description 2
- 150000007524 organic acids Chemical group 0.000 claims description 2
- 235000005985 organic acids Nutrition 0.000 claims description 2
- 229910000027 potassium carbonate Inorganic materials 0.000 claims description 2
- 235000011181 potassium carbonates Nutrition 0.000 claims description 2
- 239000001103 potassium chloride Substances 0.000 claims description 2
- 235000011164 potassium chloride Nutrition 0.000 claims description 2
- 229940086066 potassium hydrogencarbonate Drugs 0.000 claims description 2
- OTYBMLCTZGSZBG-UHFFFAOYSA-L potassium sulfate Chemical compound [K+].[K+].[O-]S([O-])(=O)=O OTYBMLCTZGSZBG-UHFFFAOYSA-L 0.000 claims description 2
- 229910052939 potassium sulfate Inorganic materials 0.000 claims description 2
- 239000001120 potassium sulphate Substances 0.000 claims description 2
- 235000011151 potassium sulphates Nutrition 0.000 claims description 2
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims description 2
- 235000017557 sodium bicarbonate Nutrition 0.000 claims description 2
- 229910000029 sodium carbonate Inorganic materials 0.000 claims description 2
- 235000017550 sodium carbonate Nutrition 0.000 claims description 2
- 239000011780 sodium chloride Substances 0.000 claims description 2
- 229910052938 sodium sulfate Inorganic materials 0.000 claims description 2
- 235000011152 sodium sulphate Nutrition 0.000 claims description 2
- 239000011975 tartaric acid Substances 0.000 claims description 2
- 235000002906 tartaric acid Nutrition 0.000 claims description 2
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 2
- 239000003826 tablet Substances 0.000 description 20
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 17
- 239000003945 anionic surfactant Substances 0.000 description 12
- 239000003599 detergent Substances 0.000 description 10
- 125000004432 carbon atom Chemical group C* 0.000 description 9
- 239000000945 filler Substances 0.000 description 9
- -1 alkali metal (e.g. Chemical class 0.000 description 8
- 125000000217 alkyl group Chemical group 0.000 description 8
- 229940117927 ethylene oxide Drugs 0.000 description 7
- 239000002245 particle Substances 0.000 description 7
- 238000005406 washing Methods 0.000 description 7
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 6
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 6
- HLZKNKRTKFSKGZ-UHFFFAOYSA-N tetradecan-1-ol Chemical compound CCCCCCCCCCCCCCO HLZKNKRTKFSKGZ-UHFFFAOYSA-N 0.000 description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 5
- 239000003093 cationic surfactant Substances 0.000 description 5
- 239000002736 nonionic surfactant Substances 0.000 description 5
- 239000002280 amphoteric surfactant Substances 0.000 description 4
- 125000000129 anionic group Chemical group 0.000 description 4
- 239000004744 fabric Substances 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 239000000523 sample Substances 0.000 description 4
- 239000007787 solid Substances 0.000 description 4
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 3
- 125000001931 aliphatic group Chemical group 0.000 description 3
- 229960003237 betaine Drugs 0.000 description 3
- 238000007906 compression Methods 0.000 description 3
- 230000006835 compression Effects 0.000 description 3
- 230000000249 desinfective effect Effects 0.000 description 3
- 238000004090 dissolution Methods 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 229940043348 myristyl alcohol Drugs 0.000 description 3
- 150000003242 quaternary ammonium salts Chemical class 0.000 description 3
- 239000000344 soap Substances 0.000 description 3
- 235000019832 sodium triphosphate Nutrition 0.000 description 3
- 229910021653 sulphate ion Inorganic materials 0.000 description 3
- 239000002888 zwitterionic surfactant Substances 0.000 description 3
- DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 2
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Natural products CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 2
- 150000004996 alkyl benzenes Chemical class 0.000 description 2
- 150000001449 anionic compounds Chemical group 0.000 description 2
- JXLHNMVSKXFWAO-UHFFFAOYSA-N azane;7-fluoro-2,1,3-benzoxadiazole-4-sulfonic acid Chemical compound N.OS(=O)(=O)C1=CC=C(F)C2=NON=C12 JXLHNMVSKXFWAO-UHFFFAOYSA-N 0.000 description 2
- 125000002091 cationic group Chemical group 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 239000007859 condensation product Substances 0.000 description 2
- 239000003995 emulsifying agent Substances 0.000 description 2
- 150000002191 fatty alcohols Chemical class 0.000 description 2
- 150000004820 halides Chemical class 0.000 description 2
- 229910001412 inorganic anion Inorganic materials 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- KCXFHTAICRTXLI-UHFFFAOYSA-N propane-1-sulfonic acid Chemical compound CCCS(O)(=O)=O KCXFHTAICRTXLI-UHFFFAOYSA-N 0.000 description 2
- 125000001453 quaternary ammonium group Chemical group 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 2
- RAADJDWNEAXLBL-UHFFFAOYSA-N 1,2-di(nonyl)naphthalene Chemical compound C1=CC=CC2=C(CCCCCCCCC)C(CCCCCCCCC)=CC=C21 RAADJDWNEAXLBL-UHFFFAOYSA-N 0.000 description 1
- UYYPOPWOFQHNHH-UHFFFAOYSA-N 1,2-dipentylnaphthalene Chemical compound C1=CC=CC2=C(CCCCC)C(CCCCC)=CC=C21 UYYPOPWOFQHNHH-UHFFFAOYSA-N 0.000 description 1
- XFRVVPUIAFSTFO-UHFFFAOYSA-N 1-Tridecanol Chemical compound CCCCCCCCCCCCCO XFRVVPUIAFSTFO-UHFFFAOYSA-N 0.000 description 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 1
- 235000013162 Cocos nucifera Nutrition 0.000 description 1
- 244000060011 Cocos nucifera Species 0.000 description 1
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical compound CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
- 229910021536 Zeolite Inorganic materials 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 150000001447 alkali salts Chemical class 0.000 description 1
- 125000002877 alkyl aryl group Chemical group 0.000 description 1
- 239000000908 ammonium hydroxide Substances 0.000 description 1
- 150000003863 ammonium salts Chemical class 0.000 description 1
- 150000001450 anions Chemical class 0.000 description 1
- 239000000440 bentonite Substances 0.000 description 1
- 229910000278 bentonite Inorganic materials 0.000 description 1
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 1
- 229960000686 benzalkonium chloride Drugs 0.000 description 1
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-M bisulphate group Chemical group S([O-])(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-M 0.000 description 1
- 238000004061 bleaching Methods 0.000 description 1
- 150000004649 carbonic acid derivatives Chemical class 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 235000010980 cellulose Nutrition 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- WOWHHFRSBJGXCM-UHFFFAOYSA-M cetyltrimethylammonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+](C)(C)C WOWHHFRSBJGXCM-UHFFFAOYSA-M 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 150000001860 citric acid derivatives Chemical class 0.000 description 1
- 239000012459 cleaning agent Substances 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 description 1
- 238000007907 direct compression Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 239000010459 dolomite Substances 0.000 description 1
- 229910000514 dolomite Inorganic materials 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 230000001804 emulsifying effect Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 238000005187 foaming Methods 0.000 description 1
- 229940083124 ganglion-blocking antiadrenergic secondary and tertiary amines Drugs 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000036571 hydration Effects 0.000 description 1
- 238000006703 hydration reaction Methods 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 1
- 238000004900 laundering Methods 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000007937 lozenge Substances 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- SXLLDUPXUVRMEE-UHFFFAOYSA-N nonanediperoxoic acid Chemical compound OOC(=O)CCCCCCCC(=O)OO SXLLDUPXUVRMEE-UHFFFAOYSA-N 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 235000020030 perry Nutrition 0.000 description 1
- 235000021317 phosphate Nutrition 0.000 description 1
- 150000004714 phosphonium salts Chemical class 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 150000003138 primary alcohols Chemical class 0.000 description 1
- 210000004761 scalp Anatomy 0.000 description 1
- PYILKOIEIHHYGD-UHFFFAOYSA-M sodium;1,5-dichloro-4,6-dioxo-1,3,5-triazin-2-olate;dihydrate Chemical compound O.O.[Na+].[O-]C1=NC(=O)N(Cl)C(=O)N1Cl PYILKOIEIHHYGD-UHFFFAOYSA-M 0.000 description 1
- IWMMSZLFZZPTJY-UHFFFAOYSA-M sodium;3-(dodecylamino)propane-1-sulfonate Chemical compound [Na+].CCCCCCCCCCCCNCCCS([O-])(=O)=O IWMMSZLFZZPTJY-UHFFFAOYSA-M 0.000 description 1
- HWCHICTXVOMIIF-UHFFFAOYSA-M sodium;3-(dodecylamino)propanoate Chemical compound [Na+].CCCCCCCCCCCCNCCC([O-])=O HWCHICTXVOMIIF-UHFFFAOYSA-M 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 239000004575 stone Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- RWSOTUBLDIXVET-UHFFFAOYSA-O sulfonium Chemical compound [SH3+] RWSOTUBLDIXVET-UHFFFAOYSA-O 0.000 description 1
- 239000001117 sulphuric acid Substances 0.000 description 1
- 235000011149 sulphuric acid Nutrition 0.000 description 1
- 239000003760 tallow Substances 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
- 239000010457 zeolite Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/02—Inorganic compounds ; Elemental compounds
- C11D3/04—Water-soluble compounds
- C11D3/046—Salts
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/0005—Other compounding ingredients characterised by their effect
- C11D3/0052—Gas evolving or heat producing compositions
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/02—Inorganic compounds ; Elemental compounds
- C11D3/04—Water-soluble compounds
- C11D3/10—Carbonates ; Bicarbonates
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/02—Inorganic compounds ; Elemental compounds
- C11D3/12—Water-insoluble compounds
- C11D3/124—Silicon containing, e.g. silica, silex, quartz or glass beads
- C11D3/1246—Silicates, e.g. diatomaceous earth
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/20—Organic compounds containing oxygen
- C11D3/22—Carbohydrates or derivatives thereof
- C11D3/222—Natural or synthetic polysaccharides, e.g. cellulose, starch, gum, alginic acid or cyclodextrin
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/20—Organic compounds containing oxygen
- C11D3/22—Carbohydrates or derivatives thereof
- C11D3/222—Natural or synthetic polysaccharides, e.g. cellulose, starch, gum, alginic acid or cyclodextrin
- C11D3/226—Natural or synthetic polysaccharides, e.g. cellulose, starch, gum, alginic acid or cyclodextrin esterified
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/37—Polymers
- C11D3/3703—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
- C11D3/3707—Polyethers, e.g. polyalkyleneoxides
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/37—Polymers
- C11D3/3746—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
- C11D3/3769—(Co)polymerised monomers containing nitrogen, e.g. carbonamides, nitriles or amines
- C11D3/3776—Heterocyclic compounds, e.g. lactam
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/02—Anionic compounds
- C11D1/04—Carboxylic acids or salts thereof
Definitions
- the present invention relates to unit dose tablet compositions.
- the invention further relates to a process for making such compositions, and methods of treating surfaces with such compositions.
- Unit dose cleaning compositions such as detergent tablets are one of the most consumer preferred products, due to ease of handling, dosage and storage. Such compositions are used to clean surfaces, such as bathroom surfaces, kitchen surfaces as well as to clean laundry surfaces.
- a low compression force improves dissolution but at the expense of tablet strength. This problem is compounded by the fact that conventional tablet compositions have relatively poor long-term storage-stability characteristics and, to compensate, have to be manufactured to a higher compression specification.
- WO 2000/43488A1 discloses a detergent tablet for use in a washing machine, the tablet having one or more phases at least one of which is in the form of a compressed particulate solid comprising: a) a polymeric disintegrant having a particle size distribution such that at least 90 % by weight thereof has a particle size below about 0.3mm and at least 30 % by weight thereof has a particle size below about 0.2mm; and b) a water-soluble hydrated salt having a solubility in distilled water of at least about 25g/100g at 25 °C.
- the detergent tablets of W00043488A1 still suffer from poor dissolvability when added to a bowl of water meaning that the detergent tablets do not meet consumer expectations, in particular in washing laundry.
- GB 2 339575 A discloses cellulose disintegrant for detergent compositions.
- DE 19843938 A1 discloses washing and cleaning agent shaped bodies which, as preparation components, contain substances selected from the group of alkali sulfates and/or alkaline-earth sulfates and/or alkaline-earth carbonates and/or alkaline-earth phosphates and/or alkaline-earth citrates. These shaped bodies are said to comprise advantageous properties with regard to application techniques if at least 60 weight percent of the designated alkali salts and/or alkaline-earth salts comprise particle sizes greater than 600 micrometers.
- US 2002/155976 A1 discloses a tablet of compacted particulate detergent composition comprising non-soap surfactant and detergency builder, and; a) disintegration-promoting particles comprising water-insoluble disintegrant which can swell to at least twice its volume on contact with water, and a water-absorbent carrier which so swells to a lesser extent, and b) water-soluble polymeric binder solid at 25 degrees centigrade, and either c) comprising 2 to 30 percent wt.
- water-soluble disintegration-promoting particles comprising at least 40 percent of materials selected from; compounds with water solubility at 20 degrees centigrade of at least 50 grams per 100 grams of water phase I sodium tripolyphosphate sodium tripolyphosphate that contains water of hydration in an amount which is at least 0.5 percent wt. of the sodium tripolyphosphate in the particles, or d) having a diametral fracture stress of at least 14 kPa.
- the tablets are said to exhibit good disintegration properties.
- US 2008/135062 A1 discloses a disinfecting tablet having rapid disintegration and low friability.
- the disinfecting tablet comprises sodium dichloro isocyanurate dihydrate and at least one swellable disintegrating agent assisting with rapid disintegration of the tablet.
- a disinfecting cleaning tool assembly and a method of cleaning.
- US 4 013581 A discloses peroxygen bleaches, especially diperazelaic acid, are provided in tablet form useful for bleaching fabrics.
- a unit-dose tablet composition comprising: a) a swellable disintegrant selected from microcrystalline cellulose, sodium starch glycolate and mixtures thereof; b) a non-swellable disintegrant selected from polyvinyl pyrrolidone, calcium silicate, starch, magnesium stearate and mixtures thereof; c) a water-soluble salt having a solubility in distilled water of in the range of 0.5 g/100 ml_ to 75 g/100 mL at 25 °C; d) an effervescent; and e) a surfactant.
- the present invention provides a process for preparing a unit dose tablet composition, comprising the steps of: a) providing a mix comprising: i) at least one surfactant; ii) a water-soluble salt having a solubility in distilled water in the range of 0.5 g/100 to 75 g/100 mL at 25 °C; iii) an effervescent; iv) a swellable disintegrant selected from microcrystalline cellulose, sodium starch glycolate and mixtures thereof; and, v) a non-swellable disintegrant, selected from polyvinyl pyrrolidone, calcium silicate, starch, magnesium stearate and mixtures thereof; b) compressing the mix to provide a unit dose tablet composition.
- step b) is carried out at pressure in the range of 2.5 to 100 kgf/cm 2 .
- the present invention provides a method of cleaning a surface comprising the step of dissolving a unit-dose tablet composition as defined herein in water to provide a solution of the cleaning composition, and contacting the surface with the cleaning composition, preferably wherein the surface is a hard surface, a soft surface or a laundry surface.
- the present invention provides a use of a unit-dose tablet composition as defined herein for cleaning a surface, preferably wherein the surface is a hard surface, a soft surface or a laundry surface.
- the unit dose tablet composition comprises a swellable disintegrant and a non-swellable disintegrant.
- a swellable disintegrant is one which has a water absorption ratio (WAR) of greater than 1 and a non-water swellable disintegrant is one which has a water absorption ratio of less than 1.
- Water Absorption Ratio is a measure as to how much water a material absorbs under controlled and defined conditions. The process described in ASTM D570 is used in this application.
- the swellable disintegrant is selected from microcrystalline cellulose, sodium starch glycolate and mixtures thereof.
- the swellable disintegrant comprises from 1 to 20% wt. of the unit dose tablet composition, more preferably from 2 to 18% wt. and most preferably from 5 to 15% wt.
- the non-swellable disintegrant is selected from polyvinyl pyrrolidone, calcium silicate, starch, magnesium stearate and mixtures thereof.
- the non-swellable disintegrant comprises from 1 to 10% wt. of the unit dose tablet composition, more preferably from 1.5 to 8% wt. and most preferably from 2 to 5% wt.
- the water-soluble salt has a solubility of at least 0.5 g/100 ml_ at 25 °C, preferably at least 1 g/100 ml_, more preferably at least 5 g/100 ml_, and most preferably at least 10 g/100 ml_ at 25 °C.
- the water-soluble salt has a solubility of at most 75 g/100 ml_, more preferably at most 70 g/100 ml_ at 25 °C, even more preferably at most 60 g/100 ml_.
- the water-soluble salt has a solubility of in the range of 0.5 g/100 ml_ to 75 g/100 ml_ at 25 °C, preferably 1 g/100 ml_ to 70 g /100 ml_ at 25 °C, more preferably 5 g/100 mL to 65 g/100 ml_ at 25 °C, even more preferably 10 g/100 mL to 60 g/100 ml_.
- the composition preferably comprises a water-soluble salt that is selected from anhydrous forms or hydrates of salts of mono or divalent alkali metals, preferably anhydrous forms or hydrates of salts of mono alkali metals, more preferably wherein the mono alkali metals is sodium or potassium.
- the anhydrous forms or hydrates of salts of mono alkali metals is selected from the group consisting of sodium chloride, sodium sulphate, sodium hydrogen carbonate, potassium chloride, potassium sulphate, potassium hydrogen carbonate and mixtures thereof.
- the unit-dose tablet composition preferably comprises 0.1 to 20 wt.% water soluble salt, preferably 1 to 15 wt.%, more preferably 5 to 10 wt.%.
- the composition comprises an effervescent.
- Suitable effervescents include organic acids such as citric acid, tartaric acid, fumaric acid, malic acid, adipic acid, succinic acid, and a carbonate salt.
- Preferred carbonate salts include sodium carbonate, potassium carbonate, calcium carbonate, sodium bicarbonate, potassium bicarbonate, calcium carbonate, calcium bicarbonate and magnesium carbonate as well as mixtures thereof.
- the level of effervescent is from 1 to 20% wt. of the composition, more preferably from 2 to 10% wt. of the composition.
- tablets comprise high amounts of filler however, we have found that this level may be significantly reduced thanks to the discovery that the claimed combination of disintegrants improve disintegration without such high levels of fillers.
- composition is also advantageous in that it requires less filler than typical tablet dose compositions.
- the unit dose cleaning composition comprises no more than 15% filler, more preferably no more than 10% wt. and most preferably no more than 7% filler.
- the composition comprises some filler though and this should be at least 5% wt. of the composition.
- Fillers suitable for use in the composition include calcium carbonate, zeolite, clays such as bentonite, dolomite and combinations thereof.
- the unit-dose tablet composition preferably has a diametral fracture stress (DFS) ratio of DFSair/DFSwater of at least 6, preferably at least 7, preferably at least 8 more preferably at least 9.
- DFS diametral fracture stress
- the unit-dose cleaning composition has a diametral fracture stress (DFS) ratio of DFSair/DFSwater in the range of 6 to 50, preferably 7 to 45.
- DFS diametral fracture stress
- the DFSair/DFSwater ratio can be measured using techniques known to the skilled person.
- the DFS can be measured using a texture analyser, for example a CT3 Brookfield Texture Analyser.
- the DFSair/DFSwater can be measured using a TA instrument, model TA-XT2i and the Texture Experte software (Texture Technologies Corp., Scarsdale, NY, USA/- Stable Micro Systems, Surrey, England, UK).
- the instrument is calibrated with a 5 kg load cell and fitted with a stainless steel flat-bottomed cylindrical probe with 1 cm 2 surface area (Kobe probe).
- the methodology consists in positioning the tablet to the flat surface of the probe.
- the probe moves until a trigger force is detected at which point the TA is set to maintain a predetermined nominal force for a given period of time (60 sec).
- the TA measures the penetration distance as the tablet is compressed while submerged in the medium (water).
- a constant temperature of the medium of 18°C is maintained during the tests by means of a thermos stated double wall cell and a heating bath/circulator (Haake, Düsseldorf, Germany).
- the unit-dose tablet composition comprises 1 to 80 wt.% surfactant system selected from anionic surfactants, cationic surfactants, non-ionic surfactants, amphoteric surfactants.
- the unit dose tablet composition of the invention preferably comprises an anionic surfactant or a mixture of anionic surfactants.
- Anionic surfactants are included in the composition for primary cleaning action by emulsifying the oil attached to the substrate. Any non-soap anionic surfactant known in the art for use in laundry detergents may be used herein. In general, these surfactants are described in well-known textbooks like "Surface Active Agents” Vol. 1, by Schwartz & Perry, Interscience 1949, Vol. 2 by Schwartz, Perry & Berch, Interscience 1958, and/or the current edition of "McCutcheon's Emulsifiers and Detergents” published by Manufacturing Confectioners Company or in "Tenside-Taschenbuch", H. Stache, 2nd Edn., Carl Hauser Verlag, 1981.
- a suitable class of anionic surfactants are water-soluble salts, particularly alkali metal (e.g., sodium or potassium), ammonium and alkylolammonium salts of organic sulphuric acid monoesters and sulphonic acids having in the molecular structure a branched or straight chain alkyl group and condensations products thereof containing 8 to 22 carbon atoms or an alkyl-aryl group containing 6 to 20 carbon atoms in the alkyl part.
- alkali metal e.g., sodium or potassium
- ammonium and alkylolammonium salts of organic sulphuric acid monoesters and sulphonic acids having in the molecular structure a branched or straight chain alkyl group and condensations products thereof containing 8 to 22 carbon atoms or an alkyl-aryl group containing 6 to 20 carbon atoms in the alkyl part.
- Preferred anionic surfactants include higher alkyl aromatic sulphonates such as higher alkyl benzene sulphonates containing from 6 to 20 carbon atoms in the alkyl group in a straight or branched chain, particular examples of which are higher alkyl benzene sulphonates or of higher-alkyl toluene, xylene or phenol sulphonates, alkyl naphthalene sulphonates, diamyl naphthalene sulphonate, and dinonyl naphthalene sulphonate; alkyl sulphates containing 8 to 22 carbon atoms and alkyl ether sulphates containing from 1 to 10 ethylene oxide or propylene oxide, preferably 2 to 3 ethylene oxide units per molecule.
- higher alkyl aromatic sulphonates such as higher alkyl benzene sulphonates containing from 6 to 20 carbon atoms in the alkyl group in a straight or
- Non-limiting examples of the anionic surfactants include any of the common anionic surfactants such as linear or modified, e. g. branched alkylbenzene sulphonates, alkylpoly(ethoxylates), sodium lauryl ether sulphates, methyl ester sulphonates, primary alkyl sulphates or mixtures thereof.
- the common anionic surfactants such as linear or modified, e. g. branched alkylbenzene sulphonates, alkylpoly(ethoxylates), sodium lauryl ether sulphates, methyl ester sulphonates, primary alkyl sulphates or mixtures thereof.
- the non-soap anionic surfactant is present in the detergent composition in a concentration of 5 to 60%, preferably not less than 10%, more preferably not less than 12%, still more preferably not less than 15% but typically not more than 40%, preferably not more than 35% or even not more than 30% by weight of the total composition.
- Anionic surfactant of the present invention may be combined with another surfactant generally chosen from non-ionic, cationic, amphoteric or zwitterionic surfactants.
- anionic surfactant In view of the anionic character of the anionic surfactant, cationic, amphoteric or zwitterionic surfactants when added are added at concentrations that do not hinder the performance of the composition.
- Suitable non-ionic surfactants include water soluble aliphatic ethoxylated nonionic surfactants commercially known, including the primary aliphatic alcohol ethoxylates and secondary aliphatic alcohol ethoxylates.
- non-ionic surfactants include, but are not limited to, the Neodol (trade mark, ex Shell) ethoxylates, which are higher aliphatic, primary alcohol containing about 9 to 15 carbon atoms, such as C9 to C11 alkanol condensed with 4 to 10 moles of ethylene oxide (Neodol 91-8 or Neodol 91-5), C12-13 alkanol condensed with 6.5 moles ethylene oxide (Neodol 23-6.5), C12-15 alkanol condensed with 12 moles ethylene oxide (Neodol 25-12), C14- 15 alkanol condensed with 13 moles ethylene oxide (Neodol 45-13), and the like.
- Neodol trade mark, ex Shell
- ethoxylates which are higher aliphatic, primary alcohol containing about 9 to 15 carbon atoms, such as C9 to C11 alkanol condensed with 4 to 10 moles of ethylene oxide (Neo
- Such ethoxamers have an HLB (hydrophobic lipophilic balance) value of about 8 to 15 and give good O/W emulsification, whereas ethoxamers with HLB values below 7 contain less than 4 ethyleneoxide groups and tend to be poor emulsifiers and poor detergents.
- HLB hydrophobic lipophilic balance
- Suitable amphoteric surfactants include derivatives of aliphatic secondary and tertiary amines containing an alkyl group of 8 to 18 carbon atoms and an aliphatic radical substituted by an anionic water-solubilizing group, such as sodium 3-dodecylamino- propionate, sodium 3- dodecylaminopropane sulphonate and sodium N-2-hydroxydodecyl-N-methyltaurate.
- Suitable cationic surfactants are quaternary ammonium salts according to the present invention are quaternary ammonium salts characterised in that the ammonium salt has the general formula: R1R2R3R4N+X- wherein R1 is a C12 to C18 alkyl group, each of R2, R3 and R4 independently is a C1 to C3 alkyl group and X is an inorganic anion.
- R1 is preferably a C14 to C16 straight chain alkyl group, more preferably C16.
- R2, R3 and R4 are preferably methyl groups.
- the inorganic anion (X-) is preferably chosen from halide, sulphate, bisulphate or hydroxide.
- a quaternary ammonium hydroxide is considered to be a quaternary ammonium salt. More preferably the anion is a halide ion or sulphate, most preferably a chloride or sulphate. Cetyl-trimethylammonium chloride is a specific example of a suitable compound and commercially abundantly available.
- quaternary ammonium cationic surfactant is the class of benzalkonium halides, also known as alkyldimethylbenzylammonium halides.
- the most common type being benzalkonium chloride, also known as alkyldimethylbenzylammonium chloride (or ADBAC).
- Suitable zwitterionic surfactants include derivatives of aliphatic quaternary ammonium, sulphonium and phosphonium compounds having an aliphatic radical of from 8 to 18 carbon atoms and an aliphatic radical substituted by an anionic water-solubilising group, for instance 3- (N-N-dimethyl-N-hexadecylammonium) propane-1 -sulphonate betaine, 3-(dodecylmethyl sulphonium) propane-1 -sulphonate betaine and 3- (cetylmethylphosphonium) ethane sulphonate betaine.
- anionic water-solubilising group for instance 3- (N-N-dimethyl-N-hexadecylammonium) propane-1 -sulphonate betaine, 3-(dodecylmethyl sulphonium) propane-1 -sulphonate betaine and 3- (cetylmethylphosphonium) ethane sulphonate betaine.
- the unit-dose tablet composition is preferably a shaped solid, preferably the unit dose shaped solid is a tablet, lozenge, block or cube.
- the composition may be used in washing machines, dishwashers, in toilet bowls, cisterns, water tanks, washing up bowls, surface cleaning and personal care applications.
- the present invention provides a process for preparing a unit dose tablet composition, comprising the steps of: a) providing a mix comprising: i) at least one surfactant; ii) adding a water-soluble salt having a solubility in distilled water in the range of 0.5 g/100 ml_ to 75 g/100 ml_ at 25 °C; iii) an effervescent; iv) a swellable disintegrant selected from microcrystalline cellulose, sodium starch glycolate and mixtures thereof; and, v) a non-swellable disintegrant, selected from polyvinyl pyrrolidone, calcium silicate, starch, magnesium stearate and mixtures thereof; b) compressing the mix to provide a unit dose tablet composition.
- step b) is carried out at pressure in the range of 2.5 to 100 kgf/cm 2 , more preferably 5 to 30 kgf/cm 2 .
- step i) also includes adding a builder and a filler.
- the amounts and ingredients described above for the unit-dose tablet composition apply mutatis mutandis to the method of preparing the unit-dose tablet composition.
- the present invention relates to a method of cleaning a surface comprising the step of dissolving a unit-dose tablet composition as defined herein in water to provide a solution of the cleaning composition and contacting a surface with the cleaning composition.
- the method of cleaning a surface comprising the step of dissolving a unit-dose tablet composition as defined herein in water, to provide a solution of the cleaning composition, and contacting a surface with the cleaning solution of the cleaning composition, preferably wherein the surface is a hard surface, a soft surface or a laundry surface.
- the surface to be cleaned is preferably selected from the group of hard, soft and laundry surfaces.
- surface is a hard surface.
- the hard surface is preferably selected from a bathroom, kitchen or floor surface.
- the bathroom surface is selected from the group consisting of baths, toilet bowls, toilet cisterns, shower surfaces, floors and tiles.
- the hard surface is a kitchen surface selected from the group of dishware, worktops, cooker tops, floors, ovens and sinks.
- the floor surface may be any stone, linoleum, tile, wood, laminate floor.
- the surface is a soft surface.
- the soft surface is selected from the skin and/or scalp.
- the unit dose composition is preferably dissolved in a container of water for washing the body, hair etc. In other words, the unit dose compositions may be used for personal care applications.
- the surface is a laundry surface.
- the laundry surface is preferably any fabric surface to be laundered.
- a fabric surface is, for example, clothes, towels, linen, bedding etc.
- the method of cleaning a surface comprises the step of dissolving a unit-dose cleaning composition as defined herein in water to provide a solution of the cleaning composition and contacting a surface with the cleaning composition wherein the surface is a laundry surface.
- the unit-dose tablet composition is added to a container of water to be used in the cleaning of hard, soft and laundry surfaces.
- the unit dose tablet composition is dosed in a bottle containing sufficient amount of water, thereby provides a cleaning composition in the bottle.
- the bottle may be equipped with a spray trigger or foaming engine.
- a consumer may dispense the cleaning composition directly on a surface as foam or spray.
- the ratio of the composition to the water is in the range from 1 : 10 to 1 :200, more preferably from 1 : 10 to 1 : 150 and most preferably from 1:10 to 1:100 by wt.
- the unit-dose tablet composition is added to a washing machine or a container of water to be used in laundering of fabrics.
- the present invention relates to the use of a unit-dose tablet composition as defined herein for cleaning a surface, wherein the surface is a hard surface, a soft surface or a laundry surface.
- Unit-dose tablet compositions were prepared according to Table 1. The water-soluble salt and disintegrant is post dosed to the remaining ingredients.
- Example A contains both microcrystalline celluloses as swellable disintegrant and crosslinked polyvinyl pyrrolidone as non-swellable disintegrant thereby falling within the scope of the invention, whereas example B to E are comparatives.
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- Oil, Petroleum & Natural Gas (AREA)
- Organic Chemistry (AREA)
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Abstract
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
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CN202280042868.0A CN117500907A (zh) | 2021-06-15 | 2022-06-01 | 单位剂量片剂组合物 |
BR112023025818A BR112023025818A2 (pt) | 2021-06-15 | 2022-06-01 | Composição em tablete de dose unitária, processo para prover uma composição em tablete de dose unitária, método de limpeza de uma superfície e uso de uma composição em tablete de dose unitária |
EP22731591.8A EP4355847A1 (fr) | 2021-06-15 | 2022-06-01 | Composition en comprimé monodose |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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EP21179488 | 2021-06-15 | ||
EP21179488.8 | 2021-06-15 |
Publications (1)
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WO2022263172A1 true WO2022263172A1 (fr) | 2022-12-22 |
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Application Number | Title | Priority Date | Filing Date |
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PCT/EP2022/064898 WO2022263172A1 (fr) | 2021-06-15 | 2022-06-01 | Composition en comprimé monodose |
Country Status (4)
Country | Link |
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EP (1) | EP4355847A1 (fr) |
CN (1) | CN117500907A (fr) |
BR (1) | BR112023025818A2 (fr) |
WO (1) | WO2022263172A1 (fr) |
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2022
- 2022-06-01 EP EP22731591.8A patent/EP4355847A1/fr active Pending
- 2022-06-01 WO PCT/EP2022/064898 patent/WO2022263172A1/fr active Application Filing
- 2022-06-01 CN CN202280042868.0A patent/CN117500907A/zh active Pending
- 2022-06-01 BR BR112023025818A patent/BR112023025818A2/pt unknown
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