WO2022226894A1 - 一种在鼻通道内缓慢释放化合物的缓释装置 - Google Patents
一种在鼻通道内缓慢释放化合物的缓释装置 Download PDFInfo
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- WO2022226894A1 WO2022226894A1 PCT/CN2021/090988 CN2021090988W WO2022226894A1 WO 2022226894 A1 WO2022226894 A1 WO 2022226894A1 CN 2021090988 W CN2021090988 W CN 2021090988W WO 2022226894 A1 WO2022226894 A1 WO 2022226894A1
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- Prior art keywords
- nasal
- arm
- nasal passage
- elastic
- expansion
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- 150000001875 compounds Chemical class 0.000 title claims abstract description 103
- 230000007246 mechanism Effects 0.000 claims abstract description 130
- 210000000492 nasalseptum Anatomy 0.000 claims description 100
- 210000001331 nose Anatomy 0.000 claims description 67
- 238000013268 sustained release Methods 0.000 claims description 63
- 239000012730 sustained-release form Substances 0.000 claims description 63
- 239000003814 drug Substances 0.000 claims description 47
- NOQGZXFMHARMLW-UHFFFAOYSA-N Daminozide Chemical compound CN(C)NC(=O)CCC(O)=O NOQGZXFMHARMLW-UHFFFAOYSA-N 0.000 claims description 18
- 239000011148 porous material Substances 0.000 claims description 14
- 238000010521 absorption reaction Methods 0.000 claims description 6
- 230000029058 respiratory gaseous exchange Effects 0.000 abstract description 11
- 238000005457 optimization Methods 0.000 description 20
- 230000000916 dilatatory effect Effects 0.000 description 16
- 239000007788 liquid Substances 0.000 description 15
- 239000007787 solid Substances 0.000 description 10
- 238000010586 diagram Methods 0.000 description 5
- 229940079593 drug Drugs 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 150000001491 aromatic compounds Chemical class 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 238000003780 insertion Methods 0.000 description 4
- 230000037431 insertion Effects 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 230000003993 interaction Effects 0.000 description 3
- 210000002850 nasal mucosa Anatomy 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 206010028735 Nasal congestion Diseases 0.000 description 2
- 206010028762 Nasal septum deviation Diseases 0.000 description 2
- 210000004204 blood vessel Anatomy 0.000 description 2
- 210000003928 nasal cavity Anatomy 0.000 description 2
- 238000009423 ventilation Methods 0.000 description 2
- 239000000341 volatile oil Substances 0.000 description 2
- 206010020751 Hypersensitivity Diseases 0.000 description 1
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- 206010039085 Rhinitis allergic Diseases 0.000 description 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
- 230000002745 absorbent Effects 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 201000010105 allergic rhinitis Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 235000019568 aromas Nutrition 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 238000005452 bending Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
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- 230000010339 dilation Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 208000001780 epistaxis Diseases 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 108091008039 hormone receptors Proteins 0.000 description 1
- 206010022437 insomnia Diseases 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 230000003447 ipsilateral effect Effects 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 239000007922 nasal spray Substances 0.000 description 1
- 230000008693 nausea Effects 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
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Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/08—Inhaling devices inserted into the nose
- A61M15/085—Fixing means therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/08—Inhaling devices inserted into the nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M29/00—Dilators with or without means for introducing media, e.g. remedies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
- A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
-
- A—HUMAN NECESSITIES
- A62—LIFE-SAVING; FIRE-FIGHTING
- A62B—DEVICES, APPARATUS OR METHODS FOR LIFE-SAVING
- A62B9/00—Component parts for respiratory or breathing apparatus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/06—Solids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2209/00—Ancillary equipment
- A61M2209/08—Supports for equipment
- A61M2209/088—Supports for equipment on the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/06—Head
- A61M2210/0618—Nose
Definitions
- the invention belongs to the technical field of medical devices, and relates to a sustained-release device for slowly releasing compounds in nasal passages.
- Nasal sprays are commonly used to treat allergic rhinitis and blocked nasal passages.
- the active ingredients of these drugs stimulate hormone receptors in the nose, constrict blood vessels, relieve nasal congestion and nasal congestion. Due to the direct contact of a large dose of the drug with the nasal mucosa in a short period of time, the number of the receptors will decrease rapidly. After a period of time, the nasal mucosa will become more congested and inflamed, and the blood vessels will become brittle and prone to nosebleeds.
- the sustained-release technology can avoid the instantaneous impact of the drug on the nasal mucosa, thereby reducing or even avoiding the occurrence of the above-mentioned side effects.
- a type of nose clip incorporates volatile aromatic compounds into the material.
- This type of nose clip has a simple structure and is easy to wear, but it will cause the aromatic compounds to directly contact and stimulate the inner wall of the nasal passage; and the aroma it carries
- this type of nose clip does not have the function of dilating the nasal passage, so it will hinder breathing to a certain extent;
- a class of nose clips is provided with an openable and closable cavity, the compound is placed in it, and the compound is released into the nasal passage through the opening on the cavity; however, because the cavity is provided, this type of nose clip is relatively thick , and does not have the function of expanding the nasal passage, so it will hinder breathing to a certain extent; in addition, because the opening and closing device of the cavity is small and complex, and its reliability is low, once it fails, it may cause an inhalation risk;
- the end of a class of nose clips is provided with a round tube, and a solid aromatic compound is placed in the round tube, and the solid compound is fixed by the narrowed part in the middle of the round tube; however, this type of nose clip cannot release the liquid compound; Moreover, since solid aromatic compounds are not hard, their fixing methods are not reliable enough, which may cause inhalation risks; in addition, such nose clips do not have the function of dilating nasal passages, so they will hinder breathing to a certain extent;
- a type of nose clip is provided with an expansion element used to expand the nasal passage and a release element fixed on the expansion element for releasing the compound; the ventilation of this type of nose clip is better than other nose clips, but its expansion element is different from the nasal passage.
- the contact area of the inner wall is small, and the pressure on the inner wall of the nasal passage is large, which is easy to cause discomfort, and it is difficult to expand the nasal passage in all directions; in addition, the expansion element is not provided with elastic support spokes, so there is insufficient expansion strength and balance. , and it is difficult to carry out targeted expansion of specific parts of the nasal passage; furthermore, its release element can only accommodate a small amount of compounds in a specific state and type, and the opening and closing device is small and complicated, and its reliability is insufficient;
- a type of nose clip has both filtering and releasing functions, and it includes a pair of cylindrical containers connected together by connecting strips, and the cylindrical container is provided with a filter and an absorbing gasket capable of absorbing liquid medicine, and the absorbing gasket can The drug is released into the inhaled air stream; however, these types of nose clips cannot release solid compounds; and the inhaled air passes through the filter and absorbent pad, and the breathing resistance is high, so it is less versatile and only suitable for specific situations.
- the present invention proposes a sustained-release device for slowly releasing a compound in a nasal passage.
- the sustained-release device includes: a connection mechanism, two expansion mechanisms, and two release mechanisms;
- the two ends of the connecting mechanism are respectively integrally or detachably connected to two expansion mechanisms symmetrically arranged in the nasal passages on both sides;
- the two release mechanisms are symmetrically arranged, and each release mechanism is correspondingly arranged in each expansion mechanism Inside;
- the connecting mechanism includes at least one connecting beam, the connecting beam half surrounds the lower end of the nasal septum, which includes: a middle part located on the lower side of the nasal septum and two connecting arms symmetrically arranged on both sides of the nasal septum; the middle part is located between the two connecting arms. between the arms; the two connecting arms are respectively connected to two expansion mechanisms symmetrically arranged in the two nasal passages;
- the release mechanism includes: at least one fixation tube and at least one release element;
- the fixing tube is a tubular structure, which is arranged on the expansion mechanism; the releasing element is a structure with wide ends and a narrow middle.
- the fixing tube surrounds the thinner middle of the releasing element.
- the two ends of the release element are located outside the two ends of the fixed tube, and the maximum width of the two ends of the release element is greater than the maximum width of the inner cavity of the fixed tube; the release element can accommodate a certain amount of compound and allow the accommodated compound to be in the nose. Slow release in the channel, when worn, at least part of the release element is located in the nasal channel.
- the expansion mechanism includes: an elastic expansion arm; the elastic expansion arm is an annular closed structure, which is connected with the end of a connecting arm; the fixing tube is arranged on the inner side of the elastic expansion arm. On the surface, the release element is sleeved in the fixed tube.
- the two connecting arms of the connecting beam are symmetrically provided with widened portions, and the width of the surface of the connecting arms toward the side of the nasal septum increases at the widened portion; the two widened portions are widened.
- the top fits both sides of the nasal septum and applies a clamping force to the nasal septum.
- the expansion mechanism includes: an elastic expansion arm and at least one elastic support spoke;
- the elastic expansion arm is an annular closed structure, which is connected with the end of one connecting arm; the elastic support spoke is bifurcated and includes a plurality of branches, one end of each branch is connected to the main part of the elastic support spoke, and the other end is fixed On the elastic expansion arm; the fixing tube is arranged on the elastic support spoke, and the releasing element is sleeved in the fixing tube.
- the elastic support spokes, the fixing tube and the releasing element are located above the elastic expansion arm, forming an inverted bowl-like structure.
- the expansion mechanism includes: an elastic expansion arm and at least one elastic support spoke;
- the elastic expansion arm is an annular closed structure, which is connected with an end of a connecting arm; the elastic support spoke is a belt-like structure, and its two ends are connected to the elastic expansion arm.
- the connecting mechanism includes a first connecting beam and a second connecting beam arranged longitudinally side by side; both the first connecting beam and the second connecting beam half surround the lower end of the nasal septum.
- the two second connecting arms of the second connecting beam are symmetrically provided with protrusions facing the wearer's nasal septum; the protrusions fit both sides of the nasal septum and apply a bag to the nasal septum clamping force.
- the ends of the two second connecting arms of the second connecting beam are provided with plugs, and the plugs are inserted into the sockets provided at the roots of the first elastic support spokes, and the plugs are
- the structure with wide ends and narrow middle realizes plug-in fixation.
- the expansion mechanism includes: an elastic expansion arm, a nasal passage engaging element and at least one elastic support spoke;
- the elastic expansion arm is an elastically compressible open band-like structure, which is connected with the end of a connecting arm, and the outer main surface of the elastic expansion arm can partially or completely fit the inner wall of the nasal passage, so that it can not only apply energy from the nose to the nose wing.
- the expansion force of the elastic expansion arms and elastic support spokes can also apply the clamping force from the connecting beam to the nasal septum;
- the nasal passage engaging element is a sheet-like structure, which is connected with the elastic expansion arm and keeps the expansion mechanism in an open structure; when worn, the nasal passage engaging element is located on the inner side of the alar of the nose, and its outer main surface is fitted with the inner wall of the alar of the nose, and faces the alar of the nose. Apply expansion force from elastic expansion arms and elastic support spokes;
- the elastic support spokes are elastically compressible belt-like or strip-like structures, the two ends of which are connected to the elastic expansion arms or the nasal passage engaging elements.
- the elastic expansion arm is integrated with the nasal passage engaging element.
- the cross section of the elastic expansion arm perpendicular to the axis of the nasal passage is a V-shaped structure or a C-shaped structure, which includes: a curved part, a proximal arm and a distal arm;
- One end of the curved portion is connected to the proximal arm, and the other end is connected to the distal arm.
- the proximal arm When worn, the proximal arm is close to the nasal septum, the distal arm is close to the nose wing, and the curved portion is close to the bridge or bottom of the nose.
- the end of the elastic expansion arm that is in contact with the inner wall of the nasal passage is bent toward the inside of the nasal passage; the end of the nasal passage engaging element is bent toward the inside of the nasal passage.
- the elastic support spoke is bifurcated and has a plurality of branches, one end of each branch is connected to the main part of the elastic support spoke, and the other end is fixed to the elastic expansion arm or the nose channel joint on the component.
- the connecting beam applies a wrapping force to the nasal septum, and the wrapping force is directly applied to the lower end of the nasal septum by the two connecting arms of the connecting beam, or the wrapping force is applied by the two connecting arms of the connecting beam After the connecting arm is transmitted to the corresponding expansion mechanism, it is applied to the lower end of the nasal septum by the corresponding expansion mechanism.
- the average cross-sectional area of the middle portion of the connecting beam is larger than the average cross-sectional area of the connecting arm.
- the release element includes: a medicine bucket, a bucket cover and a bucket bottom connected to and covering both ends of the medicine bucket; the maximum diameter of the bucket cover is greater than the maximum diameter of the medicine bucket; the maximum diameter of the bucket bottom greater than the maximum diameter of the medicine barrel;
- the medicine bucket is a hollow tubular structure, the inside of which contains the compound, and at least one opening is provided on the bucket cover and the bucket bottom, so that the compound is discharged to the nasal passage through the opening.
- an absorption block made of porous material is arranged in the medicine barrel.
- the release element is made of porous material.
- the outer surface of the release element is provided with a protuberance.
- the expansion mechanism of the sustained-release device of the present invention adopts a closed structure or an open structure, which improves the function and applicability of the sustained-release device, and also improves the diversity of its specific embodiments.
- the outer main surface of the elastic expansion arm can also fit the inner wall of the nasal passage, which increases the contact area between the expansion mechanism and the inner wall of the nasal passage, which is conducive to the all-round expansion of the nasal passage and reduces the expansion mechanism.
- the pressure on the inner wall of the nasal passage improves comfort.
- At least one elastic support spoke is adopted to ensure the strength and balance of the expansion, and can carry out targeted expansion to the specific part of the nasal passage.
- the release element does not contact the inner wall of the nasal passage, so that the compound contained therein can be prevented from contacting and irritating the inner wall of the nasal passage.
- the release element adopts a cylindrical structure, and its cross-sectional area is small, so it has less air resistance, and by increasing the length of the release element along the axis of the nasal passage, its capacity can be effectively increased without increasing air resistance.
- the fixing method of the release element is simple and reliable, avoiding the risk of falling off and inhalation.
- the rate at which it releases the compound can be adjusted by substituting different release elements or parts thereof.
- Figure 1A is a side view of a human nose
- 1B is a side cross-sectional view of a human nose
- Figure 1C is a bottom-up top view of the human nose
- FIG. 2 is a schematic structural diagram of a first preferred embodiment of a sustained-release device for slowly releasing a compound in a nasal passage and expanding the nasal passage according to the present invention
- Figure 3 is a top view of a first preferred embodiment of the sustained release device of Figure 2 for slowly releasing a compound in the nasal passage and dilating the nasal passage;
- Figure 4 is a side view from one direction of the first preferred embodiment of the sustained release device of Figure 2 for slowly releasing a compound in a nasal passage and dilating the nasal passage;
- Figure 5 is a side view from another direction of the first preferred embodiment of the sustained release device of Figure 2 for slowly releasing a compound in a nasal passage and dilating the nasal passage;
- FIG. 6 is a schematic structural diagram of a first preferred embodiment of the sustained-release device for slowly releasing a compound in the nasal passage and expanding the nasal passage of the present invention of FIG. 2 with an elastic support spoke;
- FIG. 7 is a side cross-sectional view of the release element of the first preferred embodiment of the sustained-release device of FIG. 2 for slowly releasing a compound in a nasal passage and dilating the nasal passage of the present invention
- FIG. 8 is a bottom-up plan view of the first preferred embodiment of the sustained-release device of FIG. 2 for slowly releasing a compound in the nasal passage and dilating the nasal passage of the present invention installed on the nose of a user;
- FIG. 9 is a side view of the first preferred embodiment of the sustained-release device of FIG. 2 for slowly releasing a compound in the nasal passage and dilating the nasal passage of the present invention installed on the nose of a user;
- Figure 10 is a schematic structural diagram of a second preferred embodiment of a sustained-release device for slowly releasing a compound in a nasal passage and expanding the nasal passage according to the present invention
- Figure 11 is a top plan view of a second preferred embodiment of the sustained release device of Figure 10 for slowly releasing a compound in a nasal passage and dilating the nasal passage;
- Figure 12 is a structural diagram of a second preferred embodiment of the sustained-release device for slowly releasing a compound in a nasal passage and dilating the nasal passage of Figure 10 with bifurcated elastic support spokes;
- Figure 13 is a side cross-sectional view of the release element of the second preferred embodiment of the sustained release device of Figure 10 for slowly releasing a compound in a nasal passage and dilating the nasal passage;
- FIG. 14 is a schematic structural diagram of a third preferred embodiment of a sustained-release device for slowly releasing a compound in a nasal passage and expanding the nasal passage according to the present invention
- Figure 15 is a top view of a third preferred embodiment of the sustained release device of Figure 14 for slowly releasing a compound in a nasal passage and dilating the nasal passage;
- Figure 16 is a side view of a third preferred embodiment of the sustained release device of Figure 14 for slow release of a compound in the nasal passage and expansion of the nasal passage;
- 17A is a side cross-sectional view of the release element of the third preferred embodiment of the sustained release device of FIG. 14 for slowly releasing a compound in a nasal passage and dilating the nasal passage of the present invention
- 17B is a side cross-sectional view of the release element of the third preferred embodiment of the slow release device of FIG. 14 for slowly releasing a compound in a nasal passage and dilating the nasal passage of the present invention, the two ends of the release element are provided have bulges;
- Figure 18A is a top view of a positional relationship between an elastic expansion arm and a nasal passage engaging element of another embodiment of a sustained release device for slowly releasing a compound in a nasal passage and dilating the nasal passage of the present invention
- 18B is a top view of another positional relationship between the elastic expansion arm and the nasal passage engaging element of another embodiment of a sustained release device for slowly releasing a compound in the nasal passage and dilating the nasal passage of the present invention
- the first branch 74 The second branch
- the description of the sustained-release device 1 in the present invention is as follows: Except for the connecting beam 2, the rest of the components are located in a nasal passage in quantity and structure.
- the various directions of the nose according to the present invention are: the front 11 of the nose, the rear 12 of the nose, the upper part 13 of the nose, and the lower part 14 of the nose.
- the side of the object close to the nasal passage axis 97 is “inside” and the side away from the nasal passage axis 97 is “outside”.
- connection in the present invention means that two tangible objects are integrally connected together, or are detachably connected together through a connector, and the connection methods include but are not limited to: bonding, welding, plugging, screwing Connection, snap connection.
- axis in the context of the present invention refers to the central axis of symmetry of the tubular or cylindrical object.
- the axis of the standard tube or column can be used as its approximate axis.
- FIG. 1B depicts nasal passage axis 97 .
- cross-section in the context of the present invention refers to the cross-section of the tube or column perpendicular to its axis.
- compound as used in the present invention is not strictly chemically defined, but shall include solid and liquid pure substances, compounds and mixtures, as well as other forms or combinations of substances suitable for use in the present invention, the compounds may be pharmaceutically or non-pharmaceutical Medicinal, including but not limited to drugs and aromatic substances.
- closed structure is a closed plane figure composed of n (n is a positive integer) line segments or arcs, such as: circle, ellipse, polygon;
- opening structure described in the present invention is Refers to a plane figure with an opening on a closed figure, such as C-shape, V-shape, L-shape, and arc.
- tubular structure in the present invention refers to a columnar structure with a cavity passing through in the axial direction, and the columnar structure includes but is not limited to cylinders and prisms.
- the sustained release device 1 of the present invention is applied to the nose 9 of a human being.
- the nose 9 is a visually visible protruding part of the face, including: the nasal septum 91, the alar 92, the bridge 93 and the bottom 99 of the nose, and two nasal passages 95 surrounded by them.
- the outlets of the two nasal passages 95 are the two nostrils 94 .
- the nasal passage inner wall 96 is constituted by the inner surface of each portion surrounding the nasal passage 95 as described above.
- the nasal passage 95 is limited to the nasal vestibule contained by the nose 9 , and does not include the nasal cavity 98 .
- the present invention provides a sustained-release device 1 for slowly releasing a compound in the nasal passage 95 and expanding the nasal passage 95, which comprises: a connecting mechanism, two expanding mechanisms and two releasing mechanisms;
- Two ends of the connecting mechanism are respectively integrally or detachably connected to two expansion mechanisms symmetrically arranged in the nasal passages 95 on both sides; the two release mechanisms are symmetrically arranged, and each release mechanism is correspondingly arranged in each expansion mechanism.
- the dilation mechanism is used to dilate the nasal passage 95 and the release mechanism is used to contain and release the compound.
- the connecting mechanism includes at least one connecting beam 2, the connecting beam 2 half surrounds the lower end of the nasal septum 91, which includes: a middle portion 23 located on the lower side of the nasal septum 91 and a middle portion 23 located on the lower side of the nasal septum 91.
- the connecting arms 24 are respectively connected to two expansion mechanisms symmetrically arranged in the two nasal passages 95; preferably, the connecting beam 2 is a U-shaped or C-shaped structure, wherein the C-shaped structure is more conducive to the ends of the connecting arms 24 A clamping force is applied to the nasal septum 91 .
- the connecting beam 2 also provides a fixing function for the sustained-release device 1, and the minimum distance between the two connecting arms 24 is smaller than the width of the nasal septum 91, so that it applies a clamping force to the nasal septum 91, and the clamping force
- the two connecting arms 24 of the connecting beam 2 are directly applied to both sides of the nasal septum 91, or after the two connecting arms 24 of the connecting beam 2 are conducted to the corresponding expansion mechanism, the elastic expanding arms 3 are applied to both sides of the nasal septum 91. ;
- the above-mentioned clamping force enables the sustained-release device 1 to be clamped and fixed in the nasal septum 91 .
- the average cross-sectional area of the middle portion 23 of the connecting beam 2 is larger than the average cross-sectional area of the connecting arm 24, so that the middle portion 23 is thicker than the connecting arm 24, thereby strengthening the connecting beam 2.
- the connecting beam 2 in the connecting mechanism of the slow release device 1 includes: a first connecting beam 21 and a second connecting beam 22 .
- the expansion mechanism is integrally connected and uses the same material, which cannot support the first connecting beam 21 to provide sufficient clamping force, therefore, a second connecting beam 22 is also provided at a position longitudinally juxtaposed with the first connecting beam 21, The clamping force on the nasal septum 91 is supplemented by the second connecting beam 22 .
- the two connecting arms 24 of the connecting beam 2 are provided with protrusions 242 facing the nasal septum 91, the protrusions 242 fit on both sides of the nasal septum 91, and Apply a clamping force to the nasal septum; when the protrusion 242 provides the function of clamping and fixing, the ends of the two connecting arms 24 of the connecting beam 2 can be connected to the expansion mechanism at a position deeper into the nasal passage 95, thereby helping to dilate The mechanism and release mechanism are positioned further into the nasal passage 95 .
- the two connecting arms 24 are provided with widened portions 241 , and the connecting mechanism applies a clamping force to the nasal septum 91 through the widened portions 241 ; and the connecting arms 24 are toward the nasal septum 91 .
- the width of the side surface is increased at the widened portion 241 to increase the fitting area between the widened portion 241 and the nasal septum 91 , thereby reducing the pressure of the connecting beam 2 on the nasal septum 91 to improve comfort.
- the connecting beam 2 When the connecting beam 2 is provided with the widened part 241 and the protrusion 242 at the same time, the two can be combined into the same part, and the part has the characteristics of the widened part 241 and the protrusion 242 .
- the ends of the two connecting arms 24 of the connecting beam 2 are provided with plugs 243 .
- the plugs 243 are wide at both ends and narrow in the middle.
- the connecting beam 2 is fixed on the expansion mechanism by plugging;
- the plug 243 is inserted into the insertion hole 77 provided on the elastic expansion arm 3 or the elastic support spoke 7 to realize plug-in fixation; the plug 243 is wide at both ends and narrow in the middle.
- the structure includes: a cap 2431, a post 2432 and a handle 2433, the insertion hole 77 is tightly engaged with the post 2432, the maximum width of the handle 2433 is greater than the maximum width of the post 2432, and the maximum width of the cap 2431 is greater than the maximum width of the post 2432; At the same time, the maximum width of the handle 2433 is greater than the maximum width of the inner cavity of the socket 77, and the maximum width of the cap 2431 is larger than the maximum width of the inner cavity of the socket 77; so that the plug 243 cannot be disengaged;
- the lumen may be prismatic to avoid rotation of the expansion mechanism about the plug 243.
- each expansion mechanism includes: an elastic expansion arm 3 , a nasal passage engaging element 4 and at least one elastic support spoke 7 ;
- the nasal passage engaging element 4 is a sheet-like structure, which is connected with the elastic expansion arm 3 .
- the nasal passage engaging element 4 is located on the inner side of the nasal alar 92 and is applied to the nasal alar 92 .
- a pair of surfaces of the nasal passage engaging element 4 parallel to the nasal passage axis 97 are its major and largest surfaces, in particular the inner major surface 41 and the outer major surface 42, the width of which is generally greater than the elastic expansion
- the width of the ipsilateral surface of the arm 3; the outer major surface 42 fits the inner wall of the alar 92 and applies the expansion force from the elastic expansion arm 3 and the elastic support spokes 7 to the alar 92, the nasal passage engaging element 4 is perpendicular to the nasal passage axis 97
- the surface of the subsurface is the subsurface, and the width of the subsurface is smaller than the width of the main surface, so as to reduce the breathing resistance.
- the elastic expansion arm 3 is an elastically compressible open band structure, such as a C-shaped, V-shaped, L-shaped or arc-shaped band structure, which is connected to To the connecting arm 24 and the nasal passage engaging element 4; a pair of surfaces of the elastic expansion arm 3 parallel to the nasal passage axis 97 are its main and largest surfaces, in particular the inner main surface 34 and the outer main surface 35 , the surface of the elastic expansion arm 3 perpendicular to the nasal passage axis 97 is the secondary surface, and the width of the secondary surface is smaller than the width of the main surface to reduce the breathing resistance; as shown in FIG.
- the outer main surface 35 of the elastic expansion arm 3 is partially Or fully fit the inner wall 96 of the nasal passage, so that it can not only apply the expansion force from the elastic expansion arm 3 and the elastic support spokes 7 to the nasal alar 92, but also apply the clamping force from the connecting beam 2 to the nasal septum 91; due to the elastic expansion Arm 3 is an open structure, so it has strong adaptability to nasal passages of different shapes and sizes, and is especially suitable for users with different sizes of left and right nasal passages caused by nasal septum deviation, thereby improving user experience and comfort, and Ergonomic design.
- the width of the nasal passage engaging element 4 is equal to or smaller than the width of the elastic expansion arm 3, and the main surfaces on the same side of the two are smoothly connected and merged into the same surface, that is: the inner main surface 34 and the inner
- the main surface 41 is fused into one surface
- the outer main surface 35 and the outer main surface 42 are fused into one surface.
- the elastic expansion arm 3 and the nasal passage engaging element 4 are integrated into one, and the function of the nasal passage engaging element 4 is completely controlled by the elastic expansion arm. 3
- the expansion mechanism now no longer includes the nasal passage engaging element 4, but only the elastic expansion arms 3 and the elastic support spokes 7.
- the end portion of the elastic expansion arm 3 that fits with the inner wall 96 of the nasal passage is bent toward the inside of the nasal passage 95.
- the proximal arm 32 and the distal arm 33 of the elastic expansion arm 3 are The end is a hook 36 which can flexibly contact the inner wall 96 of the nasal passage; the end of the nasal passage engaging element 4 is bent towards the inside of the nasal passage 95 .
- the cross section of the elastic expansion arm 3 perpendicular to the nasal passage axis 97 is a V-shaped or C-shaped structure, which includes: a curved portion 31 , a proximal arm 32 and the distal arm 33;
- One end of the curved portion 31 is connected to the proximal arm 32, and the other end is connected to the distal arm 31.
- the proximal arm 32 is close to the nasal septum 91
- the distal arm 33 is close to the alar 92
- the curved portion 31 is close to the bridge of the nose 93 or the bottom of the nose 99, that is,
- the opening of the elastic expansion arm 3 can be toward the bridge of the nose 93 or the bottom of the nose 99; the outer main surface 35 of the elastic expansion arm 3 is in contact with the inner wall 96 of the nasal passage, as shown in FIG.
- the inner wall 96 is compressed, the distal arm 33 and the proximal arm 32 are close to each other, and the resilient force of the curved portion 31 causes the distal arm 33 and the nasal passage engaging element 4 to apply an expansion force to the nasal alar 92, thereby expanding the nasal passage.
- the channel engaging element 4 is in close contact with the inner wall 96 of the nasal channel, and its interaction force fixes the sustained release device 1 in the nasal channel 95 .
- the elastic expansion arm 3 is an arc-shaped or L-shaped open band structure, one end of which is connected to the end of the connecting arm 24 and the other end is connected to the nasal passage engaging element 4
- the inner main surface 41 of the elastic expansion arm 3 is not integrated with the nasal passage engaging element 4.
- the outer main surface 42 of the nasal passage engaging element 4 fits the inner wall 96 of the nasal passage, but the elastic expansion arm 3 does not fit the nose.
- the inner wall 96 of the channel in addition, because the expansion mechanism and the inner wall 96 of the nasal channel have a small abutment area, there are no elastic support spokes to provide multi-point support.
- the elastic expansion arm 3 is an arc-shaped or L-shaped open band structure, one end of which is connected to the end of the connecting arm 24 and the other end is connected to the nasal passage engaging element 4
- the outer main surface 42 of the nasal passage engaging element 4 fits the inner wall 96 of the nasal passage, but the elastic expansion arm 3 does not fit the inner wall 96 of the nasal passage, because the elastic expansion arm 3 and the nasal passage engaging element 4
- the corresponding major surfaces of are not smoothly connected nor form a surface, so the two are not fused into one.
- the elastic support spokes 7 are elastically compressible belt-like or strip-like structures, the two ends of which are connected to the elastic expansion arms 3 or the nasal passage engaging elements 4. When worn, the elastic support spokes 7 compress their own The resilient force is applied to the elastic expansion arm 3 and/or the nasal passage engaging element 4; the elastic support spokes 7 can improve the expansion force of the expansion mechanism, and at the same time, it also improves the balance of expansion, because the elastic expansion arm 3 is an open structure, the more The weaker the resilient force is near the end, the elastic support spokes 7 can provide targeted support to the specific positions of the elastic expansion arm 3 and the nasal passage engaging element 4, thereby ensuring the balance of the expansion mechanism to the expansion of the nasal passage 95 ;
- the elastic support spoke 7 is bifurcated and includes a plurality of branches, specifically: a first branch 73, a second branch 74, a third branch 75 and a fourth branch 76, each of which One end of the branch is connected to the trunk part of the elastic support spoke 7, and the other end is fixed on the elastic expansion arm 3 or the nose channel engaging element 4; the multiple branches of the elastic support spoke 7 make it have stronger resilience, so as to further improve At the same time, its multiple branches also provide more support points, which further improves the pertinence and balance of expansion.
- the expansion mechanism includes: an elastic expansion arm 3; the elastic expansion arm 3 is an annular closed structure, and its outer main surface 35 fits the inner wall 96 of the nasal passage;
- the elastic expansion arm 3 is compressed by the inner wall 96 of the nasal passage, its resilience forces it to exert expansion force on all directions of the nasal passage 95; at the same time, the elastic expansion arm 3 is closely attached to the inner wall 96 of the nasal passage, and the interaction force of the two The sustained release device 1 is secured within the nasal passage 95 .
- the annular elastic expansion arm 3 can expand the nasal passage in all directions, and can increase the contact area between the expansion mechanism and the inner wall 96 of the nasal passage, thereby reducing the pressure of the expansion mechanism on the inner wall 96 of the nasal passage to improve comfort.
- the expansion mechanism includes: an elastic expansion arm 3 and at least one elastic support spoke 7; the elastic expansion arm 3 is an annular structure, and the elastic support spoke 7 is bifurcated and includes multiple There are two branches, specifically: the first branch 73, the second branch 74 and the third branch 75, one end of each branch is connected to the main part of the elastic support spoke 7, and the other end is fixed on the elastic expansion arm 3, when wearing, The elastic support spokes 7 apply their own compressed resilience to the elastic expansion arms 3; The inverted bowl-shaped structure facilitates the release of the compound deeper into the airway by the release mechanism.
- the expansion mechanism includes: an elastic expansion arm 3 and at least one elastic support spoke 7; the elastic expansion arm 3 is an annular closed structure, and the elastic support spoke 7 is a flexible The elastically compressed belt-like or strip-like structure, the two ends of which are connected to the elastic expansion arm 3 .
- each release mechanism is symmetrically arranged, each release mechanism is correspondingly arranged in each expansion mechanism, and each release mechanism includes: at least one fixing tube 5 and at least one releasing element 6 ;
- the fixing tube 5 is a tubular structure, which is used to fix the release element 6 , the fixing tube 5 is arranged at the opening direction of the elastic expansion arm 3 , and passes through the first branch 73 , the second branch 74 , the first branch 74 , the The three branches 75 and the fourth branch 76 fix the fixing tube 5 on the trunk portion of the elastic support spokes 7 ; as shown in FIGS. 10 and 14 , in other specific embodiments, the fixing tube 5 is fixed on the The inner side or the inner side of the nasal passage engaging element 4, specifically, the fixing tube 5 as shown in FIG. 10 is fixed on the inner side of the annular elastic expansion arm 3; as shown in FIG.
- the quadrangular prism-shaped The fixing tube 5 is fixed on the second elastic support spokes 72 .
- the sustained-release device 1 is provided with a plurality of fixed tubes 5 and release elements 6 to increase the capacity of the compound or increase the release rate of the compound.
- the release element 6 is a structure with wide ends and a narrow middle. When worn, the release element 6 is fixed on the fixing tube 5 , and the fixing tube 5 surrounds the lower part of the release element 6 .
- the two ends of the release element 6 are located outside the two ends of the fixed pipe 5, and its maximum width is greater than the maximum width of the inner cavity of the fixed pipe 5, so that the release element 6 cannot be disengaged from the fixed pipe 5;
- the release element 6 is capable of containing a certain amount of the compound and allows the compound to be slowly released in the nasal passage 95, and the release element 6 is located at least partially within the nasal passage 95 when worn.
- the release mechanism has the following advantages: first, the fixing method is simple and reliable; second, the cross-sectional area is small and the breathing resistance is small; Increase the breathing resistance; Fourth, by replacing different types of release elements 6, it can be adapted to different compounds or provide different release rates; Fifth, the compounds contained in the release elements 6 can be easily replaced; Sixth, it can be released by adjusting The number of openings and the size of the openings in the element 6 adjust the release rate of the compound.
- the material of the release element 6 is a porous material, which is used to absorb and store liquid compounds, and its porous surface is particularly conducive to the volatilization of the compounds, and is also conducive to The inhalation airflow from the nasal passages entrains tiny droplets of the compound, so the porous material is capable of releasing not only volatile liquid compounds, but also non-volatile liquid compounds in the form of tiny droplets.
- the surfaces of both ends of the release element 6 made of the porous material are provided with bumps 65 to further expand the surface area and increase the release speed.
- the release element 6 includes: a medicine bucket 61, a bucket lid 62 and a bucket bottom 63 connected to and covering both ends of the medicine bucket 61;
- the maximum width of the barrel cover 62 and the barrel bottom 63 is greater than the maximum width of the medicine barrel 61;
- the medicine barrel 61 is a hollow tubular structure, and its interior is used for accommodating solid and liquid compounds, and the barrel cover 62 and the barrel bottom 63 are provided with at least one Openings allow the compound to exit through the openings.
- an absorption block 641 made of a porous material is arranged in the medicine barrel 61 to absorb and accommodate the liquid compound, prevent the liquid compound from flowing out from the opening, and can also lift the compound through its porous surface. release speed.
- the sustained release device 1 includes: a connection mechanism, two expansion mechanisms and two release mechanisms.
- the connecting mechanism includes: a connecting beam 2 with a U-shaped structure, the connecting beam 2 half surrounds the lower end of the nasal septum 91, as shown in Fig. 2, the connecting beam 2 Including: the middle part 23 located on the lower side of the nasal septum 91 and the two connecting arms 24 located on both sides of the nasal septum 91, the two ends of the middle part 23 are respectively connected to the two connecting arms 24; Both sides are inserted into the two nasal passages 95, which are respectively integrally connected to the two elastic expansion arms 3 symmetrically arranged in the two nasal passages 95; the minimum distance between the two connecting arms 24 is smaller than the width of the nasal septum 91 there, Make it apply a clamping force to the nasal septum 91, thereby fixing the sustained-release device 1 on the nasal septum 91; the average cross-sectional area of the middle portion 23 is greater than the average cross-sectional area of the connecting arm 24, so that the middle portion 23 is thicker than the connecting arm 24, In order to improve the
- the two connecting arms 24 of the connecting beam 2 can be symmetrically provided with widened portions 241, and the width of the surface of the connecting arms 24 toward the nasal septum 91 side increases at the widened portion 241; the two widened portions The parts 241 fit on both sides of the nasal septum 91 and apply a clamping force to the nasal septum 91 .
- the two connecting arms 24 of the connecting beam 2 can be symmetrically provided with protrusions 242 facing the wearer's nasal septum 91 ;
- the ends of the two connecting arms 24 of the connecting beam 2 can be provided with plugs 243, the plugs 243 are inserted into the sockets 77 provided on the elastic expansion arms 3 or the supporting spokes, and the plugs 243 are at both ends
- the wide and narrow structure in the middle realizes plug-in fixation.
- each expansion mechanism includes: an elastic expansion arm 3 , a nasal passage engaging element 4 and an elastic support spoke 7 .
- the nasal passage engaging element 4 is a sheet-like structure, which is located on the inner side of the wearer’s nose 92 , and the nasal passage engaging element 4 is connected to the end of the distal arm 33 of the elastic expansion arm 3 , a pair of surfaces parallel to the nasal passage axis 97 is its main surface and the largest surface, the pair of main surfaces are the inner main surface 41 and the outer main surface 42, the outer main surface 42 fits the inner wall of the nose 92, and Thereby, the expansion force from the elastic expansion arms 3 and the elastic support spokes 7 is applied to the alar 92, and the main surface width of the nasal passage engaging element 4 is larger than that of the distal arm 33, thereby better dispersing the expansion of the alar 92 by the expansion mechanism
- the surface of the nasal passage engaging element 4 perpendicular to the nasal passage axis 97 is the secondary surface, and the width of the secondary surface is smaller than the width of the main surface to reduce air resistance.
- the distal end of the nasal passage engaging element 4 can be bent inwardly of the nasal passage 95 to avoid irritation of the inner wall 96 of the nasal passage by the distal end thereof.
- the elastic expansion arm 3 is connected with the connecting arm 24 and the nasal passage engaging element 4, and its cross section perpendicular to the nasal passage axis 97 is a V-shaped structure, the elastic expansion arm 3 comprises: a curved part 31, the proximal arm 32 and the distal arm 33; one end of the curved portion 31 is connected to the proximal arm 32, and the other end is connected to the distal arm 33; when worn, the proximal arm 32 is close to the nasal septum 91, the distal arm 33 is close to the nose 92, and the curved portion 31 Close to the bridge of the nose 93, as shown in FIGS.
- the opening of the elastic expansion arm 3 is facing the nasal base 99 at this time; as an optimization, the proximal arm 32 of the elastic expansion arm 3 is close to the nasal septum 91, the distal arm 33 is close to the alar 92, and the curved portion 31 Close to the base of the nose 99, so that the opening of the elastic expansion arm 3 faces the nose bridge 93; a pair of surfaces of the elastic expansion arm 3 parallel to the axis 97 of the nasal passage is its main surface and the largest surface, and the pair of main surfaces is the inner main surface 34 and the outer main surface 35, the surface of the elastic expansion arm 3 perpendicular to the axis 97 of the nasal passage is the secondary surface, and the width of the secondary surface is smaller than the width of the main surface to reduce air resistance; the outer main surface 35 of the elastic expansion arm 3 is completely attached The inner wall 96 of the nose channel is closed, so that it can apply the expansion force from the elastic expansion arm 3 and the elastic support spoke 7 to the nose wing 92 .
- the elastic expansion arm 3 when wearing, the elastic expansion arm 3 is compressed by the inner wall 96 of the nasal passage, the distal arm 33 and the proximal arm 32 are close to each other, and the resilient force of the curved portion 31 urges the distal arm 33 and the nasal passage engaging element 4 to apply to the nasal alar 92
- the expansion force, thereby expanding the nasal passage, at the same time, the elastic expansion arm 3 and the nasal passage engaging element 4 are in close contact with the nasal passage inner wall 96 , and their interaction force fixes the sustained release device 1 in the nasal passage 95 .
- the elastic expansion arm 3 is an open structure, it has strong adaptability to nasal passages of different shapes and sizes, and is especially suitable for users with different sizes of left and right nasal passages caused by nasal septum deviation.
- the width of the nasal passage engaging element 4 is equal to or smaller than the width of the elastic expansion arm 3, and the main surfaces on the same side of the two are smoothly connected and merged into the same surface, that is: the inner main surface 34 and the inner
- the main surface 41 is fused into one surface
- the outer main surface 35 and the outer main surface 42 are fused into one surface.
- the elastic expansion arm 3 and the nasal passage engaging element 4 are integrated into one, and the elastic expansion arm 3 and the nasal passage engaging element 4 are both attached.
- the main surfaces of the two are actually the same surface, so they can be regarded as fused.
- the function of the nasal passage engaging element 4 is completely replaced by the elastic expansion arm 3 , and the expansion mechanism no longer includes the nasal passage engaging element 4 , but only the elastic expansion arm 3 and the elastic support spokes 7 .
- the ends of the proximal arm 32 and the distal arm 33 of the elastic expansion arm 3 are bent toward the inside of the nasal passage 95 to form a hook 36 to prevent the ends from irritating the inner wall of the nasal passage.
- the expansion mechanism has a bifurcated elastic support spoke 7, which includes: a first branch 73, a second branch 74, a third branch 75 and a fourth branch 76; wherein the first branch 73 is connected to the distal arm 33 of the elastic expansion arm 3, the second branch 74 and the fourth branch 76 are connected to the proximal arm 32, and the third branch 75 is connected to the nasal passage engaging element 4; when worn, the elastic support spokes 7 compress themselves after The resilient force is applied to the elastic expansion arm 3 and the nasal passage engaging element 4; the multiple branches of the elastic support spoke 7 make it have stronger resilience, thereby further improving the expansion effect, and at the same time, its multiple branches increase the elasticity
- the expansion arm 3 and the support point of the nasal passage engaging element 4 further improve the pertinence and balance of expansion.
- the elastic support spoke 7 is an arc-shaped belt structure, the two ends of which are connected to different positions of the inner main surface 34 of the elastic expansion arm 3;
- the band-shaped elastic support spokes 7 can improve the expansion effect and strengthen the pertinence and balance of expansion. At the same time, it also has the characteristics of simple structure and low air resistance; as an optimization, multiple band-shaped elastic support spokes 7 can be arranged according to actual needs. , in order to further enhance the expansion intensity and balance.
- each release mechanism is symmetrically arranged, each release mechanism is correspondingly arranged in each expansion mechanism, and each release mechanism includes: a fixing tube 5 and a releasing element 6 ;
- the fixing tube 5 is a circular tubular structure, which is fixed on the elastic support spokes 7, and the fixing tube 5 is used to surround and fix the release element 6; as an optimization, the fixing tube 5 can also be arranged on the elastic expansion arm 3 on the inner major surface 34, or on the inner major surface 41 of the nasal passage engaging element 4.
- the release element 6 is a structure with wide ends and a narrow middle, which includes: a hollow cylindrical medicine barrel 61, a barrel cover 62 and a barrel bottom 63 connected to and covering both ends of the medicine barrel;
- the outer diameter of the barrel cover 62 and the barrel bottom 63 is larger than the outer diameter of the medicine barrel 61.
- the release element 6 is fixed on the fixing tube 5, and the fixing tube 5 surrounds the medicine barrel 61 and is tightly engaged with it.
- the barrel cover 62 and the barrel bottom 63 are located outside the two ends of the fixed pipe 5, and its outer diameter is larger than the inner diameter of the fixed pipe 5, so that the release element 6 cannot be detached from the fixed pipe 5, and the release element 6 is located in the nose channel 95 at this time;
- a hole 621 is released to the nasal passage; the content 64 of the medicine barrel 61 is an absorption block 641 made of porous material and the liquid compound absorbed therein.
- the absorption block 641 can prevent the liquid compound from flowing out of the first hole 621, and its porous surface also Can increase the release rate of the compound.
- the release mechanism can easily replace the contents 64 of the medicine bucket, and can also replace the bucket cover 62 with different opening numbers and opening sizes to adjust the release speed, and the release element 6 can be replaced with a porous material as a whole to suit different release requirements.
- the sustained release device 1 includes: a connection mechanism, two expansion mechanisms and two release mechanisms.
- the connecting mechanism includes: a connecting beam 2 with a U-shaped structure, the connecting beam 2 half surrounds the lower end of the nasal septum 91 , the connecting beam 2 includes: a middle part located on the lower side of the nasal septum 91 23 and two connecting arms 24 located on both sides of the nasal septum 91; the two connecting arms 24 of the connecting beam 2 are inserted into the two nasal passages 95 from both sides of the nasal septum 91, which are respectively integrally connected to the two nasal passages symmetrically arranged in the two nasal passages.
- the connecting beam 2 also provides a fixing function for the sustained-release device 1, and the minimum distance between the two connecting arms 24 is smaller than the width of the nasal septum 91, so that it applies a clamping force to the nasal septum 91, thereby allowing the sustained-release device 1 to be wrapped.
- the part where the connecting beam 2 exerts the clamping force on the nasal septum 91 is the widened portion 241, and the surface of the connecting arm 24 toward the nasal septum 91 becomes wider at the widened portion 241 to increase the width of the widened portion 241 and
- the fitting area of the nasal septum 91 reduces the pressure of the widened portion 241 on the nasal septum 91 to improve comfort.
- the two connecting arms 24 of the connecting beam 2 can be symmetrically arranged with protrusions 242 facing the nasal septum 91 of the wearer; the protrusions 242 fit both sides of the nasal septum 91 and apply a clamping force to the nasal septum 91; The protrusion 242 and the widening portion 241 can be merged into the same part.
- the ends of the two connecting arms 24 of the connecting beam 2 can be provided with plugs 243, the plugs 243 are inserted into the insertion holes 77 of the elastic expansion arms 3, and the plugs 243 are wide at both ends and narrow in the middle structure to achieve plug-in fixing
- each of the expansion mechanisms comprises: an annular elastic expansion arm 3 whose main and largest surfaces are a pair of surfaces parallel to the nasal passage axis 97, the pair of main surfaces It is the inner main surface 34 and the outer main surface 35, the surface of the elastic expansion arm 3 perpendicular to the nasal passage axis 97 is the secondary surface, and the width of the secondary surface is smaller than the width of the main surface to reduce breathing resistance; when wearing, the ring-shaped elastic The expansion arm 3 is inserted into the nasal passage 95 and is compressed by the inner wall 96 of the nasal passage, and its resilience forces it to exert an expansion force on the inner wall 96 of the nasal passage.
- the sustained release device 1 is secured within the nasal passage 95 .
- the annular elastic expansion arm 3 can expand the nasal passage in all directions, and can increase the contact area between the elastic expansion arm 3 and the inner wall 96 of the nasal passage, so as to reduce the pressure of the expansion mechanism on the inner wall of the nasal passage, thereby improving comfort.
- FIG. 12 depicts the second preferred embodiment provided with bifurcated elastic support spokes 7.
- the elastic support spokes 7 include: a first branch 73, a second branch 74 and a third branch 75, all of which are The elastically compressible arc-shaped strip-shaped structure, the ends of which are connected to the upper surface of the elastic expansion arm 3, and thus apply the resilient force of the elastic support spokes 7 after being pressed to the elastic expansion arm 3.
- the multiple branches have
- the elastic support spokes 7, the fixing tube 5 and the release element 6 are all located above the elastic expansion arm 3, so that the release element 6 can penetrate deeper into the nasal passage 95 , which facilitates its release of compounds into deeper parts of the respiratory tract.
- each release mechanism is symmetrically arranged, each release mechanism is correspondingly arranged in each expansion mechanism, and each release mechanism includes: a fixed tube 5 and a release element 6;
- the fixing tube 5 is a circular tubular structure, which is fixed to the inner main surface 34 of the annular elastic expansion arm 3 , and the fixing tube 5 is used to surround and fix the release element 6 ; as shown in FIG. 12 As shown, as an optimization, the fixed tube 5 is arranged on the elastic support spokes 7 .
- the release element 6 is a structure with wide ends at both ends and a narrow middle, which includes: a tubular medicine bucket 61, a bucket cover 62 and a bucket bottom 63 connected to and covering both ends of the medicine bucket; The outer diameters of the lid 62 and the bottom 63 are larger than the outer diameter of the medicine bucket 61.
- the release element 6 is fixed on the fixing tube 5, and the fixing tube 5 surrounds the medicine bucket 61 and is tightly engaged with it.
- the bucket cover 62 and the barrel bottom 63 are located outside the two ends of the fixed pipe 5, and its outer diameter is larger than the inner diameter of the fixed pipe 5, so that the release element 6 cannot be detached from the fixed pipe 5, and the release element 6 is located in the nasal passage 95 at this time;
- a cylindrical protrusion 622 is provided, and a plurality of hemispherical protrusions 624 are provided on the outside thereof. Insert the cylindrical protrusion 622 into the open end of the medicine barrel 61, so that the hemispherical protrusion 624 is connected with the plurality of clamping holes provided at the open end of the medicine barrel 61.
- the release mechanism can easily replace the contents 64 of the medicine barrel, and can also replace the barrel cover 62 with different openings to adjust the release speed, and the release element 6 can be replaced with a porous material as a whole to suit different release requirements.
- the sustained release device 1 includes: a connection mechanism, two expansion mechanisms and two release mechanisms.
- the connecting mechanism includes: two connecting beams 2, specifically a first connecting beam 21 and a second connecting beam 22 arranged longitudinally side by side, the first connecting beam 21 and the second connecting beam 22 half surround the lower end of the nasal septum 91, and the first connecting beam 21 is a C-shaped structure, which consists of a first intermediate portion 213 located on the lower side of the nasal septum 91 and two first connecting arms 214 located on both sides of the nasal septum 91.
- the two first connecting arms 214 are inserted into the two nasal passages 95 from both sides of the nasal septum 91, and are respectively integrally connected to the expansion mechanisms symmetrically arranged in the two nasal passages 95;
- the second middle portion 223 on the lower side of the nasal septum 91 and the two second connecting arms 224 on both sides of the nasal septum 91 are formed. It is detachably connected to the expansion mechanism symmetrically arranged in the two nasal passages 95 in a plug-in manner.
- the connecting mechanism is provided with a second connecting beam 22 to supplement the clamping force.
- the second connecting beam 22 applies a clamping force to the nasal septum 91 through two parts: one is that the plugs 243 arranged at the ends of the two second connecting arms 224 transmit the clamping force to the annular elastic force through the first elastic support spokes 71
- the expansion arm 3 is then applied to the nasal septum 91 by the outer main surface 35 of the elastic expansion arm 3 close to the nasal septum 91;
- the protrusions 242 fit with both sides of the nasal septum 91 and apply a clamping force to the nasal septum 91; as an optimization, the two first connecting arms 214 of the first connecting beam 21 can be provided with protrusions 242 with the same function.
- the ends of the two second connecting arms 224 of the second connecting beam 22 are provided with plugs 243 , and the plugs 243 are inserted into the insertion holes 77 provided at the roots of the first elastic support spokes 71 to realize Plug-in fixing
- the plug 243 is a structure with wide ends and a narrow middle, which includes: a cap 2431, a post 2432 and a handle 2433; wherein, the maximum width of the cap 2431 and the handle 2433 is greater than the maximum width of the post 2432; installation Afterwards, the socket 77 surrounds the post 2432 and engages closely with it.
- the cap 2431 and the handle 2433 are located on the outer sides of the two ends of the socket 77 respectively, and the maximum width of the two is larger than the maximum width of the inner cavity of the socket 77, so that the plug 243 cannot
- the inner cavity of the column 2432 and the socket 77 is a quadrangular prism structure, and the two are tightly engaged to prevent the expansion mechanism from rotating around the plug 243; as an optimization, the two first connecting arms 214 of the first connecting beam 21
- the same plug 243 can be provided at the end of the 243 and connected to the elastic expansion arm 3 or the elastic support spoke 7 in a plug-in manner.
- the two first connecting arms 214 of the first connecting beam 21 can be symmetrically provided with widened portions 241, and the width of the surface of the first connecting arm 214 toward the side of the nasal septum 91 is increased at the widened portion 241,
- the two widened parts 241 fit on both sides of the nasal septum 91 and apply a clamping force to the nasal septum 91;
- the two second connecting arms 224 of the second connecting beam 22 can be symmetrically set with widened parts 241, and the width of the surface of the second connecting arm 224 toward the side of the nasal septum 91 increases at the widened portion 241, and the two widened portions 241 fit both sides of the nasal septum 91 and add a clamping force to the nasal septum 91;
- the widened portion 241 and the protrusion 242 can be merged into the same part.
- each expansion mechanism includes: an elastic expansion arm 3 and two elastic support spokes 7 .
- the elastic expansion arm 3 is an annular structure, which is connected with the end of the connecting arm 24 , and a pair of surfaces of the elastic expansion arm 3 parallel to the axis 97 of the nasal passage are its main surface and the largest surface , the pair of main surfaces are the inner main surface 34 and the outer main surface 35, the surface of the elastic expansion arm 3 perpendicular to the nasal passage axis 97 is the subsurface, and the width of the subsurface is smaller than the width of the main surface to reduce breathing resistance;
- the outer major surface 35 fits the inner wall 96 of the nasal passage so that it can apply the expansion force from the elastic expansion arms 3 and the elastic support spokes 7 to the nasal passage 95 , and can also apply the clamping force from the second connecting beam 22 to the nasal septum 91 .
- the elastic expansion arm 3 When wearing, the elastic expansion arm 3 is compressed by the inner wall 96 of the nasal passage, and its resilience prompts it to exert an all-round expansion force on the nasal passage 95. The force holds the sustained release device 1 within the nasal passage 95 .
- the annular elastic expansion arm 3 can expand the nasal passage in all directions, and can increase the contact area of the two to reduce the pressure of the expansion mechanism on the inner wall of the nasal passage, thereby improving comfort.
- the two elastic support spokes 7 are the first elastic support spokes 71 and the second elastic support spokes 72 , both of which are belt-like structures and are placed in the elastic expansion arms 3 at intervals, that is, One end of the first elastic support spoke 71 and the second elastic support spoke 72 is connected to the inner main surface 34 of the elastic expansion arm 3 close to the nasal septum 91, and the other end is connected to the inner main surface 34 of the elastic expansion arm 3 close to the nasal alar 92, so as to ensure its The resilient force is applied to the nose 92 in a targeted manner.
- each release mechanism is symmetrically arranged, each release mechanism is correspondingly arranged in each expansion mechanism, and each release mechanism includes: a fixed tube 5 and a release element 6;
- the inner cavity of the fixing tube 5 is a quadrangular prism structure, which is fixed on the second elastic support spokes 72, and the fixing tube 5 surrounds and fixes the release element 6; as an optimization, the fixing tube 5 can also be arranged in The support spokes 71 are arranged on the inner main surface 34 of the elastic expansion arm 3 .
- the release element 6 is a structure with wide ends and a narrow middle, and both ends and the middle are quadrangular prism structures.
- the release element 6 When worn, the release element 6 is fixed on the fixing tube 5,
- the fixing tube 5 surrounds the middle part of the release element 6 and is tightly engaged with it.
- the middle part of the release element 6 and the quadrangular prism structure of the inner cavity of the fixing tube can prevent the release element 6 from rotating.
- its maximum width is greater than the maximum width of the inner cavity of the fixed tube 5, so that the release element 6 cannot be detached from the fixed tube 5; when worn, the release element 6 is located in the nasal passage 95;
- the releasing element 6 is made of porous material, which can absorb and preserve the liquid compound. Its wider ends and porous surface are conducive to the volatilization of the compound, and it is also conducive to the inhalation airflow of the nasal passage to take away tiny compound droplets, especially , the porous material is capable of releasing non-volatile liquid compounds in the form of tiny droplets.
- the two ends of the release element 6 made of the porous material are provided with bumps 65 to further expand its surface area and increase the speed of releasing the compound.
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Abstract
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Claims (20)
- 一种在鼻通道内缓慢释放化合物的缓释装置,其特征在于,所述缓释装置(1)包括:一个连接机构、两个扩张机构和两个释放机构;所述连接机构的两端分别一体式或可拆卸式地连接对称设置在两侧鼻通道(95)内的两个扩张机构;所述两个释放机构对称设置,每个释放机构对应地设置在每个扩张机构内;所述连接机构包括至少一个连接梁(2),所述连接梁(2)半环绕于鼻中隔(91)的下端,其包括:位于鼻中隔(91)下侧的中间部(23)和对称设置于鼻中隔(91)两侧的两个连接臂(24);中间部(23)位于两个连接臂(24)之间;两个连接臂(24)分别连接对称设置在两个鼻通道(95)内的两个扩张机构;所述释放机构包括:至少一个固定管(5)和至少一个释放元件(6);所述固定管(5)为管状结构,其设置在扩张机构上;所述释放元件(6)为两端宽且中部窄的结构,佩戴时,释放元件(6)固定在固定管(5)内,固定管(5)环绕于释放元件(6)较细的中部,并与其紧密咬合,释放元件(6)的两端位于固定管(5)两端的外侧,释放元件(6)两端的最大宽度大于固定管(5)内腔的最大宽度;所述释放元件(6)能够容纳一定量的化合物,并允许所容纳的化合物在鼻通道(95)内缓慢释放,佩戴时,至少部分释放元件(6)位于鼻通道(95)内。
- 根据权利要求1所述的在鼻通道内缓慢释放化合物的缓释装置,其特征在于,所述扩张机构包括:一个弹性扩张臂(3);该弹性扩张臂(3)为环状闭合结构,其与一个连接臂(24)的端部连接;固定管(5)设置在弹性扩张臂(3)的内侧主表面(34),释放元件(6)套设在固定管(5)内。
- 根据权利要求2所述的在鼻通道内缓慢释放化合物的缓释装置,其特征在于,所述连接梁(2)的两个连接臂(24)对称地设置有加宽部(241),且连接臂(24)朝向鼻中隔(91)一侧的表面的宽度在加宽部(241)增大;所述两个加宽部(241)贴合鼻中隔(91)的两侧,并向鼻中隔(91)加包夹力。
- 根据权利要求1所述的在鼻通道内缓慢释放化合物的缓释装置,其特征在于,所述扩张机构包括:一个弹性扩张臂(3)和至少一个弹性支撑辐条(7);所述弹性扩张臂(3)为环状闭合结构,其与一个连接臂(24)的端部连接;弹性支撑辐条(7)分叉并包括多个分支,每个分支的一端连接于弹性支撑辐条(7)的主干部位,其另一端固定在弹性扩张臂(3)上;固定管(5)设置于弹性支撑辐条(7)上,释放元件(6)套设在固定管(5)内。
- 根据权利要求4所述的在鼻通道内缓慢释放化合物的缓释装置,其特征在于,所述弹性支撑辐条(7)、固定管(5)和释放元件(6)位于弹性扩张臂(3)的上方,形成倒置的碗状结构。
- 根据权利要求1所述的在鼻通道内缓慢释放化合物的缓释装置,其特征在于,所述扩张机构包括:一个弹性扩张臂(3)和至少一个弹性支撑辐条(7);所述弹性扩张臂(3)为环状闭合结构,其与一个连接臂(24)的端部连接;弹性支撑辐条(7)为带状结构,其两端连接于弹性扩张臂(3)。
- 根据权利要求6所述的在鼻通道内缓慢释放化合物的缓释装置,其特征在于,所述连接机构包括纵向并列设置的第一连接梁(21)和第二连接梁(22);第一连接梁(21)和第二连接梁(22)均半环绕于鼻中隔(91)的下端。
- 根据权利要求7所述的在鼻通道内缓慢释放化合物的缓释装置,其特征在于,所述第二连接梁(22)的两个第二连接臂(224)对称设置有朝向佩戴者的鼻中隔(91)的凸起(242);所述凸起(242)贴合鼻中隔(91)的两侧,并向鼻中隔(91)施加包夹力。
- 根据权利要求7所述的在鼻通道内缓慢释放化合物的缓释装置,其特征在于,所述第二连接梁(22)的两个第二连接臂(224)的端部设有插头(243),所述插头(243)***设置于第一弹性支撑辐条(71)根部的插孔(77)中,所述插头(243)为两端宽且中部窄的结构,实现插接式固定。
- 根据权利要求1所述的在鼻通道内缓慢释放化合物的缓释装置,其特征在于,所述扩张机构包括:一个弹性扩张臂(3)、一个鼻通道接合元件(4)和至少一个弹性支撑辐条(7);弹性扩张臂(3)为可弹性压缩的开口带状结构,其与一个连接臂(24)的端部连接,弹性扩张臂(3)的外侧主表面(35)可部分地或全部地贴合鼻通道内壁(96),使其既能够向鼻翼(92)施加来自弹性扩张臂(3)和弹性支撑辐条(7)的扩张力,也能够向鼻中隔(91)施加来自连接梁(2)的包夹力;鼻通道接合元件(4)为片状结构,其与弹性扩张臂(3)连接,并使扩张机构保持开口结构;佩戴时,鼻通道接合元件(4)位于鼻翼(92)的内侧,其外主表面(42)与鼻翼(92)的内壁贴合,并向鼻翼(92)施加来自弹性扩张臂(3)和弹性支撑辐条(7)的扩张力;弹性支撑辐条(7)为可弹性压缩的带状或条状结构,其两端连接于弹性扩张臂(3)或鼻通道接合元件(4)。
- 根据权利要求10所述的在鼻通道内缓慢释放化合物的缓释装置,其特征在于,所述弹性扩张臂(3)与鼻通道接合元件(4)融合为一体。
- 根据权利要求10所述的在鼻通道内缓慢释放化合物的缓释装置,其特征在于,所述弹性扩张臂(3)垂直于鼻通道轴线(97)的横截面为V形结构或C形结构,其包括:弯曲部(31)、近臂(32)和远臂(33);所述弯曲部(31)的一端连接近臂(32),其另一端连接远臂(33),佩戴时,近臂(32)靠近鼻中隔(91),远臂(33)靠近鼻翼(92),弯曲部(31)靠近鼻梁(93)或鼻底(99)。
- 根据权利要求10所述的在鼻通道内缓慢释放化合物的缓释装置,其特征在于,所述弹性扩张臂(3)与鼻通道内壁(96)贴合的部位,其端部向鼻通道(95)内侧弯曲;所述鼻通道接合元件(4)的端部向鼻通道(95)内侧弯曲。
- 根据权利要求10所述的在鼻通道内缓慢释放化合物的缓释装置,其特征在于,所述弹性支撑辐条(7)分叉并具有多个分支,所述每个分支的一端连接于弹性支撑辐条(7)的主干部位,其另一端固定在弹性扩张臂(3)或鼻通道接合元件(4)上。
- 根据权利要求1所述的在鼻通道内缓慢释放化合物的缓释装置,其特征在于,所述连接梁(2)向鼻中隔(91)施加包夹力,该包夹力由连接梁(2)的两个连接臂(24)直接施加于鼻中隔(91)的下端,或该包夹力由连接梁(2)的两个连接臂(24)传导至对应的扩张机构后,由对应的扩张机构施加于鼻中隔(91)的下端。
- 根据权利要求1所述的在鼻通道内缓慢释放化合物的缓释装置,其特征在于,连接梁(2)的中间部(23)的平均横截面积较连接臂(24)的平均横截面积更大。
- 根据权利要求1所述的在鼻通道内缓慢释放化合物的缓释装置,其特征在于,所述释放元件(6)包括:药桶(61),以及连接并覆盖于药桶(61)两端的桶盖(62)和桶底(63);桶盖(62)的最大直径大于药桶(61)的最大直径;桶底(63)的最大直径大于药桶(61)的最大直径;所述药桶(61)为中空的管状结构,其内部容纳有化合物,所述桶盖(62)和桶底(63)上设置有至少一个开口,使化合物通过所述开口向鼻通道(95)排出。
- 根据权利要求17所述的在鼻通道内缓慢释放化合物的缓释装置,其特征在于,所述药桶(61)内设置有多孔材料制成的吸纳块(641)。
- 根据权利要求1所述的在鼻通道内缓慢释放化合物的缓释装置,其特征在于,所 述释放元件(6)采用多孔材料制成。
- 根据权利要求19所述的在鼻通道内缓慢释放化合物的缓释装置,其特征在于,所述释放元件(6)的外表面设置有***物(65)。
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EP21938374.2A EP4331657A1 (en) | 2021-04-29 | 2021-04-29 | Slow release apparatus for slowly releasing compound in nasal passage |
CA3216564A CA3216564A1 (en) | 2021-04-29 | 2021-04-29 | Slow release apparatus for slowly releasing compound in nasal passage |
AU2021443106A AU2021443106A1 (en) | 2021-04-29 | 2021-04-29 | Slow release apparatus for slowly releasing compound in nasal passage |
JP2023566713A JP2024515869A (ja) | 2021-04-29 | 2021-04-29 | 鼻道内に化合物を徐放する徐放装置 |
CN202180089069.4A CN117279683A (zh) | 2021-04-29 | 2021-04-29 | 一种在鼻通道内缓慢释放化合物的缓释装置 |
PCT/CN2021/090988 WO2022226894A1 (zh) | 2021-04-29 | 2021-04-29 | 一种在鼻通道内缓慢释放化合物的缓释装置 |
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- 2021-04-29 AU AU2021443106A patent/AU2021443106A1/en active Pending
- 2021-04-29 CA CA3216564A patent/CA3216564A1/en active Pending
- 2021-04-29 JP JP2023566713A patent/JP2024515869A/ja active Pending
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- 2021-04-29 CN CN202180089069.4A patent/CN117279683A/zh active Pending
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US20240009411A1 (en) | 2024-01-11 |
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