WO2022129047A3 - Modulators of the nmda receptor - Google Patents

Modulators of the nmda receptor Download PDF

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Publication number
WO2022129047A3
WO2022129047A3 PCT/EP2021/085688 EP2021085688W WO2022129047A3 WO 2022129047 A3 WO2022129047 A3 WO 2022129047A3 EP 2021085688 W EP2021085688 W EP 2021085688W WO 2022129047 A3 WO2022129047 A3 WO 2022129047A3
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nmda receptor
modulators
compounds
directed
inventions
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PCT/EP2021/085688
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French (fr)
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WO2022129047A2 (en
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John Paul Kilburn
Erhad ASCIC
Mauro Marigo
Laurent David
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H. Lundbeck A/S
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Publication of WO2022129047A2 publication Critical patent/WO2022129047A2/en
Publication of WO2022129047A3 publication Critical patent/WO2022129047A3/en

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    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
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    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07C233/82Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/83Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of an acyclic saturated carbon skeleton
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Abstract

The present invention is directed to novel modulators of the NMDA receptor. Separate aspects of the inventions are directed to pharmaceutical compositions comprising said compounds and uses of the compounds to treat neurological disorders or neuropsychiatric disorders such as depression.
PCT/EP2021/085688 2020-12-16 2021-12-14 Novel modulators of the nmda receptor WO2022129047A2 (en)

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EP20214461.4 2020-12-16
EP20214461 2020-12-16

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WO2022129047A2 WO2022129047A2 (en) 2022-06-23
WO2022129047A3 true WO2022129047A3 (en) 2022-07-28

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